Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23251 (1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 290 | -37.3 | 140 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23232 (1,2,5-oxadiazole, OXD1 | 4-hydroxy-1,2,5-oxadiazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | 210 | -38.1 | 650 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23242 (1,2(1,5)-Isoxazole, IOA1 | 3-hydroxy-1,2-oxazole-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | 470 | -36.1 | 1.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23229 (Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23227 (Oxamic acid derivative, 5 | [(4-{2-[(5-hydroxy-2-{...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.13E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23228 (Oxamic acid derivative, 6 | [(2-cyano-4-{2-[(5-hyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.25E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23223 (7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.54E+3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23229 (Oxamic acid derivative, 7 | [(4-{2-[(5-hydroxy-2-{...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23243 (1,2(1,5)-Isoxazole, IOA2 | 4-hydroxy-1,2-oxazole-3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23250 (1,2(1,5)-Isoxazole, IOA9 | 4-hydroxy-1,2-oxazole-3...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.10E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23224 (7-{[4-(formamidoformic acid)-3-methoxyphenyl]metho...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.73E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23222 (Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | DrugBank PDB Article PubMed | n/a | n/a | 9.25E+4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23258 (1H-1,2,3-triazole-5-carboxylic acid | Triazole, TR...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 9.80E+4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23257 (2-benzyl-5-hydroxy-2H-1,2,3-triazole-4-carboxylic ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23256 (1-benzyl-4-hydroxy-1H-1,2,3-triazole-5-carboxylic ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23255 (5-hydroxy-2-methyl-2H-1,2,3-triazole-4-carboxylic ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23254 (4-hydroxy-1-methyl-1H-1,2,3-triazole-5-carboxylic ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23253 (1,2,5-Thiadiazole, TDA3 | 4-methoxy-1,2,5-thiadiaz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23252 (1,2,5-Thiadiazole, TDA2 | 4-amino-1,2,5-thiadiazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23249 (1,2(1,5)-Isoxazole, IOA8 | ethyl 5-hydroxy-1,2-oxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23248 (1,2(1,5)-Isoxazole, IOA7 | methyl 5-hydroxy-3-meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23247 (1,2(1,5)-Isoxazole, IOA6 | ethyl 3-hydroxy-1,2-oxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23246 (1,2(1,5)-Isoxazole, IOA5 | 3-methoxy-1,2-oxazole-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23245 (1,2(1,5)-Isoxazole, IOA4 | 2-methyl-3-oxo-2,3-dihy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23244 (1,2(1,5)-Isoxazole, IOA3 | 3-hydroxy-5-methyl-1,2-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23222 (Oxalamic acid | Oxamate | Oxamate, 3 | Oxamidic Ac...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 1.23E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23228 (Oxamic acid derivative, 6 | [(2-cyano-4-{2-[(5-hyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.79E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23227 (Oxamic acid derivative, 5 | [(4-{2-[(5-hydroxy-2-{...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.87E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.91E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23237 (1,2,5-oxadiazole, OXD5 | 2-(4-hydroxy-1,2,5-oxadia...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23234 (1,2,5-oxadiazole, OXD2 | 4-amino-1,2,5-oxadiazole-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23235 (1,2,5-oxadiazole, OXD3 | 4-[(2-hydroxyethyl)amino]...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23236 (1,2,5-oxadiazole, OXD4 | 1,2,5-oxadiazole-3-carbox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23241 (1,2,5-oxadiazole, OXD9 | ethyl 4-[(4-methoxyphenyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23240 (1,2,5-oxadiazole, OXD8 | 4-{[(2E)-3-phenylprop-2-e...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23239 (1,2,5-oxadiazole, OXD7 | ethyl 4-hydroxy-1,2,5-oxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23238 ((3,4-dichlorophenyl)methyl 4-hydroxy-1,2,5-oxadiaz...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
University of Bristol | Assay Description An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou... | J Biol Chem 279: 31429-39 (2004) Article DOI: 10.1074/jbc.M402433200 BindingDB Entry DOI: 10.7270/Q2CR5RN4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23226 (7-{2-[4-(formamidoformic acid)-3-methoxyphenyl]eth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.25E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23224 (7-{[4-(formamidoformic acid)-3-methoxyphenyl]metho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.32E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase (Plasmodium falciparum) | BDBM23225 (7-{2-[4-(formamidoformic acid)phenyl]ethoxy}-5-hyd...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.41E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase B chain (Bos taurus (bovine)) | BDBM23225 (7-{2-[4-(formamidoformic acid)phenyl]ethoxy}-5-hyd...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >2.41E+5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
University of Mississippi | Assay Description LDH was assayed spectrophotometrically for reduction of pyruvate using NADH by recording the changed in absorbance at 340 nm. The reaction was initia... | J Med Chem 50: 3841-50 (2007) Article DOI: 10.1021/jm070336k BindingDB Entry DOI: 10.7270/Q2HH6HCV | |||||||||||
More data for this Ligand-Target Pair |