Compile Data Set for Download or QSAR

Found 193 hits of ic50 data for polymerid = 49000738   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558766 (CHEMBL4751065) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	2.80	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as assessed as r...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446832 ((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(2-oxo-1,2- d...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cc[nH]c(=O)c1)[C@]2(F)C(O)=O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.35	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446712 ((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(1R)-1-(4- fl...) Show SMILES COc1cc(ccc1F)[C@@H](C)O[C@@H]1C[C@@H]2[C@@H]([C@@]2(F)C(O)=O)[C@]1(N)C(O)=O |r| Show InChI InChI=1S/C17H19F2NO6/c1-7(8-3-4-10(18)11(5-8)25-2)26-12-6-9-13(16(9,19)14(21)22)17(12,20)15(23)24/h3-5,7,9,12-13H,6,20H2,1-2H3,(H,21,22)(H,23,24)/t7-,9-,12-,13+,16-,17+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.04	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558766 (CHEMBL4751065) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(F)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50434133 (CHEMBL2381643) Show SMILES N[C@]1(C[C@H](O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at mGlu3 (unknown origin)				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3				J Med Chem 41: 358-78 (1998) Article DOI: 10.1021/jm970498o BindingDB Entry DOI: 10.7270/Q2XP7423
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50434132 (CHEMBL2381642) Show SMILES N[C@]1(C[C@@H](O)[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO5/c9-8(7(13)14)1-2(10)3-4(5(3)8)6(11)12/h2-5,10H,1,9H2,(H,11,12)(H,13,14)/t2-,3+,4+,5+,8+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at mGlu3 (unknown origin)				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558769 (CHEMBL4746125) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(C)c1)[C@H]2NC(C)=O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446818 ((1R,2R,3R,5R,6R)-2-amino-3-[(5-chloropyridin-2- yl...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)cn1)[C@]2(F)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C14H14ClFN2O5/c15-6-1-2-7(18-4-6)5-23-9-3-8-10(13(8,16)11(19)20)14(9,17)12(21)22/h1-2,4,8-10H,3,5,17H2,(H,19,20)(H,21,22)/t8-,9-,10+,13-,14+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204259 (CHEMBL3913414) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2NC(C)=O)C(O)=O |r| Show InChI InChI=1S/C17H18Cl2N2O6/c1-6(22)21-13-10-11(15(23)24)12(10)17(20,16(25)26)14(13)27-5-7-2-3-8(18)9(19)4-7/h2-4,10-14H,5,20H2,1H3,(H,21,22)(H,23,24)(H,25,26)/t10-,11-,12-,13-,14+,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446701 (US10689327, Compound (II)-2) Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)c(F)c3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O Show InChI InChI=1S/C19H18F3NO7/c1-2-5-29-17(28)23-19(16(26)27)13(7-10-14(19)18(10,22)15(24)25)30-8-9-3-4-11(20)12(21)6-9/h2-4,6,10,13-14H,1,5,7-8H2,(H,23,28)(H,24,25)(H,26,27)/t10-,13-,14+,18-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.8	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446836 ((1S,2R,3R,5R,6S)-2-amino-3-[(3,4- difluorophenyl)m...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(F)c(F)c1)[C@@H]2C(O)=O)C(O)=O |r| Show InChI InChI=1S/C15H15F2NO5/c16-8-2-1-6(3-9(8)17)5-23-10-4-7-11(13(19)20)12(7)15(10,18)14(21)22/h1-3,7,10-12H,4-5,18H2,(H,19,20)(H,21,22)/t7-,10+,11-,12-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.2	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50279772 (2-[1-Amino-1-carboxy-2-(9H-xanthen-9-yl)-ethyl]-cy...) Show SMILES N[C@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Ability to block 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in non-neuronal cell line expressing human Metabotropic glutamate r...				