Found 1142 hits of ic50 data for polymerid = 1805 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36597
(FOS-69)Show SMILES [#6]-[#8]-[#6@@H]1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[C@@]1([#8])[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#6]-[#6]-[#6]Cl |r| Show InChI InChI=1S/C20H31ClO6/c1-13(2)7-8-15-18(3,27-15)20(23)17(24-4)14(9-10-19(20)12-25-19)26-16(22)6-5-11-21/h7,14-15,17,23H,5-6,8-12H2,1-4H3/t14-,15?,17-,18-,19+,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair | 
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137405
(CHEMBL176975 | Carbamic acid (3R,4S,5S,6R)-5-metho...)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](-[#7])=O Show InChI InChI=1S/C17H27NO5/c1-10(2)5-6-12-16(3,23-12)14-13(20-4)11(22-15(18)19)7-8-17(14)9-21-17/h5,11-14H,6-9H2,1-4H3,(H2,18,19)/t11-,12-,13-,14-,16+,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50295172
(4-Hydroxy-5-methoxy-4-[(2S,3R)-2-methyl-3-(3-methy...)Show SMILES [#6]-[#8]-[#6@@H]1-[#6](=O)-[#6]-[#6][C@]2([#6]-[#8]2)[C@@]1([#8])[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12-,13-,14+,15+,16+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Santa Cruz
Curated by ChEMBL
| Assay Description
Inhibition of methionine aminopeptidase 2 |
J Nat Prod 72: 588-603 (2010)
Article DOI: 10.1021/np800817y
BindingDB Entry DOI: 10.7270/Q2765G84 |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36589
(Ovalicin)Show SMILES [#6]-[#8]-[#6@@H]1-[#6](=O)-[#6]-[#6][C@]2([#6]-[#8]2)[C@@]1([#8])[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,12-13,18H,6-9H2,1-4H3/t12?,13-,14-,15+,16+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137403
(Acetyl-carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(R...)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-[#6](Cl)=O Show InChI InChI=1S/C18H26ClNO6/c1-10(2)5-6-12-17(3,26-12)14-13(23-4)11(7-8-18(14)9-24-18)25-16(22)20-15(19)21/h5,11-14H,6-9H2,1-4H3,(H,20,21,22)/t11-,12-,13-,14-,17+,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137404
(Acetic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-m...)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](-[#6])=O Show InChI InChI=1S/C18H28O5/c1-11(2)6-7-14-17(4,23-14)16-15(20-5)13(22-12(3)19)8-9-18(16)10-21-18/h6,13-16H,7-10H2,1-5H3/t13-,14-,15-,16-,17+,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50113436
(CHEMBL32838 | fumagillin)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6](-[#8])=O Show InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137402
(4-Ethyl-piperazine-1-carboxylic acid (3R,4S,5S,6R)...)Show SMILES CCN1CCN(CC1)C(=O)O[C@@H]1CC[C@]2(CO2)[C@H]([C@@H]1OC)C(\C)=N\OCC1CCCCC1 Show InChI InChI=1S/C24H41N3O5/c1-4-26-12-14-27(15-13-26)23(28)32-20-10-11-24(17-30-24)21(22(20)29-3)18(2)25-31-16-19-8-6-5-7-9-19/h19-22H,4-17H2,1-3H3/b25-18+/t20-,21+,22-,24+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50512383
(CHEMBL137766)Show SMILES [H][C@@]1([#6@H](-[#8]-[#6])-[#6@@H](-[#6]-[#6][C@]11[#6]-[#8]1)-[#8]-[#6](=O)\[#6]=[#6]\c1cc(-[#8]-[#6])c(-[#8]-[#6])c(-[#8]-[#6])c1)[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] Show InChI InChI=1S/C28H38O8/c1-17(2)8-10-22-27(3,36-22)26-25(33-7)19(12-13-28(26)16-34-28)35-23(29)11-9-18-14-20(30-4)24(32-6)21(15-18)31-5/h8-9,11,14-15,19,22,25-26H,10,12-13,16H2,1-7H3/b11-9+/t19-,22-,25-,26-,27+,28+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
Northwest University
Curated by ChEMBL
| Assay Description
Inhibition of human MetAP2 |
Eur J Med Chem 173: 213-227 (2019)
Article DOI: 10.1016/j.ejmech.2019.04.009
BindingDB Entry DOI: 10.7270/Q26M3B56 |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM17446
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)Show SMILES [H][C@@]1([#6@H](-[#8]-[#6])-[#6@@H](-[#6]-[#6][C@]11[#6]-[#8]1)-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl)[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
