Found 629 hits of ic50 data for polymerid = 2740 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human RSK2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.124 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human RSK2 using KKLNRTLSVA as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168025
(US9073926, 59)Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 |r| Show InChI InChI=1S/C22H20N6O2/c1-14-10-23-22(30)19-9-16-7-8-18(26-20(16)28(14)19)21(29)25-17-11-24-27(13-17)12-15-5-3-2-4-6-15/h2-9,11,13-14H,10,12H2,1H3,(H,23,30)(H,25,29)/t14-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168034
(US9073926, 68)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccncc2)c1 Show InChI InChI=1S/C22H21N7O2/c1-14-4-9-24-22(31)19-10-16-2-3-18(27-20(16)29(14)19)21(30)26-17-11-25-28(13-17)12-15-5-7-23-8-6-15/h2-3,5-8,10-11,13-14H,4,9,12H2,1H3,(H,24,31)(H,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50467097
(CHEMBL4292020)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C24H22F2N4O/c1-29-8-10-30(11-9-29)17-4-2-15(3-5-17)22-18-6-7-27-24(18)28-14-19(22)16-12-20(25)23(31)21(26)13-16/h2-7,12-14,31H,8-11H2,1H3,(H,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem Lett 28: 3197-3201 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.020 BindingDB Entry DOI: 10.7270/Q2F76G78 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168027
(US9073926, 61)Show SMILES C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cnn(Cc2ccccc2)c1 |r| Show InChI InChI=1S/C23H22N6O2/c1-14-15(2)29-20(23(31)25-14)10-17-8-9-19(27-21(17)29)22(30)26-18-11-24-28(13-18)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,25,31)(H,26,30)/t14-,15+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.340 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168012
(US9073926, 46)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C23H22N6O2/c1-15-9-10-24-23(31)20-11-17-7-8-19(27-21(17)29(15)20)22(30)26-18-12-25-28(14-18)13-16-5-3-2-4-6-16/h2-8,11-12,14-15H,9-10,13H2,1H3,(H,24,31)(H,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bologna
Curated by ChEMBL
| Assay Description Inhibition of RSK2 using biotinylated substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence microplate ... |
Eur J Med Chem 46: 4311-23 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.001 BindingDB Entry DOI: 10.7270/Q2NG4R1D |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168006
(US9073926, 40)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(C)c1 Show InChI InChI=1S/C17H18N6O2/c1-10-5-6-18-17(25)14-7-11-3-4-13(21-15(11)23(10)14)16(24)20-12-8-19-22(2)9-12/h3-4,7-10H,5-6H2,1-2H3,(H,18,25)(H,20,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50360301
(CHEMBL1933288 | US9150577, 93)Show SMILES C[C@@H]1CCNC(=O)c2cc3ccc(cc3n12)C(=O)Nc1nc2ccccc2n1CCCN(C)C |r| Show InChI InChI=1S/C26H30N6O2/c1-17-11-12-27-25(34)23-15-18-9-10-19(16-22(18)32(17)23)24(33)29-26-28-20-7-4-5-8-21(20)31(26)14-6-13-30(2)3/h4-5,7-10,15-17H,6,11-14H2,1-3H3,(H,27,34)(H,28,29,33)/t17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer-Ingelheim Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human RSK2 |
Bioorg Med Chem Lett 22: 738-42 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.029 BindingDB Entry DOI: 10.7270/Q2348KTR |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50360293
(CHEMBL1933280 | US9150577, 81)Show SMILES CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2ccccc12 Show InChI InChI=1S/C22H21N5O2/c1-2-26-17-7-4-3-6-16(17)24-22(26)25-20(28)15-9-8-14-12-19-21(29)23-10-5-11-27(19)18(14)13-15/h3-4,6-9,12-13H,2,5,10-11H2,1H3,(H,23,29)(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer-Ingelheim Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human RSK2 |
Bioorg Med Chem Lett 22: 738-42 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.029 BindingDB Entry DOI: 10.7270/Q2348KTR |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50536679
(CHEMBL4568087)Show SMILES Cn1cc(cn1)-c1cnc2c(cnn2c1)-c1csc(c1)C(=O)N[C@@H]1CCCC[C@@H]1N |r| Show InChI InChI=1S/C21H23N7OS/c1-27-10-15(8-24-27)14-7-23-20-16(9-25-28(20)11-14)13-6-19(30-12-13)21(29)26-18-5-3-2-4-17(18)22/h6-12,17-18H,2-5,22H2,1H3,(H,26,29)/t17-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck and Co.
