Compile Data Set for Download or QSAR

Found 1008 hits of ic50 data for polymerid = 2142   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328390 (3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(4-met...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(F)cc12 Show InChI InChI=1S/C21H22F3N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0660	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328384 (3-(difluoromethyl)-5-fluoro-1-((4-methoxy-3-(4-met...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(F)ccc12 Show InChI InChI=1S/C21H22F3N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0740	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328391 (6-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C20H20ClF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0850	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328394 (3-(difluoromethyl)-6-bromo-1-((4-methoxy-3-(4-meth...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Br)cc12 Show InChI InChI=1S/C21H22BrF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328397 (6-chloro-3-(difluoromethyl)-1-((3-(4-isopropylpipe...) Show SMILES COc1ccc(cc1N1CCN(CC1)C(C)C)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C23H26ClF2N3O3S/c1-15(2)27-8-10-28(11-9-27)21-13-17(5-7-22(21)32-3)33(30,31)29-14-19(23(25)26)18-6-4-16(24)12-20(18)29/h4-7,12-15,23H,8-11H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328396 (6-chloro-1-((3-(4-cyclopropylpiperazin-1-yl)-4-met...) Show SMILES COc1ccc(cc1N1CCN(CC1)C1CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C23H24ClF2N3O3S/c1-32-22-7-5-17(13-21(22)28-10-8-27(9-11-28)16-3-4-16)33(30,31)29-14-19(23(25)26)18-6-2-15(24)12-20(18)29/h2,5-7,12-14,16,23H,3-4,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.0920	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328392 (3-(difluoromethyl)-6-chloro-1-((4-methoxy-3-(4-met...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C21H22ClF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-5-3-14(22)11-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328395 (6-chloro-3-(difluoromethyl)-1-((3-(4-ethylpiperazi...) Show SMILES CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C22H24ClF2N3O3S/c1-3-26-8-10-27(11-9-26)20-13-16(5-7-21(20)31-2)32(29,30)28-14-18(22(24)25)17-6-4-15(23)12-19(17)28/h4-7,12-14,22H,3,8-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.130	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328400 (3-(difluoromethyl)-1-((4-methoxy-3-(4-methylpipera...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C22H22F5N3O3S/c1-28-7-9-29(10-8-28)19-12-15(4-6-20(19)33-2)34(31,32)30-13-17(21(23)24)16-5-3-14(11-18(16)30)22(25,26)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328380 (6-chloro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(Cl)cc12 Show InChI InChI=1S/C20H22ClN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156203 (CHEMBL3781299) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)NCCc1cccc2ccc(Br)cc12 Show InChI InChI=1S/C24H28BrN3O3S/c1-27-12-14-28(15-13-27)23-17-21(8-9-24(23)31-2)32(29,30)26-11-10-19-5-3-4-18-6-7-20(25)16-22(18)19/h3-9,16-17,26H,10-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328381 (6-bromo-1-((4-methoxy-3-(4-methylpiperazin-1-yl)ph...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(Br)cc12 Show InChI InChI=1S/C20H22BrN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.170	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328388 (3-(difluoromethyl)-5-bromo-1-((4-methoxy-3-(4-meth...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12 Show InChI InChI=1S/C21H22BrF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328379 (6-chloro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2ccc(Cl)cc12 Show InChI InChI=1S/C19H20ClN3O3S/c1-26-19-5-4-16(13-18(19)22-10-7-21-8-11-22)27(24,25)23-9-6-14-2-3-15(20)12-17(14)23/h2-6,9,12-13,21H,7-8,10-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328386 (5-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(4-met...