Compile Data Set for Download or QSAR

Found 47 hits of ic50 data for polymerid = 4928   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM86068 (PPC) Show SMILES Cc1ccc(cc1)-c1cc2cc(O)c(O)cc2oc1=O Show InChI InChI=1S/C16H12O4/c1-9-2-4-10(5-3-9)12-6-11-7-13(17)14(18)8-15(11)20-16(12)19/h2-8,17-18H,1H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139137 (CHEMBL3759162) Show SMILES [Cl-].CCCCn1cc[n+](Cc2cc(=O)oc3cc(C)cc(C)c23)c1 Show InChI InChI=1S/C19H23N2O2.ClH/c1-4-5-6-20-7-8-21(13-20)12-16-11-18(22)23-17-10-14(2)9-15(3)19(16)17;/h7-11,13H,4-6,12H2,1-3H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.37E+3	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50594668 (CHEMBL5174712) Show SMILES [Cl-].Cc1c(C)c(C)c(Cn2c[n+](Cc3cc(=O)oc4cc(O)ccc34)c3ccccc23)c(C)c1C Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.84E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2021.113921 BindingDB Entry DOI: 10.7270/Q2VT1X23
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144692 (CHEMBL3759251) Show SMILES [Cl-].O=C(C[n+]1cn(Cn2nnc3ccccc23)c2ccccc12)c1ccc2OCC(=O)Nc2c1 Show InChI InChI=1S/C24H18N6O3.ClH/c31-22(16-9-10-23-18(11-16)25-24(32)13-33-23)12-28-14-29(21-8-4-3-7-20(21)28)15-30-19-6-2-1-5-17(19)26-27-30;/h1-11,14H,12-13,15H2;1H	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.76E+3	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50454598 (CHEMBL4215208) Show SMILES FC(F)(F)Oc1ccc(NC(=O)N[C@H]2CC[C@@H](CC2)Oc2ccc(cc2)C(=O)OCc2ccccc2)cc1 |r,wU:16.19,wD:13.12,(30.34,-3.34,;30.34,-4.74,;31.59,-3.72,;29.09,-3.72,;30.34,-6.28,;31.68,-7.05,;31.67,-8.59,;33.01,-9.36,;34.35,-8.59,;35.68,-9.36,;37.01,-8.59,;37.01,-7.05,;38.35,-9.35,;39.68,-8.58,;41.01,-9.36,;42.34,-8.59,;42.34,-7.05,;41.01,-6.28,;39.67,-7.05,;43.68,-6.28,;45.01,-7.06,;45,-8.6,;46.33,-9.37,;47.67,-8.6,;47.67,-7.05,;46.34,-6.29,;49,-9.37,;49,-10.91,;50.34,-8.6,;51.67,-9.38,;53,-8.61,;54.33,-9.38,;55.67,-8.61,;55.67,-7.07,;54.33,-6.3,;53,-7.07,;34.34,-7.04,;33.01,-6.28,)| Show InChI InChI=1S/C28H27F3N2O5/c29-28(30,31)38-25-16-10-22(11-17-25)33-27(35)32-21-8-14-24(15-9-21)37-23-12-6-20(7-13-23)26(34)36-18-19-4-2-1-3-5-19/h1-7,10-13,16-17,21,24H,8-9,14-15,18H2,(H2,32,33,35)/t21-,24-	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Davis Curated by ChEMBL					Assay Description Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assay				Bioorg Med Chem Lett 28: 762-768 (2018) Article DOI: 10.1016/j.bmcl.2018.01.003 BindingDB Entry DOI: 10.7270/Q2PV6NZ4
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM158481 (US9029401, 1728 (t-TUCB)) Show SMILES OC(=O)c1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 |r,wU:8.7,wD:11.14,(10,,;8.67,-.77,;8.67,-2.31,;7.34,,;6,-.77,;4.67,,;4.67,1.54,;3.33,2.31,;2,1.54,;2,,;.67,-.77,;-.67,,;-.67,1.54,;.67,2.31,;-2,-.77,;-3.33,,;-3.33,1.54,;-4.67,-.77,;-6,,;-6,1.54,;-7.34,2.31,;-8.67,1.54,;-10,2.31,;-10,3.85,;-10,5.39,;-8.67,4.62,;-11.34,4.62,;-8.67,,;-7.34,-.77,;6,2.31,;7.34,1.54,)| Show InChI InChI=1S/C21H21F3N2O5/c22-21(23,24)31-18-11-5-15(6-12-18)26-20(29)25-14-3-9-17(10-4-14)30-16-7-1-13(2-8-16)19(27)28/h1-2,5-8,11-12,14,17H,3-4,9-10H2,(H,27,28)(H2,25,26,29)/t14-,17-	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Davis Curated by ChEMBL					Assay Description Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assay				Bioorg Med Chem Lett 28: 762-768 (2018) Article DOI: 10.1016/j.bmcl.2018.01.003 BindingDB Entry DOI: 10.7270/Q2PV6NZ4
