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Compile Data Set for Download or QSAR

Found 2514 hits of ic50 data for polymerid = 359   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.0200n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 17 D820Y single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.120n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 17 Y823D single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.180n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 11/17 V560G/N822K double mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot k...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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n/an/a 0.180n/an/an/an/an/an/a



Temple University—Of The Commonwealth System Of Higher Education

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...

US Patent US8889696 (2014)


BindingDB Entry DOI: 10.7270/Q2930RVR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.670n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 17 D816H single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.810n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 17 D820E single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.890n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT A loop exon 18 A829P single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ass...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50521626
PNG
(CHEMBL4448433)
Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)-c2ccc(NC(=O)Nc3cc(CC)on3)cc2)ncn1
Show InChI InChI=1S/C25H29N9O2S/c1-3-19-13-22(32-36-19)30-24(35)29-18-7-5-17(6-8-18)20-15-26-25(37-20)31-21-14-23(28-16-27-21)34-11-9-33(4-2)10-12-34/h5-8,13-16H,3-4,9-12H2,1-2H3,(H,26,27,28,31)(H2,29,30,32,35)
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n/an/a 0.980n/an/an/an/an/an/a



National Health Research Institutes

Curated by ChEMBL


Assay Description
Inhibition of human c-KIT JM domain exon 11 V560G single mutant using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase ...

J Med Chem 62: 3940-3957 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01845
BindingDB Entry DOI: 10.7270/Q2TB1B92
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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n/an/a 0.984n/an/an/an/an/an/a


TBA



Citation and Details
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50399538
PNG
(BAY-579352 | CHEMBL2079588)
Show SMILES CNC(=O)c1cc(COc2nnc(Nc3ccc(Cl)cc3)c3ccoc23)ccn1
Show InChI InChI=1S/C20H16ClN5O3/c1-22-19(27)16-10-12(6-8-23-16)11-29-20-17-15(7-9-28-17)18(25-26-20)24-14-4-2-13(21)3-5-14/h2-10H,11H2,1H3,(H,22,27)(H,24,25)
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TBA

Assay Description
Inhibition of c-Kit (unknown origin)

Citation and Details

Article DOI: 10.1021/acs.jmedchem.1c00678
BindingDB Entry DOI: 10.7270/Q2Q2443B
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397846
PNG
(US9994552, Compound 57)
Show SMILES COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C26H28N6O3/c1-33-20-6-4-5-18(12-20)11-19-15-27-26(28-16-19)32-9-7-31(8-10-32)25-21-13-23(34-2)24(35-3)14-22(21)29-17-30-25/h4-6,12-17H,7-11H2,1-3H3
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50260888
PNG
(3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-...)
Show SMILES Cc1ccn(CCC2CCCC2)c(=O)c1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C21H24N4O/c1-14-8-10-25(11-9-15-4-2-3-5-15)20(26)19(14)16-6-7-18-17(12-16)13-23-21(22)24-18/h6-8,10,12-13,15H,2-5,9,11H2,1H3,(H2,22,23,24)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by TR-FRET assay

J Med Chem 51: 3065-8 (2008)


Article DOI: 10.1021/jm800188g
BindingDB Entry DOI: 10.7270/Q2DN44TT
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50215791
PNG
(2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-di...)
Show SMILES CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C22H18F2N4O4/c1-13(29)27-20-10-14(8-9-25-20)12-26-17-5-3-2-4-16(17)21(30)28-15-6-7-18-19(11-15)32-22(23,24)31-18/h2-11,26H,12H2,1H3,(H,28,30)(H,25,27,29)
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n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay

Bioorg Med Chem Lett 17: 4378-81 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.075
BindingDB Entry DOI: 10.7270/Q28K78S7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50264392
PNG
(CHEMBL490823 | N-(6-acetamidopyridin-3-yl)-6-chlor...)
Show SMILES CC(=O)Nc1ccc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1
Show InChI InChI=1S/C22H15ClF3N5O3/c1-11(32)28-17-8-5-14(10-27-17)30-21(33)18-16(23)7-6-15-19(18)34-31-20(15)29-13-4-2-3-12(9-13)22(24,25)26/h2-10H,1H3,(H,29,31)(H,30,33)(H,27,28,32)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)

