Compile Data Set for Download or QSAR

Found 56 hits of ic50 data for polymerid = 260   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260424 (CHEMBL4091579) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260424 (CHEMBL4091579) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260390 (CHEMBL4070683) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260390 (CHEMBL4070683) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260423 (CHEMBL4104317) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(Cc3ccccc3)cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C28H29FN4O4/c1-17(2)11-20-13-22(26(35)37-3)28(21-12-19(29)9-10-23(21)31-27(28)36)33(20)25(34)24-15-32(16-30-24)14-18-7-5-4-6-8-18/h4-10,12,15-17,20,22H,11,13-14H2,1-3H3,(H,31,36)/t20-,22-,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	44	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260442 (CHEMBL4100976) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cn(C)cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C22H25FN4O4/c1-12(2)7-14-9-16(20(29)31-4)22(27(14)19(28)18-10-26(3)11-24-18)15-8-13(23)5-6-17(15)25-21(22)30/h5-6,8,10-12,14,16H,7,9H2,1-4H3,(H,25,30)/t14-,16-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239868 (CHEMBL4097764) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cccnc2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-13-24-21(16-29(25)15-19-6-2-1-3-7-19)17-30(26(32)28-24)22-9-4-10-23(12-22)33-18-20-8-5-11-27-14-20/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260424 (CHEMBL4091579) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(Cc3ccccc3)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C27H29FN4O2/c1-17(2)11-21-12-18(3)27(22-13-20(28)9-10-23(22)30-26(27)34)32(21)25(33)24-15-31(16-29-24)14-19-7-5-4-6-8-19/h4-10,13,15-18,21H,11-12,14H2,1-3H3,(H,30,34)/t18-,21+,27+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells using 5'-[FITC]-...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260438 (CHEMBL4088975) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H25N3O2/c1-14(2)12-16-13-15(3)22(17-8-4-5-9-18(17)24-21(22)27)25(16)20(26)19-10-6-7-11-23-19/h4-11,14-16H,12-13H2,1-3H3,(H,24,27)/t15-,16+,22+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260422 (CHEMBL4080080) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2c[nH]cn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C21H23FN4O4/c1-11(2)6-13-8-15(19(28)30-3)21(26(13)18(27)17-9-23-10-24-17)14-7-12(22)4-5-16(14)25-20(21)29/h4-5,7,9-11,13,15H,6,8H2,1-3H3,(H,23,24)(H,25,29)/t13-,15-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260390 (CHEMBL4070683) Show SMILES CC(C)C[C@H]1C[C@@H](C)[C@@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells using 5'-[FITC]-...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239866 (CHEMBL4065018) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccc2)c1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-25-22(17-29(26)16-20-8-3-1-4-9-20)18-30(27(32)28-25)23-12-7-13-24(14-23)33-19-21-10-5-2-6-11-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair				3D Structure (crystal)
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260392 (CHEMBL4076145) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C23H24FN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)19-6-4-5-9-25-19)16-11-14(24)7-8-18(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239869 (CHEMBL4084949) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2cncs2)c1 Show InChI InChI=1S/C24H20N4O3S/c29-23-10-22-18(13-27(23)12-17-5-2-1-3-6-17)14-28(24(30)26-22)19-7-4-8-20(9-19)31-15-21-11-25-16-32-21/h1-11,13,16H,12,14-15H2,(H,26,30)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 helicase activity expressed in baculovirus infected Sf9 cells assessed as redu...