BindingDB PrimarySearch

Found 251 hits of ic50 data for polymerid = 1808
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50267199 (CHEMBL4079583) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Colorado Mesa University Curated by ChEMBL					Assay Description Inhibition of human MetAP1				J Nat Prod 80: 740-755 (2017) Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4
Colorado Mesa University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435227 (CHEMBL2392772) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17589 ((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...				Cancer Res 63: 7861-9 (2003) BindingDB Entry DOI: 10.7270/Q2Z31WXK
Abbott Laboratories					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17589 ((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17847 (CHEMBL327579 \| pyridine-2-carboxylic acid inhibito...) Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Colorado Mesa University Curated by ChEMBL					Assay Description Inhibition of human MetAP1				J Nat Prod 80: 740-755 (2017) Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4
Colorado Mesa University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435217 (CHEMBL2392900) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435224 (CHEMBL2392893) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50433375 (CHEMBL472879 \| GNF-Pf-359) Show SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01721 BindingDB Entry DOI: 10.7270/Q2BG2SZC
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50295174 (Bengamide A \| CHEMBL256279) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Colorado Mesa University Curated by ChEMBL					Assay Description Inhibition of human MetAP1				J Nat Prod 80: 740-755 (2017) Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4
Colorado Mesa University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50267193 (CHEMBL4078211) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Colorado Mesa University Curated by ChEMBL					Assay Description Inhibition of human MetAP1				J Nat Prod 80: 740-755 (2017) Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4
Colorado Mesa University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435219 (CHEMBL2392898) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435218 (CHEMBL2392899) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435226 (CHEMBL2392891) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50433375 (CHEMBL472879 \| GNF-Pf-359) Show SMILES Cc1nc(nc(NCCc2ccccc2)c1Cl)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	860	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50497538 (CHEMBL3337748) Show SMILES Clc1ccc2C(=O)C(=C)Cc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heidelberg University Curated by ChEMBL					Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b...				Bioorg Med Chem Lett 24: 5310-4 (2014) Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8
Heidelberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435229 (CHEMBL2392771) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435223 (CHEMBL2392894) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435225 (CHEMBL2392892) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435228 (CHEMBL460432) Show SMILES Cc1nc(nc(N2CCN(CCO)CC2)c1Cl)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141738 ((2S,3R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...) Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435220 (CHEMBL2392897) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141691 ((1S,2R)-3-Amino-5-ethylsulfanyl-2-hydroxy-pentanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435222 (CHEMBL2392895) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435231 (CHEMBL2392769) Show SMILES CN(Cc1ccccc1)c1nc(nc(C)c1Cl)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17847 (CHEMBL327579 \| pyridine-2-carboxylic acid inhibito...) Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141693 ((S)-3-Amino-2-hydroxy-4-isobutylsulfanyl-N-phenoxy...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141746 ((S)-3-Amino-2-hydroxy-N-((S)-1-naphthalen-1-yl-eth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141713 ((S)-3-Amino-2-hydroxy-N-phenoxy-4-propylsulfanyl-b...) Show SMILES CCCSC[C@@H](N)[C@H](O)C(=O)NOc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435221 (CHEMBL2392896) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM68281 (Bengamide A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University					Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.				Chem Biol 14: 764-74 (2007) Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9
The Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50433377 (CHEMBL2375628) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50295174 (Bengamide A \| CHEMBL256279) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of methionine aminopeptidase 1				J Nat Prod 72: 588-603 (2010) Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84
University of California Santa Cruz Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17847 (CHEMBL327579 \| pyridine-2-carboxylic acid inhibito...) Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of methionine aminopeptidase 1				J Nat Prod 72: 588-603 (2010) Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84
