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Compile Data Set for Download or QSAR

Found 12098 hits of ic50 data for polymerid = 188,3688,50000084   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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n/an/a 0.0600n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114502
BindingDB Entry DOI: 10.7270/Q2K64P50
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM304254
PNG
(US10143695, Compound 78)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ccc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1Cc3ccccc3N1C2=O |r,c:57|
Show InChI InChI=1S/C46H43N11O7/c1-53-23-29(18-36(53)43(59)49-30-19-37(54(2)24-30)46(62)56-14-13-27-16-28(47)11-12-34(27)56)50-44(60)42-52-40(25-55(42)3)51-41(58)10-7-15-64-39-21-33-32(20-38(39)63-4)45(61)57-31(22-48-33)17-26-8-5-6-9-35(26)57/h5-6,8-9,11-14,16,18-25,31H,7,10,15,17,47H2,1-4H3,(H,49,59)(H,50,60)(H,51,58)/t31-/m0/s1
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n/an/a 0.0600n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...

US Patent US10143695 (2018)


BindingDB Entry DOI: 10.7270/Q2ZC84ZB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM356152
PNG
(2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(5-oxo-2-...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cc3C(=O)NCCc3nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N5O2/c1-35-10-8-21(34-35)15-11-16(19(27)13-18(15)26(28,29)30)25(37)33-22-12-17-20(7-9-31-24(17)36)32-23(22)14-5-3-2-4-6-14/h2-6,8,10-13H,7,9H2,1H3,(H,31,36)(H,33,37)
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n/an/a 0.0690n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...

US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50507492
PNG
(Loxo-195 | Selitrectinib | US10966985, Compound 33...)
Show SMILES C[C@@H]1CCc2ncc(F)cc2[C@H]2CCCN2c2ccn3ncc(C(=O)N1)c3n2
Show InChI InChI=1S/C20H21FN6O/c1-12-4-5-16-14(9-13(21)10-22-16)17-3-2-7-26(17)18-6-8-27-19(25-18)15(11-23-27)20(28)24-12/h6,8-12,17H,2-5,7H2,1H3,(H,24,28)/t12-,17-/m1/s1
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n/an/a 0.0700n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of wildtype human TRKA using poly (Glu,Tyr) 4:1 as substrate in presence of [gamma-33P]ATP by hotspot kinase assay

Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113673
BindingDB Entry DOI: 10.7270/Q2Z323JH
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM356096
PNG
(N-(2-((2,5-dioxoimidazolidin-1- yl)methyl)-4-pheny...)
Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CN3C(=O)CNC3=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F
Show InChI InChI=1S/C26H19F4N7O3/c1-36-8-7-19(35-36)15-9-16(18(27)10-17(15)26(28,29)30)24(39)33-20-11-31-21(13-37-22(38)12-32-25(37)40)34-23(20)14-5-3-2-4-6-14/h2-11H,12-13H2,1H3,(H,32,40)(H,33,39)
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n/an/a 0.0830n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...

US Patent US9815846 (2017)


BindingDB Entry DOI: 10.7270/Q20P129R
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM304255
PNG
(US10143695, Compound 79)
Show SMILES COc1cc2c(cc1OCCCC(=O)Nc1cn(C)c(n1)C(=O)Nc1cc(C(=O)Nc3cc(C(=O)n4ncc5cc(N)ccc45)n(C)c3)n(C)c1)N=C[C@@H]1CC(=C)CN1C2=O |r,c:57|
Show InChI InChI=1S/C42H42N12O7/c1-23-11-28-18-44-30-16-35(34(60-5)15-29(30)41(58)53(28)19-23)61-10-6-7-37(55)48-36-22-52(4)38(49-36)40(57)47-26-13-32(50(2)20-26)39(56)46-27-14-33(51(3)21-27)42(59)54-31-9-8-25(43)12-24(31)17-45-54/h8-9,12-18,20-22,28H,1,6-7,10-11,19,43H2,2-5H3,(H,46,56)(H,47,57)(H,48,55)/t28-/m0/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Mersana Therapeutics, Inc.

US Patent


Assay Description
PBD compounds and conjugates thereof were evaluated for their antiproliferation properties in tumor cell lines in vitro using CellTiter-Glo (Promega ...