J Med Chem 41: 346-57 (1998) Article DOI: 10.1021/jm970497w BindingDB Entry DOI: 10.7270/Q22F7MJ0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558768 (CHEMBL4759992) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(C)c1)[C@H]2Sc1nc[nH]n1)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204267 (CHEMBL3939492) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2NC(=O)OC)C(O)=O |r| Show InChI InChI=1S/C17H18Cl2N2O7/c1-27-16(26)21-12-9-10(14(22)23)11(9)17(20,15(24)25)13(12)28-5-6-2-3-7(18)8(19)4-6/h2-4,9-13H,5,20H2,1H3,(H,21,26)(H,22,23)(H,24,25)/t9-,10-,11-,12-,13+,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP production				Bioorg Med Chem Lett 22: 1958-62 (2012) Article DOI: 10.1016/j.bmcl.2012.01.039 BindingDB Entry DOI: 10.7270/Q2T72JJ1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204261 (CHEMBL3969063) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2Sc1nc[nH]n1)C(O)=O |r| Show InChI InChI=1S/C17H16Cl2N4O5S/c18-7-2-1-6(3-8(7)19)4-28-13-12(29-16-21-5-22-23-16)9-10(14(24)25)11(9)17(13,20)15(26)27/h1-3,5,9-13H,4,20H2,(H,24,25)(H,26,27)(H,21,22,23)/t9-,10-,11-,12-,13+,17+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558774 (CHEMBL4780402) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)c(C)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50056272 ((1S,2S,5R,6S)-2-Amino-bicyclo[3.1.0]hexane-2,6-dic...) Show SMILES N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at mGlu3 (unknown origin)				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair				3D Structure (crystal)
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204256 (CHEMBL3948272) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2Sc1ncnn1C)C(O)=O |r| Show InChI InChI=1S/C18H18Cl2N4O5S/c1-24-17(22-6-23-24)30-13-10-11(15(25)26)12(10)18(21,16(27)28)14(13)29-5-7-2-3-8(19)9(20)4-7/h2-4,6,10-14H,5,21H2,1H3,(H,25,26)(H,27,28)/t10-,11-,12-,13-,14+,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446784 ((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-2- yl...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(Cl)n1)[C@]2(F)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C14H14ClFN2O5/c15-9-3-1-2-6(18-9)5-23-8-4-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-3,7-8,10H,4-5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	32.3	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446699 (US10689327, Compound (II)-1) Show SMILES OC(=O)[C@@]1(F)[C@@H]2C[C@@H](OCc3ccc(F)cc3)[C@](NC(=O)OCC=C)([C@H]12)C(O)=O Show InChI InChI=1S/C19H19F2NO7/c1-2-7-28-17(27)22-19(16(25)26)13(8-12-14(19)18(12,21)15(23)24)29-9-10-3-5-11(20)6-4-10/h2-6,12-14H,1,7-9H2,(H,22,27)(H,23,24)(H,25,26)/t12-,13-,14+,18-,19+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36.4	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204268 (CHEMBL3977508) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2Sc1ncc[nH]1)C(O)=O |r| Show InChI InChI=1S/C18H17Cl2N3O5S/c19-8-2-1-7(5-9(8)20)6-28-14-13(29-17-22-3-4-23-17)10-11(15(24)25)12(10)18(14,21)16(26)27/h1-5,10-14H,6,21H2,(H,22,23)(H,24,25)(H,26,27)/t10-,11-,12-,13-,14+,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558775 (CHEMBL4776989) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(F)cc1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204257 (CHEMBL3947221) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H15Cl2NO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11-,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446817 ((1R,2R,3R,5R,6R)-2-amino-3-[(6-chloropyridin-3- yl...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)nc1)[C@]2(F)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C14H14ClFN2O5/c15-9-2-1-6(4-18-9)5-23-8-3-7-10(13(7,16)11(19)20)14(8,17)12(21)22/h1-2,4,7-8,10H,3,5,17H2,(H,19,20)(H,21,22)/t7-,8-,10+,13-,14+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	50.6	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204258 (CHEMBL3933829) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2N=[N+]=[N-])C(O)=O |r| Show InChI InChI=1S/C15H14Cl2N4O5/c16-6-2-1-5(3-7(6)17)4-26-12-11(20-21-19)8-9(13(22)23)10(8)15(12,18)14(24)25/h1-3,8-12H,4,18H2,(H,22,23)(H,24,25)/t8-,9-,10-,11-,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	54	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446828 ((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(4- methylphe...) Show SMILES