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Compile Data Set for Download or QSAR

Found 6375 hits of ic50 data for polymerid = 4906   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50589142
PNG
(CHEMBL5184459)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(CC2CN(CCO2)c2ncc(OCC3CCNCC3)cn2)n1
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n/an/a 0.0190n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112946
BindingDB Entry DOI: 10.7270/Q2WW7NNP
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50589141
PNG
(CHEMBL5174958)
Show SMILES O=c1ccc(nn1CC1CN(CCO1)c1ncc(cn1)-c1cnn(c1)C1CCNCC1)-c1cccnc1
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n/an/a 0.0350n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112946
BindingDB Entry DOI: 10.7270/Q2WW7NNP
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50146167
PNG
(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.130n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50091353
PNG
(CHEMBL3582305)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C22H16FN7O/c1-24-21(31)16-6-5-15(11-17(16)23)19-12-26-22-28-27-20(30(22)29-19)10-13-4-7-18-14(9-13)3-2-8-25-18/h2-9,11-12H,10H2,1H3,(H,24,31)
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n/an/a 0.130n/an/an/an/an/an/a



Shanghai Institute of Materia Medica

Curated by ChEMBL


Assay Description
Inhibition of C-Met (unknown origin) using polu (Glu,Tyr)4:1 substrate after 30 mins incubation by multi-well spectrophotometry

ACS Med Chem Lett 6: 507-12 (2015)


Article DOI: 10.1021/ml5004876
BindingDB Entry DOI: 10.7270/Q2QV3P79
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165469
PNG
(CHEMBL3797911)
Show SMILES COc1ccc2c(OCc3nnc4ncc(nn34)-c3ccccc3)ccnc2c1
Show InChI InChI=1S/C21H16N6O2/c1-28-15-7-8-16-17(11-15)22-10-9-19(16)29-13-20-24-25-21-23-12-18(26-27(20)21)14-5-3-2-4-6-14/h2-12H,13H2,1H3
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n/an/a 0.190n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50347672
PNG
(CHEMBL1802904)
Show SMILES CCN1CCC(CC1)n1cc(cn1)-c1cnc2ccc3ccc(NS(=O)(=O)N(C)C)cc3c(=O)c2c1
Show InChI InChI=1S/C26H30N6O3S/c1-4-31-11-9-22(10-12-31)32-17-20(16-28-32)19-13-24-25(27-15-19)8-6-18-5-7-21(14-23(18)26(24)33)29-36(34,35)30(2)3/h5-8,13-17,22,29H,4,9-12H2,1-3H3
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n/an/a 0.200n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of human recombinant c-Met-catalyzed phosphorylation of N-biotinylated peptide (EQEDEPEGDYFEWLE-CONH2) by time-resolved fluorescence reson...

J Med Chem 54: 4092-108 (2011)


Article DOI: 10.1021/jm200112k
BindingDB Entry DOI: 10.7270/Q2X34ZFZ
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50384024
PNG
(CHEMBL2032280 | CHEMBL2079349)
Show SMILES Cc1c(O)ccc2nc(oc12)-c1cc(cnc1N)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H22N6O2/c1-12-18(28)3-2-17-19(12)29-21(26-17)16-8-13(9-24-20(16)22)14-10-25-27(11-14)15-4-6-23-7-5-15/h2-3,8-11,15,23,28H,4-7H2,1H3,(H2,22,24)
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n/an/a 0.200n/an/an/an/an/an/a



Korea Research Institute of Chemical Technology

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met by time resolved-fluorescence resonance energy transfer analysis

Bioorg Med Chem Lett 22: 4044-8 (2012)


