Found 5107 hits of ic50 data for polymerid = 2259,5743 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359073
(CHEMBL1922653)Show SMILES COc1cccc(n1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C37H41N3O4S/c1-24-11-16-27(38-21-24)23-44-28-17-18-31-29(19-28)34(45-36(2,3)4)32(20-37(5,6)35(41)42)40(31)22-25-12-14-26(15-13-25)30-9-8-10-33(39-30)43-7/h8-19,21H,20,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359083
(CHEMBL1922663)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(F)cn4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H38FN3O3S/c1-23-7-13-27(38-19-23)22-43-28-14-16-31-29(17-28)33(44-35(2,3)4)32(18-36(5,6)34(41)42)40(31)21-24-8-10-25(11-9-24)30-15-12-26(37)20-39-30/h7-17,19-20H,18,21-22H2,1-6H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359075
(CHEMBL1922655)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cc(ccn4)C(F)(F)F)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H38F3N3O3S/c1-23-7-12-27(42-20-23)22-46-28-13-14-31-29(18-28)33(47-35(2,3)4)32(19-36(5,6)34(44)45)43(31)21-24-8-10-25(11-9-24)30-17-26(15-16-41-30)37(38,39)40/h7-18,20H,19,21-22H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359076
(CHEMBL1922656)Show SMILES CCOc1nc(cs1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C36H41N3O4S2/c1-8-42-34-38-29(22-44-34)25-12-10-24(11-13-25)20-39-30-16-15-27(43-21-26-14-9-23(2)19-37-26)17-28(30)32(45-35(3,4)5)31(39)18-36(6,7)33(40)41/h9-17,19,22H,8,18,20-21H2,1-7H3,(H,40,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359077
(CHEMBL1922657)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(nc4)C(F)(F)F)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H38F3N3O3S/c1-23-7-13-27(41-19-23)22-46-28-14-15-30-29(17-28)33(47-35(2,3)4)31(18-36(5,6)34(44)45)43(30)21-24-8-10-25(11-9-24)26-12-16-32(42-20-26)37(38,39)40/h7-17,19-20H,18,21-22H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50182306
(7-(3-fluoro-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypro...)Show SMILES OC(c1cc(F)cc(Sc2ccc3c(cc(=O)oc3c2)-c2ccccc2)c1)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C24H13F7O3S/c25-15-8-14(22(33,23(26,27)28)24(29,30)31)9-17(10-15)35-16-6-7-18-19(13-4-2-1-3-5-13)12-21(32)34-20(18)11-16/h1-12,33H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human polymorphonuclear leukocyte |
Bioorg Med Chem Lett 16: 2528-31 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.085 BindingDB Entry DOI: 10.7270/Q2NV9HVZ |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50052018
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)Show SMILES CC(C)(C)Sc1c(CC(C)(C)C([O-])=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)/p-1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359079
(CHEMBL1922659)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccc(n4)C(F)(F)F)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H38F3N3O3S/c1-23-10-15-26(41-20-23)22-46-27-16-17-30-28(18-27)33(47-35(2,3)4)31(19-36(5,6)34(44)45)43(30)21-24-11-13-25(14-12-24)29-8-7-9-32(42-29)37(38,39)40/h7-18,20H,19,21-22H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359078
(CHEMBL1922658)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(cn4)C(F)(F)F)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H38F3N3O3S/c1-23-7-13-27(41-19-23)22-46-28-14-16-31-29(17-28)33(47-35(2,3)4)32(18-36(5,6)34(44)45)43(31)21-24-8-10-25(11-9-24)30-15-12-26(20-42-30)37(38,39)40/h7-17,19-20H,18,21-22H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50182303
(6-(3-fluoro-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypro...)Show SMILES OC(c1cc(F)cc(Sc2ccc3oc(=O)cc(-c4ccc(F)cc4)c3c2)c1)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C24H12F8O3S/c25-14-3-1-12(2-4-14)18-11-21(33)35-20-6-5-16(10-19(18)20)36-17-8-13(7-15(26)9-17)22(34,23(27,28)29)24(30,31)32/h1-11,34H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human polymorphonuclear leukocyte |