Curated by ChEMBL
| Assay Description Inhibition of full-length recombinant human His-tagged RPS6KA3 expressed in baculovirus expression system by Z'-LYTE assay |
Bioorg Med Chem Lett 26: 4362-6 (2016)
Article DOI: 10.1016/j.bmcl.2016.02.003 BindingDB Entry DOI: 10.7270/Q2NP27X5 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168009
(US9073926, 43)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(c1)C(C)(C)C Show InChI InChI=1S/C20H24N6O2/c1-12-7-8-21-19(28)16-9-13-5-6-15(24-17(13)26(12)16)18(27)23-14-10-22-25(11-14)20(2,3)4/h5-6,9-12H,7-8H2,1-4H3,(H,21,28)(H,23,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168070
(US9073926, 104)Show SMILES Cn1cc(NC(=O)c2ccc3cc4C(=O)NCCCn4c3n2)nc1C(=O)NC1CCCC1 Show InChI InChI=1S/C22H25N7O3/c1-28-12-17(26-19(28)22(32)24-14-5-2-3-6-14)27-20(30)15-8-7-13-11-16-21(31)23-9-4-10-29(16)18(13)25-15/h7-8,11-12,14H,2-6,9-10H2,1H3,(H,23,31)(H,24,32)(H,27,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50431812
(CHEMBL2347053)Show SMILES [O-][N+](=O)c1ccccc1-c1n[nH]cc1C=C1C(=O)Nc2ccccc12 |w:14.15| Show InChI InChI=1S/C18H12N4O3/c23-18-14(12-5-1-3-7-15(12)20-18)9-11-10-19-21-17(11)13-6-2-4-8-16(13)22(24)25/h1-10H,(H,19,21)(H,20,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
East China University of Science and Technology
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) using AKRRRLSSLRA as substrate after 60 mins by fluorescence assay |
Bioorg Med Chem 21: 1724-34 (2013)
Article DOI: 10.1016/j.bmc.2013.01.047 BindingDB Entry DOI: 10.7270/Q2GQ704N |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168001
(US9073926, 35)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2n(CC3CCOC3)ncc2c1 Show InChI InChI=1S/C24H25N7O3/c1-14-4-6-25-24(33)20-9-16-2-3-19(29-22(16)31(14)20)23(32)28-18-8-17-10-27-30(21(17)26-11-18)12-15-5-7-34-13-15/h2-3,8-11,14-15H,4-7,12-13H2,1H3,(H,25,33)(H,28,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM286091
((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 |r| Show InChI InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
PHOENIX MOLECULAR DESIGNS
US Patent
| Assay Description Radioisotope assays were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radioactive workin... |
US Patent US10758530 (2020)
BindingDB Entry DOI: 10.7270/Q20R9SGD |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM286091
((R)¿N-(1-(4-aminobenzyl)-1H-pyrazol-4-yl)-9-methyl...)Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnn(Cc2ccc(N)cc2)c1 |r| Show InChI InChI=1S/C27H29N7O4/c1-16-12-28-25(36)22-11-18-7-10-21(32-23(18)34(16)22)24(35)30-20-13-29-33(15-20)14-17-5-8-19(9-6-17)31-26(37)38-27(2,3)4/h5-11,13,15-16H,12,14H2,1-4H3,(H,28,36)(H,30,35)(H,31,37)/t16-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
PHOENIX MOLECULAR DESIGN
US Patent
| Assay Description Radioisotope assays (SignalChem) were performed for the evaluation of the kinase target profiling and all assays were performed in a designated radio... |
US Patent US9771366 (2017)
BindingDB Entry DOI: 10.7270/Q2862JK5 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50467096
