Compile Data Set for Download or QSAR

Found 1089 hits of ec50 data for polymerid = 5747   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392432 (CHEMBL2151817) Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C |r| Show InChI InChI=1S/C19H23FN2O2/c1-13(19(2,3)4)22-18(23)15-8-9-17(21-11-15)24-12-14-6-5-7-16(20)10-14/h5-11,13H,12H2,1-4H3,(H,22,23)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.20	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392432 (CHEMBL2151817) Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C(C)(C)C |r| Show InChI InChI=1S/C19H23FN2O2/c1-13(19(2,3)4)22-18(23)15-8-9-17(21-11-15)24-12-14-6-5-7-16(20)10-14/h5-11,13H,12H2,1-4H3,(H,22,23)/t13-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.24	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187644 (4-nitro-N-(1-(2-fluorophenyl)-3-phenyl-1H-pyrazol-...) Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1F)-c1ccccc1 Show InChI InChI=1S/C22H15FN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.60	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187615 (4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide ...) Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O3/c27-22(17-11-13-19(14-12-17)26(28)29)23-21-15-20(16-7-3-1-4-8-16)24-25(21)18-9-5-2-6-10-18/h1-15H,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	10.7	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187616 (3,4-dichloro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benza...) Show SMILES Clc1ccc(cc1Cl)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H15Cl2N3O/c23-18-12-11-16(13-19(18)24)22(28)25-21-14-20(15-7-3-1-4-8-15)26-27(21)17-9-5-2-6-10-17/h1-14H,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392447 (CHEMBL2151815) Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C1CCCCC1 |r| Show InChI InChI=1S/C21H25FN2O2/c1-15(17-7-3-2-4-8-17)24-21(25)18-10-11-20(23-13-18)26-14-16-6-5-9-19(22)12-16/h5-6,9-13,15,17H,2-4,7-8,14H2,1H3,(H,24,25)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392447 (CHEMBL2151815) Show SMILES C[C@@H](NC(=O)c1ccc(OCc2cccc(F)c2)nc1)C1CCCCC1 |r| Show InChI InChI=1S/C21H25FN2O2/c1-15(17-7-3-2-4-8-17)24-21(25)18-10-11-20(23-13-18)26-14-16-6-5-9-19(22)12-16/h5-6,9-13,15,17H,2-4,7-8,14H2,1H3,(H,24,25)/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	15.1	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50337958 (CHEMBL1684242 | N-cyclobutyl-6-((3-fluorophenyl)et...) Show SMILES Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1 Show InChI InChI=1S/C18H15FN2O/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187636 (4-trifluoromethoxy-N-(1,3-diphenyl-1H-pyrazol-5-yl...) Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H16F3N3O2/c24-23(25,26)31-19-13-11-17(12-14-19)22(30)27-21-15-20(16-7-3-1-4-8-16)28-29(21)18-9-5-2-6-10-18/h1-15H,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156068 (CHEMBL190326 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-13-11-17(12-14-18)22(30)27-21-15-20(16-7-3-1-4-8-16)28-29(21)19-9-5-2-6-10-19/h1-15H,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187633 (3,4-dimethyl-N-(1,3-diphenyl-1H-pyrazol-5-yl)benza...) Show SMILES Cc1ccc(cc1C)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C24H21N3O/c1-17-13-14-20(15-18(17)2)24(28)25-23-16-22(19-9-5-3-6-10-19)26-27(23)21-11-7-4-8-12-21/h3-16H,1-2H3,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156071 (3-Cyano-N-(2,5-diphenyl-2H-pyrazol-3-yl)-benzamide...) Show SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)c1cccc(c1)C#N Show InChI