Compile Data Set for Download or QSAR

Found 14 hits of ec50 data for polymerid = 6477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50565738 (CHEMBL4794404) Show SMILES CN1CCN(CC(=O)Nc2nc(C)c(s2)-c2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)CC1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	29	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of TEL fused wild type TRKC (unknown origin) transfected in mouse BaF3 cells assessed as reduction in phosphorylation at Y516 residue afte...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112744 BindingDB Entry DOI: 10.7270/Q20V8HJN
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	30	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of TrkC by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505017 (CHEMBL4462161) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(C)c2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-7-6-8-18(15-17)27-23(29)26-24(30)28(25(27)31)19-11-12-21(22(16-19)33-14-13-32-2)34-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505011 (CHEMBL4529332) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(C)cc2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-8-10-18(11-9-17)27-23(29)26-24(30)28(25(27)31)19-12-13-21(22(16-19)33-15-14-32-2)34-20-6-4-3-5-7-20/h3-13,16H,14-15H2,1-2H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505010 (CHEMBL4455143) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-12-13-33-21-15-18(10-11-20(21)34-19-8-3-2-4-9-19)28-23(30)26-22(29)27(24(28)31)17-7-5-6-16(25)14-17/h2-11,14-15H,12-13H2,1H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505015 (CHEMBL4538772) Show SMILES Brc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C21H14BrN3O4/c22-17-13-15(11-12-18(17)29-16-9-5-2-6-10-16)25-20(27)23-19(26)24(21(25)28)14-7-3-1-4-8-14/h1-13H,(H,23,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	190	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505013 (CHEMBL4574315) Show SMILES Cn1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c1=O Show InChI InChI=1S/C20H19N3O6/c1-22-18(24)21-19(25)23(20(22)26)14-7-8-16(29-15-5-3-2-4-6-15)17(9-14)28-12-13-10-27-11-13/h2-9,13H,10-12H2,1H3,(H,21,24,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505005 (CHEMBL4455810) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(Cl)cc2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-13-14-33-21-15-18(11-12-20(21)34-19-5-3-2-4-6-19)28-23(30)26-22(29)27(24(28)31)17-9-7-16(25)8-10-17/h2-12,15H,13-14H2,1H3,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505012 (CHEMBL4472787) Show SMILES CC(C)Oc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C24H21N3O5/c1-16(2)31-21-15-18(13-14-20(21)32-19-11-7-4-8-12-19)27-23(29)25-22(28)26(24(27)30)17-9-5-3-6-10-17/h3-16H,1-2H3,(H,25,28,29)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	330	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505014 (CHEMBL4467829) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OC3CCOC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)17-7-3-1-4-8-17)18-11-12-21(33-19-9-5-2-6-10-19)22(15-18)34-20-13-14-32-16-20/h1-12,15,20H,13-14,16H2,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505016 (CHEMBL4527488) Show SMILES CCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C23H19N3O5/c1-2-30-20-15-17(13-14-19(20)31-18-11-7-4-8-12-18)26-22(28)24-21(27)25(23(26)29)16-9-5-3-6-10-16/h3-15H,2H2,1H3,(H,24,27,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	510	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505019 (CHEMBL4465865) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)18-7-3-1-4-8-18)19-11-12-21(34-20-9-5-2-6-10-20)22(13-19)33-16-17-14-32-15-17/h1-13,17H,14-16H2,(H,26,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM482158 (BDBM50242742 | TAE684) Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1 Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of TrkC by cellular assay				Proc Natl Acad Sci USA 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
NT-3 growth factor receptor (Homo sapiens (Human))	BDBM50505009 (CHEMBL4542212) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C21H15N3O4/c25-19-22-20(26)24(21(27)23(19)15-7-3-1-4-8-15)16-11-13-18(14-12-16)28-17-9-5-2-6-10-17/h1-14H,(H,22,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkC (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NT-3 by fluorescenc...				ACS Med Chem Lett 10: 1590-1591 (2019) Article DOI: 10.1021/acsmedchemlett.9b00506 BindingDB Entry DOI: 10.7270/Q2GM8BKZ
					More data for this Ligand-Target Pair