(CHEMBL4278817)Show SMILES Oc1c(F)cc(cc1F)-c1cnc2[nH]ccc2c1-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C23H19F2N3O2/c24-19-11-15(12-20(25)22(19)29)18-13-27-23-17(5-6-26-23)21(18)14-1-3-16(4-2-14)28-7-9-30-10-8-28/h1-6,11-13,29H,7-10H2,(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem Lett 28: 3197-3201 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.020 BindingDB Entry DOI: 10.7270/Q2F76G78 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50467103
(CHEMBL4289492)Show SMILES Cc1ccc(cc1)-c1c(cnc2[nH]ccc12)-c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C20H14F2N2O/c1-11-2-4-12(5-3-11)18-14-6-7-23-20(14)24-10-15(18)13-8-16(21)19(25)17(22)9-13/h2-10,25H,1H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem Lett 28: 3197-3201 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.020 BindingDB Entry DOI: 10.7270/Q2F76G78 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50360291
(CHEMBL1933278 | US9150577, 114)Show SMILES O=C(Nc1cnn(Cc2ccncc2)c1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C22H20N6O2/c29-21(26-18-12-25-27(14-18)13-15-4-7-23-8-5-15)17-3-2-16-10-20-22(30)24-6-1-9-28(20)19(16)11-17/h2-5,7-8,10-12,14H,1,6,9,13H2,(H,24,30)(H,26,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer-Ingelheim Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human RSK2 |
Bioorg Med Chem Lett 22: 738-42 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.029 BindingDB Entry DOI: 10.7270/Q2348KTR |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM167995
(US9073926, 29)Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NCCC(C)n5c4n3)cnc12 Show InChI InChI=1S/C22H23N7O2/c1-12(2)29-19-15(10-25-29)8-16(11-24-19)26-21(30)17-5-4-14-9-18-22(31)23-7-6-13(3)28(18)20(14)27-17/h4-5,8-13H,6-7H2,1-3H3,(H,23,31)(H,26,30) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM167992
(US9073926, 26)Show SMILES NC(=O)c1ccccc1NC(=O)c1ccc2cc3C(=O)NCCCn3c2n1 Show InChI InChI=1S/C19H17N5O3/c20-16(25)12-4-1-2-5-13(12)23-18(26)14-7-6-11-10-15-19(27)21-8-3-9-24(15)17(11)22-14/h1-2,4-7,10H,3,8-9H2,(H2,20,25)(H,21,27)(H,23,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM167998
(US9073926, 32)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2n(ncc2c1)C1CCOCC1 Show InChI InChI=1S/C24H25N7O3/c1-14-4-7-25-24(33)20-11-15-2-3-19(29-22(15)30(14)20)23(32)28-17-10-16-12-27-31(21(16)26-13-17)18-5-8-34-9-6-18/h2-3,10-14,18H,4-9H2,1H3,(H,25,33)(H,28,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168051
(US9073926, 85)Show SMILES C[C@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cc(C)on1 |r| Show InChI InChI=1S/C17H17N5O3/c1-8-6-14(21-25-8)20-16(23)12-5-4-11-7-13-17(24)18-9(2)10(3)22(13)15(11)19-12/h4-7,9-10H,1-3H3,(H,18,24)(H,20,21,23)/t9-,10+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50420996
(CHEMBL2086760)Show SMILES CCN1CCC(CC1)Nc1ccc2NC(=O)C(=C(c3ncc[nH]3)c3ccc(Cl)cc3)c2c1 Show InChI InChI=1S/C25H26ClN5O/c1-2-31-13-9-18(10-14-31)29-19-7-8-21-20(15-19)23(25(32)30-21)22(24-27-11-12-28-24)16-3-5-17(26)6-4-16/h3-8,11-12,15,18,29H,2,9-10,13-14H2,1H3,(H,27,28)(H,30,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of RSK2 |
Bioorg Med Chem Lett 22: 4979-85 (2012)
Article DOI: 10.1016/j.bmcl.2012.06.029 BindingDB Entry DOI: 10.7270/Q2XG9SD4 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168028
(US9073926, 62)Show SMILES C[C@@H]1NC(=O)c2cc3ccc(nc3n2[C@H]1C)C(=O)Nc1cnn(Cc2ccccc2)c1 |r| Show InChI InChI=1S/C23H22N6O2/c1-14-15(2)29-20(23(31)25-14)10-17-8-9-19(27-21(17)29)22(30)26-18-11-24-28(13-18)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H,25,31)(H,26,30)/t14-,15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168030