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260432 (CHEMBL4088974) Show SMILES CC(C)C[C@H]1C[C@@H](CF)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H24FN3O2/c1-14(2)11-16-12-15(13-23)22(17-7-3-4-8-18(17)25-21(22)28)26(16)20(27)19-9-5-6-10-24-19/h3-10,14-16H,11-13H2,1-2H3,(H,25,28)/t15-,16-,22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239867 (CHEMBL4070179) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1cccc(OCc2ccccn2)c1 Show InChI InChI=1S/C26H22N4O3/c31-25-14-24-20(16-29(25)15-19-7-2-1-3-8-19)17-30(26(32)28-24)22-10-6-11-23(13-22)33-18-21-9-4-5-12-27-21/h1-14,16H,15,17-18H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260416 (CHEMBL4074224) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2nccn2C)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C22H25FN4O4/c1-12(2)9-14-11-16(20(29)31-4)22(27(14)19(28)18-24-7-8-26(18)3)15-10-13(23)5-6-17(15)25-21(22)30/h5-8,10,12,14,16H,9,11H2,1-4H3,(H,25,30)/t14-,16-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239865 (CHEMBL4060106) Show SMILES Fc1cccnc1C1CCc2ccc(cc2O1)N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O Show InChI InChI=1S/C28H23FN4O3/c29-22-7-4-12-30-27(22)24-11-9-19-8-10-21(13-25(19)36-24)33-17-20-16-32(15-18-5-2-1-3-6-18)26(34)14-23(20)31-28(33)35/h1-8,10,12-14,16,24H,9,11,15,17H2,(H,31,35)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260427 (CHEMBL4076348) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260427 (CHEMBL4076348) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260433 (CHEMBL4072226) Show SMILES CC(C)C[C@H]1C[C@@H](CCl)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H24ClN3O2/c1-14(2)11-16-12-15(13-23)22(17-7-3-4-8-18(17)25-21(22)28)26(16)20(27)19-9-5-6-10-24-19/h3-10,14-16H,11-13H2,1-2H3,(H,25,28)/t15-,16-,22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260391 (CHEMBL4079310) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2cccc(F)c12 |r| Show InChI InChI=1S/C23H24FN3O4/c1-13(2)11-14-12-15(21(29)31-3)23(27(14)20(28)18-8-4-5-10-25-18)19-16(24)7-6-9-17(19)26-22(23)30/h4-10,13-15H,11-12H2,1-3H3,(H,26,30)/t14-,15-,23-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239871 (CHEMBL4066070) Show SMILES CCCC1=NN2C(S1)=NC(=O)\C(=C/c1ccc(o1)-c1cccc(c1)C(O)=O)C2=N |c:8,t:3| Show InChI InChI=1S/C20H16N4O4S/c1-2-4-16-23-24-17(21)14(18(25)22-20(24)29-16)10-13-7-8-15(28-13)11-5-3-6-12(9-11)19(26)27/h3,5-10,21H,2,4H2,1H3,(H,26,27)/b14-10-,21-17?	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260397 (CHEMBL4093245) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2c1cccc2F |r| Show InChI InChI=1S/C23H24FN3O4/c1-13(2)11-14-12-16(21(29)31-3)23(27(14)20(28)18-9-4-5-10-25-18)15-7-6-8-17(24)19(15)26-22(23)30/h4-10,13-14,16H,11-12H2,1-3H3,(H,26,30)/t14-,16-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260412 (CHEMBL4062845) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccn(C)n2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C22H25FN4O4/c1-12(2)9-14-11-16(20(29)31-4)22(27(14)19(28)18-7-8-26(3)25-18)15-10-13(23)5-6-17(15)24-21(22)30/h5-8,10,12,14,16H,9,11H2,1-4H3,(H,24,30)/t14-,16-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239863 (CHEMBL4087449) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(Cc3ccccc3)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C29H25FN4O3/c1-18-12-20-9-10-25(28-22(30)8-5-11-31-28)37-26(20)14-24(18)34-17-21-16-33(15-19-6-3-2-4-7-19)27(35)13-23(21)32-29(34)36/h2-8,11-14,16,25H,9-10,15,17H2,1H3,(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239861 (CHEMBL4092701) Show SMILES OC(=O)c1cccc(c1)-c1ccc(\C=C2/C(=O)N=C3SC(=NN3C2=N)C2CCCCC2)o1 |c:21,t:18| Show InChI InChI=1S/C23H20N4O4S/c24-19-17(12-16-9-10-18(31-16)14-7-4-8-15(11-14)22(29)30)20(28)25-23-27(19)26-21(32-23)13-5-2-1-3-6-13/h4,7-13,24H,1-3,5-6H2,(H,29,30)/b17-12-,24-19?	