Found 39 hits of ic50 data for polymerid = 49000265,49000267 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Type-1 angiotensin II receptor A
(RAT) | BDBM50009718
(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50009712
(5,7-Dimethyl-2-propyl-3-[2'-(2H-tetrazol-5-yl)-bip...)Show SMILES CCCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C25H25N7/c1-4-7-22-27-23-16(2)14-17(3)26-25(23)32(22)15-18-10-12-19(13-11-18)20-8-5-6-9-21(20)24-28-30-31-29-24/h5-6,8-14H,4,7,15H2,1-3H3,(H,28,29,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50369183
(CHEMBL290214 | L-163491)Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(Cc2cccc(OC)c2)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1 Show InChI InChI=1S/C36H40N4O5S/c1-6-8-18-45-36(41)39-46(42,43)32-17-14-28(20-27-10-9-11-30(21-27)44-5)22-31(32)29-15-12-26(13-16-29)23-40-33(7-2)38-34-24(3)19-25(4)37-35(34)40/h9-17,19,21-22H,6-8,18,20,23H2,1-5H3,(H,39,41) | PDB
Reactome pathway
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UniProtKB/SwissProt
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PC cid
PC sid
UniChem
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| Article
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| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
| Assay Description
Displacement of [125I]Ang II from AT1 receptor in rat liver membranes |
J Med Chem 63: 1978-1995 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01780
BindingDB Entry DOI: 10.7270/Q20868NG |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50161275
(CHEMBL3787059)Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1 Show InChI InChI=1S/C23H21ClN4O4/c1-2-3-8-18-25-20(24)19(22(29)30)28(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-26-23(31)32-27-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,29,30)(H,26,27,31) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Donghua University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method |
Bioorg Med Chem 24: 2023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.03.028
BindingDB Entry DOI: 10.7270/Q2XW4MQB |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50049186
((S)-3-Methyl-2-{pentanoyl-[2'-(1H-tetrazol-5-yl)-b...)Show SMILES CCCCC(=O)N(Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)[C@@H](C(C)C)C(O)=O Show InChI InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1 | PDB
Reactome pathway
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CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50161276
(CHEMBL3786570)Show SMILES CCCCc1nc(Cl)c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1 Show InChI InChI=1S/C23H21ClN4O3/c1-2-3-8-20-25-21(24)19(14-29)28(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-26-23(30)31-27-22/h4-7,9-12,14H,2-3,8,13H2,1H3,(H,26,27,30) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Donghua University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method |
Bioorg Med Chem 24: 2023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.03.028
BindingDB Entry DOI: 10.7270/Q2XW4MQB |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50161277
(CHEMBL3787050)Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1 Show InChI InChI=1S/C23H23ClN4O3/c1-2-3-8-20-25-21(24)19(14-29)28(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-26-23(30)31-27-22/h4-7,9-12,29H,2-3,8,13-14H2,1H3,(H,26,27,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Donghua University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method |
Bioorg Med Chem 24: 2023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.03.028
BindingDB Entry DOI: 10.7270/Q2XW4MQB |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM82258
(CAS_114798-26-4 | Losartan | NSC_3961)Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50145979
(4-(4-((2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyrid...)Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1c(cnc2ccccc12)-c1nnn[nH]1 Show InChI InChI=1S/C27H24N8/c1-4-23-30-25-16(2)13-17(3)29-27(25)35(23)15-18-9-11-19(12-10-18)24-20-7-5-6-8-22(20)28-14-21(24)26-31-33-34-32-26/h5-14H,4,15H2,1-3H3,(H,31,32,33,34) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376928
(CHEMBL259114)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O Show InChI InChI=1S/C24H23N7O/c1-2-3-15-30-24(32)21-9-6-14-25-23(21)31(30)16-17-10-12-18(13-11-17)19-7-4-5-8-20(19)22-26-28-29-27-22/h4-14H,2-3,15-16H2,1H3,(H,26,27,28,29) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
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PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM82258
(CAS_114798-26-4 | Losartan | NSC_3961)Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1 Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28) | PDB
Reactome pathway
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PC sid
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PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Donghua University
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Ang II from Angiotensin 2 type-1A receptor in rat vascular smooth muscle cells after 150 mins by gamma counting method |