The Johns Hopkins University School of Medicine
Curated by ChEMBL
| Assay Description
Inhibition of human MetAP2 |
J Med Chem 49: 5645-8 (2006)
Article DOI: 10.1021/jm060559v
BindingDB Entry DOI: 10.7270/Q2PN959W |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM17446
((3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-m...)Show SMILES [H][C@@]1([#6@H](-[#8]-[#6])-[#6@@H](-[#6]-[#6][C@]11[#6]-[#8]1)-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl)[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Santa Cruz
Curated by ChEMBL
| Assay Description
Inhibition of methionine aminopeptidase 2 |
J Nat Prod 72: 588-603 (2010)
Article DOI: 10.1021/np800817y
BindingDB Entry DOI: 10.7270/Q2765G84 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50131562
(CHEMBL117603 | Deca-2,4,6,8-tetraenedioic acid mon...)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6](-[#8])=O Show InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23+,24+,25-,26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Johns Hopkins University School of Medicine
Curated by ChEMBL
| Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2) |
J Med Chem 46: 3452-4 (2003)
Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36588
(AGM-1470)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6]-1[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl |r| Show InChI InChI=1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,16?,18-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137408
(CHEMBL172883 | Carbamic acid (3R,4S,5S,6R)-4-{1-[(...)Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=N\OCc1ccccc1)OC(N)=O Show InChI InChI=1S/C18H24N2O5/c1-12(20-24-10-13-6-4-3-5-7-13)15-16(22-2)14(25-17(19)21)8-9-18(15)11-23-18/h3-7,14-16H,8-11H2,1-2H3,(H2,19,21)/b20-12+/t14-,15+,16-,18+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137406
(Acetic acid (3R,4S,5S,6R)-4-{1-[(E)-benzyloxyimino...)Show SMILES CO[C@@H]1[C@@H](CC[C@]2(CO2)[C@H]1\C(C)=N\OCc1ccccc1)OC(C)=O Show InChI InChI=1S/C19H25NO5/c1-13(20-24-11-15-7-5-4-6-8-15)17-18(22-3)16(25-14(2)21)9-10-19(17)12-23-19/h4-8,16-18H,9-12H2,1-3H3/b20-13+/t16-,17+,18-,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188704
(US9169246, 246)Show SMILES OC1CCN(C1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 1.46 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM50137409
(CHEMBL369152 | Carbamic acid (3R,4S,5S,6R)-4-((E)-...)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1\[#6](-[#6])=[#6]\[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](-[#7])=O Show InChI InChI=1S/C17H27NO4/c1-11(2)6-5-7-12(3)14-15(20-4)13(22-16(18)19)8-9-17(14)10-21-17/h6-7,13-15H,5,8-10H2,1-4H3,(H2,18,19)/b12-7+/t13-,14+,15-,17+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences
Curated by ChEMBL
| Assay Description
Inhibitory activity against Methionine aminopeptidase 2 |
Bioorg Med Chem Lett 14: 91-4 (2003)
BindingDB Entry DOI: 10.7270/Q27P8ZXD |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36595
(FOS-68)Show SMILES [#6]-[#8]-[#6@@H]1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[C@@]1([#8])[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#7]-[#6](=O)-[#6]Cl |r| Show InChI InChI=1S/C19H28ClNO7/c1-11(2)5-6-13-17(3,28-13)19(24)15(25-4)12(7-8-18(19)10-26-18)27-16(23)21-14(22)9-20/h5,12-13,15,24H,6-10H2,1-4H3,(H,21,22,23)/t12-,13?,15-,17-,18+,19+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188545
(US9169246, 30)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H20F3N5O/c23-22(24,25)13-30-19-11-15(3-6-17(19)20-18(21(30)31)12-27-28-20)14-1-4-16(5-2-14)29-9-7-26-8-10-29/h1-6,11-12,26H,7-10,13H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 2.13 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM364220