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260440 (CHEMBL4100905) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccc(Cl)cc12 |r| Show InChI InChI=1S/C23H24ClN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)19-6-4-5-9-25-19)16-11-14(24)7-8-18(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260437 (CHEMBL4097700) Show SMILES CC(C)C[C@H]1C[C@@H](CO)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H25N3O3/c1-14(2)11-16-12-15(13-26)22(17-7-3-4-8-18(17)24-21(22)28)25(16)20(27)19-9-5-6-10-23-19/h3-10,14-16,26H,11-13H2,1-2H3,(H,24,28)/t15-,16-,22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50235738 (Hippuristanol) Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition towards glutamate racemase from Lactobacillus fermenti was determined and expressed as KI				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239872 (CHEMBL4095148) Show SMILES Cc1cc2CCC(Oc2cc1N1Cc2cn(CC(F)(F)F)c(=O)cc2NC1=O)c1ncccc1F Show InChI InChI=1S/C24H20F4N4O3/c1-13-7-14-4-5-19(22-16(25)3-2-6-29-22)35-20(14)9-18(13)32-11-15-10-31(12-24(26,27)28)21(33)8-17(15)30-23(32)34/h2-3,6-10,19H,4-5,11-12H2,1H3,(H,30,34)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50239870 (CHEMBL4061514) Show SMILES O=C1Nc2cc(=O)n(Cc3ccccc3)cc2CN1c1ccccc1OCc1ccccc1 Show InChI InChI=1S/C27H23N3O3/c31-26-15-23-22(17-29(26)16-20-9-3-1-4-10-20)18-30(27(32)28-23)24-13-7-8-14-25(24)33-19-21-11-5-2-6-12-21/h1-15,17H,16,18-19H2,(H,28,32)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda California Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				J Med Chem 60: 5759-5771 (2017) Article DOI: 10.1021/acs.jmedchem.7b00461 BindingDB Entry DOI: 10.7270/Q2MC925G
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260425 (CHEMBL4099313) Show SMILES CC(C)C[C@@H]1C[C@H](C)[C@]2(N1C(=O)c1cn(C)cn1)C(=O)Nc1ccc(F)cc21 |r| Show InChI InChI=1S/C21H25FN4O2/c1-12(2)7-15-8-13(3)21(26(15)19(27)18-10-25(4)11-23-18)16-9-14(22)5-6-17(16)24-20(21)28/h5-6,9-13,15H,7-8H2,1-4H3,(H,24,28)/t13-,15+,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260396 (CHEMBL4065602) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2cc(F)ccc12 |r| Show InChI InChI=1S/C23H24FN3O4/c1-13(2)10-15-12-17(21(29)31-3)23(27(15)20(28)18-6-4-5-9-25-18)16-8-7-14(24)11-19(16)26-22(23)30/h4-9,11,13,15,17H,10,12H2,1-3H3,(H,26,30)/t15-,17-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50265561 (CHEMBL4073833) Show SMILES Cc1c(cnn1-c1cccc(c1)C#N)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cc1 |r| Show InChI InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of human recombinant full-length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cells using si...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM65493 (eIF4A3 inhibitor, 2) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
BC Cancer Agency					Assay Description Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...				ACS Chem Biol 12: 1760-1768 (2017) Article DOI: 10.1021/acschembio.7b00041 BindingDB Entry DOI: 10.7270/Q2T151TG
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50283443 (CHEMBL4170030) Show SMILES Cn1cc(cc(-c2cccc(c2)C#N)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r| Show InChI InChI=1S/C30H23BrClN5O3/c1-35-17-22(14-25(29(35)39)21-4-2-3-19(13-21)15-33)28(38)36-11-12-37(30(40)26-10-7-23(31)16-34-26)27(18-36)20-5-8-24(32)9-6-20/h2-10,13-14,16-17,27H,11-12,18H2,1H3/t27-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM65493 (eIF4A3 inhibitor, 2) Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12 |r| Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50283445 (CHEMBL4175313) Show SMILES FC(F)(F)c1cccc(c1)-c1cc(cn(-c2ccccc2)c1=O)C(=O)N1CCN([C@H](C1)c1ccc(Cl)cc1)C(=O)c1ccc(Br)cn1 |r| Show InChI InChI=1S/C35H25BrClF3N4O3/c36-26-11-14-30(41-19-26)34(47)43-16-15-42(21-31(43)22-9-12-27(37)13-10-22)32(45)24-18-29(23-5-4-6-25(17-23)35(38,39)40)33(46)44(20-24)28-7-2-1-3-8-28/h1-14,17-20,31H,15-16,21H2/t31-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Ltd. Curated by ChEMBL					Assay Description Inhibition of human recombinant N-terminal full length His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				ACS Med Chem Lett 8: 1077-1082 (2017) Article DOI: 10.1021/acsmedchemlett.7b00283 BindingDB Entry DOI: 10.7270/Q2QJ7KT3