Bioorg Med Chem Lett 16: 2528-31 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.085 BindingDB Entry DOI: 10.7270/Q2NV9HVZ |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | CHEMBL5283430
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359082
(CHEMBL1922662)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(C)cn4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H41N3O3S/c1-24-8-14-28(38-20-24)23-43-29-15-17-32-30(18-29)34(44-36(3,4)5)33(19-37(6,7)35(41)42)40(32)22-26-10-12-27(13-11-26)31-16-9-25(2)21-39-31/h8-18,20-21H,19,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50297385
(3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-...)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)cc1 Show InChI InChI=1S/C36H39N3O4S/c1-35(2,3)44-33-29-19-28(43-23-27-9-7-8-18-37-27)15-16-30(29)39(31(33)20-36(4,5)34(40)41)22-24-10-12-25(13-11-24)26-14-17-32(42-6)38-21-26/h7-19,21H,20,22-23H2,1-6H3,(H,40,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359061
(CHEMBL1922532)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C37H41N3O4S/c1-24-8-14-28(38-20-24)23-44-29-15-16-31-30(18-29)34(45-36(2,3)4)32(19-37(5,6)35(41)42)40(31)22-25-9-11-26(12-10-25)27-13-17-33(43-7)39-21-27/h8-18,20-21H,19,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359062
(CHEMBL1922642)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4cccc(C)n4)ccc23)cc1 Show InChI InChI=1S/C37H41N3O4S/c1-24-9-8-10-28(39-24)23-44-29-16-17-31-30(19-29)34(45-36(2,3)4)32(20-37(5,6)35(41)42)40(31)22-25-11-13-26(14-12-25)27-15-18-33(43-7)38-21-27/h8-19,21H,20,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359085
(CHEMBL1922665)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cccnc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H39N3O3S/c1-24-9-14-28(38-20-24)23-42-29-15-16-31-30(18-29)33(43-35(2,3)4)32(19-36(5,6)34(40)41)39(31)22-25-10-12-26(13-11-25)27-8-7-17-37-21-27/h7-18,20-21H,19,22-23H2,1-6H3,(H,40,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359088
(CHEMBL1229205)Show SMILES COc1cnc(nc1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C36H40N4O4S/c1-23-8-13-26(37-18-23)22-44-27-14-15-30-29(16-27)32(45-35(2,3)4)31(17-36(5,6)34(41)42)40(30)21-24-9-11-25(12-10-24)33-38-19-28(43-7)20-39-33/h8-16,18-20H,17,21-22H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359081
(CHEMBL1922661)Show SMILES CCOc1cccc(n1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-44-34-11-9-10-31(40-34)27-15-13-26(14-16-27)23-41-32-19-18-29(45-24-28-17-12-25(2)22-39-28)20-30(32)35(46-37(3,4)5)33(41)21-38(6,7)36(42)43/h9-20,22H,8,21,23-24H2,1-7H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359065
(CHEMBL1922645)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)c(C)n4)ccc23)cc1 Show InChI InChI=1S/C38H43N3O4S/c1-24-9-15-29(40-25(24)2)23-45-30-16-17-32-31(19-30)35(46-37(3,4)5)33(20-38(6,7)36(42)43)41(32)22-26-10-12-27(13-11-26)28-14-18-34(44-8)39-21-28/h9-19,21H,20,22-23H2,1-8H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359086
(CHEMBL1922666)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccccn4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H39N3O3S/c1-24-10-15-27(38-21-24)23-42-28-16-17-31-29(19-28)33(43-35(2,3)4)32(20-36(5,6)34(40)41)39(31)22-25-11-13-26(14-12-25)30-9-7-8-18-37-30/h7-19,21H,20,22-23H2,1-6H3,(H,40,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359084