Article DOI: 10.1016/j.bmcl.2012.04.083
BindingDB Entry DOI: 10.7270/Q2FF3TC4
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99280
PNG
(US8497368, 72)
Show SMILES CC(=NNC(N)=O)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:2.2|
Show InChI InChI=1S/C17H14FN9O/c1-9(23-25-17(19)28)14-7-21-15-16(22-14)27(26-24-15)8-11-5-10-3-2-4-20-13(10)6-12(11)18/h2-7H,8H2,1H3,(H3,19,25,28)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99254
PNG
(US8497368, 46)
Show SMILES C[C@H](c1nnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1 |r,w:13.15|
Show InChI InChI=1S/C19H18N8O/c1-11(13-5-6-16-14(10-13)4-3-9-21-16)18-24-23-17-8-7-15(26-27(17)18)12(2)22-25-19(20)28/h3-11H,1-2H3,(H3,20,25,28)/t11-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99273
PNG
(US8497368, 65)
Show SMILES NC(=O)NNC(=N)c1cnc2nnn(Cc3ccc4ncccc4c3)c2n1
Show InChI InChI=1S/C16H14N10O/c17-13(22-24-16(18)27)12-7-20-14-15(21-12)26(25-23-14)8-9-3-4-11-10(6-9)2-1-5-19-11/h1-7H,8H2,(H2,17,22)(H3,18,24,27)
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n/an/a 0.200n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM344393
PNG
((E)-N1-(3-fluoro-4-(6-methoxy-7-(3-(piperidin-1-yl...)
Show SMILES CC\C(=N/N(C(N)=O)c1ccc(Oc2ccnc3cc(OCCCN4CCCCC4)c(OC)cc23)c(F)c1)c1ccccc1
Show InChI InChI=1S/C34H38FN5O4/c1-3-28(24-11-6-4-7-12-24)38-40(34(36)41)25-13-14-31(27(35)21-25)44-30-15-16-37-29-23-33(32(42-2)22-26(29)30)43-20-10-19-39-17-8-5-9-18-39/h4,6-7,11-16,21-23H,3,5,8-10,17-20H2,1-2H3,(H2,36,41)/b38-28+
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n/an/a 0.200n/an/an/an/an/an/a



Shenyang Pharmaceutical University

US Patent


Assay Description
c-Met Kinase Activity was Measured with an ELISA Reader. The Specific Operation as Follows:To the plate filled with 0.25 mg/mL PGT, the compounds, 50...

US Patent US9783499 (2017)


BindingDB Entry DOI: 10.7270/Q2DV1N1N
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165465
PNG
(CHEMBL3797579)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H11F3N6/c21-15-6-3-12(4-7-15)17-11-25-19-27-26-18(29(19)28-17)20(22,23)14-5-8-16-13(10-14)2-1-9-24-16/h1-11H
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n/an/a 0.240n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50242000
PNG
(CHEMBL4061378)
Show SMILES CC(c1ccc2ncc(cc2c1)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1ccncc1
Show InChI InChI=1S/C24H19N9/c1-15(33-24-23(30-31-33)27-13-22(29-24)16-5-7-25-8-6-16)17-3-4-21-18(9-17)10-19(11-26-21)20-12-28-32(2)14-20/h3-15H,1-2H3
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n/an/a 0.300n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99274
PNG
(US8497368, 66)
Show SMILES NC(=O)NN=Cc1cnc2nnn(Cc3ccc4ncccc4c3)c2n1 |w:5.5|
Show InChI InChI=1S/C16H13N9O/c17-16(26)23-20-8-12-7-19-14-15(21-12)25(24-22-14)9-10-3-4-13-11(6-10)2-1-5-18-13/h1-8H,9H2,(H3,17,23,26)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99248
PNG
(US8497368, 40)
Show SMILES CC(=NNC(N)=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1 |w:2.2|
Show InChI InChI=1S/C18H14F2N8O/c1-9(23-26-18(21)29)13-4-5-15-24-25-16(28(15)27-13)7-11-12(19)8-14-10(17(11)20)3-2-6-22-14/h2-6,8H,7H2,1H3,(H3,21,26,29)
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n/an/a 0.300n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50242005
PNG
(CHEMBL4104884)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1ccc(C(N)=O)c(F)c1
Show InChI InChI=1S/C26H18F3N9O/c1-12(22-19(28)7-20-17(23(22)29)5-14(8-31-20)15-9-33-37(2)11-15)38-26-25(35-36-38)32-10-21(34-26)13-3-4-16(24(30)39)18(27)6-13/h3-12H,1-2H3,(H2,30,39)
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n/an/a 0.300n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50432878
PNG
(CHEMBL2376640)
Show SMILES C[C@@H](Oc1c[nH]c(=O)c(c1)C(=O)NC1CCOCC1)c1c(Cl)ccc(F)c1Cl |r|
Show InChI InChI=1S/C19H19Cl2FN2O4/c1-10(16-14(20)2-3-15(22)17(16)21)28-12-8-13(18(25)23-9-12)19(26)24-11-4-6-27-7-5-11/h2-3,8-11H,4-7H2,1H3,(H,23,25)(H,24,26)/t10-/m1/s1
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n/an/a 0.320n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) after 60 mins by ELISA

