BindingDB PrimarySearch

Found 16 hits of ec50 data for polymerid = 5580,9613
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin S (Homo sapiens (Human))	BDBM19859 ((2S)-N-(cyanomethyl)-3-cyclohexyl-2-(phenylformami...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30	n/a	10	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19859 ((2S)-N-(cyanomethyl)-3-cyclohexyl-2-(phenylformami...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	40	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50322923 (6-(4-(3-(4-methylpiperazin-1-yl)propoxy)-3-(triflu...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	n/a	n/a	138	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of cathepsin S in human JY cells assessed as induction of accumulation of lip10				Bioorg Med Chem Lett 20: 4507-10 (2010) Article DOI: 10.1016/j.bmcl.2010.06.043 BindingDB Entry DOI: 10.7270/Q2SJ1KTF
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cathepsin S (Mus musculus (Mouse))	BDBM19854 (CHEMBL426819 \| CRA-013783/L-006235 \| N-{1-[(cyanom...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	318	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19855 (Balicatib \| CHEMBL371064 \| N-[1-(cyanomethylcarbam...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.35E+3	n/a	480	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50546794 (CHEMBL4777335) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	580	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Cathepsin S in human Raji cells assessed as increase in Lip10 accumulation after 24 hrs by SDS-PAGE analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00949 BindingDB Entry DOI: 10.7270/Q2NV9NVM
TBA					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19856 ((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.41E+4	n/a	740	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19854 (CHEMBL426819 \| CRA-013783/L-006235 \| N-{1-[(cyanom...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+4	n/a	790	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50546795 (CHEMBL4777740) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Cathepsin S in human Raji cells assessed as increase in Lip10 accumulation after 24 hrs by SDS-PAGE analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00949 BindingDB Entry DOI: 10.7270/Q2NV9NVM
TBA					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19856 ((2R)-N-(cyanomethyl)-4-methyl-2-{3-[4-(piperazin-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	1.34E+3	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19855 (Balicatib \| CHEMBL371064 \| N-[1-(cyanomethylcarbam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.50E+4	n/a	2.90E+3	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19858 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-(morpho...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.20E+4	n/a	4.80E+3	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19857 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(mor...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.50E+3	n/a	6.70E+3	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19858 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-(morpho...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.50E+3	n/a	8.50E+3	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Mus musculus (Mouse))	BDBM19860 (4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]-N-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM19857 (N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(mor...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	>1.00E+4	n/a	n/a	6.5	22
Merck Frosst Centre for Therapeutic Research					Assay Description Prior to the addition of substrate, different concentrations of the inhibitor ranging from 100 uM to 0.2 nM were preincubated for 15 min with enzyme ...				J Med Chem 48: 7535-43 (2005) Article DOI: 10.1021/jm0504961 BindingDB Entry DOI: 10.7270/Q28S4N63
Merck Frosst Centre for Therapeutic Research					More data for this Ligand-Target Pair