Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50250656 (CHEMBL4081890 | US11247971, Cmpd ID 276) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572933 (CHEMBL4861379) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572931 (CHEMBL4855986) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572930 (CHEMBL4873879) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572934 (CHEMBL4847068) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572932 (CHEMBL4850573) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572929 (CHEMBL4864519) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant mouse LDHA expressed in BL21 gold (DE3) using sodium pyruvate as substrate preincubated for 10 mins followed by sodium pyru... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572929 (CHEMBL4864519) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 136 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572931 (CHEMBL4855986) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 143 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572934 (CHEMBL4847068) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572932 (CHEMBL4850573) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 198 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572933 (CHEMBL4861379) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM50572930 (CHEMBL4873879) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 732 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of LDHA in wild type CD1 mouse primary hepatocyte assessed as inhibition of lactate production using pyruvate as substrate measured after ... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00196 BindingDB Entry DOI: 10.7270/Q2V128MV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM23222 (Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM234443 (N-Ethyl oxamate) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM234444 (N-Propyl oxamate) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.75E+6 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM234446 (N-Isobutyl oxamate) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.00E+6 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM234445 (N-Butyl oxamate) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.10E+6 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Mus musculus (Mouse)) | BDBM234447 (N-sec-Butyl oxamate) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.25E+7 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Instituto Politécnico Nacional | Assay Description Lactate dehydrogenase activity was determined by recording the absorbance change at 340 nm produced by the oxidation of NADH. Assays were performed a... | J Enzyme Inhib Med Chem 26: 579-86 (2011) Article DOI: 10.3109/14756366.2011.566221 BindingDB Entry DOI: 10.7270/Q2R78D36 | |||||||||||
More data for this Ligand-Target Pair |