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)ccc12 Show InChI InChI=1S/C21H22ClF2N3O3S/c1-25-7-9-26(10-8-25)19-12-15(4-6-20(19)30-2)31(28,29)27-13-17(21(23)24)16-11-14(22)3-5-18(16)27/h3-6,11-13,21H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.220	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM111790 (US8618114, 1.2.22(5).HCl) Show SMILES CNc1nn2c(C)c(CN)c(C)nc2c1S(=O)(=O)c1cccc(Cl)c1 Show InChI InChI=1S/C16H18ClN5O2S/c1-9-13(8-18)10(2)22-16(20-9)14(15(19-3)21-22)25(23,24)12-6-4-5-11(17)7-12/h4-7H,8,18H2,1-3H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.227	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328401 (3-(difluoromethyl)-1-((3-(4-ethylpiperazin-1-yl)-4...) Show SMILES CCN1CCN(CC1)c1cc(ccc1OC)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C23H24F5N3O3S/c1-3-29-8-10-30(11-9-29)20-13-16(5-7-21(20)34-2)35(32,33)31-14-18(22(24)25)17-6-4-15(12-19(17)31)23(26,27)28/h4-7,12-14,22H,3,8-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328389 (3-(difluoromethyl)-6-fluoro-1-((4-methoxy-3-(piper...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(F)cc12 Show InChI InChI=1S/C20H20F3N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156201 (CHEMBL3781323) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)NCCc1cccc2ccc(F)cc12 Show InChI InChI=1S/C24H28FN3O3S/c1-27-12-14-28(15-13-27)23-17-21(8-9-24(23)31-2)32(29,30)26-11-10-19-5-3-4-18-6-7-20(25)16-22(18)19/h3-9,16-17,26H,10-15H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.280	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM111771 (US8618114, 1.2.11(1)) Show SMILES CNc1nn2c(N)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C14H15N5O2S/c1-9-8-11(15)19-14(17-9)12(13(16-2)18-19)22(20,21)10-6-4-3-5-7-10/h3-8H,15H2,1-2H3,(H,16,18)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.293	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156209 (CHEMBL3780579) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)NCC(C)(C)c1cccc2ccc(Br)cc12 Show InChI InChI=1S/C26H32BrN3O3S/c1-26(2,23-7-5-6-19-8-9-20(27)16-22(19)23)18-28-34(31,32)21-10-11-25(33-4)24(17-21)30-14-12-29(3)13-15-30/h5-11,16-17,28H,12-15,18H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328393 (3-(difluoromethyl)-6-bromo-1-((4-methoxy-3-(pipera...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Br)cc12 Show InChI InChI=1S/C20H20BrF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-4-2-13(21)10-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50417932 (CHEMBL1668587 | US8618114, 1.2.4(1)) Show SMILES CNc1nn2c(COC)cc(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H18N4O3S/c1-11-9-12(10-23-3)20-16(18-11)14(15(17-2)19-20)24(21,22)13-7-5-4-6-8-13/h4-9H,10H2,1-3H3,(H,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50158027 (4-[5-Methoxy-3-(1,2,3,6-tetrahydro-pyridin-4-yl)-i...) Show SMILES COc1ccc2n(cc(C3=CCNCC3)c2c1)S(=O)(=O)c1ccc(N)cc1 |t:9| Show InChI InChI=1S/C20H21N3O3S/c1-26-16-4-7-20-18(12-16)19(14-8-10-22-11-9-14)13-23(20)27(24,25)17-5-2-15(21)3-6-17/h2-8,12-13,22H,9-11,21H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor				Bioorg Med Chem Lett 15: 379-83 (2004) Article DOI: 10.1016/j.bmcl.2004.10.064 BindingDB Entry DOI: 10.7270/Q20G3JNQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328399 (3-(difluoromethyl)-1-((4-methoxy-3-(piperazin-1-yl...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C21H20F5N3O3S/c1-32-19-5-3-14(11-18(19)28-8-6-27-7-9-28)33(30,31)29-12-16(20(22)23)15-4-2-13(10-17(15)29)21(24,25)26/h2-5,10-12,20,27H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328402 (1-((3-(4-cyclopropylpiperazin-1-yl)-4-methoxypheny...) Show SMILES COc1ccc(cc1N1CCN(CC1)C1CC1)S(=O)(=O)n1cc(C(F)F)c2ccc(cc12)C(F)(F)F Show InChI InChI=1S/C24H24F5N3O3S/c1-35-22-7-5-17(13-21(22)31-10-8-30(9-11-31)16-3-4-16)36(33,34)32-14-19(23(25)26)18-6-2-15(12-20(18)32)24(27,28)29/h2,5-7,12-14,16,23H,3-4,8-11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328408 (5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(F)ccc12 Show InChI InChI=1S/C20H22FN3O3S/c1-14-13-24(18-5-3-15(21)11-17(14)18)28(25,26)16-4-6-20(27-2)19(12-16)23-9-7-22-8-10-23/h3-6,11-13,22H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328366 (4-fluoro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2c(F)cccc12 Show InChI InChI=1S/C20H22FN3O3S/c1-22-10-12-23(13-11-22)19-14-15(6-7-20(19)27-2)28(25,26)24-9-8-16-17(21)4-3-5-18(16)24/h3-9,14H,10-13H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.430	