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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50116515 (CHEMBL3609729) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 9 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor | Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563242 (CHEMBL4744533) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | >10 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50241575 (CHEMBL4067875) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Prexton Therapeutics Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium ... | J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50217031 ((1S,2R)-1-amino-2-phosphonomethylcyclopropane-carb...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559790 (CHEMBL4744407) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay | J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559789 (CHEMBL4762369) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559791 (CHEMBL4740929) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559787 (CHEMBL4786847) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563239 (CHEMBL4758183) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM55082 (N-[4-[(2-chlorobenzoyl)amino]-3-methoxy-phenyl]pic...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 34 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM55087 (N-[3-chloranyl-4-[4-chloranyl-1,3-bis(oxidanyliden...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 34.9 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assay | J Med Chem 54: 7639-47 (2011) Article DOI: 10.1021/jm200956q BindingDB Entry DOI: 10.7270/Q25Q4WHD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559788 (CHEMBL4777845) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563240 (CHEMBL4742127) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 35 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50559786 (CHEMBL4800093) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells coexpressing GIRK assessed as thallium influx in presence of EC20 glut... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127212 BindingDB Entry DOI: 10.7270/Q27H1P86 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50220011 (CHEMBL243925 | L-(+)-2-amino-4-thiophosphonobutyri...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 39 | n/a | n/a | n/a | n/a |
Université Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | J Med Chem 50: 4656-64 (2007) Article DOI: 10.1021/jm070400y BindingDB Entry DOI: 10.7270/Q2XP74NQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50241580 (CHEMBL4089083) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Prexton Therapeutics Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co-expressing Gi/Gq assessed as increase in glutamate-induced calcium ... | J Med Chem 60: 8515-8537 (2017) Article DOI: 10.1021/acs.jmedchem.7b00991 BindingDB Entry DOI: 10.7270/Q2GF0WNQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50166956 (CHEMBL3798517) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 47 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor | Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50503360 (CHEMBL4459205) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM196924 (US9212196, Derivative 20) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563245 (CHEMBL4743836) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50503361 (CHEMBL4451827) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM55086 (N-(3-chloro-4-phthalimido-phenyl)picolinamide | N-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 66.8 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assay | J Med Chem 54: 7639-47 (2011) Article DOI: 10.1021/jm200956q BindingDB Entry DOI: 10.7270/Q25Q4WHD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563246 (CHEMBL4742838) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 76 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Université Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 receptor expressed HEK293 cells assessed as effect on inositol phosphate production | J Med Chem 50: 4656-64 (2007) Article DOI: 10.1021/jm070400y BindingDB Entry DOI: 10.7270/Q2XP74NQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM196910 (US9212196, Derivative 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux | J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor | Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM361373 (6-((1H-pyrazolo[3,4-b] pyrazin-3- yl)amino)-N-(3,3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 82 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50516018 (CHEMBL4436022) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 82 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat M4 receptor expressed in CHO cells co-expressing Gqi5 assessed as increase in acetylcholine-induced calcium mob... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126678 BindingDB Entry DOI: 10.7270/Q26D5XB5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM361347 (6-((1H-pyrazolo[4,3-b] pyridin- 3-yl)amino)-N-(3,3...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 83 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50503364 (CHEMBL4522695) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 96 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 96 | n/a | n/a | n/a | n/a |
Universite Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ... | J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM196907 (US9212196, Derivative 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50088290 (CHEMBL3427499) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50358177 (CHEMBL1921952) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | n/a | n/a | 105 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assay | J Med Chem 54: 7639-47 (2011) Article DOI: 10.1021/jm200956q BindingDB Entry DOI: 10.7270/Q25Q4WHD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM55082 (N-[4-[(2-chlorobenzoyl)amino]-3-methoxy-phenyl]pic...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 106 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGluR4 expressed in CHO cells coexpressing Gqi5 assessed as calcium mobilization | J Med Chem 54: 1106-10 (2011) Article DOI: 10.1021/jm101271s BindingDB Entry DOI: 10.7270/Q27P90C1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50293721 (CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on thallium flux | J Med Chem 52: 4115-8 (2009) Article DOI: 10.1021/jm9005065 BindingDB Entry DOI: 10.7270/Q2RJ4JHT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM196906 (US9212196, Derivative 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50563241 (CHEMBL4763684) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 115 | n/a | n/a | n/a | n/a |
TBA | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK293 cells co- expressing GIRK channel by thallium mobilization assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127838 BindingDB Entry DOI: 10.7270/Q2T43XTH | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50088290 (CHEMBL3427499) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50088290 (CHEMBL3427499) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a |
Univ. Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGluR4 expressed in HEK293 cells assessed as induction of inositol phosphate production by HTRF assay | Bioorg Med Chem Lett 25: 2523-6 (2015) Article DOI: 10.1016/j.bmcl.2015.04.043 BindingDB Entry DOI: 10.7270/Q21Z464C | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50503365 (CHEMBL4483053) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 123 | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Positive allosteric modulation of rat mGlu4 receptor expressed in HEK cells co-expressing GIRK1/2 assessed as increase in glutamate-induced thallium ... | J Med Chem 62: 342-358 (2019) Article DOI: 10.1021/acs.jmedchem.8b00994 BindingDB Entry DOI: 10.7270/Q29K4FHW | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50166968 (CHEMBL3798234) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 128 | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Positive allosteric modulator activity at rat mGlu4 receptor | Bioorg Med Chem Lett 26: 2915-2919 (2016) Article DOI: 10.1016/j.bmcl.2016.04.041 BindingDB Entry DOI: 10.7270/Q2348N9V | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
Universite Paris Descartes Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells co-transfected with G-protein alpha and EAAC1 assessed as increase in intracellular ... | J Med Chem 53: 2797-813 (2010) Article DOI: 10.1021/jm901523t BindingDB Entry DOI: 10.7270/Q28W3F7Q | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50007548 ((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
INSA de Rouen and Universit£ de Rouen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells coexpressing Gq/Gi and EAAC1 assessed as intracellular calcium production measured e... | Bioorg Med Chem 20: 4716-26 (2012) Article DOI: 10.1016/j.bmc.2012.06.006 BindingDB Entry DOI: 10.7270/Q2BG2Q2W | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM82006 (D-AP4 | D-APB | US9212196, L-AP4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM50159148 (CHEMBL3786667) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
University of Copenhagen Curated by ChEMBL | Assay Description Agonist activity at rat mGlu4 receptor expressed in HEK293 cells assessed as IP1 accumulation by IP-One functional assay | J Med Chem 59: 914-24 (2016) Article DOI: 10.1021/acs.jmedchem.5b01333 BindingDB Entry DOI: 10.7270/Q2000408 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat)) | BDBM196911 (US9212196, Derivative 7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
UNIVERSITE PARIS DESCARTES; UNIVERSITE D'AUVERGNE US Patent | Assay Description Metabotropic glutamate receptors were transiently transfected in HEK293 cells by electroporation as described elsewhere (Brabet I. et al., 1998) and ... | US Patent US9212196 (2015) BindingDB Entry DOI: 10.7270/Q28G8JJR | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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