Compile Data Set for Download or QSAR

Found 1663 hits of ec50 data for polymerid = 8880   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) Show SMILES N[C@]1(CS(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C7H9NO5S/c8-7(6(11)12)1-14(13)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+,14?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0890	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cells				J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50202406 ((+)-(1R,2R,4S,5S,6S)-4-amino-2-thiabicyclo[3.1.0]h...) Show SMILES N[C@]1(CS(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C7H9NO5S/c8-7(6(11)12)1-14(13)4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+,14?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.0890	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cells				J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50434136 (CHEMBL2381640) Show SMILES N[C@]1(CC(=O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H9NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h3-5H,1,9H2,(H,11,12)(H,13,14)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.160	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assay				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160821 (US9682980, 3-(Cyclopropylmethyl)-7-(4-(3,6-difluor...) Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C22H22F5N5O/c1-33-20-15(24)5-4-14(23)18(20)13-6-8-31(9-7-13)16-11-28-32-17(10-12-2-3-12)29-30-21(32)19(16)22(25,26)27/h4-5,11-13H,2-3,6-10H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.200	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160822 (US9682980, 7-(4-(3,6-Difluoro-2-methoxyphenyl)pipe...) Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F Show InChI InChI=1S/C20H17F8N5O/c1-34-17-12(22)3-2-11(21)15(17)10-4-6-32(7-5-10)13-9-29-33-14(8-19(23,24)25)30-31-18(33)16(13)20(26,27)28/h2-3,9-10H,4-8H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	0.400	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209108 (CHEMBL3884532) Show SMILES FC(F)(F)c1c(O[C@H]2CC[C@@H](CC2)c2ccccc2)ccn2c(CC3CC3)nnc12 |r,wU:10.13,wD:7.6,(11.67,-8.41,;12.88,-9.12,;12.63,-7.53,;11.37,-9.68,;14.21,-9.9,;14.21,-11.43,;12.87,-12.19,;12.86,-13.73,;11.51,-14.49,;11.5,-16.02,;12.82,-16.8,;14.16,-16.05,;14.18,-14.5,;12.8,-18.34,;11.46,-19.09,;11.44,-20.62,;12.77,-21.41,;14.11,-20.65,;14.12,-19.11,;15.54,-12.21,;16.87,-11.44,;16.88,-9.91,;18.02,-8.88,;19.53,-9.21,;20.62,-8.12,;21.02,-6.65,;22.11,-7.73,;17.41,-7.48,;15.88,-7.63,;15.55,-9.14,)| Show InChI InChI=1S/C23H24F3N3O/c24-23(25,26)21-19(12-13-29-20(14-15-6-7-15)27-28-22(21)29)30-18-10-8-17(9-11-18)16-4-2-1-3-5-16/h1-5,12-13,15,17-18H,6-11,14H2/t17-,18-	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209116 (CHEMBL3883435) Show SMILES Fc1ccc(cc1)C1CC(C1)Oc1ccn2c(CC3CC3)nnc2c1C(F)(F)F |(14.5,-23.72,;14.51,-22.18,;13.18,-21.4,;13.19,-19.86,;14.53,-19.1,;15.86,-19.87,;15.85,-21.41,;14.54,-17.57,;13.46,-16.47,;14.56,-15.39,;15.64,-16.49,;14.57,-13.85,;15.92,-13.09,;17.25,-13.87,;18.58,-13.1,;18.59,-11.56,;19.73,-10.54,;21.24,-10.87,;22.33,-9.78,;22.74,-8.3,;23.83,-9.39,;19.12,-9.13,;17.58,-9.28,;17.26,-10.79,;15.92,-11.55,;14.59,-10.77,;13.37,-10.07,;14.34,-9.18,;13.07,-11.34,)| Show InChI InChI=1S/C21H19F4N3O/c22-15-5-3-13(4-6-15)14-10-16(11-14)29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	0.400	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209220 (CHEMBL3884187) Show SMILES FC(F)(F)c1c(OC2CC(C2)c2ccccc2)ccn2c(CC3CC3)nnc12 |(13.37,-10.07,;14.59,-10.77,;14.34,-9.18,;13.07,-11.34,;15.92,-11.55,;15.92,-13.09,;14.57,-13.85,;14.56,-15.39,;13.46,-16.47,;14.54,-17.57,;15.64,-16.49,;14.53,-19.1,;13.19,-19.86,;13.18,-21.4,;14.51,-22.18,;15.85,-21.41,;15.86,-19.87,;17.25,-13.87,;18.58,-13.1,;18.59,-11.56,;19.73,-10.54,;21.24,-10.87,;22.33,-9.78,;22.74,-8.3,;23.83,-9.39,;19.12,-9.13,;17.58,-9.28,;17.26,-10.79,)| Show InChI InChI=1S/C21H20F3N3O/c22-21(23,24)19-17(28-16-11-15(12-16)14-4-2-1-3-5-14)8-9-27-18(10-13-6-7-13)25-26-20(19)27/h1-5,8-9,13,15-16H,6-7,10-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50434135 (CHEMBL2381652) Show SMILES N[C@]1(C[C@@H](F)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H10FNO4/c9-2-1-8(10,7(13)14)5-3(2)4(5)6(11)12/h2-5H,1,10H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.560	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assay				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Agonist activity at mGLUR2 expressed in CHO cells				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50094843 ((+)-2-Amino-6-fluoro-4-oxo-bicyclo[3.1.0]hexane-2,...) Show SMILES N[C@]1(CC(=O)[C@@H]2[C@H]1[C@@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C8H8FNO5/c9-8(6(14)15)3-2(11)1-7(10,4(3)8)5(12)13/h3-4H,1,10H2,(H,12,13)(H,14,15)/t3-,4-,7+,8-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	n/a	n/a	0.570	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Agonist activity against Metabotropic glutamate receptor 2 expressed in CHO cells was evaluated by measuring forskolin-induced cyclic AMP formation				J Med Chem 43: 4893-909 (2000) BindingDB Entry DOI: 10.7270/Q24J0DC8
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50121540 (CHEMBL3616857) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@@H]2Sc1nnc([nH]1)C(F)F)C(O)=O |r| Show InChI InChI=1S/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3-,4-,5-,11-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.580	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...				J Med Chem 58: 7526-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b01124 BindingDB Entry DOI: 10.7270/Q29S1ST0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50121539 (CHEMBL3616856) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@@H]2Sc1nnc([nH]1)C(F)(F)F)C(O)=O |r| Show InChI InChI=1S/C11H11F3N4O4S/c12-11(13,14)7-16-9(18-17-7)23-2-1-10(15,8(21)22)5-3(2)4(5)6(19)20/h2-5H,1,15H2,(H,19,20)(H,21,22)(H,16,17,18)/t2-,3-,4-,5-,10-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	0.650	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...				J Med Chem 58: 7526-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b01124 BindingDB Entry DOI: 10.7270/Q29S1ST0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257518 (CHEMBL4063313) Show SMILES O[C@@]1(CC[C@@H](CC1)Nc1ccc(cc1Cl)-c1ccn2c(CC3CC3)nnc2c1C(F)(F)F)C1CC1 |r,wU:1.0,4.7,(52.8,-12.87,;53.57,-11.55,;54.91,-10.78,;54.92,-9.24,;53.59,-8.48,;52.25,-9.24,;52.24,-10.77,;53.59,-6.94,;54.92,-6.17,;56.26,-6.94,;57.59,-6.17,;57.59,-4.61,;56.25,-3.85,;54.92,-4.62,;53.59,-3.85,;58.92,-3.84,;60.25,-4.61,;61.58,-3.84,;61.58,-2.29,;62.72,-1.26,;64.23,-1.57,;64.71,-3.04,;64.4,-4.54,;65.86,-4.06,;62.09,.15,;60.56,-.02,;60.24,-1.53,;58.91,-2.3,;57.57,-1.53,;57.57,.01,;56.24,-2.31,;56.23,-.76,;54.33,-12.88,;54.33,-14.41,;55.66,-13.65,)| Show InChI InChI=1S/C26H28ClF3N4O/c27-20-14-16(3-6-21(20)31-18-7-10-25(35,11-8-18)17-4-5-17)19-9-12-34-22(13-15-1-2-15)32-33-24(34)23(19)26(28,29)30/h3,6,9,12,14-15,17-18,31,35H,1-2,4-5,7-8,10-11,13H2/t18-,25+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209117 (CHEMBL3884636) Show SMILES FC(F)(F)c1c(OCC2CC2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 Show InChI InChI=1S/C21H19ClF3N3O/c22-15-5-3-13(4-6-15)16-10-14(16)11-29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50434134 (CHEMBL2381641) Show SMILES N[C@]1(CC(=C)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C9H11NO4/c1-3-2-9(10,8(13)14)6-4(3)5(6)7(11)12/h4-6H,1-2,10H2,(H,11,12)(H,13,14)/t4-,5-,6-,9-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by HTRF assay				J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209103 (CHEMBL3885379) Show SMILES FC(F)(F)c1c(OC[C@H]2C[C@@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 |r| Show InChI InChI=1S/C21H19ClF3N3O/c22-15-5-3-13(4-6-15)16-10-14(16)11-29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2/t14-,16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209189 (CHEMBL3883634) Show SMILES Fc1ccc(cc1)C1CC1COc1ccn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C21H19F4N3O/c22-15-5-3-13(4-6-15)16-10-14(16)11-29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209221 (CHEMBL3884094) Show SMILES FC(F)(F)c1c(OCC2(CCCCC2)c2ccccc2)ccn2c(CC3CC3)nnc12 Show InChI InChI=1S/C24H26F3N3O/c25-24(26,27)21-19(11-14-30-20(15-17-9-10-17)28-29-22(21)30)31-16-23(12-5-2-6-13-23)18-7-3-1-4-8-18/h1,3-4,7-8,11,14,17H,2,5-6,9-10,12-13,15-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.80	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160743 (US9682980, 8-Chloro-7-(4-(2-fluoro-6-methoxyphenyl...) Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl Show InChI InChI=1S/C19H18ClF4N5O/c1-30-14-4-2-3-12(21)16(14)11-5-7-28(8-6-11)13-10-25-29-15(9-19(22,23)24)26-27-18(29)17(13)20/h2-4,10-11H,5-9H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160772 (US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...) Show SMILES FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C21H20ClF4N5O/c22-18-15(10-27-31-16(9-11-1-2-11)28-29-20(18)31)30-7-5-12(6-8-30)17-13(23)3-4-14(24)19(17)32-21(25)26/h3-4,10-12,21H,1-2,5-9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50194614 (CHEMBL3901998) Show SMILES CC1(CCCN(Cc2ccn3c(CC4CC4)nnc3c2C(F)(F)F)C1)c1ccccc1 Show InChI InChI=1S/C24H27F3N4/c1-23(19-6-3-2-4-7-19)11-5-12-30(16-23)15-18-10-13-31-20(14-17-8-9-17)28-29-22(31)21(18)24(25,26)27/h2-4,6-7,10,13,17H,5,8-9,11-12,14-16H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.60	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in CHO cell membranes assessed as potentiation of glutamate-induced effect incubated...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.69	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Agonist activity at human mGLUR2 assessed as inhibition of forskolin-stimulated cAMP production by cell-based assay				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cells				J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50074749 ((1R,4R,5S,6R)-4-Amino-2-oxa-bicyclo[3.1.0]hexane-4...) Show SMILES N[C@]1(CO[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO5/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.70	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human Metabotropic glutamate receptor 2				J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50257556 (CHEMBL4101354) Show SMILES Cc1ccc(Oc2ccc(cc2Cl)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)c(C)n1 Show InChI InChI=1S/C24H20ClF3N4O/c1-13-3-7-19(14(2)29-13)33-20-8-6-16(12-18(20)25)17-9-10-32-21(11-15-4-5-15)30-31-23(32)22(17)24(26,27)28/h3,6-10,12,15H,4-5,11H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a
Division of Medicinal Chemistry, Leiden Academic Centre for Drug Research (LACDR), Leiden University , P.O. Box 9502, 2300RA Leiden, The Netherlands. Curated by ChEMBL					Assay Description Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...				J Med Chem 60: 6704-6720 (2017) Article DOI: 10.1021/acs.jmedchem.7b00669 BindingDB Entry DOI: 10.7270/Q24B33RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160773 (US9682980, 8-Chloro-7-(4-(2-(difluoromethoxy)-3,6-...) Show SMILES FC(F)Oc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl Show InChI InChI=1S/C19H15ClF7N5O/c20-15-12(8-28-32-13(7-19(25,26)27)29-30-17(15)32)31-5-3-9(4-6-31)14-10(21)1-2-11(22)16(14)33-18(23)24/h1-2,8-9,18H,3-7H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50343325 (CHEMBL1774233 | cis-2-(((3R,4R)-4-(2-fluoro-4-(tri...) Show SMILES C[C@H]1CN(Cc2nc3ncccc3n2C)CC[C@H]1c1ccc(cc1F)C(F)(F)F |r| Show InChI InChI=1S/C21H22F4N4/c1-13-11-29(12-19-27-20-18(28(19)2)4-3-8-26-20)9-7-15(13)16-6-5-14(10-17(16)22)21(23,24)25/h3-6,8,10,13,15H,7,9,11-12H2,1-2H3/t13-,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced i...				J Med Chem 54: 1724-39 (2011) Article DOI: 10.1021/jm101414h BindingDB Entry DOI: 10.7270/Q2222V3C