(CHEMBL1922664)Show SMILES Cc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4cncc(F)c4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C36H38FN3O3S/c1-23-7-12-28(39-18-23)22-43-29-13-14-31-30(16-29)33(44-35(2,3)4)32(17-36(5,6)34(41)42)40(31)21-24-8-10-25(11-9-24)26-15-27(37)20-38-19-26/h7-16,18-20H,17,21-22H2,1-6H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [3H]-3-[5-(pyrid-2-ylmethoxy)-3-tert-butylthio-1-benzylindol-2-yl]-2,2-dimethylpropionic acid from FLAP in human polymorphonuclear ce... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359063
(CHEMBL1922643)Show SMILES CCc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-25-11-15-29(39-21-25)24-45-30-16-17-32-31(19-30)35(46-37(2,3)4)33(20-38(5,6)36(42)43)41(32)23-26-9-12-27(13-10-26)28-14-18-34(44-7)40-22-28/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359066
(CHEMBL1922646)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(Cl)cn4)ccc23)cc1 Show InChI InChI=1S/C36H38ClN3O4S/c1-35(2,3)45-33-29-17-28(44-22-27-13-12-26(37)20-38-27)14-15-30(29)40(31(33)18-36(4,5)34(41)42)21-23-7-9-24(10-8-23)25-11-16-32(43-6)39-19-25/h7-17,19-20H,18,21-22H2,1-6H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359096
(CHEMBL1922525)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5cc(F)ccc5n4)ccc23)cc1 Show InChI InChI=1S/C40H40FN3O4S/c1-39(2,3)49-37-32-20-31(48-24-30-14-11-27-19-29(41)13-16-33(27)43-30)15-17-34(32)44(35(37)21-40(4,5)38(45)46)23-25-7-9-26(10-8-25)28-12-18-36(47-6)42-22-28/h7-20,22H,21,23-24H2,1-6H3,(H,45,46) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359095
(CHEMBL1922524)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4cnc5ccccc5n4)ccc23)cc1 Show InChI InChI=1S/C39H40N4O4S/c1-38(2,3)48-36-30-19-29(47-24-28-22-40-31-9-7-8-10-32(31)42-28)16-17-33(30)43(34(36)20-39(4,5)37(44)45)23-25-11-13-26(14-12-25)27-15-18-35(46-6)41-21-27/h7-19,21-22H,20,23-24H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | CHEMBL5274418
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | CHEMBL5269712
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359080
(CHEMBL1922660)Show SMILES CCOc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359067
(CHEMBL1922647)Show SMILES COc1ccc(COc2ccc3n(Cc4ccc(cc4)-c4ccc(OC)nc4)c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3c2)nc1 Show InChI InChI=1S/C37H41N3O5S/c1-36(2,3)46-34-30-18-28(45-23-27-13-14-29(43-6)21-38-27)15-16-31(30)40(32(34)19-37(4,5)35(41)42)22-24-8-10-25(11-9-24)26-12-17-33(44-7)39-20-26/h8-18,20-21H,19,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | CHEMBL5267320
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | CHEMBL5267685
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50182308
(7-(3-fluoro-5-(1,1,1,3,3,3-hexafluoro-2-hydroxypro...)Show SMILES OC(c1cc(F)cc(Sc2ccc3c(cc(=O)oc3c2)-c2ccoc2)c1)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C22H11F7O4S/c23-13-5-12(20(31,21(24,25)26)22(27,28)29)6-15(7-13)34-14-1-2-16-17(11-3-4-32-10-11)9-19(30)33-18(16)8-14/h1-10,31H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human polymorphonuclear leukocyte |
Bioorg Med Chem Lett 16: 2528-31 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.085 BindingDB Entry DOI: 10.7270/Q2NV9HVZ |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359074
(CHEMBL1922654)Show SMILES COc1cccnc1-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C37H41N3O4S/c1-24-10-15-27(39-21-24)23-44-28-16-17-30-29(19-28)34(45-36(2,3)4)31(20-37(5,6)35(41)42)40(30)22-25-11-13-26(14-12-25)33-32(43-7)9-8-18-38-33/h8-19,21H,20,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359094
(CHEMBL1922523)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc5ccccc5n4)ccc23)cc1 Show InChI InChI=1S/C40H41N3O4S/c1-39(2,3)48-37-32-21-31(47-25-30-17-15-28-9-7-8-10-33(28)42-30)18-19-34(32)43(35(37)22-40(4,5)38(44)45)24-26-11-13-27(14-12-26)29-16-20-36(46-6)41-23-29/h7-21,23H,22,24-25H2,1-6H3,(H,44,45) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50383916
