Compile Data Set for Download or QSAR

Found 1222 hits of ec50 data for polymerid = 8455   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) Show SMILES CCC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H17F4N9/c1-2-15(14-10-34-36(11-14)18-6-4-3-5-17(18)25)20-16(7-29)19(21-22(30)33-12-35-37(20)21)13-8-31-23(32-9-13)24(26,27)28/h3-6,8-12,15H,2H2,1H3,(H2,30,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50566263 (CHEMBL4776653) Show SMILES Nc1cc(cnc1C(=O)NC[C@@H](O)C(F)(F)F)S(=O)(=O)c1ccccc1OC(F)(F)F |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<0.310	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595765 (CHEMBL5178232) Show SMILES COc1ccc(C)cc1C1(CC1c1cccc(n1)C(F)F)C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301470 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...) Show SMILES C[C@H](c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)F)c2c(N)ncnn12 |r| Show InChI InChI=1S/C23H16F3N9/c1-12(14-9-32-34(10-14)17-5-3-2-4-16(17)24)19-15(6-27)18(20-22(28)31-11-33-35(19)20)13-7-29-23(21(25)26)30-8-13/h2-5,7-12,21H,1H3,(H2,28,31,33)/t12-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301443 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...) Show SMILES Nc1ncnn2c(Cc3cnn(c3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)F)c12 Show InChI InChI=1S/C22H14F3N9/c23-15-3-1-2-4-16(15)33-10-12(7-31-33)5-17-14(6-26)18(19-21(27)30-11-32-34(17)19)13-8-28-22(20(24)25)29-9-13/h1-4,7-11,20H,5H2,(H2,27,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.410	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) Show SMILES CC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H15F4N9/c1-12(14-9-33-35(10-14)17-5-3-2-4-16(17)24)19-15(6-28)18(20-21(29)32-11-34-36(19)20)13-7-30-22(31-8-13)23(25,26)27/h2-5,7-12H,1H3,(H2,29,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.420	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) Show SMILES CCC(c1cnn(c1)-c1ccc(F)cc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H16F5N9/c1-2-15(13-9-35-37(10-13)18-4-3-14(25)5-17(18)26)20-16(6-30)19(21-22(31)34-11-36-38(20)21)12-7-32-23(33-8-12)24(27,28)29/h3-5,7-11,15H,2H2,1H3,(H2,31,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.420	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50516910 (CHEMBL4558190) Show SMILES OC(=O)c1ccc(cc1)C1CC(NC(=O)C2(CC2)c2ccc3OC(F)(F)Oc3c2)c2ccc(OC(F)F)cc2O1 Show InChI InChI=1S/C28H21F4NO7/c29-26(30)37-17-6-7-18-19(13-21(38-22(18)12-17)14-1-3-15(4-2-14)24(34)35)33-25(36)27(9-10-27)16-5-8-20-23(11-16)40-28(31,32)39-20/h1-8,11-12,19,21,26H,9-10,13H2,(H,33,36)(H,34,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
University of Palermo Curated by ChEMBL					Assay Description Corrector activity at CFTR F508del mutant (unknown origin)				Eur J Med Chem 180: 430-448 (2019) Article DOI: 10.1016/j.ejmech.2019.07.037 BindingDB Entry DOI: 10.7270/Q2TT4VBP
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595762 (CHEMBL5193680) Show SMILES COc1ccc(C)cc1C1(CC1c1cccc(c1)C(F)(F)F)C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.510	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) Show SMILES CCC(c1cnn(c1)-c1ccc(F)cc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H16F5N9/c1-2-15(13-9-35-37(10-13)18-4-3-14(25)5-17(18)26)20-16(6-30)19(21-22(31)34-11-36-38(20)21)12-7-32-23(33-8-12)24(27,28)29/h3-5,7-11,15H,2H2,1H3,(H2,31,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.560	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) Show SMILES CCC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H17F4N9/c1-2-15(14-10-34-36(11-14)18-6-4-3-5-17(18)25)20-16(7-29)19(21-22(30)33-12-35-37(20)21)13-8-31-23(32-9-13)24(26,27)28/h3-6,8-12,15H,2H2,1H3,(H2,30,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.560	