Bioorg Med Chem Lett 23: 2408-13 (2013)


Article DOI: 10.1016/j.bmcl.2013.02.037
BindingDB Entry DOI: 10.7270/Q2TQ62XH
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2021.113268
BindingDB Entry DOI: 10.7270/Q2TF029D
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human full length MET by scintillation counting method in presence of 33P-gammaATP

J Med Chem 59: 3593-608 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01273
BindingDB Entry DOI: 10.7270/Q24M96FS
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



St. John's University

Curated by ChEMBL


Assay Description
Inhibition of NH2-terminal His-tagged MET kinase domain (1051 to 1348 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells p...

J Med Chem 59: 8712-8756 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00472
BindingDB Entry DOI: 10.7270/Q29G5PR8
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Eur J Med Chem 64: 62-73 (2013)


Article DOI: 10.1016/j.ejmech.2013.04.001
BindingDB Entry DOI: 10.7270/Q27082SZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50146167
PNG
(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50242011
PNG
(CHEMBL4070258)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C24H20F2N10O/c1-13(36-24-23(32-33-36)28-10-20(31-24)16-9-30-35(12-16)3-4-37)21-18(25)6-19-17(22(21)26)5-14(7-27-19)15-8-29-34(2)11-15/h5-13,37H,3-4H2,1-2H3
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity by displacement of [3H]- DAMPGO from opioid receptor mu by using opioid radioligand binding assay

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50242021
PNG
(CHEMBL4097173)
Show SMILES CC(c1c(F)cc2ncc(cc2c1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(C)c1
Show InChI InChI=1S/C23H18F2N10/c1-12(35-23-22(31-32-35)27-9-19(30-23)15-8-29-34(3)11-15)20-17(24)5-18-16(21(20)25)4-13(6-26-18)14-7-28-33(2)10-14/h4-12H,1-3H3
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n/an/a 0.400n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin)

Eur J Med Chem 158: 814-831 (2018)


Article DOI: 10.1016/j.ejmech.2018.09.050
BindingDB Entry DOI: 10.7270/Q25H7JZ5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Bioorg Med Chem Lett 26: 4483-4486 (2016)