US Patent US10143695 (2018)


BindingDB Entry DOI: 10.7270/Q2ZC84ZB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412264
PNG
(US10399945, Example 3 | US10399945, Example 9 | US...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1 |r|
Show InChI InChI=1S/C30H31N5O2/c1-18-14-24(27(20-10-6-5-7-11-20)34-26(18)21-16-31-19(2)32-17-21)33-29(37)35-28-22-12-8-9-13-23(22)30(3,4)15-25(28)36/h5-14,16-17,25,28,36H,15H2,1-4H3,(H2,33,35,37)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412265
PNG
(US10399945, Example 10 | US10399945, Example 4 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)-c1ccccc1 |r|
Show InChI InChI=1S/C29H31N5O2/c1-18-14-23(26(19-10-6-5-7-11-19)32-25(18)20-16-30-34(4)17-20)31-28(36)33-27-21-12-8-9-13-22(21)29(2,3)15-24(27)35/h5-14,16-17,24,27,35H,15H2,1-4H3,(H2,31,33,36)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412272
PNG
(US10399945, Example 11 | US10927079, Compound 11)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cncc(c1)C(F)(F)F)-c1ccccc1 |r|
Show InChI InChI=1S/C31H29F3N4O2/c1-18-13-24(36-29(40)38-28-22-11-7-8-12-23(22)30(2,3)15-25(28)39)27(19-9-5-4-6-10-19)37-26(18)20-14-21(17-35-16-20)31(32,33)34/h4-14,16-17,25,28,39H,15H2,1-3H3,(H2,36,38,40)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50590817
PNG
(CHEMBL5170464)
Show SMILES CCn1cc(cn1)-c1cnn2ccc(N[C@H](C)c3cc(F)ccc3F)nc12 |r|
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114654
BindingDB Entry DOI: 10.7270/Q21Z48CB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50590818
PNG
(CHEMBL5170096)
Show SMILES C[C@@H](Nc1ccn2ncc(-c3cnn(c3)C(F)F)c2n1)c1cc(F)ccc1F |r|
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114654
BindingDB Entry DOI: 10.7270/Q21Z48CB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50590823
PNG
(CHEMBL5189971)
Show SMILES C[C@@H](Nc1ccn2ncc(-c3cnn(c3)C3CCC3)c2n1)c1cc(F)ccc1F |r|
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TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114654
BindingDB Entry DOI: 10.7270/Q21Z48CB
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412273
PNG
(US10399945, Example 12 | US10927079, Compound 12)
Show SMILES Cc1ccc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C)-c1ccccc1 |r|
Show InChI InChI=1S/C31H32N4O2/c1-19-16-25(28(21-10-6-5-7-11-21)34-27(19)22-15-14-20(2)32-18-22)33-30(37)35-29-23-12-8-9-13-24(23)31(3,4)17-26(29)36/h5-16,18,26,29,36H,17H2,1-4H3,(H2,33,35,37)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483547
PNG
(US10927079, Compound 13)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)C#N)-c1ccccc1
Show InChI InChI=1S/C31H29N5O2/c1-19-15-25(34-30(38)36-29-23-11-7-8-12-24(23)31(2,3)16-26(29)37)28(20-9-5-4-6-10-20)35-27(19)21-13-14-22(17-32)33-18-21/h4-15,18,26,29,37H,16H2,1-3H3,(H2,34,36,38)/t26-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412275
PNG
(US10399945, Example 14 | US10927079, Compound 14)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(nc1)S(C)(=O)=O)-c1ccccc1 |r|
Show InChI InChI=1S/C31H32N4O4S/c1-19-16-24(33-30(37)35-29-22-12-8-9-13-23(22)31(2,3)17-25(29)36)28(20-10-6-5-7-11-20)34-27(19)21-14-15-26(32-18-21)40(4,38)39/h5-16,18,25,29,36H,17H2,1-4H3,(H2,33,35,37)/t25-,29-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412276
PNG
(US10399945, Example 15 | US10927079, Compound 15)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(nc1)C(F)(F)F)-c1ccccc1 |r|
Show InChI InChI=1S/C30H28F3N5O2/c1-17-13-22(36-28(40)38-26-20-11-7-8-12-21(20)29(2,3)14-23(26)39)25(18-9-5-4-6-10-18)37-24(17)19-15-34-27(35-16-19)30(31,32)33/h4-13,15-16,23,26,39H,14H2,1-3H3,(H2,36,38,40)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412277
PNG
(US10399945, Example 16 | US10669239, Compound 16 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(cc1)C#N)-c1ccccc1 |r|