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160807 (US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...) Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160573 (US9682980, 3-(Cyclopropylmethyl)-7-(4-phenylpiperi...) Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C21H22F3N5/c22-21(23,24)19-17(13-25-29-18(12-14-6-7-14)26-27-20(19)29)28-10-8-16(9-11-28)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160739 (US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...) Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C21H23ClFN5O/c1-29-17-4-2-3-15(23)19(17)14-7-9-27(10-8-14)16-12-24-28-18(11-13-5-6-13)25-26-21(28)20(16)22/h2-4,12-14H,5-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50244202 (CHEMBL4091735) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@@H]2NC(=O)c1cccc(O)c1)C(O)=O |r| Show InChI InChI=1S/C15H16N2O6/c16-15(14(22)23)5-8(9-10(11(9)15)13(20)21)17-12(19)6-2-1-3-7(18)4-6/h1-4,8-11,18H,5,16H2,(H,17,19)(H,20,21)(H,22,23)/t8-,9-,10-,11-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.80	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in HEK cells assessed as inhibition of forskolin-stimulated cAMP formation after 20 mins by HTRF a...				J Med Chem 61: 2303-2328 (2018) Article DOI: 10.1021/acs.jmedchem.7b01481 BindingDB Entry DOI: 10.7270/Q2W95CM9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) Show SMILES N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Inhibition of forskolin stimulated cAMP production in RGT cells expressingrecombinant human Metabotropic glutamate receptor 2				J Med Chem 42: 1027-40 (1999) Article DOI: 10.1021/jm980616n BindingDB Entry DOI: 10.7270/Q2WM1CKF
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50074750 ((1R,4S,5S,6S)-4-amino-2-thia-bicyclo[3.1.0]hexane-...) Show SMILES N[C@]1(CS[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O Show InChI InChI=1S/C7H9NO4S/c8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	3.90	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human mGluR2 assessed as effect on cAMP production in RGT cells				J Med Chem 50: 233-40 (2007) Article DOI: 10.1021/jm060917u BindingDB Entry DOI: 10.7270/Q21Z442N
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160826 (US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluorophe...) Show SMILES Fc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C21H21F4N5/c22-16-4-2-1-3-15(16)14-7-9-29(10-8-14)17-12-26-30-18(11-13-5-6-13)27-28-20(30)19(17)21(23,24)25/h1-4,12-14H,5-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160807 (US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...) Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160805 (US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...) Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl Show InChI InChI=1S/C20H21ClFN5/c21-18-19(23-12-27-17(11-13-5-6-13)24-25-20(18)27)26-9-7-14(8-10-26)15-3-1-2-4-16(15)22/h1-4,12-14H,5-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50209142 (CHEMBL3884833) Show SMILES FC(F)(F)c1c(OC[C@@H]2C[C@H]2c2ccc(Cl)cc2)ccn2c(CC3CC3)nnc12 |r| Show InChI InChI=1S/C21H19ClF3N3O/c22-15-5-3-13(4-6-15)16-10-14(16)11-29-17-7-8-28-18(9-12-1-2-12)26-27-20(28)19(17)21(23,24)25/h3-8,12,14,16H,1-2,9-11H2/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu2 receptor expressed in HEK293 cells coexpressing rat glutamate transporter assessed as inhibition of for...				Bioorg Med Chem 25: 496-513 (2017) Article DOI: 10.1016/j.bmc.2016.11.018 BindingDB Entry DOI: 10.7270/Q2QR504D
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160817 (US9682980, 2-(1-(3-(Cyclopropylmethyl)-8-(trifluor...) Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N Show InChI InChI=1S/C22H21F3N6/c23-22(24,25)20-18(13-27-31-19(11-14-5-6-14)28-29-21(20)31)30-9-7-15(8-10-30)17-4-2-1-3-16(17)12-26/h1-4,13-15H,5-11H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50401391 (CHEMBL2206449) Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1ccn2c(CC3CC3)nnc2c1C(F)(F)F Show InChI InChI=1S/C23H23F5N4O/c1-33-21-16(25)5-4-15(24)19(21)14-6-9-31(10-7-14)17-8-11-32-18(12-13-2-3-13)29-30-22(32)20(17)23(26,27)28/h4-5,8,11,13-14H,2-3,6-7,9-10,12H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.10	n/a	n/a	n/a	n/a