University of California Santa Cruz Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17590 ((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...				Cancer Res 63: 7861-9 (2003) BindingDB Entry DOI: 10.7270/Q2Z31WXK
Abbott Laboratories					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17590 ((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM68286 (Bengamide N \| Bengamide O) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University					Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.				Chem Biol 14: 764-74 (2007) Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9
The Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17849 (3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...) Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	DrugBank MMDB PDB Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50267195 (CHEMBL4061080) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Colorado Mesa University Curated by ChEMBL					Assay Description Inhibition of human MetAP1				J Nat Prod 80: 740-755 (2017) Article DOI: 10.1021/acs.jnatprod.6b00970 BindingDB Entry DOI: 10.7270/Q2SN0CG4
Colorado Mesa University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50295173 (Bengamide O \| CHEMBL539894) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California Santa Cruz Curated by ChEMBL					Assay Description Inhibition of methionine aminopeptidase 1				J Nat Prod 72: 588-603 (2010) Article DOI: 10.1021/np800817y BindingDB Entry DOI: 10.7270/Q2765G84
University of California Santa Cruz Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM17850 (3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...) Show SMILES O=C(CCc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	7.5	22
Johns Hopkins University					Assay Description The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...				Proc Natl Acad Sci U S A 103: 18148-53 (2006) Article DOI: 10.1073/pnas.0608389103 BindingDB Entry DOI: 10.7270/Q2RB72VK
Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50497521 (CHEMBL3337749) Show SMILES Brc1ccc2C(=O)C(=C)Cc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heidelberg University Curated by ChEMBL					Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b...				Bioorg Med Chem Lett 24: 5310-4 (2014) Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8
Heidelberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50497528 (CHEMBL3337742) Show SMILES Cl.CN(C)CC1Cc2cc(Br)ccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Heidelberg University Curated by ChEMBL					Assay Description Inhibition of N-terminal poly-His-tagged human MetAP-1 expressed in Escherichia coli BL21(DE3) incubated for 30 mins before MGMM substrate addition b...				Bioorg Med Chem Lett 24: 5310-4 (2014) Article DOI: 10.1016/j.bmcl.2014.09.047 BindingDB Entry DOI: 10.7270/Q2057JW8
Heidelberg University Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50398199 (CHEMBL1738934) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	3.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM				J Med Chem 55: 8021-7 (2012) Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50435237 (CHEMBL2392764) Show SMILES Cc1nc(nc(NCCc2ccccc2)c1F)-c1ccccn1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escherichia coli BL21(DE3) using Met-Pro-p-nitroanilide as substrate after ...				Bioorg Med Chem 21: 2600-17 (2013) Article DOI: 10.1016/j.bmc.2013.02.023 BindingDB Entry DOI: 10.7270/Q290256X
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141708 ((R)-3-Amino-2-hydroxy-5-isopropylsulfanyl-pentanoi...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141697 (3-Amino-2-(S)-hydroxy-4-propylsulfanyl-butyric aci...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50398196 (CHEMBL2181034) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM				J Med Chem 55: 8021-7 (2012) Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50141699 ((2S,3R)-3-Amino-4-cyclohexyl-2-hydroxy-N-(1-naphth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human methionine aminopeptidase-1				Bioorg Med Chem Lett 14: 865-8 (2004) Article DOI: 10.1016/j.bmcl.2003.12.031 BindingDB Entry DOI: 10.7270/Q2Z31Z3N
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM68285 (Bengamide M) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Johns Hopkins University					Assay Description The determined effects of seven bengamide analogs on the enzymatic activity of both recombinated human MetAP1 and MetAP2 in vitro.				Chem Biol 14: 764-74 (2007) Article DOI: 10.1016/j.chembiol.2007.05.010 BindingDB Entry DOI: 10.7270/Q2NC5ZN9
The Johns Hopkins University					More data for this Ligand-Target Pair
Methionine aminopeptidase 1 (Homo sapiens (Human))	BDBM50398197 (CHEMBL1738933) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	5.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
Indiana University School of Medicine Curated by ChEMBL					Assay Description Inhibition of Mn(II) form of human methionine aminopeptidase1 expressed in Escherichia coli at 100 mM				J Med Chem 55: 8021-7 (2012) Article DOI: 10.1021/jm3008695 BindingDB Entry DOI: 10.7270/Q2T43V72
Indiana University School of Medicine Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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