Show InChI InChI=1S/C32H30N4O2/c1-20-17-26(34-31(38)36-30-24-11-7-8-12-25(24)32(2,3)18-27(30)37)29(22-9-5-4-6-10-22)35-28(20)23-15-13-21(19-33)14-16-23/h4-17,27,30,37H,18H2,1-3H3,(H2,34,36,38)/t27-,30-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412278
PNG
(US10399945, Example 17 | US10669239, Compound 17 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccnc(c1)C(F)(F)F)-c1ccccc1 |r|
Show InChI InChI=1S/C31H29F3N4O2/c1-18-15-23(36-29(40)38-28-21-11-7-8-12-22(21)30(2,3)17-24(28)39)27(19-9-5-4-6-10-19)37-26(18)20-13-14-35-25(16-20)31(32,33)34/h4-16,24,28,39H,17H2,1-3H3,(H2,36,38,40)/t24-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412266
PNG
(US10399945, Example 18 | US10399945, Example 5 | U...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)-c1ccccc1 |r|
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412280
PNG
(US10399945, Example 19 | US10669239, Compound 19 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnc(O)nc1)-c1ccccc1 |r|
Show InChI InChI=1S/C29H29N5O3/c1-17-13-22(25(18-9-5-4-6-10-18)33-24(17)19-15-30-27(36)31-16-19)32-28(37)34-26-20-11-7-8-12-21(20)29(2,3)14-23(26)35/h4-13,15-16,23,26,35H,14H2,1-3H3,(H,30,31,36)(H2,32,34,37)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412267
PNG
(US10399945, Example 6 | US10669239, Compound 20 | ...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)-c1ccccc1 |r|
Show InChI InChI=1S/C30H30N4O3/c1-18-15-23(27(19-9-5-4-6-10-19)33-26(18)20-13-14-25(36)31-17-20)32-29(37)34-28-21-11-7-8-12-22(21)30(2,3)16-24(28)35/h4-15,17,24,28,35H,16H2,1-3H3,(H,31,36)(H2,32,34,37)/t24-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483555
PNG
(US10927079, Compound 21)
Show SMILES Cc1cc(NC(=O)N[C@H]2CCC(C)(C)c3ccccc23)c(nc1-c1cnc(nc1)C(C)(C)O)-c1ccccc1
Show InChI InChI=1S/C32H35N5O2/c1-20-17-26(36-30(38)35-25-15-16-31(2,3)24-14-10-9-13-23(24)25)28(21-11-7-6-8-12-21)37-27(20)22-18-33-29(34-19-22)32(4,5)39/h6-14,17-19,25,39H,15-16H2,1-5H3,(H2,35,36,38)/t25-/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412283
PNG
(US10399945, Example 22 | US10669239, Compound 22 |...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(Br)ccc23)c1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H26BrN3O2/c1-15-11-20(22(27-14-15)16-7-5-4-6-8-16)28-24(31)29-23-18-10-9-17(26)12-19(18)25(2,3)13-21(23)30/h4-12,14,21,23,30H,13H2,1-3H3,(H2,28,29,31)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412284
PNG
(US10399945, Example 23 | US10669239, Compound 23 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(Br)ccc23)c(nc1C(N)=O)-c1ccccc1 |r|
Show InChI InChI=1S/C26H27BrN4O3/c1-14-11-19(22(30-21(14)24(28)33)15-7-5-4-6-8-15)29-25(34)31-23-17-10-9-16(27)12-18(17)26(2,3)13-20(23)32/h4-12,20,23,32H,13H2,1-3H3,(H2,28,33)(H2,29,31,34)/t20-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412285
PNG
(US10399945, Example 24 | US10669239, Compound 24 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1C(N)=O)-c1ccccc1 |r|
Show InChI InChI=1S/C26H28N4O3/c1-15-13-19(22(29-21(15)24(27)32)16-9-5-4-6-10-16)28-25(33)30-23-17-11-7-8-12-18(17)26(2,3)14-20(23)31/h4-13,20,23,31H,14H2,1-3H3,(H2,27,32)(H2,28,30,33)/t20-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412286
PNG
(US10399945, Example 25 | US10669239, Compound 25 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1C(=O)NCC(C)(C)O)-c1ccccc1 |r|
Show InChI InChI=1S/C30H36N4O4/c1-18-15-22(25(19-11-7-6-8-12-19)33-24(18)27(36)31-17-30(4,5)38)32-28(37)34-26-20-13-9-10-14-21(20)29(2,3)16-23(26)35/h6-15,23,26,35,38H,16-17H2,1-5H3,(H,31,36)(H2,32,34,37)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412287
PNG
(US10399945, Example 26 | US10669239, Compound 26 |...)
Show SMILES Cc1cnc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c1 |r|
Show InChI InChI=1S/C24H31N3O3/c1-15-12-19(21(25-14-15)16-8-10-30-11-9-16)26-23(29)27-22-17-6-4-5-7-18(17)24(2,3)13-20(22)28/h4-7,12,14,16,20,22,28H,8-11,13H2,1-3H3,(H2,26,27,29)/t20-,22-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412289