Bioorg Med Chem 24: 2023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.03.028
BindingDB Entry DOI: 10.7270/Q2XW4MQB |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376913
(CHEMBL259353)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2cccnc12 Show InChI InChI=1S/C24H23N7O/c1-2-3-15-30-23-21(9-6-14-25-23)24(32)31(30)16-17-10-12-18(13-11-17)19-7-4-5-8-20(19)22-26-28-29-27-22/h4-14H,2-3,15-16H2,1H3,(H,26,27,28,29) | PDB
Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376926
(CHEMBL258685)Show SMILES CCCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O Show InChI InChI=1S/C25H25N7O/c1-2-3-6-16-31-25(33)22-10-7-15-26-24(22)32(31)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,7-15H,2-3,6,16-17H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376919
(CHEMBL408188)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncc(F)cc2c1=O Show InChI InChI=1S/C24H22FN7O/c1-2-3-12-31-24(33)21-13-18(25)14-26-23(21)32(31)15-16-8-10-17(11-9-16)19-6-4-5-7-20(19)22-27-29-30-28-22/h4-11,13-14H,2-3,12,15H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376918
(CHEMBL262098)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncc(Cl)cc2c1=O Show InChI InChI=1S/C24H22ClN7O/c1-2-3-12-31-24(33)21-13-18(25)14-26-23(21)32(31)15-16-8-10-17(11-9-16)19-6-4-5-7-20(19)22-27-29-30-28-22/h4-11,13-14H,2-3,12,15H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376922
(CHEMBL410105)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(C)ccc2c1=O Show InChI InChI=1S/C25H25N7O/c1-3-4-15-31-25(33)22-14-9-17(2)26-24(22)32(31)16-18-10-12-19(13-11-18)20-7-5-6-8-21(20)23-27-29-30-28-23/h5-14H,3-4,15-16H2,1-2H3,(H,27,28,29,30) | PDB
Reactome pathway
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PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376912
(CHEMBL265208)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2ccc(C)nc12 Show InChI InChI=1S/C25H25N7O/c1-3-4-15-31-24-22(14-9-17(2)26-24)25(33)32(31)16-18-10-12-19(13-11-18)20-7-5-6-8-21(20)23-27-29-30-28-23/h5-14H,3-4,15-16H2,1-2H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376907
(CHEMBL410325)Show SMILES CCCCc1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2ccc[nH]c12 Show InChI InChI=1S/C25H24N6O/c1-2-3-10-22-23-21(9-6-15-26-23)25(32)31(22)16-17-11-13-18(14-12-17)19-7-4-5-8-20(19)24-27-29-30-28-24/h4-9,11-15,26H,2-3,10,16H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376930
(CHEMBL409744)Show SMILES CCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O Show InChI InChI=1S/C23H21N7O/c1-2-14-29-23(31)20-8-5-13-24-22(20)30(29)15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)21-25-27-28-26-21/h3-13H,2,14-15H2,1H3,(H,25,26,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 108 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376903
(CHEMBL260578)Show SMILES CCCCn1nc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2cccnc2c1=O Show InChI InChI=1S/C25H23N7O2/c1-2-3-15-32-25(33)22-21(9-6-14-26-22)24(29-32)34-16-17-10-12-18(13-11-17)19-7-4-5-8-20(19)23-27-30-31-28-23/h4-14H,2-3,15-16H2,1H3,(H,27,28,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 114 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376916
(CHEMBL265958)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(NC)ccc2c1=O Show InChI InChI=1S/C25H26N8O/c1-3-4-15-32-25(34)21-13-14-22(26-2)27-24(21)33(32)16-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-28-30-31-29-23/h5-14H,3-4,15-16H2,1-2H3,(H,26,27)(H,28,29,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376927
(CHEMBL261765)Show SMILES CC(C)CCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O Show InChI InChI=1S/C25H25N7O/c1-17(2)13-15-31-25(33)22-8-5-14-26-24(22)32(31)16-18-9-11-19(12-10-18)20-6-3-4-7-21(20)23-27-29-30-28-23/h3-12,14,17H,13,15-16H2,1-2H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376905
(CHEMBL258891)Show SMILES CCCn1nc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2cccnc12 Show InChI InChI=1S/C23H21N7O/c1-2-14-30-22-20(8-5-13-24-22)23(27-30)31-15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)21-25-28-29-26-21/h3-13H,2,14-15H2,1H3,(H,25,26,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 146 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376908
(CHEMBL261248)Show SMILES CCCc1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2ccc[nH]c12 Show InChI InChI=1S/C24H22N6O/c1-2-6-21-22-20(9-5-14-25-22)24(31)30(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)23-26-28-29-27-23/h3-5,7-14,25H,2,6,15H2,1H3,(H,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 154 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376921
(CHEMBL408227)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(Cl)ccc2c1=O Show InChI InChI=1S/C24H22ClN7O/c1-2-3-14-31-24(33)20-12-13-21(25)26-23(20)32(31)15-16-8-10-17(11-9-16)18-6-4-5-7-19(18)22-27-29-30-28-22/h4-13H,2-3,14-15H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 168 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376904