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301442 (4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...) Show SMILES Nc1ncnn2c(Cc3cnn(c3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)(F)F)c12 Show InChI InChI=1S/C22H13F4N9/c23-15-3-1-2-4-16(15)34-10-12(7-32-34)5-17-14(6-27)18(19-20(28)31-11-33-35(17)19)13-8-29-21(30-9-13)22(24,25)26/h1-4,7-11H,5H2,(H2,28,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) Show SMILES CC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H15F4N9/c1-12(14-9-33-35(10-14)17-5-3-2-4-16(17)24)19-15(6-28)18(20-21(29)32-11-34-36(19)20)13-7-30-22(31-8-13)23(25,26)27/h2-5,7-12H,1H3,(H2,29,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.620	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301438 (4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...) Show SMILES C[C@@H](c1cnn(c1)-c1ccc(F)cc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 |r| Show InChI InChI=1S/C23H14F5N9/c1-11(13-8-34-36(9-13)17-3-2-14(24)4-16(17)25)19-15(5-29)18(20-21(30)33-10-35-37(19)20)12-6-31-22(32-7-12)23(26,27)28/h2-4,6-11H,1H3,(H2,30,33,35)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.660	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595764 (CHEMBL5178488) Show SMILES COc1ccc(cc1)C1CC1(C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12)c1cc(C)ccc1OC Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.660	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595761 (CHEMBL5202275) Show SMILES COc1ccc(C)cc1C1(CC1c1ccc(C)cc1)C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595763 (CHEMBL5186971) Show SMILES COc1cccc(c1)C1CC1(C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12)c1cc(C)ccc1OC Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.840	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301442 (4-amino-7-{[1-(2-fluorophenyl)-1H-pyrazol-4-yl]met...) Show SMILES Nc1ncnn2c(Cc3cnn(c3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)(F)F)c12 Show InChI InChI=1S/C22H13F4N9/c23-15-3-1-2-4-16(15)34-10-12(7-32-34)5-17-14(6-27)18(19-20(28)31-11-33-35(17)19)13-8-29-21(30-9-13)22(24,25)26/h1-4,7-11H,5H2,(H2,28,31,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.860	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50595766 (CHEMBL5171054) Show SMILES COc1ccc(C)cc1C1(CC1c1cccc(OC(C)C)n1)C(=O)NS(=O)(=O)c1cccc2nc(C)ccc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.900	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00406 BindingDB Entry DOI: 10.7270/Q26M3BV5
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301443 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{[1...) Show SMILES Nc1ncnn2c(Cc3cnn(c3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)F)c12 Show InChI InChI=1S/C22H14F3N9/c23-15-3-1-2-4-16(15)33-10-12(7-31-33)5-17-14(6-26)18(19-21(27)30-11-32-34(17)19)13-8-28-22(20(24)25)29-9-13/h1-4,7-11,20H,5H2,(H2,27,30,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.05	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50566262 (CHEMBL4799994) Show SMILES Nc1cc(cnc1C(=O)N1CC(O)(C1)C(F)(F)F)S(=O)(=O)c1ccc(F)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301463 (BDBM301464 | US10131670, Example 87 | {1-[1-(2-Flu...) Show SMILES CCC(c1cnn(c1)-c1ccccc1F)n1nc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnc12 Show InChI InChI=1S/C22H17F4N9/c1-2-15(13-9-32-34(10-13)16-6-4-3-5-14(16)23)35-20-17(19(27)30-11-31-20)18(33-35)12-7-28-21(29-8-12)22(24,25)26/h3-11,15H,2H2,1H3,(H2,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.53	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) Show SMILES CC(c1cc(no1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H14F4N8O/c1-11(17-6-16(34-36-17)13-4-2-3-5-15(13)24)19-14(7-28)18(20-21(29)32-10-33-35(19)20)12-8-30-22(31-9-12)23(25,26)27/h2-6,8-11H,1H3,(H2,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.67	