Compile Data Set for Download or QSAR

Found 11 hits of ec50 data for polymerid = 50004580,50006284   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50526578 (CHEMBL4468490) Show SMILES [Na;v0+].[H][C@@]12[#6]-[#8]P([#8-])(=O)[#8][C@@]1([H])[#6@@H](-[#8])-[#6@@H](-[#8]2)-n1ccc2c(-[#7])ncnc12 |r| Show InChI InChI=1S/C11H13N4O6P.Na/c12-9-5-1-2-15(10(5)14-4-13-9)11-7(16)8-6(20-11)3-19-22(17,18)21-8;/h1-2,4,6-8,11,16H,3H2,(H,17,18)(H2,12,13,14);/q;+1/p-1/t6-,7-,8-,11-;/m1./s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
University Hospital Jena Curated by ChEMBL					Assay Description Activation of recombinant mouse HCN2 expressed in Xenopus laevis oocyte assessed as increase in current amplitude at -30 mV holding potential by patc...				Bioorg Med Chem 27: 1704-1713 (2019) Article DOI: 10.1016/j.bmc.2019.03.024 BindingDB Entry DOI: 10.7270/Q2BK1GTH
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326989 (3-((Z)-4-(((R)-2-(3,4-dimethoxyphenyl)propyl)(meth...) Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21| Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326992 (CHEMBL471737 | ivabradine) Show SMILES COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC |r| Show InChI InChI=1S/C27H36N2O5/c1-28(17-21-11-20-14-25(33-4)26(34-5)16-22(20)21)8-6-9-29-10-7-18-12-23(31-2)24(32-3)13-19(18)15-27(29)30/h12-14,16,21H,6-11,15,17H2,1-5H3/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	4.52E+3	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326988 (3-(3-{[2-(3,4-Dimethoxy-phenyl)-ethyl]-methyl-amin...) Show SMILES COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC Show InChI InChI=1S/C26H36N2O5/c1-27(13-9-19-7-8-22(30-2)23(15-19)31-3)11-6-12-28-14-10-20-16-24(32-4)25(33-5)17-21(20)18-26(28)29/h7-8,15-17H,6,9-14,18H2,1-5H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	5.45E+3	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326991 (3-((E)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...) Show SMILES COc1ccc(CCN(C)C\C=C\CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15| Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.72E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326990 (3,3'-((2Z,2'Z)-4,4'-((R)-2-(3,4-dimethoxyphenyl)pr...) Show SMILES COc1ccc(cc1OC)[C@@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42| Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.83E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50535442 (CHEMBL4453882) Show SMILES COc1ccc(CCN(C)[C@@H]2CCC[C@@H](C2)N2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC |r| Show InChI InChI=1S/C29H40N2O5/c1-30(13-11-20-9-10-25(33-2)26(15-20)34-3)23-7-6-8-24(19-23)31-14-12-21-16-27(35-4)28(36-5)17-22(21)18-29(31)32/h9-10,15-17,23-24H,6-8,11-14,18-19H2,1-5H3/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.94E+4	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Inhibition of mouse HCN2 expressed in HEK293 cells assessed as reduction in hyperpolarization activated current at holding potential of -80 mV by pat...				ACS Med Chem Lett 10: 584-589 (2019) Article DOI: 10.1021/acsmedchemlett.8b00587 BindingDB Entry DOI: 10.7270/Q2M61PRS
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326993 (3-((Z)-4-((3,4-dimethoxyphenethyl)(methyl)amino)bu...) Show SMILES COc1ccc(CCN(C)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:15| Show InChI InChI=1S/C27H34N2O5/c1-28(14-10-20-8-9-23(31-2)24(16-20)32-3)12-6-7-13-29-15-11-21-17-25(33-4)26(34-5)18-22(21)19-27(29)30/h6-9,11,15-18H,10,12-14,19H2,1-5H3/b7-6-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.46E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326987 (3-((Z)-4-(((S)-2-(3,4-dimethoxyphenyl)propyl)(meth...) Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:21| Show InChI InChI=1S/C28H36N2O5/c1-20(21-9-10-24(32-3)25(15-21)33-4)19-29(2)12-7-8-13-30-14-11-22-16-26(34-5)27(35-6)17-23(22)18-28(30)31/h7-11,14-17,20H,12-13,18-19H2,1-6H3/b8-7-/t20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.55E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326986 (3,3'-((2Z,2'Z)-4,4'-((S)-2-(3,4-dimethoxyphenyl)pr...) Show SMILES COc1ccc(cc1OC)[C@H](C)CN(C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O)C\C=C/CN1C=Cc2cc(OC)c(OC)cc2CC1=O |r,c:20,42| Show InChI InChI=1S/C43H51N3O8/c1-30(31-12-13-36(49-2)37(22-31)50-3)29-44(16-8-10-18-45-20-14-32-23-38(51-4)40(53-6)25-34(32)27-42(45)47)17-9-11-19-46-21-15-33-24-39(52-5)41(54-7)26-35(33)28-43(46)48/h8-15,20-26,30H,16-19,27-29H2,1-7H3/b10-8-,11-9-/t30-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.01E+4	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (Mus musculus)	BDBM50326985 (3,3'-((2Z,2'Z)-4,4'-(3,4-dimethoxyphenethylazanedi...) Show SMILES COc1ccc(CCN(C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)C\C=C/CN2C=Cc3cc(OC)c(OC)cc3CC2=O)cc1OC |c:14,36| Show InChI InChI=1S/C42H49N3O8/c1-48-35-12-11-30(23-36(35)49-2)13-20-43(16-7-9-18-44-21-14-31-24-37(50-3)39(52-5)26-33(31)28-41(44)46)17-8-10-19-45-22-15-32-25-38(51-4)40(53-6)27-34(32)29-42(45)47/h7-12,14-15,21-27H,13,16-20,28-29H2,1-6H3/b9-7-,10-8-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.47E+5	n/a	n/a	n/a	n/a
Laboratory of Design, Synthesis, and Study of Biologically Active Heterocycles (HeteroBioLab) Curated by ChEMBL					Assay Description Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assay				J Med Chem 53: 6773-7 (2010) Article DOI: 10.1021/jm1006758 BindingDB Entry DOI: 10.7270/Q2T43T9J
					More data for this Ligand-Target Pair