(CHEMBL409722)Show SMILES CCCCn1nc(OCc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2cccnc12 Show InChI InChI=1S/C24H23N7O/c1-2-3-15-31-23-21(9-6-14-25-23)24(28-31)32-16-17-10-12-18(13-11-17)19-7-4-5-8-20(19)22-26-29-30-27-22/h4-14H,2-3,15-16H2,1H3,(H,26,27,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376917
(CHEMBL409095)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(OC)ccc2c1=O Show InChI InChI=1S/C25H25N7O2/c1-3-4-15-31-25(33)21-13-14-22(34-2)26-24(21)32(31)16-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-14H,3-4,15-16H2,1-2H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 258 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376923
(CHEMBL265452)Show SMILES CCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(C)ccc2c1=O Show InChI InChI=1S/C24H23N7O/c1-3-14-30-24(32)21-13-8-16(2)25-23(21)31(30)15-17-9-11-18(12-10-17)19-6-4-5-7-20(19)22-26-28-29-27-22/h4-13H,3,14-15H2,1-2H3,(H,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 291 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376920
(CHEMBL259575)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(Cl)c(F)cc2c1=O Show InChI InChI=1S/C24H21ClFN7O/c1-2-3-12-32-24(34)19-13-20(26)21(25)27-23(19)33(32)14-15-8-10-16(11-9-15)17-6-4-5-7-18(17)22-28-30-31-29-22/h4-11,13H,2-3,12,14H2,1H3,(H,28,29,30,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 427 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376911
(CHEMBL410487)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2ccc(Cl)nc12 Show InChI InChI=1S/C24H22ClN7O/c1-2-3-14-31-23-20(12-13-21(25)26-23)24(33)32(31)15-16-8-10-17(11-9-16)18-6-4-5-7-19(18)22-27-29-30-28-22/h4-13H,2-3,14-15H2,1H3,(H,27,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 461 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376906
(CHEMBL410125)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ccccc2c1=O Show InChI InChI=1S/C25H24N6O/c1-2-3-16-30-25(32)22-10-6-7-11-23(22)31(30)17-18-12-14-19(15-13-18)20-8-4-5-9-21(20)24-26-28-29-27-24/h4-15H,2-3,16-17H2,1H3,(H,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 598 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376915
(CHEMBL427738)Show SMILES CCCCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(ccc2c1=O)N1CCOCC1 Show InChI InChI=1S/C28H30N8O2/c1-2-3-14-35-28(37)24-12-13-25(34-15-17-38-18-16-34)29-27(24)36(35)19-20-8-10-21(11-9-20)22-6-4-5-7-23(22)26-30-32-33-31-26/h4-13H,2-3,14-19H2,1H3,(H,30,31,32,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376924
(CHEMBL265697)Show SMILES CCn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2nc(C)ccc2c1=O Show InChI InChI=1S/C23H21N7O/c1-3-29-23(31)20-13-8-15(2)24-22(20)30(29)14-16-9-11-17(12-10-16)18-6-4-5-7-19(18)21-25-27-28-26-21/h4-13H,3,14H2,1-2H3,(H,25,26,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376929
(CHEMBL259116)Show SMILES CC(C)Cn1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc2c1=O Show InChI InChI=1S/C24H23N7O/c1-16(2)14-31-24(32)21-8-5-13-25-23(21)30(31)15-17-9-11-18(12-10-17)19-6-3-4-7-20(19)22-26-28-29-27-22/h3-13,16H,14-15H2,1-2H3,(H,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376914
(CHEMBL408187)Show SMILES CCCn1c(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2[nH]cccc2c1=O Show InChI InChI=1S/C24H22N6O/c1-2-14-30-21(22-20(24(30)31)8-5-13-25-22)15-16-9-11-17(12-10-16)18-6-3-4-7-19(18)23-26-28-29-27-23/h3-13,25H,2,14-15H2,1H3,(H,26,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376925
(CHEMBL258684)Show SMILES O=c1n(Cc2ccccc2)n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c2ncccc12 Show InChI InChI=1S/C27H21N7O/c35-27-24-11-6-16-28-26(24)33(34(27)18-19-7-2-1-3-8-19)17-20-12-14-21(15-13-20)22-9-4-5-10-23(22)25-29-31-32-30-25/h1-16H,17-18H2,(H,29,30,31,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376910
(CHEMBL264946)Show SMILES O=c1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)cc2[nH]cccc12 Show InChI InChI=1S/C21H16N6O/c28-21-18-6-3-11-22-19(18)13-27(21)12-14-7-9-15(10-8-14)16-4-1-2-5-17(16)20-23-25-26-24-20/h1-11,13,22H,12H2,(H,23,24,25,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50376909
(CHEMBL259397)Show SMILES CCc1n(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)c2ccc[nH]c12 Show InChI InChI=1S/C23H20N6O/c1-2-20-21-19(8-5-13-24-21)23(30)29(20)14-15-9-11-16(12-10-15)17-6-3-4-7-18(17)22-25-27-28-26-22/h3-13,24H,2,14H2,1H3,(H,25,26,27,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description
Displacement of [125I]Sar1,Ile8-Ang2 from AT1 receptor in Wistar rat hepatic membrane |
J Med Chem 51: 2137-46 (2008)
Article DOI: 10.1021/jm7011563
BindingDB Entry DOI: 10.7270/Q20P10X0 |
More data for this
Ligand-Target Pair | |
Type-1 angiotensin II receptor A
(RAT) | BDBM50514582
(CHEMBL155836)Show SMILES COc1ccc2CN(C(Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 2.90E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre Hospitalier Universitaire Vaudois (CHUV) and University of Lausanne (UNIL)
Curated by ChEMBL
| Assay Description
Inhibition of rat AT1 receptor |
J Med Chem 63: 1978-1995 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01780
BindingDB Entry DOI: 10.7270/Q20868NG |
More data for this
Ligand-Target Pair | |
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