Janssen-Cilag S.A. Curated by ChEMBL					Assay Description Agonist activity at human mGLuR2 expressed in CHO cell membrane assessed as [32S]GTPgammaS after 30 mins by scintillation counting				J Med Chem 55: 8685-99 (2012) Article DOI: 10.1021/jm300912k BindingDB Entry DOI: 10.7270/Q2FQ9XSS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50121652 (CHEMBL3616851) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@H]2Sc1nnc(N)[nH]1)C(O)=O |r| Show InChI InChI=1S/C10H13N5O4S/c11-8-13-9(15-14-8)20-2-1-10(12,7(18)19)5-3(2)4(5)6(16)17/h2-5H,1,12H2,(H,16,17)(H,18,19)(H3,11,13,14,15)/t2-,3+,4+,5+,10+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...				J Med Chem 58: 7526-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b01124 BindingDB Entry DOI: 10.7270/Q29S1ST0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50399088 (CHEMBL2179319) Show SMILES FC(F)(F)c1c(ccn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H23F3N4/c23-22(24,25)20-18(10-13-29-19(14-15-6-7-15)26-27-21(20)29)28-11-8-17(9-12-28)16-4-2-1-3-5-16/h1-5,10,13,15,17H,6-9,11-12,14H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.80	n/a	n/a	n/a	n/a
Janssen Research& Development Curated by ChEMBL					Assay Description Positive allosteric modulation of wild-type human mGlu2 receptor expressed in CHO-K1 cells assessed as potentiation of glutamate-induced effect incub...				J Med Chem 59: 8495-507 (2016) Article DOI: 10.1021/acs.jmedchem.6b00913 BindingDB Entry DOI: 10.7270/Q27M09WC
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50138784 ((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...) Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50277846 ((5R)-3-(4-(1-cyclohexylethoxy)benzyl)-5-methyloxaz...) Show SMILES CC(Oc1ccc(CN2C[C@@H](C)OC2=O)cc1)C1CCCCC1 |r| Show InChI InChI=1S/C19H27NO3/c1-14-12-20(19(21)22-14)13-16-8-10-18(11-9-16)23-15(2)17-6-4-3-5-7-17/h8-11,14-15,17H,3-7,12-13H2,1-2H3/t14-,15?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Agonist activity at mGluR2 (unknown origin) expressed in HEK cells by FLIPR assay in presence of glutamate				Bioorg Med Chem Lett 19: 2524-9 (2009) Article DOI: 10.1016/j.bmcl.2009.03.032 BindingDB Entry DOI: 10.7270/Q2F18ZK7
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160756 (US9682980, 8-Chloro-7-(4-(2,4-dimethoxyphenyl)pipe...) Show SMILES COc1ccc(C2CCN(CC2)c2cnn3c(CC(F)(F)F)nnc3c2Cl)c(OC)c1 Show InChI InChI=1S/C20H21ClF3N5O2/c1-30-13-3-4-14(16(9-13)31-2)12-5-7-28(8-6-12)15-11-25-29-17(10-20(22,23)24)26-27-19(29)18(15)21/h3-4,9,11-12H,5-8,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50138784 ((1R,2S,3R)-2-((S)-Amino-carboxy-methyl)-3-hydroxy-...) Show SMILES N[C@@H]([C@H]1[C@@H](O)[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C6H9NO5/c7-3(6(11)12)1-2(4(1)8)5(9)10/h1-4,8H,7H2,(H,9,10)(H,11,12)/t1-,2+,3-,4+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5	n/a	n/a	n/a	n/a
Lilly, SA Curated by ChEMBL					Assay Description Metabotropic glutamate receptor 2 agonist activity against forskolin stimulated c-AMP formation in rat nonneuronal cells				J Med Chem 47: 456-66 (2004) Article DOI: 10.1021/jm030967o BindingDB Entry DOI: 10.7270/Q2K936Z5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM160800 (US9682980, 8-Chloro-7-(4-(2-fluorophenyl)piperidin...) Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC(F)(F)F)nnc2c1Cl Show InChI InChI=1S/C18H16ClF4N5/c19-15-16(24-10-28-14(9-18(21,22)23)25-26-17(15)28)27-7-5-11(6-8-27)12-3-1-2-4-13(12)20/h1-4,10-11H,5-9H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	5	n/a	n/a	7.0	n/a
Bristol-Myers Squibb Company US Patent					Assay Description Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...				US Patent US9682980 (2017) BindingDB Entry DOI: 10.7270/Q2J964JS
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Compound was evaluated for agonist activity against human mGluR2				Bioorg Med Chem Lett 8: 925-30 (1999) BindingDB Entry DOI: 10.7270/Q2J103NP
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a
Georgetown University Medical Center Curated by ChEMBL					Assay Description Agonistic activity against Human Metabotropic glutamate receptor 2				J Med Chem 41: 1641-50 (1998) Article DOI: 10.1021/jm970719q BindingDB Entry DOI: 10.7270/Q27945BZ
					More data for this Ligand-Target Pair				3D Structure (crystal)

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