PNG
(US10399945, Example 28 | US10669239, Compound 28 |...)
Show SMILES Cc1ncc(cn1)-c1nc(C2CCOCC2)c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)cc1C |r|
Show InChI InChI=1S/C29H35N5O3/c1-17-13-23(26(19-9-11-37-12-10-19)33-25(17)20-15-30-18(2)31-16-20)32-28(36)34-27-21-7-5-6-8-22(21)29(3,4)14-24(27)35/h5-8,13,15-16,19,24,27,35H,9-12,14H2,1-4H3,(H2,32,34,36)/t24-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412290
PNG
(US10399945, Example 29 | US10669239, Compound 29 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cnn(C)c1)C1CCOCC1 |r|
Show InChI InChI=1S/C28H35N5O3/c1-17-13-22(25(18-9-11-36-12-10-18)31-24(17)19-15-29-33(4)16-19)30-27(35)32-26-20-7-5-6-8-21(20)28(2,3)14-23(26)34/h5-8,13,15-16,18,23,26,34H,9-12,14H2,1-4H3,(H2,30,32,35)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412291
PNG
(US10399945, Example 30 | US10669239, Compound 30 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1cn[nH]c1)C1CCOCC1 |r|
PDB
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412292
PNG
(US10399945, Example 31 | US10669239, Compound 31 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccccc23)c(nc1-c1ccc(O)nc1)C1CCOCC1 |r|
Show InChI InChI=1S/C29H34N4O4/c1-17-14-22(26(18-10-12-37-13-11-18)32-25(17)19-8-9-24(35)30-16-19)31-28(36)33-27-20-6-4-5-7-21(20)29(2,3)15-23(27)34/h4-9,14,16,18,23,27,34H,10-13,15H2,1-3H3,(H,30,35)(H2,31,33,36)/t23-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412293
PNG
(US10399945, Example 32 | US10927079, Compound 32)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(Br)cc23)c1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H26BrN3O2/c1-15-11-20(22(27-14-15)16-7-5-4-6-8-16)28-24(31)29-23-18-12-17(26)9-10-19(18)25(2,3)13-21(23)30/h4-12,14,21,23,30H,13H2,1-3H3,(H2,28,29,31)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483567
PNG
(US10927079, Compound 33)
Show SMILES COCc1ccc2c(c1)[C@@H](NC(=O)Nc1cc(C)cnc1C1CCOCC1)[C@H](O)CC2(C)C
Show InChI InChI=1S/C26H35N3O4/c1-16-11-21(23(27-14-16)18-7-9-33-10-8-18)28-25(31)29-24-19-12-17(15-32-4)5-6-20(19)26(2,3)13-22(24)30/h5-6,11-12,14,18,22,24,30H,7-10,13,15H2,1-4H3,(H2,28,29,31)/t22-,24-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412295
PNG
(US10399945, Example 34a | US10669239, Compound 34a...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3ccc(F)cc23)cc1C)-c1ccccc1 |r|
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-13-21(31)10-11-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483597
PNG
(US10927079, Compound 34b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3ccc(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-13-21(31)10-11-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412297
PNG
(US10399945, Example 35a | US10669239, Compound 35a...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)ccc23)cc1C)-c1ccccc1 |r|
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-11-10-21(31)13-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483598
PNG
(US10927079, Compound 35b)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)ccc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H30FN5O2/c1-17-12-24(27(19-8-6-5-7-9-19)35-26(17)20-15-32-18(2)33-16-20)34-29(38)36-28-22-11-10-21(31)13-23(22)30(3,4)14-25(28)37/h5-13,15-16,25,28,37H,14H2,1-4H3,(H2,34,36,38)/t25-,28+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412299
PNG
(US10399945, Example 36 | US10669239, Compound 36 |...)
Show SMILES CC1(C)C[C@@H](O)[C@H](NC(=O)Nc2cccnc2-c2ccccc2)c2cc(F)c(F)cc12 |r|
Show InChI InChI=1S/C24H23F2N3O2/c1-24(2)13-20(30)22(15-11-17(25)18(26)12-16(15)24)29-23(31)28-19-9-6-10-27-21(19)14-7-4-3-5-8-14/h3-12,20,22,30H,13H2,1-2H3,(H2,28,29,31)/t20-,22-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483571
PNG
(US10927079, Compound 37)
Show SMILES Cc1cnc(c(NC(=O)NC2C(O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412300
PNG