Article DOI: 10.1016/j.bmcl.2016.07.077
BindingDB Entry DOI: 10.7270/Q2KH0RTX
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99228
PNG
(US8497368, 20)
Show SMILES CC(=NNC(N)=O)c1ccc2ncc(Cc3c(F)cc4ncccc4c3F)n2n1 |w:2.2|
Show InChI InChI=1S/C19H15F2N7O/c1-10(25-26-19(22)29)15-4-5-17-24-9-11(28(17)27-15)7-13-14(20)8-16-12(18(13)21)3-2-6-23-16/h2-6,8-9H,7H2,1H3,(H3,22,26,29)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99238
PNG
(US8497368, 30)
Show SMILES C[C@H](c1cnc2ccc(nn12)C(C)=NNC(N)=O)c1ccc2ncccc2c1 |r,w:13.15|
Show InChI InChI=1S/C20H19N7O/c1-12(14-5-6-17-15(10-14)4-3-9-22-17)18-11-23-19-8-7-16(26-27(18)19)13(2)24-25-20(21)28/h3-12H,1-2H3,(H3,21,25,28)/t12-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM99281
PNG
(US8497368, 73)
Show SMILES CC(=O)NN=C(C)c1cnc2nnn(Cc3cc4cccnc4cc3F)c2n1 |w:4.3|
Show InChI InChI=1S/C18H15FN8O/c1-10(23-24-11(2)28)16-8-21-17-18(22-16)27(26-25-17)9-13-6-12-4-3-5-20-15(12)7-14(13)19/h3-8H,9H2,1-2H3,(H,24,28)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8497368 (2013)


BindingDB Entry DOI: 10.7270/Q2KW5DN7
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100728
PNG
(US8507676, 78)
Show SMILES CC(N=O)c1ccc2nnc(Cc3c(F)cc4ncccc4c3F)n2n1
Show InChI InChI=1S/C17H12F2N6O/c1-9(24-26)13-4-5-15-21-22-16(25(15)23-13)7-11-12(18)8-14-10(17(11)19)3-2-6-20-14/h2-6,8-9H,7H2,1H3
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Fudan University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Eur J Med Chem 80: 254-66 (2014)


Article DOI: 10.1016/j.ejmech.2014.04.056
BindingDB Entry DOI: 10.7270/Q2930VQ6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Eur J Med Chem 83: 581-93 (2014)


Article DOI: 10.1016/j.ejmech.2014.06.068
BindingDB Entry DOI: 10.7270/Q2R78GTF
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Korea University of Science and Technology

Curated by ChEMBL


Assay Description
Inhibition of c-Met kinase (unknown origin)

Eur J Med Chem 90: 195-208 (2015)


Article DOI: 10.1016/j.ejmech.2014.11.023
BindingDB Entry DOI: 10.7270/Q2M61MX6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of Met (unknown origin) using poly(Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to ...

Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50347659
PNG
(CHEMBL1802916 | MK-2461)
Show SMILES CN(C[C@@H]1COCCO1)S(=O)(=O)Nc1ccc2ccc3ncc(cc3c(=O)c2c1)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C24H25N5O5S/c1-28-13-18(12-26-28)17-9-22-23(25-11-17)6-4-16-3-5-19(10-21(16)24(22)30)27-35(31,32)29(2)14-20-15-33-7-8-34-20/h3-6,9-13,20,27H,7-8,14-15H2,1-2H3/t20-/m1/s1
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n/an/a 0.400n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin)

Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 ...

Bioorg Med Chem 24: 3353-8 (2016)


Article DOI: 10.1016/j.bmc.2016.03.061
BindingDB Entry DOI: 10.7270/Q28W3G6P
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.400n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly(Glu, Tyr)4:1 as substrate preincubated for 60 mins followed by substrate addition measured after 2 to...

Eur J Med Chem 123: 431-446 (2016)


Article DOI: 10.1016/j.ejmech.2016.07.059
BindingDB Entry DOI: 10.7270/Q2KK9DR0
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165571
PNG
(CHEMBL3800471)
Show SMILES Oc1cccc(c1)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H14N6O/c27-16-5-1-3-15(11-16)18-12-22-20-24-23-19(26(20)25-18)10-13-6-7-17-14(9-13)4-2-8-21-17/h1-9,11-12,27H,10H2
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n/an/a 0.420n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165466
PNG
(CHEMBL3800420)
Show SMILES Cn1cc(cn1)-c1cnc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C18H12F2N8/c1-27-10-12(8-23-27)15-9-22-17-25-24-16(28(17)26-15)18(19,20)13-4-5-14-11(7-13)3-2-6-21-14/h2-10H,1H3
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n/an/a 0.430n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of c-Met in human EBC-1 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assay