Bioorg Med Chem Lett 18: 5115-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.111
BindingDB Entry DOI: 10.7270/Q2B56JJH
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50264437
PNG
(CHEMBL488984 | N-(2-aminopyrimidin-5-yl)-6-chloro-...)
Show SMILES Nc1ncc(NC(=O)c2c(Cl)ccc3c(Nc4cccc(c4)C(F)(F)F)noc23)cn1
Show InChI InChI=1S/C19H12ClF3N6O2/c20-13-5-4-12-15(14(13)17(30)28-11-7-25-18(24)26-8-11)31-29-16(12)27-10-3-1-2-9(6-10)19(21,22)23/h1-8H,(H,27,29)(H,28,30)(H2,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-kit (unknown origin)

Bioorg Med Chem Lett 18: 5115-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.111
BindingDB Entry DOI: 10.7270/Q2B56JJH
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay

Bioorg Med Chem 23: 7340-7 (2015)


Article DOI: 10.1016/j.bmc.2015.10.035
BindingDB Entry DOI: 10.7270/Q2BZ67VR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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n/an/a 1n/an/an/an/an/an/a



Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay

Bioorg Med Chem 23: 7340-7 (2015)


Article DOI: 10.1016/j.bmc.2015.10.035
BindingDB Entry DOI: 10.7270/Q2BZ67VR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50331029
PNG
((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(C[C@H](O)CN3CCOCC3)C(=O)c12 |r|
Show InChI InChI=1S/C24H27FN4O4/c1-14-21(11-18-17-10-15(25)2-3-19(17)27-23(18)31)26-20-4-5-29(24(32)22(14)20)13-16(30)12-28-6-8-33-9-7-28/h2-3,10-11,16,26,30H,4-9,12-13H2,1H3,(H,27,31)/b18-11-/t16-/m1/s1
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Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA

J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50331028
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(CCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C23H25FN4O3/c1-14-20(13-17-16-12-15(24)2-3-18(16)26-22(17)29)25-19-4-5-28(23(30)21(14)19)7-6-27-8-10-31-11-9-27/h2-3,12-13,25H,4-11H2,1H3,(H,26,29)/b17-13-
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Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA

J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50331026
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O
Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-
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n/an/a 1n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA

J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST/His6-tagged c-KIT (544 to 976 residues) expressed in baculovirus infected sf9 cells using biotinylated...

Eur J Med Chem 126: 476-490 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.052
BindingDB Entry DOI: 10.7270/Q2445PQT
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397898
PNG
(US9994552, Compound 109)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC(=O)C1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-16-25-24(15-27(26)40-19-22-7-8-31-28(38)14-22)29(35-20-34-25)36-9-11-37(12-10-36)30-32-17-23(18-33-30)13-21-5-3-2-4-6-21/h2-6,15-18,20,22H,7-14,19H2,1H3,(H,31,38)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397894
PNG
(US9994552, Compound 105)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM13216
PNG
(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
Show InChI InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
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n/an/a 1n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of c-kit (unknown origin)