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) Show SMILES CCC(c1cn(nn1)-c1ccccc1F)c1cc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C22H17F4N9/c1-2-13(16-10-34(33-32-16)17-6-4-3-5-15(17)23)18-7-14(19-20(27)30-11-31-35(18)19)12-8-28-21(29-9-12)22(24,25)26/h3-11,13H,2H2,1H3,(H2,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.88	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) Show SMILES CCC(c1cn(nn1)-c1ccccc1F)c1cc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C22H17F4N9/c1-2-13(16-10-34(33-32-16)17-6-4-3-5-15(17)23)18-7-14(19-20(27)30-11-31-35(18)19)12-8-28-21(29-9-12)22(24,25)26/h3-11,13H,2H2,1H3,(H2,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50035582 (CHEMBL3357142) Show SMILES CC(C)(C)c1cc(F)c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O Show InChI InChI=1S/C20H19FN2O3/c1-20(2,3)13-8-14(21)16(9-17(13)24)23-19(26)12-10-22-15-7-5-4-6-11(15)18(12)25/h4-10,24H,1-3H3,(H,22,25)(H,23,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay				J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301431 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]p...) Show SMILES CCC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H17F4N9/c1-2-15(14-10-34-36(11-14)18-6-4-3-5-17(18)25)20-16(7-29)19(21-22(30)33-12-35-37(20)21)13-8-31-23(32-9-13)24(26,27)28/h3-6,8-12,15H,2H2,1H3,(H2,30,33,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301451 (7-{1-[1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl...) Show SMILES CCC(c1cn(nn1)-c1ccc(F)cc1F)c1cc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C22H16F5N9/c1-2-13(16-9-35(34-33-16)17-4-3-12(23)5-15(17)24)18-6-14(19-20(28)31-10-32-36(18)19)11-7-29-21(30-8-11)22(25,26)27/h3-10,13H,2H2,1H3,(H2,28,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301421 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...) Show SMILES CCC(c1cn(nn1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H16F4N10/c1-2-13(16-10-36(35-34-16)17-6-4-3-5-15(17)24)19-14(7-28)18(20-21(29)32-11-33-37(19)20)12-8-30-22(31-9-12)23(25,26)27/h3-6,8-11,13H,2H2,1H3,(H2,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.13	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50566258 (CHEMBL4787310) Show SMILES Nc1cc(cnc1C(=O)NCC1(O)CC1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.80	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50035581 (CHEMBL3357141) Show SMILES CC(C)(C)c1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O Show InChI InChI=1S/C20H20N2O3/c1-20(2,3)15-9-8-12(10-17(15)23)22-19(25)14-11-21-16-7-5-4-6-13(16)18(14)24/h4-11,23H,1-3H3,(H,21,24)(H,22,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay				J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50035583 (CHEMBL3357143) Show SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(F)(F)F Show InChI InChI=1S/C21H19F3N2O3/c1-20(2,3)14-8-13(21(22,23)24)16(9-17(14)27)26-19(29)12-10-25-15-7-5-4-6-11(15)18(12)28/h4-10,27H,1-3H3,(H,25,28)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay				J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301433 (4-amino-7-{1-[1-(2,4-difluorophenyl)-1H-pyrazol-4-...) Show SMILES CCC(c1cnn(c1)-c1ccc(F)cc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C24H16F5N9/c1-2-15(13-9-35-37(10-13)18-4-3-14(25)5-17(18)26)20-16(6-30)19(21-22(31)34-11-36-38(20)21)12-7-32-23(33-8-12)24(27,28)29/h3-5,7-11,15H,2H2,1H3,(H2,31,34,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50032693 (CHEBI:66901 | Ivacaftor | Kalydeco | VX-770) Show SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C Show InChI InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
