Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50426655 (CHEMBL2326201) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0240 | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured... | Bioorg Med Chem 21: 547-52 (2012) Article DOI: 10.1016/j.bmc.2012.10.060 BindingDB Entry DOI: 10.7270/Q29W0GTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50426657 (CHEMBL2326199) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured... | Bioorg Med Chem 21: 547-52 (2012) Article DOI: 10.1016/j.bmc.2012.10.060 BindingDB Entry DOI: 10.7270/Q29W0GTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575514 (CHEMBL4852440) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0500 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575513 (CHEMBL4873903) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.0690 | n/a | n/a | n/a | n/a |
IQM-CSIC Curated by ChEMBL | Assay Description Agonist activity at human melatonin receptor-2 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay | J Med Chem 58: 4998-5014 (2015) Article DOI: 10.1021/acs.jmedchem.5b00245 BindingDB Entry DOI: 10.7270/Q2JM2CDG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230959 (CHEMBL4084612) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575516 (CHEMBL4874954) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50114703 (CHEMBL287560 | N-[2-(5-Methoxy-2-phenyl-benzofuran...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 0.0960 | n/a | n/a | n/a | n/a |
Institut de Chimie Pharmaceutique Albert Lespagnol Curated by ChEMBL | Assay Description Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cells | J Med Chem 45: 2788-800 (2002) BindingDB Entry DOI: 10.7270/Q2Q52P0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230951 (CHEMBL4095210) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
University of Lille 2 Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 16: 8339-48 (2008) Article DOI: 10.1016/j.bmc.2008.08.052 BindingDB Entry DOI: 10.7270/Q24B314N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Univ Lille Nord de France Curated by ChEMBL | Assay Description Agonist activity at human human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay | Bioorg Med Chem 18: 3426-36 (2010) Article DOI: 10.1016/j.bmc.2010.04.008 BindingDB Entry DOI: 10.7270/Q29S1S07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B | J Med Chem 46: 1127-9 (2003) Article DOI: 10.1021/jm0255872 BindingDB Entry DOI: 10.7270/Q2FT8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50426656 (CHEMBL2326200) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured... | Bioorg Med Chem 21: 547-52 (2012) Article DOI: 10.1016/j.bmc.2012.10.060 BindingDB Entry DOI: 10.7270/Q29W0GTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50114707 (But-3-enoic acid [2-(2-benzyl-5-methoxy-benzofuran...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 0.170 | n/a | n/a | n/a | n/a |
Institut de Chimie Pharmaceutique Albert Lespagnol Curated by ChEMBL | Assay Description Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cells | J Med Chem 45: 2788-800 (2002) BindingDB Entry DOI: 10.7270/Q2Q52P0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.174 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00717 BindingDB Entry DOI: 10.7270/Q2Z323P9 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 141: 552-566 (2017) Article DOI: 10.1016/j.ejmech.2017.10.025 BindingDB Entry DOI: 10.7270/Q2CC13BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.180 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 109: 360-70 (2016) Article DOI: 10.1016/j.ejmech.2015.12.047 BindingDB Entry DOI: 10.7270/Q2VM4F3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575515 (CHEMBL4872217) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.190 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230958 (CHEMBL4071572) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230961 (CHEMBL4062947) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50464412 (CHEMBL4278248) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 141: 552-566 (2017) Article DOI: 10.1016/j.ejmech.2017.10.025 BindingDB Entry DOI: 10.7270/Q2CC13BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230955 (CHEMBL4102177) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50464400 (CHEMBL4293386) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 141: 552-566 (2017) Article DOI: 10.1016/j.ejmech.2017.10.025 BindingDB Entry DOI: 10.7270/Q2CC13BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50426653 (CHEMBL2326203) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured... | Bioorg Med Chem 21: 547-52 (2012) Article DOI: 10.1016/j.bmc.2012.10.060 BindingDB Entry DOI: 10.7270/Q29W0GTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50035179 (Agomelatine | CHEMBL10878 | N-[2-(7-Methoxy-naphth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112078 BindingDB Entry DOI: 10.7270/Q2SF30SP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50426654 (CHEMBL2326202) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a |
Hong Kong University of Science and Technology Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured... | Bioorg Med Chem 21: 547-52 (2012) Article DOI: 10.1016/j.bmc.2012.10.060 BindingDB Entry DOI: 10.7270/Q29W0GTX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575511 (CHEMBL4859677) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.260 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM463444 (US10781182, Compound IA2-121 | US11091445, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.270 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM463446 (US10781182, Compound IA2-142 | US11091445, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50464421 (CHEMBL4286896) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 141: 552-566 (2017) Article DOI: 10.1016/j.ejmech.2017.10.025 BindingDB Entry DOI: 10.7270/Q2CC13BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM463443 (US10781182, Compound IA2-120 | US11091445, Compoun...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.350 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50114701 (But-3-enoic acid {2-[5-methoxy-2-(3-methoxy-benzyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | n/a | 0.390 | n/a | n/a | n/a | n/a |