(US9073926, 64)Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cnc2ccccc2c1 |r| Show InChI InChI=1S/C21H17N5O2/c1-12-10-23-21(28)18-9-14-6-7-17(25-19(14)26(12)18)20(27)24-15-8-13-4-2-3-5-16(13)22-11-15/h2-9,11-12H,10H2,1H3,(H,23,28)(H,24,27)/t12-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168060
(US9073926, 94)Show SMILES CC1CCNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1 Show InChI InChI=1S/C23H21N5O3/c1-14-9-10-24-23(30)19-12-16-7-8-18(25-21(16)28(14)19)22(29)26-20-13-17(31-27-20)11-15-5-3-2-4-6-15/h2-8,12-14H,9-11H2,1H3,(H,24,30)(H,26,27,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168061
(US9073926, 95)Show SMILES O=C(Nc1cc(Cc2ccccc2)no1)c1ccc2cc3C(=O)NCCCn3c2n1 Show InChI InChI=1S/C22H19N5O3/c28-21(25-19-13-16(26-30-19)11-14-5-2-1-3-6-14)17-8-7-15-12-18-22(29)23-9-4-10-27(18)20(15)24-17/h1-3,5-8,12-13H,4,9-11H2,(H,23,29)(H,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168013
(US9073926, 47)Show SMILES O=C(Nc1cnn(Cc2ccccc2)c1)c1ccc2cc3C(=O)NCCCn3c2n1 Show InChI InChI=1S/C22H20N6O2/c29-21(25-17-12-24-27(14-17)13-15-5-2-1-3-6-15)18-8-7-16-11-19-22(30)23-9-4-10-28(19)20(16)26-18/h1-3,5-8,11-12,14H,4,9-10,13H2,(H,23,30)(H,25,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168004
(US9073926, 38)Show InChI InChI=1S/C18H17N5O2/c1-11-5-7-19-15(9-11)22-17(24)13-4-3-12-10-14-18(25)20-6-2-8-23(14)16(12)21-13/h3-5,7,9-10H,2,6,8H2,1H3,(H,20,25)(H,19,22,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168064
(US9073926, 98)Show SMILES C[C@@H]1CNC(=O)c2cc3ccc(nc3n12)C(=O)Nc1cc(Cc2ccccc2)on1 |r| Show InChI InChI=1S/C22H19N5O3/c1-13-12-23-22(29)18-10-15-7-8-17(24-20(15)27(13)18)21(28)25-19-11-16(30-26-19)9-14-5-3-2-4-6-14/h2-8,10-11,13H,9,12H2,1H3,(H,23,29)(H,25,26,28)/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111385
(CHEMBL3604793)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of full length recombinant His-tagged human RSK2 expressed in baculovirus expression system using biotin-labelled AGAGRSRHSSYPAGT-OH as su... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00969 BindingDB Entry DOI: 10.7270/Q2WD44DC |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50361851
(CHEMBL1938803 | US9150577, 55)Show SMILES O=C(Nc1nc2ccccc2[nH]1)c1ccc2cc3C(=O)NCCCn3c2c1 Show InChI InChI=1S/C20H17N5O2/c26-18(24-20-22-14-4-1-2-5-15(14)23-20)13-7-6-12-10-17-19(27)21-8-3-9-25(17)16(12)11-13/h1-2,4-7,10-11H,3,8-9H2,(H,21,27)(H2,22,23,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer-Ingelheim Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of RSK2 phosphorylation by luminescence assay |
Bioorg Med Chem Lett 22: 733-7 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.030 BindingDB Entry DOI: 10.7270/Q2XW4K7N |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168032
(US9073926, 66)Show SMILES CC(C)n1ncc2cc(NC(=O)c3ccc4cc5C(=O)NC[C@@H](C)n5c4n3)cnc12 |r| Show InChI InChI=1S/C21H21N7O2/c1-11(2)28-18-14(9-24-28)6-15(10-22-18)25-20(29)16-5-4-13-7-17-21(30)23-8-12(3)27(17)19(13)26-16/h4-7,9-12H,8H2,1-3H3,(H,23,30)(H,25,29)/t12-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111394