JL3Pharma LLC Curated by ChEMBL					Assay Description Corrector activity at CFTR mutant (unknown origin) by phenotypic screening assay				J Med Chem 57: 9774-5 (2014) Article DOI: 10.1021/jm5016928 BindingDB Entry DOI: 10.7270/Q2J96808
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50032693 (CHEBI:66901 | Ivacaftor | Kalydeco | VX-770) Show SMILES CC(C)(C)c1cc(c(NC(=O)c2c[nH]c3ccccc3c2=O)cc1O)C(C)(C)C Show InChI InChI=1S/C24H28N2O3/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28/h7-13,27H,1-6H3,(H,25,28)(H,26,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay				J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K
					More data for this Ligand-Target Pair				3D Structure (crystal)
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301421 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-...) Show SMILES CCC(c1cn(nn1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H16F4N10/c1-2-13(16-10-36(35-34-16)17-6-4-3-5-15(17)24)19-14(7-28)18(20-21(29)32-11-33-37(19)20)12-8-30-22(31-9-12)23(25,26)27/h3-6,8-11,13H,2H2,1H3,(H2,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.02	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) Show SMILES CC(c1cc(no1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H14F4N8O/c1-11(17-6-16(34-36-17)13-4-2-3-5-15(13)24)19-14(7-28)18(20-21(29)32-10-33-35(19)20)12-8-30-22(31-9-12)23(25,26)27/h2-6,8-11H,1H3,(H2,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301438 (4-amino-7-{(1R)-1-[1-(2,4-difluorophenyl)-1H-pyraz...) Show SMILES C[C@@H](c1cnn(c1)-c1ccc(F)cc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 |r| Show InChI InChI=1S/C23H14F5N9/c1-11(13-8-34-36(9-13)17-3-2-14(24)4-16(17)25)19-15(5-29)18(20-21(30)33-10-35-37(19)20)12-6-31-22(32-7-12)23(26,27)28/h2-4,6-11H,1H3,(H2,30,33,35)/t11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.13	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301451 (7-{1-[1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl...) Show SMILES CCC(c1cn(nn1)-c1ccc(F)cc1F)c1cc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C22H16F5N9/c1-2-13(16-9-35(34-33-16)17-4-3-12(23)5-15(17)24)18-6-14(19-20(28)31-10-32-36(18)19)11-7-29-21(30-8-11)22(25,26)27/h3-10,13H,2H2,1H3,(H2,28,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.36	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50566256 (CHEMBL4798183) Show SMILES Nc1cc(cnc1C(=O)NC[C@@H](O)C(F)(F)F)S(=O)(=O)c1ccc(OC(F)(F)F)cc1 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.40	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50165000 ((S)-2-(3-Isopropoxy-4-methoxy-benzoyl)-1,2,3,4-tet...) Show SMILES CCCCCc1ccc(NC(=O)[C@@H]2Cc3ccccc3CN2C(=O)c2ccc(OC)c(OC(C)C)c2)cc1 Show InChI InChI=1S/C32H38N2O4/c1-5-6-7-10-23-13-16-27(17-14-23)33-31(35)28-19-24-11-8-9-12-26(24)21-34(28)32(36)25-15-18-29(37-4)30(20-25)38-22(2)3/h8-9,11-18,20,22,28H,5-7,10,19,21H2,1-4H3,(H,33,35)/t28-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.5	n/a	n/a	n/a	n/a
Genzyme Corp. Curated by ChEMBL					Assay Description Effective concentration for cellular chloride transport in C127 mouse epithelial cell transfected with recombinant Delta F508 CFTR				Bioorg Med Chem Lett 15: 2087-91 (2005) Article DOI: 10.1016/j.bmcl.2005.02.041 BindingDB Entry DOI: 10.7270/Q2J965WP
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301471 (4-amino-5-[2-(difluoromethyl)pyrimidin-5-yl]-7-{1-...) Show SMILES C[C@@H](c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)F)c2c(N)ncnn12 |r| Show InChI InChI=1S/C23H16F3N9/c1-12(14-9-32-34(10-14)17-5-3-2-4-16(17)24)19-15(6-27)18(20-22(28)31-11-33-35(19)20)13-7-29-23(21(25)26)30-8-13/h2-5,7-12,21H,1H3,(H2,28,31,33)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.87	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301444 (4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...) Show SMILES Nc1ncnn2c(Cc3cc(no3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)(F)F)c12 