Citation and Details

Article DOI: 10.1016/j.bmc.2020.115657
BindingDB Entry DOI: 10.7270/Q21J9FHZ
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397899
PNG
(US9994552, Compound 110)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCN1CCCC1=O
Show InChI InChI=1S/C30H33N7O3/c1-39-26-18-25-24(17-27(26)40-15-14-35-9-5-8-28(35)38)29(34-21-33-25)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397900
PNG
(US9994552, Compound 111)
Show SMILES COc1cc2c(ncnc2cc1OCCN1CCCC1=O)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-17-24-25(18-27(26)40-15-14-35-9-5-8-28(35)38)33-21-34-29(24)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397901
PNG
(US9994552, Compound 112)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-8-24(9-11-36)21-40-29-17-26-27(18-28(29)39-2)34-22-35-30(26)37-12-14-38(15-13-37)31-32-19-25(20-33-31)16-23-6-4-3-5-7-23/h3-7,17-20,22,24H,8-16,21H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397902
PNG
(US9994552, Compound 113)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@@H]1CCCN(C)C1 |r|
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3/t24-/m1/s1
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397903
PNG
(US9994552, Compound 114)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397906
PNG
(US9994552, Compound 117)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)CCO1
Show InChI InChI=1S/C30H35N7O3/c1-35-12-13-39-24(19-35)20-40-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-8-10-37(11-9-36)30-31-17-23(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,24H,8-14,19-20H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397908
PNG
(US9994552, Compound 119)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CNCCO1
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397909
PNG
(US9994552, Compound 120)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@H]1CNCCO1 |r|
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397910
PNG
(US9994552, Compound 121)
Show SMILES COc1cc2ncnc(N3CC4CCC(C3)N4c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C31H35N7O3/c1-39-28-13-27-26(12-29(28)41-19-25-16-32-9-10-40-25)30(36-20-35-27)37-17-23-7-8-24(18-37)38(23)31-33-14-22(15-34-31)11-21-5-3-2-4-6-21/h2-6,12-15,20,23-25,32H,7-11,16-19H2,1H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397911
PNG
(US9994552, Compound 122)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O2/c1-3-40-30-19-28-27(18-29(30)41-22-25-9-11-37(2)12-10-25)31(36-23-35-28)38-13-15-39(16-14-38)32-33-20-26(21-34-32)17-24-7-5-4-6-8-24/h4-8,18-21,23,25H,3,9-17,22H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397913
PNG
(US9994552, Compound 124)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC[C@@H]1CCCN(C)C1 |r|
Show InChI InChI=1S/C31H38N8O2/c1-37-10-6-9-23(19-37)20-41-28-16-25-26(17-27(28)40-2)34-21-35-30(25)38-11-13-39(14-12-38)31-33-18-24(29(32)36-31)15-22-7-4-3-5-8-22/h3-5,7-8,16-18,21,23H,6,9-15,19-20H2,1-2H3,(H2,32,33,36)/t23-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397914
PNG
(US9994552, Compound 125)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-8-23(9-11-37)20-41-28-17-25-26(18-27(28)40-2)34-21-35-30(25)38-12-14-39(15-13-38)31-33-19-24(29(32)36-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H2,32,33,36)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397916
PNG
(US9994552, Compound 127)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-36-10-8-23(9-11-36)20-41-28-17-25-26(18-27(28)40-2)33-21-34-29(25)37-12-14-38(15-13-37)31-32-19-24(30(39)35-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H,32,35,39)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397920
PNG
(US9994552, Compound 131)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1(F)CCN(C)CC1
Show InChI InChI=1S/C31H36FN7O2/c1-37-10-8-31(32,9-11-37)21-41-28-17-25-26(18-27(28)40-2)35-22-36-29(25)38-12-14-39(15-13-38)30-33-19-24(20-34-30)16-23-6-4-3-5-7-23/h3-7,17-20,22H,8-16,21H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397925
PNG
(US9994552, Compound 136)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-20-27-28(21-29(30)41-2)35-24-36-31(27)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397818
PNG
(US9994552, Compound 29)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC
Show InChI InChI=1S/C25H27N7O2/c1-33-21-13-19-20(14-22(21)34-2)28-16-29-24(19)31-8-10-32(11-9-31)25-27-15-18(23(26)30-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H2,26,27,30)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397824
PNG
(US9994552, Compound 35)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(O)n3)c2cc1OC
Show InChI InChI=1S/C25H26N6O3/c1-33-21-13-19-20(14-22(21)34-2)27-16-28-23(19)30-8-10-31(11-9-30)25-26-15-18(24(32)29-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H,26,29,32)
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of Kit

Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397878
PNG
(US9994552, Compound 89)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC1
Show InChI InChI=1S/C29H33N7O2/c1-37-26-15-25-24(14-27(26)38-19-22-7-8-30-16-22)28(34-20-33-25)35-9-11-36(12-10-35)29-31-17-23(18-32-29)13-21-5-3-2-4-6-21/h2-6,14-15,17-18,20,22,30H,7-13,16,19H2,1H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397879
PNG
(US9994552, Compound 90)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)C1
Show InChI InChI=1S/C29H33N7O2/c1-34-17-23(18-34)19-38-27-13-24-25(14-26(27)37-2)32-20-33-28(24)35-8-10-36(11-9-35)29-30-15-22(16-31-29)12-21-6-4-3-5-7-21/h3-7,13-16,20,23H,8-12,17-19H2,1-2H3
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Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397885
PNG
(US9994552, Compound 96)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)C1
Show InChI InChI=1S/C30H35N7O2/c1-35-9-8-23(19-35)20-39-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-10-12-37(13-11-36)30-31-17-24(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,23H,8-14,19-20H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397886
PNG
(US9994552, Compound 97)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCNC1
Show InChI InChI=1S/C30H35N7O2/c1-38-27-16-26-25(15-28(27)39-20-23-8-5-9-31-17-23)29(35-21-34-26)36-10-12-37(13-11-36)30-32-18-24(19-33-30)14-22-6-3-2-4-7-22/h2-4,6-7,15-16,18-19,21,23,31H,5,8-14,17,20H2,1H3
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n/an/a<1n/an/an/an/an/an/a



Duquesne University



Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

J Med Chem 52: 4892-902 (2009)


BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
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