(US10399945, Example 37 | US10399945, Example 37a |...)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483600
PNG
(US10927079, Compound 37b)
Show SMILES Cc1cnc(c(NC(=O)N[C@H]2[C@@H](O)CC(C)(C)c3cc(F)c(F)cc23)c1)-c1ccccc1
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-20(22(28-13-14)15-7-5-4-6-8-15)29-24(32)30-23-16-10-18(26)19(27)11-17(16)25(2,3)12-21(23)31/h4-11,13,21,23,31H,12H2,1-3H3,(H2,29,30,32)/t21-,23+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412304
PNG
(US10399945, Example 39 | US10669239, Compound 39 |...)
Show SMILES Cc1ccc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(n1)-c1ccccc1 |r|
Show InChI InChI=1S/C25H25F2N3O2/c1-14-9-10-20(22(28-14)15-7-5-4-6-8-15)29-24(32)30-23-16-11-18(26)19(27)12-17(16)25(2,3)13-21(23)31/h4-12,21,23,31H,13H2,1-3H3,(H2,29,30,32)/t21-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483574
PNG
(US10927079, Compound 40)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(N)=O)-c1ccccc1
Show InChI InChI=1S/C26H26F2N4O3/c1-13-9-19(22(31-21(13)24(29)34)14-7-5-4-6-8-14)30-25(35)32-23-15-10-17(27)18(28)11-16(15)26(2,3)12-20(23)33/h4-11,20,23,33H,12H2,1-3H3,(H2,29,34)(H2,30,32,35)/t20-,23-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483575
PNG
(US10927079, Compound 41)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)NC3C(O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412307
PNG
(US10399945, Example 41a | US10669239, Compound 41a...)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)N[C@H]3[C@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1 |r|
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483606
PNG
(US10927079, Compound 41b)
Show SMILES Cc1nnc(CNC(=O)c2nc(c(NC(=O)N[C@H]3[C@@H](O)CC(C)(C)c4cc(F)c(F)cc34)cc2C)-c2ccccc2)o1
Show InChI InChI=1S/C30H30F2N6O4/c1-15-10-22(34-29(41)36-27-18-11-20(31)21(32)12-19(18)30(3,4)13-23(27)39)26(17-8-6-5-7-9-17)35-25(15)28(40)33-14-24-38-37-16(2)42-24/h5-12,23,27,39H,13-14H2,1-4H3,(H,33,40)(H2,34,36,41)/t23-,27+/m0/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412309
PNG
(US10399945, Example 42 | US10669239, Compound 42 |...)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1C(=O)NCC(C)(C)O)-c1ccccc1 |r|
Show InChI InChI=1S/C30H34F2N4O4/c1-16-11-22(25(17-9-7-6-8-10-17)35-24(16)27(38)33-15-30(4,5)40)34-28(39)36-26-18-12-20(31)21(32)13-19(18)29(2,3)14-23(26)37/h6-13,23,26,37,40H,14-15H2,1-5H3,(H,33,38)(H2,34,36,39)/t23-,26-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM445314
PNG
(US10669239, Compound 43 | US10927079, Compound 43)
Show SMILES Cc1cc(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)c(nc1CO)-c1ccccc1 |r|
Show InChI InChI=1S/C26H27F2N3O3/c1-14-9-20(23(29-21(14)13-32)15-7-5-4-6-8-15)30-25(34)31-24-16-10-18(27)19(28)11-17(16)26(2,3)12-22(24)33/h4-11,22,24,32-33H,12-13H2,1-3H3,(H2,30,31,34)/t22-,24-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM483578
PNG
(US10927079, Compound 44)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)NC2C(O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM412311
PNG
(US10399945, Example 44 | US10399945, Example 44a |...)
Show SMILES Cc1ncc(cn1)-c1nc(c(NC(=O)N[C@H]2[C@H](O)CC(C)(C)c3cc(F)c(F)cc23)cc1C)-c1ccccc1 |r|
Show InChI InChI=1S/C30H29F2N5O2/c1-16-10-24(27(18-8-6-5-7-9-18)36-26(16)19-14-33-17(2)34-15-19)35-29(39)37-28-20-11-22(31)23(32)12-21(20)30(3,4)13-25(28)38/h5-12,14-15,25,28,38H,13H2,1-4H3,(H2,35,37,39)/t25-,28-/m1/s1
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n/an/a<0.100n/an/an/an/an/an/a



MOCHIDA PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
Measurement was carried out using TrkA LanthaScreen (registered trademark) Eu Kinase Binding Assay (ThermoFisher SCIENTIFIC). To a 384 well plate (Co...

US Patent US10927079 (2021)


BindingDB Entry DOI: 10.7270/Q2988B3P
More data for this
Ligand-Target Pair
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