(CHEMBL2031657)Show SMILES O=c1[nH]nc(o1)-c1ccc(OCc2ccc3ccccc3n2)cc1[C@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:31:24:27.28:30,THB:23:24:27.28:30| Show InChI InChI=1S/C31H27N3O3/c35-30-34-33-29(37-30)26-15-14-25(36-19-24-13-11-21-6-4-5-9-28(21)32-24)17-27(26)31(22-7-2-1-3-8-22)18-20-10-12-23(31)16-20/h1-9,11,13-15,17,20,23H,10,12,16,18-19H2,(H,34,35)/t20-,23-,31+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]L-691,831 from 5-lipoxygenase-activating protein in human polymorphonuclear cells |
Bioorg Med Chem Lett 22: 4133-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.064 BindingDB Entry DOI: 10.7270/Q2348MCB |
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | CHEMBL5270325
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Homo sapiens (Human)) | BDBM50182304
(7-((3-fluoro-5-(3-hydroxypentan-3-yl)phenoxy)methy...)Show SMILES CCC(O)(CC)c1cc(F)cc(OCc2ccc3c(cc(=O)oc3c2)-c2ccoc2)c1 Show InChI InChI=1S/C25H23FO5/c1-3-25(28,4-2)18-10-19(26)12-20(11-18)30-14-16-5-6-21-22(17-7-8-29-15-17)13-24(27)31-23(21)9-16/h5-13,15,28H,3-4,14H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Frosst Centre for Therapeutic Research
Curated by ChEMBL
| Assay Description Inhibition of LTB4 production in calcium ionophore A-23187-stimulated human polymorphonuclear leukocyte |
Bioorg Med Chem Lett 16: 2528-31 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.085 BindingDB Entry DOI: 10.7270/Q2NV9HVZ |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM130670
(US8829200, 3)Show SMILES CC(C)(C)n1c(nc2cc(ccc12)-c1cnc(N)nc1)-c1ccccc1C(=O)Nc1ccncc1 Show InChI InChI=1S/C27H25N7O/c1-27(2,3)34-23-9-8-17(18-15-30-26(28)31-16-18)14-22(23)33-24(34)20-6-4-5-7-21(20)25(35)32-19-10-12-29-13-11-19/h4-16H,1-3H3,(H2,28,30,31)(H,29,32,35) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.910 | n/a | n/a | n/a | n/a | n/a | 7.5 |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in... |
US Patent US8829200 (2014)
BindingDB Entry DOI: 10.7270/Q2G73CDF |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359080
(CHEMBL1922660)Show SMILES CCOc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 1 hr by ELISA in a... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50262004
(CHEMBL4088763)Show SMILES CN(C(=O)Cn1cc(cn1)-c1nc(no1)C1(CCC1)c1ccc(cc1)-c1cnc(N)nc1)C(C)(C)C Show InChI InChI=1S/C26H30N8O2/c1-25(2,3)33(4)21(35)16-34-15-19(14-30-34)22-31-23(32-36-22)26(10-5-11-26)20-8-6-17(7-9-20)18-12-28-24(27)29-13-18/h6-9,12-15H,5,10-11,16H2,1-4H3,(H2,27,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877-0368, USA. Electronic address: abartolozzi@gmail.com.
Curated by ChEMBL
| Assay Description Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount method |
Bioorg Med Chem Lett 27: 4652-4659 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.007 BindingDB Entry DOI: 10.7270/Q2HQ42CS |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50052018
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)Show SMILES CC(C)(C)Sc1c(CC(C)(C)C([O-])=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)/p-1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 1 hr by ELISA in a... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50262010
(CHEMBL4080876)Show SMILES Nc1ncc(cn1)-c1ccc(cc1)C1(CCC1)c1noc(n1)-c1cnn(CCC#N)c1 Show InChI InChI=1S/C22H20N8O/c23-9-2-10-30-14-17(13-27-30)19-28-20(29-31-19)22(7-1-8-22)18-5-3-15(4-6-18)16-11-25-21(24)26-12-16/h3-6,11-14H,1-2,7-8,10H2,(H2,24,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Small Molecule Discovery Research, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, CT 06877-0368, USA. Electronic address: abartolozzi@gmail.com.