(US9856257, 5)Show SMILES Cc1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1 Show InChI InChI=1S/C18H13F3N4O/c1-10-4-2-3-5-11(10)14-6-15-12(7-22-14)16-13(8-23-24-16)17(26)25(15)9-18(19,20)21/h2-8H,9H2,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir... |
Bioorg Med Chem 15: 3321-33 (2007)
BindingDB Entry DOI: 10.7270/Q26T0PZK |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188567
(US9169246, 66)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccc(nc1)N1CCNCC1 Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-3-15(17)19-16(20(30)31)11-27-28-19)14-2-4-18(26-10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.06 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188731
(US9169246, 273)Show SMILES FC1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C22H19F4N5O/c23-14-5-8-30(9-6-14)20-15(2-1-7-27-20)13-3-4-16-18(10-13)31(12-22(24,25)26)21(32)17-11-28-29-19(16)17/h1-4,7,10-11,14H,5-6,8-9,12H2,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.45 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36592
(FOS-70)Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6]-1[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6])-[#8]-[#6](=O)-[#6]-[#6]-[#6]Cl |r| Show InChI InChI=1S/C20H31ClO5/c1-13(2)7-8-15-19(3,26-15)18-17(23-4)14(9-10-20(18)12-24-20)25-16(22)6-5-11-21/h7,14-15,17-18H,5-6,8-12H2,1-4H3/t14-,15?,17-,18?,19-,20+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188706
(US9169246, 248)Show SMILES CN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C19H16F3N5O/c1-26(2)17-12(4-3-7-23-17)11-5-6-13-15(8-11)27(10-19(20,21)22)18(28)14-9-24-25-16(13)14/h3-9H,10H2,1-2H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.87 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188541
(US9169246, 19)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C23H22F3N5O/c1-29-8-10-30(11-9-29)17-5-2-15(3-6-17)16-4-7-18-20(12-16)31(14-23(24,25)26)22(32)19-13-27-28-21(18)19/h2-7,12-13H,8-11,14H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 3.94 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM364234
(US9856257, 19)Show SMILES CNS(=O)(=O)c1ccccc1-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1 Show InChI InChI=1S/C18H14F3N5O3S/c1-22-30(28,29)15-5-3-2-4-10(15)13-6-14-11(7-23-13)16-12(8-24-25-16)17(27)26(14)9-18(19,20)21/h2-8,22H,9H2,1H3,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir... |
Bioorg Med Chem 15: 3321-33 (2007)
BindingDB Entry DOI: 10.7270/Q26T0PZK |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36596
(FOS-34)Show SMILES [#6]-[#8]-[#6@@H]1-[#6@H](-[#8])-[#6]-[#6][C@]2([#6]-[#8]2)[C@@]1([#8])[C@]1([#6])[#8]-[#6]1-[#6]\[#6]=[#6](\[#6])-[#6] |r| Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-14(3,21-12)16(18)13(19-4)11(17)7-8-15(16)9-20-15/h5,11-13,17-18H,6-9H2,1-4H3/t11-,12?,13-,14-,15+,16+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair |
3D Structure (docked) |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188569
(US9169246, 68)Show SMILES CN1CCN(CC1)c1cc(ccn1)-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C22H21F3N6O/c1-29-6-8-30(9-7-29)19-11-15(4-5-26-19)14-2-3-16-18(10-14)31(13-22(23,24)25)21(32)17-12-27-28-20(16)17/h2-5,10-12H,6-9,13H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.12 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188707
(US9169246, 249)Show SMILES CCN(C)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C20H18F3N5O/c1-3-27(2)18-13(5-4-8-24-18)12-6-7-14-16(9-12)28(11-20(21,22)23)19(29)15-10-25-26-17(14)15/h4-10H,3,11H2,1-2H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.19 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188621
(US9169246, 121)Show SMILES CCC(=O)Nc1ccc(C)cc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C22H19F3N4O2/c1-3-19(30)27-17-7-4-12(2)8-15(17)13-5-6-14-18(9-13)29(11-22(23,24)25)21(31)16-10-26-28-20(14)16/h4-10H,3,11H2,1-2H3,(H,26,28)(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.29 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188708