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50457072
PNG
(CHEMBL4214018)
Show SMILES Cn1cc(cn1)-c1ccc(=O)n(CCOc2ccnc3cc(OCc4ccc(cc4)C(=O)Nc4ccccc4N)ccc23)n1
Show InChI InChI=1S/C33H29N7O4/c1-39-20-24(19-36-39)28-12-13-32(41)40(38-28)16-17-43-31-14-15-35-30-18-25(10-11-26(30)31)44-21-22-6-8-23(9-7-22)33(42)37-29-5-3-2-4-27(29)34/h2-15,18-20H,16-17,21,34H2,1H3,(H,37,42)
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n/an/a 0.440n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged c-Met cytoplasmic domain (956 to 1390 residues) expressed in baculovirus expression system using poly (Glu...

ACS Med Chem Lett 8: 830-834 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00172
BindingDB Entry DOI: 10.7270/Q29026D1
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165567
PNG
(CHEMBL3797914)
Show SMILES Cn1cc(cn1)-c1cnc2nnc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C18H14N8/c1-25-11-14(9-21-25)16-10-20-18-23-22-17(26(18)24-16)8-12-4-5-15-13(7-12)3-2-6-19-15/h2-7,9-11H,8H2,1H3
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n/an/a 0.460n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165465
PNG
(CHEMBL3797579)
Show SMILES Fc1ccc(cc1)-c1cnc2nnc(n2n1)C(F)(F)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H11F3N6/c21-15-6-3-12(4-7-15)17-11-25-19-27-26-18(29(19)28-17)20(22,23)14-5-8-16-13(10-14)2-1-9-24-16/h1-11H
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n/an/a 0.460n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of c-Met in human MKN45 cells assessed as reduction in cell proliferation after 72 hrs by SRB or MTT assay

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50241992
PNG
(CHEMBL4074262)
Show SMILES CC(c1cc2cc(cnc2cc1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C24H21FN10O/c1-14(19-6-15-5-16(17-9-28-33(2)12-17)8-26-21(15)7-20(19)25)35-24-23(31-32-35)27-11-22(30-24)18-10-29-34(13-18)3-4-36/h5-14,36H,3-4H2,1-2H3
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n/an/a 0.480n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-MET (unknown origin) using TK substrate-biotin peptide as substrate preincubated for 5 to 10 mins followed by ATP addition measured a...

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM100726
PNG
(US8507676, 77-S)
Show SMILES C[C@@H](c1nnc2ccc(nn12)C(C)=NOC(N)=O)c1c(F)cc2ncccc2c1F |r,w:13.15|
Show InChI InChI=1S/C19H15F2N7O2/c1-9(16-12(20)8-14-11(17(16)21)4-3-7-23-14)18-25-24-15-6-5-13(26-28(15)18)10(2)27-30-19(22)29/h3-9H,1-2H3,(H2,22,29)/t9-/m1/s1
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n/an/a 0.480n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The kinase assay is based on the LanthaScreen technology. LanthaScreen is the detection of Time-Resolved Fluorescence Resonance Energy Transfer (TR-...

US Patent US8507676 (2013)


BindingDB Entry DOI: 10.7270/Q2MS3RC9
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50241992
PNG
(CHEMBL4074262)
Show SMILES CC(c1cc2cc(cnc2cc1F)-c1cnn(C)c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C24H21FN10O/c1-14(19-6-15-5-16(17-9-28-33(2)12-17)8-26-21(15)7-20(19)25)35-24-23(31-32-35)27-11-22(30-24)18-10-29-34(13-18)3-4-36/h5-14,36H,3-4H2,1-2H3
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n/an/a 0.480n/an/an/an/an/an/a



Shanghai Pharmaceuticals Holding Co., Ltd.

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity by displacement [3H]- DSLET from Opioid receptor delta 1 by using opioid radioligand binding assay

Eur J Med Chem 134: 147-158 (2017)


Article DOI: 10.1016/j.ejmech.2017.03.085
BindingDB Entry DOI: 10.7270/Q2CF9S81
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50165578
PNG
(CHEMBL3799192)
Show SMILES C(c1nnc2ncc(nn12)-c1ccccc1)c1ccc2ncccc2c1
Show InChI InChI=1S/C20H14N6/c1-2-5-15(6-3-1)18-13-22-20-24-23-19(26(20)25-18)12-14-8-9-17-16(11-14)7-4-10-21-17/h1-11,13H,12H2
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n/an/a 0.490n/an/an/an/an/an/a



Chinese Academy of Sciences (CAS)

Curated by ChEMBL


Assay Description
Inhibition of recombinant c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate incubated for 60 mins by ELISA

Eur J Med Chem 116: 239-251 (2016)


Article DOI: 10.1016/j.ejmech.2016.03.076
BindingDB Entry DOI: 10.7270/Q2P27111
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50351665
PNG
(CHEMBL1822369)
Show SMILES OC[C@H]1CCCN1CCCNC(=O)c1cc2NC(=O)C(=NNC(=O)Cc3ccc4OCCc4c3)c2c(Br)c1 |r,w:20.21|
Show InChI InChI=1S/C27H30BrN5O5/c28-20-13-18(26(36)29-7-2-9-33-8-1-3-19(33)15-34)14-21-24(20)25(27(37)30-21)32-31-23(35)12-16-4-5-22-17(11-16)6-10-38-22/h4-5,11,13-14,19,34H,1-3,6-10,12,15H2,(H,29,36)(H,31,35)(H,30,32,37)/t19-/m1/s1
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n/an/a 0.5n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET

Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50440905
PNG
(CHEMBL2431835)
Show SMILES C[C@@H](c1ccc2ncccc2c1)n1nnc2ncc(nc12)-c1cnn(CCO)c1 |r|
Show InChI InChI=1S/C20H18N8O/c1-13(14-4-5-17-15(9-14)3-2-6-21-17)28-20-19(25-26-28)22-11-18(24-20)16-10-23-27(12-16)7-8-29/h2-6,9-13,29H,7-8H2,1H3/t13-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of c-Met autophosphorylation in human A549 cells after 1 hr by ELISA

J Med Chem 56: 6651-65 (2013)


Article DOI: 10.1021/jm400926x
BindingDB Entry DOI: 10.7270/Q2HM59WR
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50202376
PNG
(CHEMBL3919012)
Show SMILES OC[C@@H]1CCCN1CCCCNC(=O)c1cc2NC\C(=N/NC(=O)Cc3ccc4OCCc4c3)c2c(Br)c1 |r|
Show InChI InChI=1S/C28H34BrN5O4/c29-22-14-20(28(37)30-8-1-2-9-34-10-3-4-21(34)17-35)15-23-27(22)24(16-31-23)32-33-26(36)13-18-5-6-25-19(12-18)7-11-38-25/h5-6,12,14-15,21,31,35H,1-4,7-11,13,16-17H2,(H,30,37)(H,33,36)/b32-24+/t21-/m0/s1
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n/an/a 0.5n/an/an/an/an/an/a



Egyptian Russian University

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged c-Met (unknown origin) assessed as phosphotyrosine levels preincubated foe 15 mins followed by addition of poly(glutamic aci...

Eur J Med Chem 122: 366-381 (2016)


Article DOI: 10.1016/j.ejmech.2016.06.034
BindingDB Entry DOI: 10.7270/Q2154K1N
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50399540
PNG
(FORETINIB | US10464902, Foretinib | US10882853, Co...)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1
Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42)
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n/an/a 0.5n/an/an/an/an/an/a



University of Genoa

Curated by ChEMBL


Assay Description
Inhibition of MET

J Med Chem 55: 10797-822 (2012)


Article DOI: 10.1021/jm301085w
BindingDB Entry DOI: 10.7270/Q2BP03XZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
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