Show InChI InChI=1S/C22H12F4N8O/c23-15-4-2-1-3-13(15)16-5-12(35-33-16)6-17-14(7-27)18(19-20(28)31-10-32-34(17)19)11-8-29-21(30-9-11)22(24,25)26/h1-5,8-10H,6H2,(H2,28,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301429 (4-amino-7-{1-[1-(2-fluorophenyl)-1H-pyrazol-4-yl]e...) Show SMILES CC(c1cnn(c1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H15F4N9/c1-12(14-9-33-35(10-14)17-5-3-2-4-16(17)24)19-15(6-28)18(20-21(29)32-11-34-36(19)20)13-7-30-22(31-8-13)23(25,26)27/h2-5,7-12H,1H3,(H2,29,32,34)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301427 (4-amino-7-{1-[1-(propan-2-yl)-1H-pyrazol-4-yl]prop...) Show SMILES CCC(c1cnn(c1)C(C)C)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C21H20F3N9/c1-4-14(13-8-30-32(9-13)11(2)3)17-15(5-25)16(18-19(26)29-10-31-33(17)18)12-6-27-20(28-7-12)21(22,23)24/h6-11,14H,4H2,1-3H3,(H2,26,29,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.17	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301444 (4-Amino-7-{[3-(2-fluorophenyl)-1,2-oxazol-5-yl]met...) Show SMILES Nc1ncnn2c(Cc3cc(no3)-c3ccccc3F)c(C#N)c(-c3cnc(nc3)C(F)(F)F)c12 Show InChI InChI=1S/C22H12F4N8O/c23-15-4-2-1-3-13(15)16-5-12(35-33-16)6-17-14(7-27)18(19-20(28)31-10-32-34(17)19)11-8-29-21(30-9-11)22(24,25)26/h1-5,8-10H,6H2,(H2,28,31,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.65	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301463 (BDBM301464 | US10131670, Example 87 | {1-[1-(2-Flu...) Show SMILES CCC(c1cnn(c1)-c1ccccc1F)n1nc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnc12 Show InChI InChI=1S/C22H17F4N9/c1-2-15(13-9-32-34(10-13)16-6-4-3-5-14(16)23)35-20-17(19(27)30-11-31-20)18(33-35)12-7-28-21(29-8-12)22(24,25)26/h3-11,15H,2H2,1H3,(H2,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.76	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Fischer rat thyroid (FRT) cell lines stably expressing recombinant F508del V470 CFTR and halide-sensitive yellow fluorescent protein (Pedemonte et al...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301449 (7-{1-[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]pro...) Show SMILES CCC(c1cn(nn1)-c1ccccc1F)c1cc(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C22H17F4N9/c1-2-13(16-10-34(33-32-16)17-6-4-3-5-15(17)23)18-7-14(19-20(27)30-11-31-35(18)19)12-8-28-21(29-9-12)22(24,25)26/h3-11,13H,2H2,1H3,(H2,27,30,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.93	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50566264 (CHEMBL4781857) Show SMILES Nc1cc(cnc1C(=O)NCC(O)C(F)(F)F)S(=O)(=O)N1CCC(CC1)OC(F)(F)F Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
TBA					Assay Description Potentiation of CFTR F508del mutant (unknown origin) expressed in human CFBE41o- cells co-expressing YFP incubated for 10 mins by halide potentiator ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01796 BindingDB Entry DOI: 10.7270/Q2HQ43P7
					More data for this Ligand-Target Pair
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM301435 (4-amino-7-{1-[3-(2-fluorophenyl)-1,2-oxazol-5-yl]e...) Show SMILES CC(c1cc(no1)-c1ccccc1F)c1c(C#N)c(-c2cnc(nc2)C(F)(F)F)c2c(N)ncnn12 Show InChI InChI=1S/C23H14F4N8O/c1-11(17-6-16(34-36-17)13-4-2-3-5-15(13)24)19-14(7-28)18(20-21(29)32-10-33-35(19)20)12-8-30-22(31-9-12)23(25,26)27/h2-6,8-11H,1H3,(H2,29,32,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
CYSTIC FIBROSIS FOUNDATION THERAPEUTICS, INC. US Patent					Assay Description Primary cystic fibrosis human bronchial epithelial (CF hBE) cells were expanded and cultured according to published methods (Neuberger et al., Ch. 4 ...				US Patent US10131670 (2018) BindingDB Entry DOI: 10.7270/Q29025VF
					More data for this Ligand-Target Pair

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