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50235737 (CHEMBL4070102) Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O Show InChI InChI=1S/C12H11ClFNO2/c1-5(2)6-3-8(13)7-4-9(12(16)17)15-11(7)10(6)14/h3-5,15H,1-2H3,(H,16,17)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 insect cel...				Bioorg Med Chem 25: 2200-2209 (2017) Article DOI: 10.1016/j.bmc.2017.02.035 BindingDB Entry DOI: 10.7270/Q2902613
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260441 (CHEMBL4085493) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2cccnc2)[C@@]11C(=O)Nc2ccc(F)cc12 |r| Show InChI InChI=1S/C23H24FN3O4/c1-13(2)9-16-11-18(21(29)31-3)23(27(16)20(28)14-5-4-8-25-12-14)17-10-15(24)6-7-19(17)26-22(23)30/h4-8,10,12-13,16,18H,9,11H2,1-3H3,(H,26,30)/t16-,18-,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260429 (CHEMBL4060638) Show SMILES COC(=O)[C@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17+,23+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260439 (CHEMBL4098071) Show SMILES COC(=O)[C@@H]1C[C@H](Cc2ccccc2)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C26H23N3O4/c1-33-24(31)20-16-18(15-17-9-3-2-4-10-17)29(23(30)22-13-7-8-14-27-22)26(20)19-11-5-6-12-21(19)28-25(26)32/h2-14,18,20H,15-16H2,1H3,(H,28,32)/t18-,20-,26+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260436 (CHEMBL4088033) Show SMILES COC(=O)[C@@H]1C[C@H](C)N(C(=O)c2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C20H19N3O4/c1-12-11-14(18(25)27-2)20(13-7-3-4-8-15(13)22-19(20)26)23(12)17(24)16-9-5-6-10-21-16/h3-10,12,14H,11H2,1-2H3,(H,22,26)/t12-,14-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260435 (CHEMBL4066737) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)Cc2ccccn2)[C@@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C24H27N3O4/c1-15(2)12-17-14-19(22(29)31-3)24(18-9-4-5-10-20(18)26-23(24)30)27(17)21(28)13-16-8-6-7-11-25-16/h4-11,15,17,19H,12-14H2,1-3H3,(H,26,30)/t17-,19-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260434 (CHEMBL4060758) Show SMILES COC(=O)[C@@H]1C[C@H](CC(C)C)N(C(=O)c2ccccn2)[C@@]11C(=O)N(C)c2ccccc12 |r| Show InChI InChI=1S/C24H27N3O4/c1-15(2)13-16-14-18(22(29)31-4)24(27(16)21(28)19-10-7-8-12-25-19)17-9-5-6-11-20(17)26(3)23(24)30/h5-12,15-16,18H,13-14H2,1-4H3/t16-,18-,24+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260431 (CHEMBL4076160) Show SMILES CC(C)C[C@H]1C[C@@H](C(N)=O)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H24N4O3/c1-13(2)11-14-12-16(19(23)27)22(15-7-3-4-8-17(15)25-21(22)29)26(14)20(28)18-9-5-6-10-24-18/h3-10,13-14,16H,11-12H2,1-2H3,(H2,23,27)(H,25,29)/t14-,16-,22+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260430 (CHEMBL4076134) Show SMILES Cl.CC(C)C[C@H]1C[C@@H](C(O)=O)[C@@]2(N1C(=O)c1ccccn1)C(=O)Nc1ccccc21 |r| Show InChI InChI=1S/C22H23N3O4.ClH/c1-13(2)11-14-12-16(20(27)28)22(15-7-3-4-8-17(15)24-21(22)29)25(14)19(26)18-9-5-6-10-23-18;/h3-10,13-14,16H,11-12H2,1-2H3,(H,24,29)(H,27,28);1H/t14-,16-,22+;/m0./s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair
U5 small nuclear ribonucleoprotein 200 kDa helicase (Homo sapiens (Human))	BDBM50260428 (CHEMBL4098860) Show SMILES COC(=O)[C@H]1C[C@@H](CC(C)C)N(C(=O)c2ccccn2)[C@]11C(=O)Nc2ccccc12 |r| Show InChI InChI=1S/C23H25N3O4/c1-14(2)12-15-13-17(21(28)30-3)23(16-8-4-5-9-18(16)25-22(23)29)26(15)20(27)19-10-6-7-11-24-19/h4-11,14-15,17H,12-13H2,1-3H3,(H,25,29)/t15-,17-,23+/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of full length recombinant human N-terminal His-tagged BRR2 RNA dependent ATPase activity expressed in baculovirus infected Sf9 cells usin...				Bioorg Med Chem 25: 4753-4767 (2017) Article DOI: 10.1016/j.bmc.2017.07.017 BindingDB Entry DOI: 10.7270/Q27M0BDH
					More data for this Ligand-Target Pair

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