(CHEMBL3604784)Show InChI InChI=1S/C19H16F2N2O2/c20-17-9-13(10-18(21)19(17)24)16-11-23-6-4-15(16)12-2-1-3-14(8-12)25-7-5-22/h1-4,6,8-11,24H,5,7,22H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst... |
J Med Chem 58: 6766-83 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00450 BindingDB Entry DOI: 10.7270/Q21C1ZN6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50403059
(CHEMBL2216829 | US9505766, 64)Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC(C)(C)C)n(CCCO)c2ncnc(N)c12 Show InChI InChI=1S/C24H28N6O2/c1-15-6-8-16(9-7-15)19-18(12-17(13-25)23(32)29-24(2,3)4)30(10-5-11-31)22-20(19)21(26)27-14-28-22/h6-9,12,14,31H,5,10-11H2,1-4H3,(H,29,32)(H2,26,27,28)/b17-12+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Covalution Pharma BV
Curated by ChEMBL
| Assay Description Inhibition of RSK2 transfected in HEK293 cells |
J Med Chem 55: 6243-62 (2012)
Article DOI: 10.1021/jm3003203 BindingDB Entry DOI: 10.7270/Q2X92CGP |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111384
(CHEMBL3604794)Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem Lett 28: 3197-3201 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.020 BindingDB Entry DOI: 10.7270/Q2F76G78 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM25017
(2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimeth...)Show SMILES CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 Show InChI InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Colorado Anschutz Medical Campus
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem 28: (2020)
Article DOI: 10.1016/j.bmc.2019.115303 BindingDB Entry DOI: 10.7270/Q2XW4PCP |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50021658
(CHEMBL3298194)Show SMILES COc1cc(Nc2nc3cccc(-c4cccc5[nH]cnc45)c3o2)cc(OC)c1OC Show InChI InChI=1S/C23H20N4O4/c1-28-18-10-13(11-19(29-2)22(18)30-3)26-23-27-17-9-5-7-15(21(17)31-23)14-6-4-8-16-20(14)25-12-24-16/h4-12H,1-3H3,(H,24,25)(H,26,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant full length RSK2 (unknown origin) using biotin-AGAGRSRHSSYPAGT-OH as substrate after 150 mins |
Bioorg Med Chem Lett 24: 1592-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.058 BindingDB Entry DOI: 10.7270/Q2V126DB |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50360300
(CHEMBL1933287 | US9150577, 105)Show SMILES CCn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc2cccnc12 Show InChI InChI=1S/C21H20N6O2/c1-2-26-18-15(5-3-8-22-18)24-21(26)25-19(28)14-7-6-13-11-17-20(29)23-9-4-10-27(17)16(13)12-14/h3,5-8,11-12H,2,4,9-10H2,1H3,(H,23,29)(H,24,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer-Ingelheim Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human RSK2 |
Bioorg Med Chem Lett 22: 738-42 (2011)
Article DOI: 10.1016/j.bmcl.2011.10.029 BindingDB Entry DOI: 10.7270/Q2348KTR |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111373
(CHEMBL3604889)Show SMILES CC(C)CCN1[C@H](C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12 |r| Show InChI InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst... |
J Med Chem 58: 6766-83 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00450 BindingDB Entry DOI: 10.7270/Q21C1ZN6 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111384
(CHEMBL3604794)Show SMILES Oc1c(F)cc(cc1F)-c1cnccc1-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C21H18F2N2O2/c22-19-11-15(12-20(23)21(19)26)18-13-24-6-5-17(18)14-1-3-16(4-2-14)25-7-9-27-10-8-25/h1-6,11-13,26H,7-10H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst... |