(US9169246, 250)Show SMILES CN(CCO)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C20H18F3N5O2/c1-27(7-8-29)18-13(3-2-6-24-18)12-4-5-14-16(9-12)28(11-20(21,22)23)19(30)15-10-25-26-17(14)15/h2-6,9-10,29H,7-8,11H2,1H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.41 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188686
(US9169246, 226)Show SMILES CC(=O)Nc1cnccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C19H14F3N5O2/c1-10(28)25-15-8-23-5-4-12(15)11-2-3-13-16(6-11)27(9-19(20,21)22)18(29)14-7-24-26-17(13)14/h2-8H,9H2,1H3,(H,24,26)(H,25,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.68 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188659
(US9169246, 199)Show SMILES FC(F)(F)Cn1c2cc(c(Cl)cc2c2[nH]ncc2c1=O)-c1cccnc1Cl Show InChI InChI=1S/C17H9Cl2F3N4O/c18-12-4-10-13(5-9(12)8-2-1-3-23-15(8)19)26(7-17(20,21)22)16(27)11-6-24-25-14(10)11/h1-6H,7H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188693
(US9169246, 235)Show SMILES CN(C)CCS(=O)(=O)Nc1ccccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C22H22F3N5O3S/c1-29(2)9-10-34(32,33)28-18-6-4-3-5-15(18)14-7-8-16-19(11-14)30(13-22(23,24)25)21(31)17-12-26-27-20(16)17/h3-8,11-12,28H,9-10,13H2,1-2H3,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 4.99 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM364246
(US9856257, 31)Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cc2n(CC(F)(F)F)c(=O)c3cn[nH]c3c2cn1 Show InChI InChI=1S/C21H20F3N7O/c1-29-4-6-30(7-5-29)18-3-2-13(9-26-18)16-8-17-14(10-25-16)19-15(11-27-28-19)20(32)31(17)12-21(22,23)24/h2-3,8-11H,4-7,12H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir... |
Bioorg Med Chem 15: 3321-33 (2007)
BindingDB Entry DOI: 10.7270/Q26T0PZK |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188692
(US9169246, 234)Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C19H15F3N4O3S/c1-30(28,29)25-15-5-3-2-4-12(15)11-6-7-13-16(8-11)26(10-19(20,21)22)18(27)14-9-23-24-17(13)14/h2-9,25H,10H2,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.33 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188709
(US9169246, 251)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1 Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)12-29-17-10-13(5-6-15(17)18-16(20(29)30)11-26-27-18)14-4-3-7-25-19(14)28-8-1-2-9-28/h3-7,10-11H,1-2,8-9,12H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.34 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188571
(US9169246, 70)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccnc(c1)N1CCNCC1 Show InChI InChI=1S/C21H19F3N6O/c22-21(23,24)12-30-17-9-13(1-2-15(17)19-16(20(30)31)11-27-28-19)14-3-4-26-18(10-14)29-7-5-25-6-8-29/h1-4,9-11,25H,5-8,12H2,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 5.62 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM364248
(US9856257, 33)Show SMILES FC(F)(F)Cn1c2cc(ncc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCC1 Show InChI InChI=1S/C20H17F3N6O/c21-20(22,23)11-29-16-8-15(12-4-3-5-24-18(12)28-6-1-2-7-28)25-9-13(16)17-14(19(29)30)10-26-27-17/h3-5,8-10H,1-2,6-7,11H2,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir... |
Bioorg Med Chem 15: 3321-33 (2007)
BindingDB Entry DOI: 10.7270/Q26T0PZK |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM364272
(US9856257, 57)Show SMILES OCCc1ccccc1-c1cnc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C19H15F3N4O2/c20-19(21,22)10-26-15-7-12(13-4-2-1-3-11(13)5-6-27)8-23-17(15)16-14(18(26)28)9-24-25-16/h1-4,7-9,27H,5-6,10H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
| Assay Description
For the enzymatic test, human MetAP2 protein was obtained from a culture supernatant of insect cells (sf9) infected with MetAP2 recombinant baculovir... |
Bioorg Med Chem 15: 3321-33 (2007)
BindingDB Entry DOI: 10.7270/Q26T0PZK |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM36590