InChI=1S/C23H16N4O/c24-16-17-8-7-11-19(14-17)23(28)25-22-15-21(18-9-3-1-4-10-18)26-27(22)20-12-5-2-6-13-20/h1-15H,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156076 (CHEMBL191147 | N-(2,5-Diphenyl-2H-pyrazol-3-yl)-3,...) Show SMILES Fc1ccc(cc1F)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H15F2N3O/c23-18-12-11-16(13-19(18)24)22(28)25-21-14-20(15-7-3-1-4-8-15)26-27(21)17-9-5-2-6-10-17/h1-14H,(H,25,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	20	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392439 (CHEMBL2151806) Show SMILES Fc1cccc(COc2ccc(cn2)C(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C19H21FN2O2/c20-16-6-4-5-14(11-16)13-24-18-10-9-15(12-21-18)19(23)22-17-7-2-1-3-8-17/h4-6,9-12,17H,1-3,7-8,13H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	28.8	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392439 (CHEMBL2151806) Show SMILES Fc1cccc(COc2ccc(cn2)C(=O)NC2CCCCC2)c1 Show InChI InChI=1S/C19H21FN2O2/c20-16-6-4-5-14(11-16)13-24-18-10-9-15(12-21-18)19(23)22-17-7-2-1-3-8-17/h4-6,9-12,17H,1-3,7-8,13H2,(H,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392425 (CHEMBL2151790) Show SMILES CCCCOc1ccc(cc1)C(=O)Nc1ccc(F)cc1F Show InChI InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392438 (CHEMBL2151805) Show SMILES O=C(NC1CCCCC1)c1ccc(OCc2ccccc2)nc1 Show InChI InChI=1S/C19H22N2O2/c22-19(21-17-9-5-2-6-10-17)16-11-12-18(20-13-16)23-14-15-7-3-1-4-8-15/h1,3-4,7-8,11-13,17H,2,5-6,9-10,14H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	33.9	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50231741 (2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one | CH...) Show SMILES O=C1CCCc2nc(ccc12)C#Cc1ccccc1 Show InChI InChI=1S/C17H13NO/c19-17-8-4-7-16-15(17)12-11-14(18-16)10-9-13-5-2-1-3-6-13/h1-3,5-6,11-12H,4,7-8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Institute of Organic Synthesis Curated by ChEMBL					Assay Description Antagonist activity at mGluR5 in Sprague-Dawley rat astrocyte assessed as L-quisqualate induced potensiation of intracellular calcium level by FLIPR ...				J Med Chem 51: 634-47 (2008) Article DOI: 10.1021/jm0611298 BindingDB Entry DOI: 10.7270/Q2QC04B2
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50392438 (CHEMBL2151805) Show SMILES O=C(NC1CCCCC1)c1ccc(OCc2ccccc2)nc1 Show InChI InChI=1S/C19H22N2O2/c22-19(21-17-9-5-2-6-10-17)16-11-12-18(20-13-16)23-14-15-7-3-1-4-8-15/h1,3-4,7-8,11-13,17H,2,5-6,9-10,14H2,(H,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	34	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR5 expressed in human HEK293 cells assessed as calcium mobilization				Bioorg Med Chem Lett 22: 6481-5 (2012) Article DOI: 10.1016/j.bmcl.2012.08.043 BindingDB Entry DOI: 10.7270/Q2KD200S
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047409 (CHEMBL3309851) Show SMILES Fc1ccc(cc1)C1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C20H17FN2O2/c21-15-8-6-14(7-9-15)18-10-11-23-19(20(18)24)12-16(22-23)13-25-17-4-2-1-3-5-17/h1-9,12,18H,10-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047409 (CHEMBL3309851) Show SMILES Fc1ccc(cc1)C1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C20H17FN2O2/c21-15-8-6-14(7-9-15)18-10-11-23-19(20(18)24)12-16(22-23)13-25-17-4-2-1-3-5-17/h1-9,12,18H,10-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	35	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156068 (CHEMBL190326 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES FC(F)(F)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-13-11-17(12-14-18)22(30)27-21-15-20(16-7-3-1-4-8-16)28-29(21)19-9-5-2-6-10-19/h1-15H,(H,27,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	38	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187650 (3-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide ...) Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H16N4O3/c27-22(17-10-7-13-19(14-17)26(28)29)23-21-15-20(16-8-3-1-4-9-16)24-25(21)18-11-5-2-6-12-18/h1-15H,(H,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	39	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187625 (4-nitro-N-(1-(2-chlorophenyl)-3-phenyl-1H-pyrazol-...) Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1Cl)-c1ccccc1 Show InChI InChI=1S/C22H15ClN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187622 ((5-(4-cyanobenzoyl)imino-2-(4-cyanobenzoyl)-1,3-di...) Show SMILES O=C(\N=c1/cc(-c2ccccc2)n(C(=O)c2ccc(cc2)C#N)n1-c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C31H19N5O2/c32-20-22-11-15-25(16-12-22)30(37)34-29-19-28(24-7-3-1-4-8-24)36(35(29)27-9-5-2-6-10-27)31(38)26-17-13-23(21-33)14-18-26/h1-19H/b34-29+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047408 (CHEMBL3309852) Show SMILES COc1ccccc1C1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C21H20N2O3/c1-25-20-10-6-5-9-17(20)18-11-12-23-19(21(18)24)13-15(22-23)14-26-16-7-3-2-4-8-16/h2-10,13,18H,11-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047408 (CHEMBL3309852) Show SMILES COc1ccccc1C1CCn2nc(COc3ccccc3)cc2C1=O Show InChI InChI=1S/C21H20N2O3/c1-25-20-10-6-5-9-17(20)18-11-12-23-19(21(18)24)13-15(22-23)14-26-16-7-3-2-4-8-16/h2-10,13,18H,11-12,14H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	44	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122118 (CHEMBL3617495) Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccccc3)nn12)c1ccc(F)cc1 |r| Show InChI InChI=1S/C20H18FN3O2/c1-14-12-23(17-9-7-15(21)8-10-17)20(25)19-11-16(22-24(14)19)13-26-18-5-3-2-4-6-18/h2-11,14H,12-13H2,1H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay				J Med Chem 58: 7485-500 (2015) Article DOI: 10.1021/acs.jmedchem.5b01005 BindingDB Entry DOI: 10.7270/Q2H9970P
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50122118 (CHEMBL3617495) Show SMILES C[C@@H]1CN(C(=O)c2cc(COc3ccccc3)nn12)c1ccc(F)cc1 |r| Show InChI InChI=1S/C20H18FN3O2/c1-14-12-23(17-9-7-15(21)8-10-17)20(25)19-11-16(22-24(14)19)13-26-18-5-3-2-4-6-18/h2-11,14H,12-13H2,1H3/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	46	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Modulation of rat mGlu5 receptor assessed as calcium mobilization by cell based fluorescence assay				J Med Chem 58: 7485-500 (2015) Article DOI: 10.1021/acs.jmedchem.5b01005 BindingDB Entry DOI: 10.7270/Q2H9970P
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047407 (CHEMBL3310739) Show SMILES O=C1c2cc(COc3ccccc3)nn2CCC11CCCC1 Show InChI InChI=1S/C18H20N2O2/c21-17-16-12-14(13-22-15-6-2-1-3-7-15)19-20(16)11-10-18(17)8-4-5-9-18/h1-3,6-7,12H,4-5,8-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50047407 (CHEMBL3310739) Show SMILES O=C1c2cc(COc3ccccc3)nn2CCC11CCCC1 Show InChI InChI=1S/C18H20N2O2/c21-17-16-12-14(13-22-15-6-2-1-3-7-15)19-20(16)11-10-18(17)8-4-5-9-18/h1-3,6-7,12H,4-5,8-11,13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 24: 3641-6 (2014) Article DOI: 10.1016/j.bmcl.2014.04.087 BindingDB Entry DOI: 10.7270/Q2GT5PT5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156064 (CHEMBL362527 | N-(2,5-Diphenyl-2H-pyrazol-3-yl)-4-...) Show SMILES Fc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H16FN3O/c23-18-13-11-17(12-14-18)22(27)24-21-15-20(16-7-3-1-4-8-16)25-26(21)19-9-5-2-6-10-19/h1-15H,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187629 (3-cyano-N-(1-(2-bromophenyl)-3-phenyl-1H-pyrazol-5...) Show SMILES Brc1ccccc1-n1nc(cc1NC(=O)c1cccc(c1)C#N)-c1ccccc1 Show InChI InChI=1S/C23H15BrN4O/c24-19-11-4-5-12-21(19)28-22(14-20(27-28)17-8-2-1-3-9-17)26-23(29)18-10-6-7-16(13-18)15-25/h1-14H,(H,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393885 (US10597367, Example 182 | US9969726, Example 182) Show SMILES Brc1ccc2N=C(CC(=O)Nc2c1)c1ccnc(c1)C#N |c:5| Show InChI InChI=1S/C15H9BrN4O/c16-10-1-2-12-14(6-10)20-15(21)7-13(19-12)9-3-4-18-11(5-9)8-17/h1-6H,7H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	50	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187639 (4-methoxy-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamid...) Show SMILES COc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O2/c1-28-20-14-12-18(13-15-20)23(27)24-22-16-21(17-8-4-2-5-9-17)25-26(22)19-10-6-3-7-11-19/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	54	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50416941 (CHEMBL1257595) Show SMILES CCC(=O)N1[C@@H](Oc2nc(SCC=C)nnc2-c2ccccc12)c1cccs1 |r| Show InChI InChI=1S/C20H18N4O2S2/c1-3-11-28-20-21-18-17(22-23-20)13-8-5-6-9-14(13)24(16(25)4-2)19(26-18)15-10-7-12-27-15/h3,5-10,12,19H,1,4,11H2,2H3/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	57.5	n/a	n/a	n/a	n/a
Vanderbilt University Curated by ChEMBL					Assay Description Inhibition of rat mGluR1 expressed in HEK293 cells				Bioorg Med Chem Lett 20: 5922-4 (2010) Article DOI: 10.1016/j.bmcl.2010.07.061 BindingDB Entry DOI: 10.7270/Q2XS5WN3
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50132507 (CHEMBL3633943) Show SMILES CC(=O)N1CCCn2nc(COc3ccccc3)cc12 Show InChI InChI=1S/C15H17N3O2/c1-12(19)17-8-5-9-18-15(17)10-13(16-18)11-20-14-6-3-2-4-7-14/h2-4,6-7,10H,5,8-9,11H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Effective concentration against retinoic acid receptor gamma in COS-7 cells co-expressing DR5-tk-CAT reporter; value range (0.6-1.5)				Bioorg Med Chem Lett 25: 5115-20 (2015) Article DOI: 10.1016/j.bmcl.2015.10.009 BindingDB Entry DOI: 10.7270/Q2445P80
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM393849 (US10597367, Example 137 | US9969726, Example 137) Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)S(=O)(=O)c1ncccn1 |c:4| Show InChI InChI=1S/C21H15F3N4O3S/c1-12-8-17-18(10-15(12)21(22,23)24)28-19(29)11-16(27-17)13-4-2-5-14(9-13)32(30,31)20-25-6-3-7-26-20/h2-10H,11H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	n/a
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10597367 (2020) BindingDB Entry DOI: 10.7270/Q2GB272Z
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187631 (4-nitro-N-(1-(2-bromophenyl)-3-phenyl-1H-pyrazol-5...) Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1Br)-c1ccccc1 Show InChI InChI=1S/C22H15BrN4O3/c23-18-8-4-5-9-20(18)26-21(14-19(25-26)15-6-2-1-3-7-15)24-22(28)16-10-12-17(13-11-16)27(29)30/h1-14H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	61	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187621 (CHEMBL377307 | N-(1-(2-chlorophenyl)-3-phenyl-1H-p...) Show SMILES Clc1ccccc1-n1nc(cc1NC(=O)c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H16ClN3O/c23-18-13-7-8-14-20(18)26-21(24-22(27)17-11-5-2-6-12-17)15-19(25-26)16-9-3-1-4-10-16/h1-15H,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50022821 (CHEMBL3298275) Show SMILES Clc1cccc(COc2ccc3C(=O)NCCc3n2)c1 Show InChI InChI=1S/C15H13ClN2O2/c16-11-3-1-2-10(8-11)9-20-14-5-4-12-13(18-14)6-7-17-15(12)19/h1-5,8H,6-7,9H2,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	62	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...				J Med Chem 57: 5620-37 (2014) Article DOI: 10.1021/jm500259z BindingDB Entry DOI: 10.7270/Q2736SHB