Curated by ChEMBL
| Assay Description Displacement of [125I]-L-691831 from human FLAP expressed in Sf9 cell membranes after 2 hrs by Topcount method |
Bioorg Med Chem Lett 27: 4652-4659 (2017)
Article DOI: 10.1016/j.bmcl.2017.09.007 BindingDB Entry DOI: 10.7270/Q2HQ42CS |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50052018
(3-[3-tert-Butylsulfanyl-1-(4-chloro-benzyl)-5-(qui...)Show SMILES CC(C)(C)Sc1c(CC(C)(C)C([O-])=O)n(Cc2ccc(Cl)cc2)c2ccc(OCc3ccc4ccccc4n3)cc12 Show InChI InChI=1S/C34H35ClN2O3S/c1-33(2,3)41-31-27-18-26(40-21-25-15-12-23-8-6-7-9-28(23)36-25)16-17-29(27)37(20-22-10-13-24(35)14-11-22)30(31)19-34(4,5)32(38)39/h6-18H,19-21H2,1-5H3,(H,38,39)/p-1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 5 mins by ELISA in... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359080
(CHEMBL1922660)Show SMILES CCOc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccc(C)cn4)ccc23)cc1 Show InChI InChI=1S/C38H43N3O4S/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 5 mins by ELISA in... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50359059
(CHEMBL1922530)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ncccc4C)ccc23)cc1 Show InChI InChI=1S/C37H41N3O4S/c1-24-9-8-18-38-30(24)23-44-28-15-16-31-29(19-28)34(45-36(2,3)4)32(20-37(5,6)35(41)42)40(31)22-25-10-12-26(13-11-25)27-14-17-33(43-7)39-21-27/h8-19,21H,20,22-23H2,1-7H3,(H,41,42) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 10 mins by ELISA |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | CHEMBL5278870
| PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL UniChem
| | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50297385
(3-[3-tert-Butylsulfanyl-1-[4-(6-methoxy-pyridin-3-...)Show SMILES COc1ccc(cn1)-c1ccc(Cn2c(CC(C)(C)C(O)=O)c(SC(C)(C)C)c3cc(OCc4ccccn4)ccc23)cc1 Show InChI InChI=1S/C36H39N3O4S/c1-35(2,3)44-33-29-19-28(43-23-27-9-7-8-18-37-27)15-16-30(29)39(31(33)20-36(4,5)34(40)41)22-24-10-12-25(13-11-24)26-14-17-32(42-6)38-21-26/h7-19,21H,20,22-23H2,1-6H3,(H,40,41) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amira Pharmaceuticals
Curated by ChEMBL
| Assay Description Inhibition of FLAP in human peripheral leukocytes assessed as inhibition of calcium ionophore A23187-induced LTB4 production after 1 hr by ELISA in a... |
J Med Chem 54: 8013-29 (2011)
Article DOI: 10.1021/jm2008369 BindingDB Entry DOI: 10.7270/Q269740W |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50078118
(CHEMBL3417524)Show SMILES CN(C)C(=O)Cn1cc(cn1)-c1nc(no1)[C@](C)(C1CC1)c1ccc(cc1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C25H27N7O2/c1-25(20-9-10-20,19-7-4-16(5-8-19)17-6-11-21(26)27-12-17)24-29-23(34-30-24)18-13-28-32(14-18)15-22(33)31(2)3/h4-8,11-14,20H,9-10,15H2,1-3H3,(H2,26,27)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
| Assay Description Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysis |
J Med Chem 58: 1669-90 (2015)
Article DOI: 10.1021/jm501185j BindingDB Entry DOI: 10.7270/Q2SB47GW |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50383917
(CHEMBL2031658)Show SMILES COc1cccc(c1)[C@@]1(C[C@H]2CC[C@H]1C2)c1cc(OCc2ccc3ccccc3n2)ccc1-c1n[nH]c(=O)o1 |r,TLB:6:8:11.12:14,THB:15:8:11.12:14| Show InChI InChI=1S/C32H29N3O4/c1-37-25-7-4-6-22(16-25)32(18-20-9-11-23(32)15-20)28-17-26(13-14-27(28)30-34-35-31(36)39-30)38-19-24-12-10-21-5-2-3-8-29(21)33-24/h2-8,10,12-14,16-17,20,23H,9,11,15,18-19H2,1H3,(H,35,36)/t20-,23-,32+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]L-691,831 from 5-lipoxygenase-activating protein in human polymorphonuclear cells |
Bioorg Med Chem Lett 22: 4133-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.064 BindingDB Entry DOI: 10.7270/Q2348MCB |
More data for this Ligand-Target Pair | |
Arachidonate 5-lipoxygenase-activating protein
(Homo sapiens (Human)) | BDBM50383906
(CHEMBL2031647)Show SMILES Sc1nnc(o1)-c1ccc(OCc2ccc3ccccc3n2)cc1[C@@]1(C[C@H]2CC[C@H]1C2)c1ccccc1 |r,TLB:31:24:28.27:30,THB:23:24:28.27:30| Show InChI InChI=1S/C31H27N3O2S/c37-30-34-33-29(36-30)26-15-14-25(35-19-24-13-11-21-6-4-5-9-28(21)32-24)17-27(26)31(22-7-2-1-3-8-22)18-20-10-12-23(31)16-20/h1-9,11,13-15,17,20,23H,10,12,16,18-19H2,(H,34,37)/t20-,23-,31-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Displacement of [125I]L-691,831 from 5-lipoxygenase-activating protein in human polymorphonuclear cells |
Bioorg Med Chem Lett 22: 4133-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.064 BindingDB Entry DOI: 10.7270/Q2348MCB |
More data for this Ligand-Target Pair | |