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328412 (6-chloro-3-ethyl-1-((4-methoxy-3-(piperazin-1-yl)p...) Show SMILES CCc1cn(c2cc(Cl)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C21H24ClN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.450	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156226 (CHEMBL3781452) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)NCCc1ccc(F)c2ccccc12 Show InChI InChI=1S/C24H28FN3O3S/c1-27-13-15-28(16-14-27)23-17-19(8-10-24(23)31-2)32(29,30)26-12-11-18-7-9-22(25)21-6-4-3-5-20(18)21/h3-10,17,26H,11-16H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328383 (3-(difluoromethyl)-5-fluoro-1-((4-methoxy-3-(piper...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(F)ccc12 Show InChI InChI=1S/C20H20F3N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.460	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328398 (6-chloro-1-((3-(4-cyclobutylpiperazin-1-yl)-4-meth...) Show SMILES COc1ccc(cc1N1CCN(CC1)C1CCC1)S(=O)(=O)n1cc(C(F)F)c2ccc(Cl)cc12 Show InChI InChI=1S/C24H26ClF2N3O3S/c1-33-23-8-6-18(14-22(23)29-11-9-28(10-12-29)17-3-2-4-17)34(31,32)30-15-20(24(26)27)19-7-5-16(25)13-21(19)30/h5-8,13-15,17,24H,2-4,9-12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156199 (CHEMBL3779904) Show SMILES COc1ccc2cccc(CCNS(=O)(=O)c3ccc(OC)c(c3)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C25H31N3O4S/c1-27-13-15-28(16-14-27)24-18-22(9-10-25(24)32-3)33(29,30)26-12-11-20-6-4-5-19-7-8-21(31-2)17-23(19)20/h4-10,17-18,26H,11-16H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328404 (5,6-dichloro-3-(difluoromethyl)-1-((4-methoxy-3-(p...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)c(Cl)cc12 Show InChI InChI=1S/C20H19Cl2F2N3O3S/c1-30-19-3-2-12(8-18(19)26-6-4-25-5-7-26)31(28,29)27-11-14(20(23)24)13-9-15(21)16(22)10-17(13)27/h2-3,8-11,20,25H,4-7H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.540	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328387 (5-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Br)ccc12 Show InChI InChI=1S/C20H20BrF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM111787 (US8618114, 1.2.22(2).HCl) Show SMILES CNc1nn2c(C)c(CN)c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C16H19N5O2S/c1-10-13(9-17)11(2)21-16(19-10)14(15(18-3)20-21)24(22,23)12-7-5-4-6-8-12/h4-8H,9,17H2,1-3H3,(H,18,20)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328382 (7-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1ccc2cccc(F)c12 Show InChI InChI=1S/C19H20FN3O3S/c1-26-18-6-5-15(13-17(18)22-11-8-21-9-12-22)27(24,25)23-10-7-14-3-2-4-16(20)19(14)23/h2-7,10,13,21H,8-9,11-12H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328407 (6-bromo-3-(difluoromethyl)-1-((4-methoxy-3-(pipera...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1nc(C(F)F)c2ccc(Br)cc12 Show InChI InChI=1S/C19H19BrF2N4O3S/c1-29-17-5-3-13(11-16(17)25-8-6-23-7-9-25)30(27,28)26-15-10-12(20)2-4-14(15)18(24-26)19(21)22/h2-5,10-11,19,23H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328362 (1-((4-methoxy-3-(4-methylpiperazin-1-yl)phenyl)sul...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1cc(C#N)c2ccccc12 Show InChI InChI=1S/C21H22N4O3S/c1-23-9-11-24(12-10-23)20-13-17(7-8-21(20)28-2)29(26,27)25-15-16(14-22)18-5-3-4-6-19(18)25/h3-8,13,15H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.590	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50169599 (1-Benzenesulfonyl-3-((R)-1-methyl-pyrrolidin-2-ylm...) Show SMILES CN1CCC[C@@H]1Cc1cn(c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C20H22N2O2S/c1-21-13-7-8-17(21)14-16-15-22(20-12-6-5-11-19(16)20)25(23,24)18-9-3-2-4-10-18/h2-6,9-12,15,17H,7-8,13-14H2,1H3/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibition of cAMP production in HeLa cells expressing human 5-HT6 receptor				Bioorg Med Chem Lett 15: 4780-5 (2005) Article DOI: 10.1016/j.bmcl.2005.07.028 BindingDB Entry DOI: 10.7270/Q2RN37DD