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156069 (CHEMBL365409 | N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-...) Show SMILES Cc1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H19N3O/c1-17-12-14-19(15-13-17)23(27)24-22-16-21(18-8-4-2-5-9-18)25-26(22)20-10-6-3-7-11-20/h2-16H,1H3,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187653 (3,5-dinitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzam...) Show SMILES [O-][N+](=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H15N5O5/c28-22(16-11-18(26(29)30)13-19(12-16)27(31)32)23-21-14-20(15-7-3-1-4-8-15)24-25(21)17-9-5-2-6-10-17/h1-14H,(H,23,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50156073 (CHEMBL194051 | N-(2,5-Diphenyl-2H-pyrazol-3-yl)-3-...) Show SMILES Fc1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C22H16FN3O/c23-18-11-7-10-17(14-18)22(27)24-21-15-20(16-8-3-1-4-9-16)25-26(21)19-12-5-2-6-13-19/h1-15H,(H,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	65	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Effective concentration against metabotropic glutamate receptor 5 of rat				J Med Chem 47: 5825-8 (2004) Article DOI: 10.1021/jm049400d BindingDB Entry DOI: 10.7270/Q2HQ3ZC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50187617 (3-nitro-N-(1-(2-bromophenyl)-3-phenyl-1H-pyrazol-5...) Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)Nc1cc(nn1-c1ccccc1Br)-c1ccccc1 Show InChI InChI=1S/C22H15BrN4O3/c23-18-11-4-5-12-20(18)26-21(14-19(25-26)15-7-2-1-3-8-15)24-22(28)16-9-6-10-17(13-16)27(29)30/h1-14H,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	68	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Activity at mGluR5 assessed as potentiation of glutamate-induced calcium flux in rat astrocytes				J Med Chem 49: 3332-44 (2006) Article DOI: 10.1021/jm051252j BindingDB Entry DOI: 10.7270/Q2PR7VK1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50402800 (CHEMBL2208412) Show SMILES CC(N(c1ccccc1Cl)S(C)(=O)=O)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C16H16Cl2N2O3S/c1-11(16(21)19-13-7-5-6-12(17)10-13)20(24(2,22)23)15-9-4-3-8-14(15)18/h3-11H,1-2H3,(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	68	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Ago-positive allosteric modulation of rat mGlu5 receptor expressed in HEK293 cells by fluorescence-based calcium flux assay				Bioorg Med Chem Lett 22: 7388-92 (2012) Article DOI: 10.1016/j.bmcl.2012.10.068 BindingDB Entry DOI: 10.7270/Q2H996BR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50064432 (CHEMBL3400160) Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3cccc(F)c3)cn2C1=O Show InChI InChI=1S/C19H15F2N3O2/c20-13-4-6-16(7-5-13)23-9-8-18-22-15(11-24(18)19(23)25)12-26-17-3-1-2-14(21)10-17/h1-7,10-11H,8-9,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50064432 (CHEMBL3400160) Show SMILES Fc1ccc(cc1)N1CCc2nc(COc3cccc(F)c3)cn2C1=O Show InChI InChI=1S/C19H15F2N3O2/c20-13-4-6-16(7-5-13)23-9-8-18-22-15(11-24(18)19(23)25)12-26-17-3-1-2-14(21)10-17/h1-7,10-11H,8-9,12H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a
Janssen Research and Development Curated by ChEMBL					Assay Description Positive allosteric modulation at rat mGluR5 expressed in HEK293 cells by calcium mobilization assay				Bioorg Med Chem Lett 25: 1310-7 (2015) Article DOI: 10.1016/j.bmcl.2015.01.038 BindingDB Entry DOI: 10.7270/Q2057HNQ
					More data for this Ligand-Target Pair

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