(FOS-72)Show SMILES [#6]-[#8]-[#6@H]-1-[#6]([C@]2([#6])[#8]-[#6]2-[#6]\[#6]=[#6](\[#6])-[#6])[C@@]2([#6]-[#8]2)[#6]-[#6]-[#6]-1=O |r| Show InChI InChI=1S/C16H24O4/c1-10(2)5-6-12-15(3,20-12)14-13(18-4)11(17)7-8-16(14)9-19-16/h5,12-14H,6-9H2,1-4H3/t12?,13-,14?,15-,16+/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.35 | 37 |
Massachusetts Institute of Technology
| Assay Description
Enzymatic assay using recombinant human type 2 methionine aminopeptidase (MetAP2). |
Chem Biol 4: 461-71 (1997)
Article DOI: 10.1016/s1074-5521(97)90198-8
BindingDB Entry DOI: 10.7270/Q2NG4P04 |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188728
(US9169246, 270)Show SMILES CN1CCCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C23H23F3N6O/c1-30-8-3-9-31(11-10-30)21-16(4-2-7-27-21)15-5-6-17-19(12-15)32(14-23(24,25)26)22(33)18-13-28-29-20(17)18/h2,4-7,12-13H,3,8-11,14H2,1H3,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188702
(US9169246, 244)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1N1CCCNCC1 Show InChI InChI=1S/C22H21F3N6O/c23-22(24,25)13-31-18-11-14(4-5-16(18)19-17(21(31)32)12-28-29-19)15-3-1-7-27-20(15)30-9-2-6-26-8-10-30/h1,3-5,7,11-12,26H,2,6,8-10,13H2,(H,28,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.08 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188705
(US9169246, 247)Show SMILES OC1CN(CC1O)c1ncccc1-c1ccc2c3n[nH]cc3c(=O)n(CC(F)(F)F)c2c1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 6.41 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188531
(US9169246, 2)Show SMILES Nc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C17H12F3N5O/c18-17(19,20)8-25-13-6-9(10-2-1-5-22-15(10)21)3-4-11(13)14-12(16(25)26)7-23-24-14/h1-7H,8H2,(H2,21,22)(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.06 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188609
(US9169246, 109)Show SMILES Fc1cc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2cc1-c1ccccn1 Show InChI InChI=1S/C17H10F4N4O/c18-12-5-10-14(6-9(12)13-3-1-2-4-22-13)25(8-17(19,20)21)16(26)11-7-23-24-15(10)11/h1-7H,8H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188628
(US9169246, 166)Show SMILES CN1CCN(CC1)c1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C22H21F3N6O/c1-29-7-9-30(10-8-29)20-15(3-2-6-26-20)14-4-5-16-18(11-14)31(13-22(23,24)25)21(32)17-12-27-28-19(16)17/h2-6,11-12H,7-10,13H2,1H3,(H,27,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.24 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188573
(US9169246, 72)Show SMILES Cc1ncccc1-c1ccc2c3[nH]ncc3c(=O)n(CC(F)(F)F)c2c1 Show InChI InChI=1S/C18H13F3N4O/c1-10-12(3-2-6-22-10)11-4-5-13-15(7-11)25(9-18(19,20)21)17(26)14-8-23-24-16(13)14/h2-8H,9H2,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.38 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188611
(US9169246, 111)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1cccnc1Cl Show InChI InChI=1S/C17H10ClF3N4O/c18-15-10(2-1-5-22-15)9-3-4-11-13(6-9)25(8-17(19,20)21)16(26)12-7-23-24-14(11)12/h1-7H,8H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.42 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
Methionine aminopeptidase 2
(Homo sapiens (Human)) | BDBM188530
(US9169246, 1)Show SMILES FC(F)(F)Cn1c2cc(ccc2c2[nH]ncc2c1=O)-c1ccccn1 Show InChI InChI=1S/C17H11F3N4O/c18-17(19,20)9-24-14-7-10(13-3-1-2-6-21-13)4-5-11(14)15-12(16(24)25)8-22-23-15/h1-8H,9H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 7.53 | n/a | n/a | n/a | n/a | n/a | n/a |
SANOFI
US Patent
| Assay Description
The enzymatic test is a test in two steps.In a first step, it consists in placing in contact the compound according to the invention, the dialysed Me... |
US Patent US9169246 (2015)
BindingDB Entry DOI: 10.7270/Q2B856XZ |
More data for this
Ligand-Target Pair | |
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