Cc1ccc(CO[C@@H]2C[C@@H]3[C@@H]([C@@]3(F)C(O)=O)[C@]2(N)C(O)=O)cc1 |r| Show InChI InChI=1S/C16H18FNO5/c1-8-2-4-9(5-3-8)7-23-11-6-10-12(15(10,17)13(19)20)16(11,18)14(21)22/h2-5,10-12H,6-7,18H2,1H3,(H,19,20)(H,21,22)/t10-,11-,12+,15-,16+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	54.4	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558772 (CHEMBL4748699) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446857 (US10689327, Compound (II)-15) Show SMILES CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)O[C@H](C)OC(=O)[C@@]1(N)[C@H]2[C@@H](C[C@H]1OCc1ccc(F)cc1)[C@@H]2C(O)=O |r| Show InChI InChI=1S/C28H38FNO8/c1-14(2)19-10-5-15(3)11-21(19)38-27(34)37-16(4)36-26(33)28(30)22(12-20-23(24(20)28)25(31)32)35-13-17-6-8-18(29)9-7-17/h6-9,14-16,19-24H,5,10-13,30H2,1-4H3,(H,31,32)/t15-,16-,19+,20+,21-,22-,23+,24+,28+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.5	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558773 (CHEMBL4757159) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSc1ccc(C)c(C)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	61	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50558771 (CHEMBL4760856) Show SMILES Cl.[H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](CSCc1ccc(Cl)c(Cl)c1)[C@H]2O)C(O)=O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204266 (CHEMBL3961306) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@H]2F)C(O)=O |r| Show InChI InChI=1S/C15H14Cl2FNO5/c16-6-2-1-5(3-7(6)17)4-24-12-11(18)8-9(13(20)21)10(8)15(12,19)14(22)23/h1-3,8-12H,4,19H2,(H,20,21)(H,22,23)/t8-,9-,10-,11-,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM446739 ((1R,2R,3R,5R,6R)-2-amino-6-fluoro-3-[(3- fluorophe...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1cccc(F)c1)[C@]2(F)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C15H15F2NO5/c16-8-3-1-2-7(4-8)6-23-10-5-9-11(14(9,17)12(19)20)15(10,18)13(21)22/h1-4,9-11H,5-6,18H2,(H,19,20)(H,21,22)/t9-,10-,11+,14-,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75.5	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204253 (CHEMBL3956934) Show SMILES [H][C@@]12C[C@@H](Cc3ccc(F)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O |r| Show InChI InChI=1S/C15H15ClFNO4/c16-9-4-6(1-2-10(9)17)3-7-5-8-11(13(19)20)12(8)15(7,18)14(21)22/h1-2,4,7-8,11-12H,3,5,18H2,(H,19,20)(H,21,22)/t7-,8+,11+,12+,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	76	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50408697 (CHEMBL2112634) Show SMILES NC(CCc1cccc(c1)C(O)=O)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C15H17NO6/c16-15(14(21)22,11-7-10(11)13(19)20)5-4-8-2-1-3-9(6-8)12(17)18/h1-3,6,10-11H,4-5,7,16H2,(H,17,18)(H,19,20)(H,21,22)/t10-,11-,15?/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3				J Med Chem 41: 358-78 (1998) Article DOI: 10.1021/jm970498o BindingDB Entry DOI: 10.7270/Q2XP7423
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062520 ((1S,2S)-2-((R)-1-Amino-1-carboxy-3-m-tolyl-propyl)...) Show SMILES Cc1cccc(CC[C@@](N)([C@H]2C[C@@H]2C(O)=O)C(O)=O)c1 Show InChI InChI=1S/C15H19NO4/c1-9-3-2-4-10(7-9)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12-,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3				J Med Chem 41: 358-78 (1998) Article DOI: 10.1021/jm970498o BindingDB Entry DOI: 10.7270/Q2XP7423
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204270 (CHEMBL3918170) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1cccc(Cl)c1Cl)[C@@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H15Cl2NO6/c16-6-3-1-2-5(10(6)17)4-24-12-11(19)7-8(13(20)21)9(7)15(12,18)14(22)23/h1-3,7-9,11-12,19H,4,18H2,(H,20,21)(H,22,23)/t7-,8-,9-,11+,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204255 (CHEMBL3927108) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(F)c(C)c1)[C@@H]2O)C(O)=O |r| Show InChI InChI=1S/C16H18FNO6/c1-6-4-7(2-3-8(6)17)5-24-13-12(19)9-10(14(20)21)11(9)16(13,18)15(22)23/h2-4,9-13,19H,5,18H2,1H3,(H,20,21)(H,22,23)/t9-,10-,11-,12+,13+,16+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50121652 (CHEMBL3616851) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@H]2Sc1nnc(N)[nH]1)C(O)=O |r| Show InChI InChI=1S/C10H13N5O4S/c11-8-13-9(15-14-8)20-2-1-10(12,7(18)19)5-3(2)4(5)6(16)17/h2-5H,1,12H2,(H,16,17)(H,18,19)(H3,11,13,14,15)/t2-,3+,4+,5+,10+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...				