Institut de Chimie Pharmaceutique Albert Lespagnol Curated by ChEMBL | Assay Description Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cells | J Med Chem 45: 2788-800 (2002) BindingDB Entry DOI: 10.7270/Q2Q52P0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50464407 (CHEMBL4292336) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Univ. Lille Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 141: 552-566 (2017) Article DOI: 10.1016/j.ejmech.2017.10.025 BindingDB Entry DOI: 10.7270/Q2CC13BX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50230957 (CHEMBL4082097) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a |
Universit£ de Lille Curated by ChEMBL | Assay Description Intrinsic activity at human MT2 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay | Eur J Med Chem 127: 621-631 (2017) Article DOI: 10.1016/j.ejmech.2016.12.013 BindingDB Entry DOI: 10.7270/Q24F1SZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50114702 (CHEMBL329960 | N-{2-[5-Methoxy-2-(2-methoxy-benzyl...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | n/a | n/a | 0.410 | n/a | n/a | n/a | n/a |
Institut de Chimie Pharmaceutique Albert Lespagnol Curated by ChEMBL | Assay Description Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cells | J Med Chem 45: 2788-800 (2002) BindingDB Entry DOI: 10.7270/Q2Q52P0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50598933 (CHEMBL5174929) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.417 | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00717 BindingDB Entry DOI: 10.7270/Q2Z323P9 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.420 | n/a | n/a | n/a | n/a |
Universit£ d'Orl£ans Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay | Bioorg Med Chem Lett 21: 2316-9 (2011) Article DOI: 10.1016/j.bmcl.2011.02.097 BindingDB Entry DOI: 10.7270/Q27H1JWM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank PubMed | n/a | n/a | n/a | n/a | 0.470 | n/a | n/a | n/a | n/a |
Institut de Chimie Pharmaceutique Albert Lespagnol Curated by ChEMBL | Assay Description Intrinsic activity at human Melatonin receptor type 1B evaluated on [35S]-GTP-gammaS, binding in Chinese hamster ovarian (CHO) cells | J Med Chem 45: 2788-800 (2002) BindingDB Entry DOI: 10.7270/Q2Q52P0W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
University of Lille 2 Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 16: 8339-48 (2008) Article DOI: 10.1016/j.bmc.2008.08.052 BindingDB Entry DOI: 10.7270/Q24B314N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
Université de Lille 2 Curated by ChEMBL | Assay Description Agonist potency determined by [35S]-GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1B | J Med Chem 46: 1127-9 (2003) Article DOI: 10.1021/jm0255872 BindingDB Entry DOI: 10.7270/Q2FT8KDC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM9019 (CHEMBL45 | Melatonin | N-[2-(5-methoxy-1H-indol-3-...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank Article PubMed | n/a | n/a | n/a | n/a | 0.490 | n/a | n/a | n/a | n/a |
Univ Lille Nord de France Curated by ChEMBL | Assay Description Agonist activity at human human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay | Bioorg Med Chem 18: 3426-36 (2010) Article DOI: 10.1016/j.bmc.2010.04.008 BindingDB Entry DOI: 10.7270/Q29S1S07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50263551 (CHEMBL477835 | N-[2-(3-(3-Methylaminophenyl)-7-met...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a |
University of Lille 2 Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 16: 8339-48 (2008) Article DOI: 10.1016/j.bmc.2008.08.052 BindingDB Entry DOI: 10.7270/Q24B314N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM103443 (US8552037, 90) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.510 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaS... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01836 BindingDB Entry DOI: 10.7270/Q25H7M2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575512 (CHEMBL4854625) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.520 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50347588 (CHEMBL1802025) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.530 | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel p... | J Med Chem 54: 4207-18 (2011) Article DOI: 10.1021/jm200385u BindingDB Entry DOI: 10.7270/Q2HT2PN3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50575517 (CHEMBL4869463) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.560 | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00627 BindingDB Entry DOI: 10.7270/Q2Z03CZJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50263662 (CHEMBL476341 | N-[2-(3-(3-Hydroxymethylphenyl)-7-m...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
University of Lille 2 Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgammaS binding assay | Bioorg Med Chem 16: 8339-48 (2008) Article DOI: 10.1016/j.bmc.2008.08.052 BindingDB Entry DOI: 10.7270/Q24B314N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Melatonin receptor type 1B (Homo sapiens (Human)) | BDBM50343992 (CHEMBL1779804 | N-(2-(5-fluoro-2-(4-fluorophenylth...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a |
Universit£ Lille Nord de France Curated by ChEMBL | Assay Description Agonist activity at human MT2 receptor expressed in CHO cells by [35S]GTPgamma binding assay | Eur J Med Chem 46: 1835-40 (2011) Article DOI: 10.1016/j.ejmech.2011.02.044 BindingDB Entry DOI: 10.7270/Q27D2VG9 | |||||||||||
More data for this Ligand-Target Pair |
Displayed 1 to 50 (of 205 total ) | Next | Last >> |