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328413 (6-bromo-3-ethyl-1-((4-methoxy-3-(piperazin-1-yl)ph...) Show SMILES CCc1cn(c2cc(Br)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C21H24BrN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328411 (3-ethyl-6-fluoro-1-((4-methoxy-3-(piperazin-1-yl)p...) Show SMILES CCc1cn(c2cc(F)ccc12)S(=O)(=O)c1ccc(OC)c(c1)N1CCNCC1 Show InChI InChI=1S/C21H24FN3O3S/c1-3-15-14-25(19-12-16(22)4-6-18(15)19)29(26,27)17-5-7-21(28-2)20(13-17)24-10-8-23-9-11-24/h4-7,12-14,23H,3,8-11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.630	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328385 (5-chloro-3-(difluoromethyl)-1-((4-methoxy-3-(piper...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C(F)F)c2cc(Cl)ccc12 Show InChI InChI=1S/C20H20ClF2N3O3S/c1-29-19-5-3-14(11-18(19)25-8-6-24-7-9-25)30(27,28)26-12-16(20(22)23)15-10-13(21)2-4-17(15)26/h2-5,10-12,20,24H,6-9H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.640	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM111788 (US8618114, 1.2.22(3).HCl) Show SMILES CNc1nn2c(C)c(CCN)c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C17H21N5O2S/c1-11-14(9-10-18)12(2)22-17(20-11)15(16(19-3)21-22)25(23,24)13-7-5-4-6-8-13/h4-8H,9-10,18H2,1-3H3,(H,19,21)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.645	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328409 (5-chloro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(Cl)ccc12 Show InChI InChI=1S/C20H22ClN3O3S/c1-14-13-24(18-5-3-15(21)11-17(14)18)28(25,26)16-4-6-20(27-2)19(12-16)23-9-7-22-8-10-23/h3-6,11-13,22H,7-10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM328378 (6-fluoro-1-((4-methoxy-3-(4-methylpiperazin-1-yl)p...) Show SMILES COc1ccc(cc1N1CCN(C)CC1)S(=O)(=O)n1ccc2ccc(F)cc12 Show InChI InChI=1S/C20H22FN3O3S/c1-22-9-11-23(12-10-22)19-14-17(5-6-20(19)27-2)28(25,26)24-8-7-15-3-4-16(21)13-18(15)24/h3-8,13-14H,9-12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
SUNSHINE LAKE PHARMA CO., LTD. US Patent					Assay Description The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...				US Patent US9663498 (2017) BindingDB Entry DOI: 10.7270/Q22N54C8
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM111785 (US8618114, 1.2.22(1).HCl) Show SMILES CNc1nn2c(C)c(N)c(C)nc2c1S(=O)(=O)c1ccccc1 Show InChI InChI=1S/C15H17N5O2S/c1-9-12(16)10(2)20-15(18-9)13(14(17-3)19-20)23(21,22)11-7-5-4-6-8-11/h4-8H,16H2,1-3H3,(H,17,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.670	n/a	n/a	n/a	n/a	n/a	n/a
TBA US Patent					Assay Description Screening of the disclosed compounds for their potential ability to interact with serotonin 5-HT6 receptors was carried out by method of radioligand ...				US Patent US8618114 (2013) BindingDB Entry DOI: 10.7270/Q2B56HD9
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50156200 (CHEMBL3780274) Show SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)NCCc1cccc2ccc(F)cc12 Show InChI InChI=1S/C23H26FN3O3S/c1-30-23-8-7-20(16-22(23)27-13-11-25-12-14-27)31(28,29)26-10-9-18-4-2-3-17-5-6-19(24)15-21(17)18/h2-8,15-16,25-26H,9-14H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in CHO cell membranes after 120 mins by liquid scintillation counting method				ACS Med Chem Lett 7: 12-4 (2016) Article DOI: 10.1021/acsmedchemlett.5b00466 BindingDB Entry DOI: 10.7270/Q2Z89F8F
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50158048 (1-(2-Chloro-benzenesulfonyl)-3-(1-methyl-1,2,3,6-t...) Show SMILES CN1CCC(=CC1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1Cl |c:4| Show InChI InChI=1S/C20H19ClN2O2S/c1-22-12-10-15(11-13-22)17-14-23(19-8-4-2-6-16(17)19)26(24,25)20-9-5-3-7-18(20)21/h2-10,14H,11-13H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Inhibitory concentration against 5-HT stimulated cAMP production in HeLa cells stably transfected with human 5-HT6 receptor				Bioorg Med Chem Lett 15: 379-83 (2004) Article DOI: 10.1016/j.bmcl.2004.10.064 BindingDB Entry DOI: 10.7270/Q20G3JNQ
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50139789 (CHEMBL353389 | {3-[2-(3-Bromo-phenyl)-1H-indol-3-y...) Show SMILES CN(C)CCCc1c([nH]c2ccccc12)-c1cccc(Br)c1 Show InChI InChI=1S/C19H21BrN2/c1-22(2)12-6-10-17-16-9-3-4-11-18(16)21-19(17)14-7-5-8-15(20)13-14/h3-5,7-9,11,13,21H,6,10,12H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of the compound against human 5-hydroxytryptamine 6 receptor				J Med Chem 47: 888-99 (2004) Article DOI: 10.1021/jm0309452 BindingDB Entry DOI: 10.7270/Q2SN08D0
					More data for this Ligand-Target Pair

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