J Med Chem 58: 7526-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b01124 BindingDB Entry DOI: 10.7270/Q29S1ST0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50151462 ((1R,2R,3R,5R,6R)-2-Amino-3-cyclopentyloxy-6-fluoro...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OC1CCCC1)[C@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C13H18FNO5/c14-12(10(16)17)7-5-8(20-6-3-1-2-4-6)13(15,9(7)12)11(18)19/h6-9H,1-5,15H2,(H,16,17)(H,18,19)/t7-,8-,9+,12-,13+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	97.6	n/a	n/a	n/a	n/a	n/a	n/a
TAISHO PHARMACEUTICAL CO., LTD. US Patent					Assay Description CHO cells stably expressing human metabotropic glutamate receptors mGluR2 and mGluR3 were cultured at 37° C. under 5% CO2 using a Dulbecco's modi...				US Patent US10689327 (2020) BindingDB Entry DOI: 10.7270/Q2FR00NR
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204253 (CHEMBL3956934) Show SMILES [H][C@@]12C[C@@H](Cc3ccc(F)c(Cl)c3)[C@@](N)(C(O)=O)[C@]1([H])[C@H]2C(O)=O |r| Show InChI InChI=1S/C15H15ClFNO4/c16-9-4-6(1-2-10(9)17)3-7-5-8-11(13(19)20)12(8)15(7,18)14(21)22/h1-2,4,7-8,11-12H,3,5,18H2,(H,19,20)(H,21,22)/t7-,8+,11+,12+,15+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human recombinant mGlu3 receptor stably expressed in golden hamster AV12 cells co-expressing rat EAAT1 assessed as reduction i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2611419
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204264 (CHEMBL3890112) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(F)c1)[C@@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H15ClFNO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11+,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204260 (CHEMBL3971347) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)cc1)[C@@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H16ClNO6/c16-7-3-1-6(2-4-7)5-23-12-11(18)8-9(13(19)20)10(8)15(12,17)14(21)22/h1-4,8-12,18H,5,17H2,(H,19,20)(H,21,22)/t8-,9-,10-,11+,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50204269 (CHEMBL3909237) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)([C@H](OCc1ccc(Cl)c(Cl)c1)[C@@H]2O)C(O)=O |r| Show InChI InChI=1S/C15H15Cl2NO6/c16-6-2-1-5(3-7(6)17)4-24-12-11(19)8-9(13(20)21)10(8)15(12,18)14(22)23/h1-3,8-12,19H,4,18H2,(H,20,21)(H,22,23)/t8-,9-,10-,11+,12+,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	153	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Antagonist activity at recombinant human mGlu3 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as reduction of DCG-4-inhi...				Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50121651 (CHEMBL3616850) Show SMILES [H][C@]12[C@H](C(O)=O)[C@@]1([H])[C@@](N)(C[C@H]2Sc1nnc([nH]1)C(F)F)C(O)=O |r| Show InChI InChI=1S/C11H12F2N4O4S/c12-6(13)7-15-10(17-16-7)22-2-1-11(14,9(20)21)5-3(2)4(5)8(18)19/h2-6H,1,14H2,(H,18,19)(H,20,21)(H,15,16,17)/t2-,3+,4+,5+,11+/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	154	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of glutamate-stimulated Ca2+ mobilization afte...				J Med Chem 58: 7526-48 (2015) Article DOI: 10.1021/acs.jmedchem.5b01124 BindingDB Entry DOI: 10.7270/Q29S1ST0
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50062534 ((S)-2-[(R)-1-Amino-1-carboxy-3-(3-methoxy-phenyl)-...) Show SMILES COc1cccc(CC[C@@](N)(C2C[C@@H]2C(O)=O)C(O)=O)c1 Show InChI InChI=1S/C15H19NO5/c1-21-10-4-2-3-9(7-10)5-6-15(16,14(19)20)12-8-11(12)13(17)18/h2-4,7,11-12H,5-6,8,16H2,1H3,(H,17,18)(H,19,20)/t11-,12?,15+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratories Curated by ChEMBL					Assay Description Effect on 1S,3R-ACPD-induced inhibition of forskolin stimulated cyclic-AMP in RGT cells expressing human Metabotropic glutamate receptor 3				J Med Chem 41: 358-78 (1998) Article DOI: 10.1021/jm970498o BindingDB Entry DOI: 10.7270/Q2XP7423
					More data for this Ligand-Target Pair

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