Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50434134 (CHEMBL2381641) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 267 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim... | J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299471 (CHEMBL566136 | Ethyl 2-amino-4-methyl-5-phenylthio...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 750 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50434136 (CHEMBL2381640) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.38E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim... | J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50434130 (CHEMBL2381645) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim... | J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299477 (CHEMBL568515 | Propyl 2-amino-4-methyl-5-phenylthi...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50434133 (CHEMBL2381643) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company Curated by ChEMBL | Assay Description Antagonist activity at human mGlu6 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 assessed as inhibition of forskolin-stim... | J Med Chem 56: 4442-55 (2013) Article DOI: 10.1021/jm4000165 BindingDB Entry DOI: 10.7270/Q20003G4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50204257 (CHEMBL3947221) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Antagonist activity at recombinant human mGlu6 receptor expressed in hamster AV12 cells co-expressing human EAAT1 assessed as inhibition of L-AP4-inh... | Bioorg Med Chem Lett 26: 5663-5668 (2016) Article DOI: 10.1016/j.bmcl.2016.10.067 BindingDB Entry DOI: 10.7270/Q2JS9SDT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299481 (2-isothiocyanato-4-methyl-5-phenylthiophene-3-carb...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299478 (CHEMBL577069 | Tert-Butyl 2-amino-4-methyl-5-pheny...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50031704 ((2S,4R)-2-Amino-4-methyl-pentanedioic acid | (2S,4...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50558766 (CHEMBL4751065) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 4.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human recombinant mGlu6 stably expressed in golden hamster AV12 cell membrane co-expressing Galpha15 assessed as reduction in ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2611419 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299472 (CHEMBL568300 | Methyl 2-amino-4-methyl-5-phenylthi...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299476 (2-Amino-4,5-diphenyl-thiophene-3-carboxylic acid e...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299475 (CHEMBL566530 | Ethyl 2-amino-5-(2-chlorophenyl)-4-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM31772 (1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299473 (CHEMBL577248 | Ethyl 2-amino-5-(4-methoxyphenyl)-4...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM212860 (US9278960, 2-7 | US9663506, Example 2-7) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Curated by ChEMBL | Assay Description Antagonist activity at mGluR6 (unknown origin) by FLIPR assay | Bioorg Med Chem Lett 30: (2020) Article DOI: 10.1016/j.bmcl.2020.127066 BindingDB Entry DOI: 10.7270/Q2G44TTJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50531687 (CHEMBL4445682) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Negative allosteric modulation of mGlu6 receptor (unknown origin) | J Med Chem 62: 1690-1695 (2019) Article DOI: 10.1021/acs.jmedchem.8b01810 BindingDB Entry DOI: 10.7270/Q2QC070T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50523865 (CHEMBL4476495) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Negative allosteric modulation of mGlu6 receptor (unknown origin) | Bioorg Med Chem Lett 29: 1211-1214 (2019) Article DOI: 10.1016/j.bmcl.2019.03.016 BindingDB Entry DOI: 10.7270/Q2WH2TDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50283472 (CHEMBL4160748) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK channel assessed as decrease in glutamate-induced thalli... | ACS Med Chem Lett 8: 1110-1115 (2017) Article DOI: 10.1021/acsmedchemlett.7b00317 BindingDB Entry DOI: 10.7270/Q2B85BN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50280368 (CHEMBL4176971) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Curated by ChEMBL | Assay Description In vitro inhibitory activity against angiotensin I converting enzyme of rats. | ACS Med Chem Lett 8: 1326-1330 (2017) Article DOI: 10.1021/acsmedchemlett.7b00429 BindingDB Entry DOI: 10.7270/Q25X2CG2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299485 (CHEMBL575059 | Ethyl 2-chloro-4-methyl-5-phenylthi...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299480 ((2-Amino-4-methyl-5-phenylthiophen-3-yl)(phenyl)me...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299474 (CHEMBL565503 | Ethyl 2-amino-5-(4-fluorophenyl)-4-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299484 (CHEMBL584345 | Ethyl 2-(cyanodiazenyl)-4-methyl-5-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50185321 (6-cyano-7-nitroquinoxaline-2,3-dione | 7-nitro-2,3...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50094841 ((+)-2-Amino-3-fluoro-bicyclo[3.1.0]hexane-2,6-dica...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human mGlu6 receptor expressed in HEK293T cell membranes in presence of glutamate by GTPgammaS binding assay | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112521 BindingDB Entry DOI: 10.7270/Q2CR5Z03 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50116512 (CHEMBL3609741) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital Curated by ChEMBL | Assay Description Activity at mGlu6 receptor (unknown origin) expressed in HEK293 cells pre-treated for 15 mins before addition of EC80 concentration of reference agon... | Bioorg Med Chem Lett 25: 3956-60 (2015) Article DOI: 10.1016/j.bmcl.2015.07.031 BindingDB Entry DOI: 10.7270/Q28C9Z1B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM430126 (4-(4-fluorophenyl)-5-((1-methyl-1H-pyrazol-3-yl)me...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Negative allosteric modulation of mGlu6R (unknown origin) | J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50503462 (CHEMBL4527834) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux... | J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50503456 (CHEMBL4435396) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University School of Medicine Curated by ChEMBL | Assay Description Negative allosteric modulation of human mGlu6 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux... | J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299482 (CHEMBL567862 | Ethyl 2-(3,3-dimethyltriaz-1-enyl)-...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299483 (CHEMBL566754 | Ethyl 4-methyl-2-(morpholinodiazeny...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50299479 (2-Amino-4-methyl-5-phenylthiophene-3-carbonitrile ...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50207594 (2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig Curated by ChEMBL | Assay Description Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressing aequorine assessed as inhibition of glutamate-induced Ca2+ influx ... | Eur J Med Chem 45: 69-77 (2010) Article DOI: 10.1016/j.ejmech.2009.09.025 BindingDB Entry DOI: 10.7270/Q28S4QVF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50288204 ((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its agonist activity against mGluR 6 receptor in CHO cells. | Bioorg Med Chem Lett 6: 2559-2564 (1996) Article DOI: 10.1016/0960-894X(96)00464-7 BindingDB Entry DOI: 10.7270/Q2HX1CN1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM50288204 ((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for its agonist activity against mGluR 2 receptor in CHO cells. | Bioorg Med Chem Lett 6: 2559-2564 (1996) Article DOI: 10.1016/0960-894X(96)00464-7 BindingDB Entry DOI: 10.7270/Q2HX1CN1 | |||||||||||
More data for this Ligand-Target Pair |