J Med Chem 58: 6766-83 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00450 BindingDB Entry DOI: 10.7270/Q21C1ZN6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111391
(CHEMBL3604787)Show SMILES CN1CCN(CC1)c1cccc(c1)-c1ccncc1-c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C22H21F2N3O/c1-26-7-9-27(10-8-26)17-4-2-3-15(11-17)18-5-6-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-6,11-14,28H,7-10H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Histidine-tagged RSK2 using biotin-AGAGRSRHSSYPAGT-OH as substrate preincubated for 30 mins followed by ATP and subst... |
J Med Chem 58: 6766-83 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00450 BindingDB Entry DOI: 10.7270/Q21C1ZN6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168047
(US9073926, 81)Show SMILES O=C(Nc1cc(no1)-c1ccccc1)c1ccc2cc3C(=O)NCCCn3c2n1 Show InChI InChI=1S/C21H17N5O3/c27-20(24-18-12-16(25-29-18)13-5-2-1-3-6-13)15-8-7-14-11-17-21(28)22-9-4-10-26(17)19(14)23-15/h1-3,5-8,11-12H,4,9-10H2,(H,22,28)(H,24,27) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM167984
(US9073926, 18)Show SMILES CC(C)n1c(NC(=O)c2ccc3nc4C(=O)NCCC(C)(C)n4c3c2)nc2ccccc12 Show InChI InChI=1S/C24H26N6O2/c1-14(2)29-18-8-6-5-7-16(18)27-23(29)28-21(31)15-9-10-17-19(13-15)30-20(26-17)22(32)25-12-11-24(30,3)4/h5-10,13-14H,11-12H2,1-4H3,(H,25,32)(H,27,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM168007
(US9073926, 41)Show InChI InChI=1S/C16H16N6O2/c1-21-9-11(8-18-21)19-15(23)12-4-3-10-7-13-16(24)17-5-2-6-22(13)14(10)20-12/h3-4,7-9H,2,5-6H2,1H3,(H,17,24)(H,19,23) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingelheim International GmbH
US Patent
| Assay Description Human RSK2 protein, purchased from Invitrogen, is used to measure kinase activity utilizing Kinase Glo Plus (Promega) a homogeneous assay technology,... |
US Patent US9073926 (2015)
BindingDB Entry DOI: 10.7270/Q2BP01J6 |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM259808
(US9505766, 74 | US9505766, CN-NHiPr (7))Show SMILES CC(C)NC(=O)C(=C\c1c(-c2ccc(C)cc2)c2c(N)ncnc2n1CCCO)\C#N Show InChI InChI=1S/C23H26N6O2/c1-14(2)28-23(31)17(12-24)11-18-19(16-7-5-15(3)6-8-16)20-21(25)26-13-27-22(20)29(18)9-4-10-30/h5-8,11,13-14,30H,4,9-10H2,1-3H3,(H,28,31)(H2,25,26,27)/b17-11+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Pittsburgh
Curated by ChEMBL
| Assay Description Inhibition of RSK2 in human MDA-MB-231 cells after 2 hrs |
J Med Chem 60: 839-885 (2017)
Article DOI: 10.1021/acs.jmedchem.6b00788 BindingDB Entry DOI: 10.7270/Q2JW8H9T |
More data for this Ligand-Target Pair | |
Ribosomal protein S6 kinase alpha-3
(Homo sapiens (Human)) | BDBM50111385
(CHEMBL3604793)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1ccncc1-c1cc(F)c(O)c(F)c1 Show InChI InChI=1S/C22H21F2N3O/c1-26-8-10-27(11-9-26)17-4-2-15(3-5-17)18-6-7-25-14-19(18)16-12-20(23)22(28)21(24)13-16/h2-7,12-14,28H,8-11H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for Biomedical Research
Curated by ChEMBL
| Assay Description Inhibition of RSK2 (unknown origin) |
Bioorg Med Chem Lett 28: 3197-3201 (2018)
Article DOI: 10.1016/j.bmcl.2018.08.020 BindingDB Entry DOI: 10.7270/Q2F76G78 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |