Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endochitinase B1 (Aspergillus fumigatus) | BDBM10853 ((2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50559069 (CHEMBL4756641) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Aspergillus fumigatus chitinase B1 expressed in Escherichia coli using 4MU-GlcNAc2 as substrate by fluorescence method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00748 BindingDB Entry DOI: 10.7270/Q2348Q30 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM81508 (Bisdionin C) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Aspergillus fumigatus ChitinaseB1 expressed in Escherichia coli using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins | ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM10854 (4-[(1S,4R,10S,13S,16S,18R)-10-{3-[(acetamidomethan...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MCE MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee | Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... | Chem Biol 12: 65-76 (2005) Article DOI: 10.1016/j.chembiol.2004.10.013 BindingDB Entry DOI: 10.7270/Q23F4MV6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM10853 ((2R,5S,8S,11S,15S)-8-benzyl-2,7-dimethyl-5-[3-({[(...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee | Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... | Chem Biol 12: 65-76 (2005) Article DOI: 10.1016/j.chembiol.2004.10.013 BindingDB Entry DOI: 10.7270/Q23F4MV6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM81341 (Tetrapeptide) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50388141 (CHEMBL1232048) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Aspergillus fumigatus ChitinaseB1 expressed in Escherichia coli using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins | ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM81342 (Tripeptide) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50388143 (CHEMBL2058174) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Aspergillus fumigatus ChitinaseB1 expressed in Escherichia coli using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins | ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50388142 (CHEMBL2058173) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of Aspergillus fumigatus ChitinaseB1 expressed in Escherichia coli using 4-methyumbelliferyl-beta-B-N,N'-diacetylchitobiose after 10 mins | ACS Med Chem Lett 2: 428-432 (2011) Article DOI: 10.1021/ml200008b BindingDB Entry DOI: 10.7270/Q2RJ4KH7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50257243 ((2S)-2-[[(2S)-2-acetamido-5-[[N-(methylcarbamoyl)c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM81343 (Monopeptide) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid UniChem | MMDB Article PubMed | n/a | n/a | 8.10E+4 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM10850 (1-(5-Oxohexyl)theobromine (pentoxifylline) | 3,7-d...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 3.70E+4 | -26.3 | 1.26E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee | Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... | Chem Biol 12: 973-80 (2005) Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM10849 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 4.69E+5 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee | Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... | Chem Biol 12: 973-80 (2005) Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM50559066 (CHEMBL1236848) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of Aspergillus fumigatus chitinase B1 expressed in Escherichia coli using 4MU-GlcNAc2 as substrate by fluorescence method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00748 BindingDB Entry DOI: 10.7270/Q2348Q30 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM81344 (Argifin-Derived Fragments, 1 | Dimethylguanylurea) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | 5.5 | n/a |
University of Dundee | Assay Description Inhibition of argifin and other peptide derivatives against AfchiB1 and hCHT. | Chem Biol 15: 295-301 (2008) Article DOI: 10.1016/j.chembiol.2008.02.015 BindingDB Entry DOI: 10.7270/Q2JH3JN1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Endochitinase B1 (Aspergillus fumigatus) | BDBM10847 (1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.50E+6 | n/a | n/a | n/a | n/a | 5.5 | 37 |
University of Dundee | Assay Description The IC50s of inhibitor against the human chitinase were determined using the fluorogenic substrate 4MU-NAG3. The fluorescence of the liberated 4MU wa... | Chem Biol 12: 973-80 (2005) Article DOI: 10.1016/j.chembiol.2005.07.009 BindingDB Entry DOI: 10.7270/Q2765CJG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |