Found 3079 hits of ic50 data for polymerid = 3662,49000716 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258478
(2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[fur...)Show SMILES FCCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C27H29F4N5O2/c28-7-14-35(26(37)25(36-11-1-8-33-36)19-3-4-22(29)23(30)15-19)10-2-9-34-12-5-27(6-13-34)21-17-32-24(31)16-20(21)18-38-27/h1,3-4,8,11,15-17,25H,2,5-7,9-10,12-14,18H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258478
(2-(3,4-difluorophenyl)-N-(3-(6-fluoro-1H-spiro[fur...)Show SMILES FCCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C27H29F4N5O2/c28-7-14-35(26(37)25(36-11-1-8-33-36)19-3-4-22(29)23(30)15-19)10-2-9-34-12-5-27(6-13-34)21-17-32-24(31)16-20(21)18-38-27/h1,3-4,8,11,15-17,25H,2,5-7,9-10,12-14,18H2 | Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50214034
((1S,3S)-N1-(7-methoxy-4-methylquinolin-2-yl)-N3-(t...)Show SMILES COc1ccc2c(C)cc(N[C@H]3CCC[C@@H](C3)NCc3ccsc3)nc2c1 Show InChI InChI=1S/C22H27N3OS/c1-15-10-22(25-21-12-19(26-2)6-7-20(15)21)24-18-5-3-4-17(11-18)23-13-16-8-9-27-14-16/h6-10,12,14,17-18,23H,3-5,11,13H2,1-2H3,(H,24,25)/t17-,18-/m0/s1 | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca R&D Mölndal
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells |
Bioorg Med Chem Lett 17: 4232-41 (2007)
Article DOI: 10.1016/j.bmcl.2007.05.034
BindingDB Entry DOI: 10.7270/Q27W6BVC |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50192528
(1-(2-(4-fluoro-3-methylphenoxy)-5-((2-(pyrrolidin-...)Show SMILES Cc1cc(Oc2ccc(cc2NC(=O)Nc2cccc(F)c2)C(=O)NCCN2CCCC2)ccc1F Show InChI InChI=1S/C27H28F2N4O3/c1-18-15-22(8-9-23(18)29)36-25-10-7-19(26(34)30-11-14-33-12-2-3-13-33)16-24(25)32-27(35)31-21-6-4-5-20(28)17-21/h4-10,15-17H,2-3,11-14H2,1H3,(H,30,34)(H2,31,32,35) | Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [125I]MCH binding to human MCHR1 expressed in HEK293 cells by HT-SPA |
Bioorg Med Chem Lett 16: 5066-72 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.040
BindingDB Entry DOI: 10.7270/Q2FJ2GD3 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50301705
((Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[fur...)Show SMILES CCO\N=C(\c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc32)cc1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C27H26F3N3O2/c1-2-35-32-26(20-7-8-23(28)24(29)13-20)19-5-3-18(4-6-19)16-33-11-9-27(10-12-33)22-15-31-25(30)14-21(22)17-34-27/h3-8,13-15H,2,9-12,16-17H2,1H3/b32-26- | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50258477
(2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-1H-s...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1cc(F)ncc21)C(=O)C(c1ccc(F)c(F)c1)n1cccn1 Show InChI InChI=1S/C27H30F3N5O2/c1-2-34(26(36)25(35-12-3-9-32-35)19-5-6-22(28)23(29)15-19)11-4-10-33-13-7-27(8-14-33)21-17-31-24(30)16-20(21)18-37-27/h3,5-6,9,12,15-17,25H,2,4,7-8,10-11,13-14,18H2,1H3 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.150 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells |
Bioorg Med Chem Lett 19: 3072-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.016
BindingDB Entry DOI: 10.7270/Q2668D3W |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50169371
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-cyclopropylmethyl-...)Show SMILES Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC3CC3)CC2)c2ccc(cc2)-c2cccc(c2)C#N)c1 Show InChI InChI=1S/C30H30Cl2N4O/c31-26-15-27(32)17-28(16-26)35-29(37)34-20-30(10-12-36(13-11-30)19-21-4-5-21)25-8-6-23(7-9-25)24-3-1-2-22(14-24)18-33/h1-3,6-9,14-17,21H,4-5,10-13,19-20H2,(H2,34,35,37) | Reactome pathway
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| Article
PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Science and Technology
Curated by ChEMBL
| Assay Description
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.126741
BindingDB Entry DOI: 10.7270/Q2GH9NDS |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50301704
((Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[fur...)Show SMILES CO\N=C(\c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc32)cc1)c1ccc(F)c(F)c1 Show InChI InChI=1S/C26H24F3N3O2/c1-33-31-25(19-6-7-22(27)23(28)12-19)18-4-2-17(3-5-18)15-32-10-8-26(9-11-32)21-14-30-24(29)13-20(21)16-34-26/h2-7,12-14H,8-11,15-16H2,1H3/b31-25- | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295692
(CHEMBL555055 | tert-butyl 4-(1-(3,4-difluorophenyl...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)C(=O)OC(C)(C)C)c1ccc(F)c(F)c1 Show InChI InChI=1S/C34H43F3N4O5/c1-5-39(14-6-13-38-15-11-34(12-16-38)26-20-25(35)9-7-24(26)22-45-34)31(43)30(23-8-10-27(36)28(37)19-23)41-18-17-40(21-29(41)42)32(44)46-33(2,3)4/h7-10,19-20,30H,5-6,11-18,21-22H2,1-4H3 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295692
(CHEMBL555055 | tert-butyl 4-(1-(3,4-difluorophenyl...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)C(=O)OC(C)(C)C)c1ccc(F)c(F)c1 Show InChI InChI=1S/C34H43F3N4O5/c1-5-39(14-6-13-38-15-11-34(12-16-38)26-20-25(35)9-7-24(26)22-45-34)31(43)30(23-8-10-27(36)28(37)19-23)41-18-17-40(21-29(41)42)32(44)46-33(2,3)4/h7-10,19-20,30H,5-6,11-18,21-22H2,1-4H3 | Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50301702
((Z)-(3,4-difluorophenyl)(4-((6-fluoro-1H-spiro[fur...)Show SMILES Fc1cc2COC3(CCN(Cc4ccc(cc4)C(N=O)c4ccc(F)c(F)c4)CC3)c2cn1 Show InChI InChI=1S/C25H22F3N3O2/c26-21-6-5-18(11-22(21)27)24(30-32)17-3-1-16(2-4-17)14-31-9-7-25(8-10-31)20-13-29-23(28)12-19(20)15-33-25/h1-6,11-13,24H,7-10,14-15H2 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 0.260 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50193637
((E)-N-(4-amino-2-tert-butylquinolin-6-yl)-3-(4-(tr...)Show SMILES CC(C)(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C23H22F3N3O/c1-22(2,3)20-13-18(27)17-12-16(9-10-19(17)29-20)28-21(30)11-6-14-4-7-15(8-5-14)23(24,25)26/h4-13H,1-3H3,(H2,27,29)(H,28,30)/b11-6+ | Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 |
Bioorg Med Chem Lett 16: 5275-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50193645
((E)-N-(4-amino-2-sec-butylquinolin-6-yl)-3-(4-(tri...)Show SMILES CCC(C)c1cc(N)c2cc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)ccc2n1 Show InChI InChI=1S/C23H22F3N3O/c1-3-14(2)21-13-19(27)18-12-17(9-10-20(18)29-21)28-22(30)11-6-15-4-7-16(8-5-15)23(24,25)26/h4-14H,3H2,1-2H3,(H2,27,29)(H,28,30)/b11-6+ | Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 |
Bioorg Med Chem Lett 16: 5275-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50169377
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-propyl-piperidin-4...)Show SMILES CCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N Show InChI InChI=1S/C29H30Cl2N4O/c1-2-12-35-13-10-29(11-14-35,20-33-28(36)34-27-17-25(30)16-26(31)18-27)24-8-6-22(7-9-24)23-5-3-4-21(15-23)19-32/h3-9,15-18H,2,10-14,20H2,1H3,(H2,33,34,36) | Reactome pathway
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PC cid
PC sid
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Patents
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| Article
PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Science and Technology
Curated by ChEMBL
| Assay Description
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.126741
BindingDB Entry DOI: 10.7270/Q2GH9NDS |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50301706
((Z)-(3,4-difluorophenyl)(5-((6-fluoro-1H-spiro[fur...)Show SMILES CCO\N=C(\c1ccc(F)c(F)c1)c1ccc(CN2CCC3(CC2)OCc2cc(F)ncc32)cn1 Show InChI InChI=1S/C26H25F3N4O2/c1-2-35-32-25(18-4-5-21(27)22(28)11-18)23-6-3-17(13-30-23)15-33-9-7-26(8-10-33)20-14-31-24(29)12-19(20)16-34-26/h3-6,11-14H,2,7-10,15-16H2,1H3/b32-25- | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.350 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295690
((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)S(C)(=O)=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H37F3N4O5S/c1-3-35(12-4-11-34-13-9-30(10-14-34)24-18-23(31)7-5-22(24)20-42-30)29(39)28(21-6-8-25(32)26(33)17-21)37-16-15-36(19-27(37)38)43(2,40)41/h5-8,17-18,28H,3-4,9-16,19-20H2,1-2H3 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 5339-45 (2009)
Article DOI: 10.1016/j.bmcl.2009.07.132
BindingDB Entry DOI: 10.7270/Q27P90BK |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383116
(CHEMBL2031736)Show SMILES Cc1c(NC(=O)c2ccc(cc2)-c2ccc(Cl)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C28H26ClN3O/c1-19-26(13-10-24-16-20(17-30-27(19)24)18-32-14-2-3-15-32)31-28(33)23-6-4-21(5-7-23)22-8-11-25(29)12-9-22/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33) | Reactome pathway
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PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h
BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295690
((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)S(C)(=O)=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H37F3N4O5S/c1-3-35(12-4-11-34-13-9-30(10-14-34)24-18-23(31)7-5-22(24)20-42-30)29(39)28(21-6-8-25(32)26(33)17-21)37-16-15-36(19-27(37)38)43(2,40)41/h5-8,17-18,28H,3-4,9-16,19-20H2,1-2H3 | Reactome pathway
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| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50199266
(6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-2-na...)Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4cc(CN5CCCCC5)ccc4c3)c(=O)c2s1 Show InChI InChI=1S/C28H24ClN3OS/c29-23-9-6-20(7-10-23)26-16-25-27(34-26)28(33)32(18-30-25)24-11-8-21-14-19(4-5-22(21)15-24)17-31-12-2-1-3-13-31/h4-11,14-16,18H,1-3,12-13,17H2 | Reactome pathway
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| n/a | n/a | 0.390 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay |
J Med Chem 49: 7108-18 (2006)
Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50152472
(CHEMBL182261 | N-[3-(2-Amino-quinolin-8-yloxy)-pro...)Show InChI InChI=1S/C19H18ClN3O2/c20-15-6-1-5-14(12-15)19(24)22-10-3-11-25-16-7-2-4-13-8-9-17(21)23-18(13)16/h1-2,4-9,12H,3,10-11H2,(H2,21,23)(H,22,24) | Reactome pathway
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes |
Bioorg Med Chem Lett 14: 4879-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50169374
(1-[4-(3'-Cyano-biphenyl-4-yl)-1-(2-methoxy-ethyl)-...)Show SMILES COCCN1CCC(CNC(=O)Nc2cc(Cl)cc(Cl)c2)(CC1)c1ccc(cc1)-c1cccc(c1)C#N Show InChI InChI=1S/C29H30Cl2N4O2/c1-37-14-13-35-11-9-29(10-12-35,20-33-28(36)34-27-17-25(30)16-26(31)18-27)24-7-5-22(6-8-24)23-4-2-3-21(15-23)19-32/h2-8,15-18H,9-14,20H2,1H3,(H2,33,34,36) | Reactome pathway
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| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Science and Technology
Curated by ChEMBL
| Assay Description
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.126741
BindingDB Entry DOI: 10.7270/Q2GH9NDS |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50358743
(CHEMBL1922270)Show SMILES C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N2O/c1-16-21-15-30(9-2-3-17-7-11-31-12-8-17)10-6-18(21)13-23-24(16)20-14-19(25(26,27)28)4-5-22(20)29-23/h4-5,14,16-18,21,29H,2-3,6-13,15H2,1H3/t16-,18-,21-/m1/s1 | Reactome pathway
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen San Francisco
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH from MCHR1 after 2 hrs by scintillation counting |
Bioorg Med Chem Lett 22: 3781-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.006
BindingDB Entry DOI: 10.7270/Q2542PMN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50193700
(CHEMBL217502 | N-(2-(2,7-diazaspiro[4.4]nonan-2-yl...)Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc(ccc3c2)N2CCC3(CCNC3)C2)cc1 Show InChI InChI=1S/C26H27F3N4O/c27-26(28,29)20-5-1-18(2-6-20)3-10-24(34)31-21-7-8-22-19(15-21)4-9-23(32-22)33-14-12-25(17-33)11-13-30-16-25/h1-2,4-9,15,30H,3,10-14,16-17H2,(H,31,34) | Reactome pathway
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 |
Bioorg Med Chem Lett 16: 5270-4 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.006
BindingDB Entry DOI: 10.7270/Q2ZC82HP |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50358743
(CHEMBL1922270)Show SMILES C[C@@H]1[C@H]2CN(CCCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C25H33F3N2O/c1-16-21-15-30(9-2-3-17-7-11-31-12-8-17)10-6-18(21)13-23-24(16)20-14-19(25(26,27)28)4-5-22(20)29-23/h4-5,14,16-18,21,29H,2-3,6-13,15H2,1H3/t16-,18-,21-/m1/s1 | Reactome pathway
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| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH from MCHR1 after 2 hrs by beta scintillation counting |
Bioorg Med Chem Lett 21: 7001-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.110
BindingDB Entry DOI: 10.7270/Q29887FX |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50241083
(6-(4-chlorophenyl)-3-(3-methoxy-4-(2-(pyrrolidin-1...)Show SMILES COc1cc(ccc1OCCN1CCCC1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3 | Reactome pathway
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PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 16: 4723-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.07.008
BindingDB Entry DOI: 10.7270/Q24B32MB |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383114
(CHEMBL2031734)Show SMILES COc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)cnc2c1C Show InChI InChI=1S/C29H29N3O2/c1-20-27(14-11-25-17-21(18-30-28(20)25)19-32-15-3-4-16-32)31-29(33)24-7-5-22(6-8-24)23-9-12-26(34-2)13-10-23/h5-14,17-18H,3-4,15-16,19H2,1-2H3,(H,31,33) | Reactome pathway
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| n/a | n/a | 0.530 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h
BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383112
(CHEMBL2029372)Show SMILES Cc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C28H26FN3O/c1-19-26(13-10-24-16-20(17-30-27(19)24)18-32-14-2-3-15-32)31-28(33)23-6-4-21(5-7-23)22-8-11-25(29)12-9-22/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33) | Reactome pathway
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| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h
BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383112
(CHEMBL2029372)Show SMILES Cc1c(NC(=O)c2ccc(cc2)-c2ccc(F)cc2)ccc2cc(CN3CCCC3)cnc12 Show InChI InChI=1S/C28H26FN3O/c1-19-26(13-10-24-16-20(17-30-27(19)24)18-32-14-2-3-15-32)31-28(33)23-6-4-21(5-7-23)22-8-11-25(29)12-9-22/h4-13,16-17H,2-3,14-15,18H2,1H3,(H,31,33) | Reactome pathway
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| n/a | n/a | 0.540 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 60 mins by liquid scintillation counting |
J Med Chem 55: 4336-51 (2012)
Article DOI: 10.1021/jm300167z
BindingDB Entry DOI: 10.7270/Q2JS9RHR |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383522
(CHEMBL2032049)Show SMILES C[C@@H]1[C@H]2CN(CCC3(CCCCC3)C(O)=O)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1 | Reactome pathway
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| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen San Francisco
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH from MCHR1 after 2 hrs by scintillation counting |
Bioorg Med Chem Lett 22: 3781-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.006
BindingDB Entry DOI: 10.7270/Q2542PMN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50325971
(CHEMBL1224229 | N-(3-(1-(4-(1-(4-fluorophenyl)-1H-...)Show SMILES CC(=O)Nc1cccc(c1)C1CCN(CCCCc2nc3ccccc3n2-c2ccc(F)cc2)CC1 Show InChI InChI=1S/C30H33FN4O/c1-22(36)32-26-8-6-7-24(21-26)23-16-19-34(20-17-23)18-5-4-11-30-33-28-9-2-3-10-29(28)35(30)27-14-12-25(31)13-15-27/h2-3,6-10,12-15,21,23H,4-5,11,16-20H2,1H3,(H,32,36) | Reactome pathway
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| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Dr. Reddy's Laboratories Ltd
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human recombinant MCHR1 expressed in CHOK1 cells by scintillation proximity assay |
Bioorg Med Chem Lett 20: 5443-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.086
BindingDB Entry DOI: 10.7270/Q2J38SSG |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50193606
(CHEMBL385957 | N-(4-amino-2-propylquinolin-6-yl)-4...)Show SMILES CCCc1cc(N)c2cc(NC(=O)c3ccc(cc3)-c3ccc(Cl)cc3)ccc2n1 Show InChI InChI=1S/C25H22ClN3O/c1-2-3-20-15-23(27)22-14-21(12-13-24(22)28-20)29-25(30)18-6-4-16(5-7-18)17-8-10-19(26)11-9-17/h4-15H,2-3H2,1H3,(H2,27,28)(H,29,30) | Reactome pathway
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| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 |
Bioorg Med Chem Lett 16: 5275-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295689
(2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-s...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCCC1=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C29H34F3N3O3/c1-2-34(28(37)27(35-14-3-5-26(35)36)20-7-9-24(31)25(32)17-20)13-4-12-33-15-10-29(11-16-33)23-18-22(30)8-6-21(23)19-38-29/h6-9,17-18,27H,2-5,10-16,19H2,1H3 | Reactome pathway
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| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295690
((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)S(C)(=O)=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H37F3N4O5S/c1-3-35(12-4-11-34-13-9-30(10-14-34)24-18-23(31)7-5-22(24)20-42-30)29(39)28(21-6-8-25(32)26(33)17-21)37-16-15-36(19-27(37)38)43(2,40)41/h5-8,17-18,28H,3-4,9-16,19-20H2,1-2H3 | Reactome pathway
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| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295690
((+/-)-2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluor...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCN(CC1=O)S(C)(=O)=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C30H37F3N4O5S/c1-3-35(12-4-11-34-13-9-30(10-14-34)24-18-23(31)7-5-22(24)20-42-30)29(39)28(21-6-8-25(32)26(33)17-21)37-16-15-36(19-27(37)38)43(2,40)41/h5-8,17-18,28H,3-4,9-16,19-20H2,1-2H3 | Reactome pathway
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| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50199205
(6-(4-chlorophenyl)-3-{2-[(dimethylamino)methyl]-6-...)Show SMILES CN(C)Cc1ccc2cc(ccc2n1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1 Show InChI InChI=1S/C24H19ClN4OS/c1-28(2)13-18-8-5-16-11-19(9-10-20(16)27-18)29-14-26-21-12-22(31-23(21)24(29)30)15-3-6-17(25)7-4-15/h3-12,14H,13H2,1-2H3 | Reactome pathway
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| n/a | n/a | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay |
J Med Chem 49: 7095-107 (2006)
Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383096
(CHEMBL2031716)Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)cnc2c1 Show InChI InChI=1S/C27H24ClN3O/c28-24-10-7-21(8-11-24)20-3-5-22(6-4-20)27(32)30-25-12-9-23-15-19(17-29-26(23)16-25)18-31-13-1-2-14-31/h3-12,15-17H,1-2,13-14,18H2,(H,30,32) | Reactome pathway
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PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 0.740 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h
BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50199251
(6-(4-chlorophenyl)-3-[6-(1-piperidinylmethyl)-7,8-...)Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCCC5)CCc4c3)c(=O)c2s1 |t:18| Show InChI InChI=1S/C28H26ClN3OS/c29-23-9-6-20(7-10-23)26-16-25-27(34-26)28(33)32(18-30-25)24-11-8-21-14-19(4-5-22(21)15-24)17-31-12-2-1-3-13-31/h6-11,14-16,18H,1-5,12-13,17H2 | Reactome pathway
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UniChem
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| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay |
J Med Chem 49: 7108-18 (2006)
Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50383091
(CHEMBL2031573)Show SMILES Fc1ccc(cc1)-c1ccc(cc1)C(=O)Nc1ccc2cc(CN3CCCC3)ccc2c1 Show InChI InChI=1S/C28H25FN2O/c29-26-12-9-22(10-13-26)21-5-7-23(8-6-21)28(32)30-27-14-11-24-17-20(3-4-25(24)18-27)19-31-15-1-2-16-31/h3-14,17-18H,1-2,15-16,19H2,(H,30,32) | Reactome pathway
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| Article
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| n/a | n/a | 0.760 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells after 1 hr by scintillation counting |
J Med Chem 55: 2353-66 (2012)
Article DOI: 10.1021/jm201596h
BindingDB Entry DOI: 10.7270/Q2GH9JZQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(RAT) | BDBM50383522
(CHEMBL2032049)Show SMILES C[C@@H]1[C@H]2CN(CCC3(CCCCC3)C(O)=O)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1 | Reactome pathway
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PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen San Francisco
Curated by ChEMBL
| Assay Description
Antagonist activity at rat MCHR1 assessed inhibition of MCH-mediated intracellular Ca2+ calcium mobilization |
Bioorg Med Chem Lett 22: 3781-5 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.006
BindingDB Entry DOI: 10.7270/Q2542PMN |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50183964
(4-(1-(benzo[d][1,3]dioxol-5-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2n(Cc3ccccc3)c(=O)cc(NC3CCN(Cc4ccc5OCOc5c4)CC3)c2c1 Show InChI InChI=1S/C29H28ClN3O3/c30-22-7-8-26-24(15-22)25(16-29(34)33(26)18-20-4-2-1-3-5-20)31-23-10-12-32(13-11-23)17-21-6-9-27-28(14-21)36-19-35-27/h1-9,14-16,23,31H,10-13,17-19H2 | Reactome pathway
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| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from MCHr1 expressed in IMR32 cells |
Bioorg Med Chem Lett 16: 2621-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.044
BindingDB Entry DOI: 10.7270/Q2SB45CQ |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50193638
((E)-N-(4-amino-2-cyclopentylquinolin-6-yl)-3-(4-(t...)Show SMILES Nc1cc(nc2ccc(NC(=O)\C=C\c3ccc(cc3)C(F)(F)F)cc12)C1CCCC1 Show InChI InChI=1S/C24H22F3N3O/c25-24(26,27)17-8-5-15(6-9-17)7-12-23(31)29-18-10-11-21-19(13-18)20(28)14-22(30-21)16-3-1-2-4-16/h5-14,16H,1-4H2,(H2,28,30)(H,29,31)/b12-7+ | Reactome pathway
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PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of 125I-[Phe13,Tyr19]-MCH from human MCH-R1 |
Bioorg Med Chem Lett 16: 5275-9 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.008
BindingDB Entry DOI: 10.7270/Q26T0M8S |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50199249
(6-(4-chlorophenyl)-3-[6-(1-pyrrolidinylmethyl)-7,8...)Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4C=C(CN5CCCC5)CCc4c3)c(=O)c2s1 |t:18| Show InChI InChI=1S/C27H24ClN3OS/c28-22-8-5-19(6-9-22)25-15-24-26(33-25)27(32)31(17-29-24)23-10-7-20-13-18(3-4-21(20)14-23)16-30-11-1-2-12-30/h5-10,13-15,17H,1-4,11-12,16H2 | Reactome pathway
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PubMed
| n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCH1 receptor stably-expressed in CHO cells by Gal4/Elk1-Luc reporter assay |
J Med Chem 49: 7108-18 (2006)
Article DOI: 10.1021/jm060814b
BindingDB Entry DOI: 10.7270/Q2JD4WFT |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50295694
(2-(3,4-difluorophenyl)-N-ethyl-N-(3-(6-fluoro-3H-s...)Show SMILES CCN(CCCN1CCC2(CC1)OCc1ccc(F)cc21)C(=O)C(N1CCNCC1=O)c1ccc(F)c(F)c1 Show InChI InChI=1S/C29H35F3N4O3/c1-2-35(28(38)27(36-15-10-33-18-26(36)37)20-5-7-24(31)25(32)16-20)12-3-11-34-13-8-29(9-14-34)23-17-22(30)6-4-21(23)19-39-29/h4-7,16-17,27,33H,2-3,8-15,18-19H2,1H3 | Reactome pathway
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PubMed
| n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
Tsukuba Research Institute
Curated by ChEMBL
| Assay Description
Displacement of[125I]MCH from human MCH1R expressed in CHO cells |
Bioorg Med Chem Lett 19: 2835-9 (2009)
Article DOI: 10.1016/j.bmcl.2009.03.102
BindingDB Entry DOI: 10.7270/Q2R49QS7 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50168812
(1-[2-(3'-Cyano-biphenyl-4-yl)-4-dimethylamino-buty...)Show SMILES CN(C)CCC(CNC(=O)Nc1cc(F)cc(F)c1)c1ccc(cc1)-c1cccc(c1)C#N Show InChI InChI=1S/C26H26F2N4O/c1-32(2)11-10-22(17-30-26(33)31-25-14-23(27)13-24(28)15-25)20-8-6-19(7-9-20)21-5-3-4-18(12-21)16-29/h3-9,12-15,22H,10-11,17H2,1-2H3,(H2,30,31,33) | Reactome pathway
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PubMed
| n/a | n/a | 0.880 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Science and Technology
Curated by ChEMBL
| Assay Description
Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.126741
BindingDB Entry DOI: 10.7270/Q2GH9NDS |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50199202
(6-(4-chlorophenyl)-3-[2-(1-piperidinylmethyl)-6-qu...)Show SMILES Clc1ccc(cc1)-c1cc2ncn(-c3ccc4nc(CN5CCCCC5)ccc4c3)c(=O)c2s1 Show InChI InChI=1S/C27H23ClN4OS/c28-20-7-4-18(5-8-20)25-15-24-26(34-25)27(33)32(17-29-24)22-10-11-23-19(14-22)6-9-21(30-23)16-31-12-2-1-3-13-31/h4-11,14-15,17H,1-3,12-13,16H2 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 0.890 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description
Antagonist activity against human MCHR1 expressed in CHO cells by Gal4/Elk1-Luc reporter assay |
J Med Chem 49: 7095-107 (2006)
Article DOI: 10.1021/jm060572f
BindingDB Entry DOI: 10.7270/Q2P26XS8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50358742
(CHEMBL1922269)Show SMILES C[C@@H]1[C@H]2CN(CCC3CCOCC3)CC[C@@H]2Cc2[nH]c3ccc(cc3c12)C(F)(F)F |r| Show InChI InChI=1S/C24H31F3N2O/c1-15-20-14-29(8-4-16-6-10-30-11-7-16)9-5-17(20)12-22-23(15)19-13-18(24(25,26)27)2-3-21(19)28-22/h2-3,13,15-17,20,28H,4-12,14H2,1H3/t15-,17-,20-/m1/s1 | Reactome pathway
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PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen
Curated by ChEMBL
| Assay Description
Displacement of [125I]-MCH from MCHR1 after 2 hrs by beta scintillation counting |
Bioorg Med Chem Lett 21: 7001-5 (2011)
Article DOI: 10.1016/j.bmcl.2011.09.110
BindingDB Entry DOI: 10.7270/Q29887FX |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50172441
((E)-N-{2-[(2-Hydroxy-ethyl)-methyl-amino]-4-methyl...)Show SMILES CN(CCO)c1cc(C)c2cc(NC(=O)\C=C\c3ccc(OC(F)(F)F)cc3)ccc2n1 Show InChI InChI=1S/C23H22F3N3O3/c1-15-13-21(29(2)11-12-30)28-20-9-6-17(14-19(15)20)27-22(31)10-5-16-3-7-18(8-4-16)32-23(24,25)26/h3-10,13-14,30H,11-12H2,1-2H3,(H,27,31)/b10-5+ | Reactome pathway
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PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
7TM Pharma A/S
Curated by ChEMBL
| Assay Description
Displacement of 15 pM [125I]-MCH from human MCH1R expressed in CHO-K1 in whole-cell binding assay |
J Med Chem 48: 5684-97 (2005)
Article DOI: 10.1021/jm050103y
BindingDB Entry DOI: 10.7270/Q2H41QZ8 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50152479
(1-[3-(2-Amino-quinolin-8-yloxy)-propyl]-3-(3-chlor...)Show InChI InChI=1S/C19H19ClN4O2/c20-14-5-2-6-15(12-14)23-19(25)22-10-3-11-26-16-7-1-4-13-8-9-17(21)24-18(13)16/h1-2,4-9,12H,3,10-11H2,(H2,21,24)(H2,22,23,25) | Reactome pathway
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| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes |
Bioorg Med Chem Lett 14: 4879-82 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.034
BindingDB Entry DOI: 10.7270/Q2M32V61 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50152494
(8-[1-(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-pyrrolid...)Show SMILES Nc1ccc2cccc(OC3CCN(C3)c3ccc4OC(F)(F)Oc4c3)c2n1 Show InChI InChI=1S/C20H17F2N3O3/c21-20(22)27-15-6-5-13(10-17(15)28-20)25-9-8-14(11-25)26-16-3-1-2-12-4-7-18(23)24-19(12)16/h1-7,10,14H,8-9,11H2,(H2,23,24) | Reactome pathway
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PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes |
Bioorg Med Chem Lett 14: 4883-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.035
BindingDB Entry DOI: 10.7270/Q2GB23H4 |
More data for this
Ligand-Target Pair | |
Melanin-concentrating hormone receptor 1
(Homo sapiens (Human)) | BDBM50183965
(6-chloro-4-(1-(naphthalen-2-ylmethyl)piperidin-4-y...)Show SMILES Clc1ccc2n(Cc3ccccn3)c(=O)cc(NC3CCN(Cc4ccc5ccccc5c4)CC3)c2c1 Show InChI InChI=1S/C31H29ClN4O/c32-25-10-11-30-28(18-25)29(19-31(37)36(30)21-27-7-3-4-14-33-27)34-26-12-15-35(16-13-26)20-22-8-9-23-5-1-2-6-24(23)17-22/h1-11,14,17-19,26,34H,12-13,15-16,20-21H2 | Reactome pathway
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| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Millennium Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]MCH from MCHr1 expressed in IMR32 cells |
Bioorg Med Chem Lett 16: 2621-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.044
BindingDB Entry DOI: 10.7270/Q2SB45CQ |
More data for this
Ligand-Target Pair | |
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