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50454599 (CHEMBL4216368) Show SMILES Oc1ccc(O[C@H]2CC[C@@H](CC2)NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1 |r,wU:6.5,wD:9.12,(74.54,-31.49,;73.21,-30.71,;71.87,-31.48,;70.54,-30.71,;70.55,-29.17,;69.22,-28.4,;67.88,-29.16,;67.88,-30.7,;66.55,-31.47,;65.22,-30.69,;65.21,-29.16,;66.55,-28.39,;63.89,-31.47,;62.55,-30.7,;62.55,-29.16,;61.22,-31.47,;59.89,-30.7,;58.55,-31.47,;57.22,-30.7,;57.22,-29.16,;55.88,-28.39,;55.88,-26.85,;55.88,-25.45,;57.13,-25.83,;54.63,-25.83,;58.55,-28.39,;59.88,-29.15,;71.88,-28.4,;73.21,-29.17,)| Show InChI InChI=1S/C20H21F3N2O4/c21-20(22,23)29-18-9-3-14(4-10-18)25-19(27)24-13-1-7-16(8-2-13)28-17-11-5-15(26)6-12-17/h3-6,9-13,16,26H,1-2,7-8H2,(H2,24,25,27)/t13-,16-	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of California Davis Curated by ChEMBL					Assay Description Inhibition of PON1 (unknown origin) expressed in baculovirus system using CMNA substrate by fluorescence based assay				Bioorg Med Chem Lett 28: 762-768 (2018) Article DOI: 10.1016/j.bmcl.2018.01.003 BindingDB Entry DOI: 10.7270/Q2PV6NZ4
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144693 (CHEMBL3758983) Show SMILES [Cl-].Cn1cc[n+](Cc2nc3ccccc3[nH]2)c1 Show InChI InChI=1S/C12H13N4.ClH/c1-15-6-7-16(9-15)8-12-13-10-4-2-3-5-11(10)14-12;/h2-7,9H,8H2,1H3,(H,13,14);1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.91E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139133 (CHEMBL3759178) Show SMILES Cc1ccc2c(CCl)cc(=O)oc2c1C Show InChI InChI=1S/C12H11ClO2/c1-7-3-4-10-9(6-13)5-11(14)15-12(10)8(7)2/h3-5H,6H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139135 (CHEMBL3759775) Show SMILES [Cl-].Cc1cc(C)c2c(C[n+]3ccn(C)c3)cc(=O)oc2c1 Show InChI InChI=1S/C16H17N2O2.ClH/c1-11-6-12(2)16-13(8-15(19)20-14(16)7-11)9-18-5-4-17(3)10-18;/h4-8,10H,9H2,1-3H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144739 (CHEMBL3759516) Show SMILES [Cl-].CCCCn1cc[n+](Cc2nc3ccccc3[nH]2)c1 Show InChI InChI=1S/C15H19N4.ClH/c1-2-3-8-18-9-10-19(12-18)11-15-16-13-6-4-5-7-14(13)17-15;/h4-7,9-10,12H,2-3,8,11H2,1H3,(H,16,17);1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139132 (CHEMBL1462074) Show SMILES Cc1cc(C)c2c(CCl)cc(=O)oc2c1 Show InChI InChI=1S/C12H11ClO2/c1-7-3-8(2)12-9(6-13)5-11(14)15-10(12)4-7/h3-5H,6H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.14E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139134 (CHEMBL3758686) Show SMILES CC(C)(C)c1ccc2oc(=O)cc(CCl)c2c1 Show InChI InChI=1S/C14H15ClO2/c1-14(2,3)10-4-5-12-11(7-10)9(8-15)6-13(16)17-12/h4-7H,8H2,1-3H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50001839 (CHEMBL428647 | PACLITAXEL | taxol) Show SMILES CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)[C@@H]3[C@@]4(CO[C@@H]4C[C@H](O)[C@@]3(C)C1=O)OC(C)=O)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c1ccccc1)c1ccccc1 |r,wU:4.3,28.30,26.26,10.10,22.23,30.33,wD:23.37,8.45,44.49,46.51,12.12,c:5,(23.85,-5.1,;25.19,-4.32,;25.18,-2.78,;26.52,-5.08,;26.53,-6.61,;23.91,-8.14,;22.57,-8.89,;21.25,-8.11,;22.55,-10.43,;23.89,-11.22,;25.21,-10.45,;25.2,-11.99,;26.54,-11.23,;26.53,-12.77,;25.19,-13.53,;23.87,-12.75,;25.19,-15.05,;23.85,-15.82,;23.84,-17.36,;25.17,-18.14,;26.51,-17.37,;26.52,-15.82,;27.88,-10.47,;29.2,-11.23,;29.96,-12.57,;31.31,-11.81,;30.55,-10.47,;30.55,-8.91,;29.2,-8.13,;30.52,-7.35,;27.88,-8.91,;26.78,-10,;27.87,-7.37,;29.19,-6.59,;28.1,-12.3,;28.1,-13.84,;29.43,-14.62,;26.76,-14.61,;25.23,-8.91,;25.98,-7.57,;26.76,-8.91,;21.21,-11.18,;19.89,-10.4,;19.91,-8.87,;18.55,-11.16,;18.54,-12.7,;17.22,-10.38,;17.24,-8.84,;15.92,-8.06,;14.57,-8.82,;15.93,-6.52,;17.27,-5.78,;17.28,-4.24,;15.95,-3.46,;14.61,-4.23,;14.6,-5.76,;15.89,-11.14,;14.57,-10.36,;13.23,-11.11,;13.21,-12.65,;14.56,-13.43,;15.89,-12.67,)| Show InChI InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.65E+4	n/a	4.20E+4	n/a	n/a	n/a	n/a	10.5	n/a
Ahi Evran University					Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...				Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243044 ((2-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...) Show SMILES COc1cc(Br)c(cc1OC)C(=O)c1c(Br)c(Br)cc(OC)c1OC Show InChI InChI=1S/C17H15Br3O5/c1-22-11-5-8(9(18)6-12(11)23-2)16(21)14-15(20)10(19)7-13(24-3)17(14)25-4/h5-7H,1-4H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.23E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243045 ((3-Bromo-4,5-dimethoxyphenyl)(2,3-dibromo-5,6-dime...) Show SMILES COc1cc(Br)c(Br)c(C(=O)c2cc(Br)c(OC)c(OC)c2)c1OC Show InChI InChI=1S/C17H15Br3O5/c1-22-11-6-8(5-10(19)16(11)24-3)15(21)13-14(20)9(18)7-12(23-2)17(13)25-4/h5-7H,1-4H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.25E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM92331 (Lornoxicam) Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sc(Cl)cc2S1(=O)=O |t:12| Show InChI InChI=1S/C13H10ClN3O4S2/c1-17-10(13(19)16-9-4-2-3-5-15-9)11(18)12-7(23(17,20)21)6-8(14)22-12/h2-6,18H,1H3,(H,15,16,19)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	9.00E+3	-28.8	1.36E+5	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243043 ((2,3-dibromo-5,6-dimethoxyphenyl)(3,4-dimethoxyphe...) Show SMILES COc1ccc(cc1OC)C(=O)c1c(Br)c(Br)cc(OC)c1OC Show InChI InChI=1S/C17H16Br2O5/c1-21-11-6-5-9(7-12(11)22-2)16(20)14-15(19)10(18)8-13(23-3)17(14)24-4/h5-8H,1-4H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.74E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50316126 (Bleph-10 | Bleph-30 | Blephamide | CHEMBL455 | Cet...) Show SMILES CC(=O)NS(=O)(=O)c1ccc(N)cc1 Show InChI InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid UniChem Patents	Article PubMed	8.60E+4	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM10860 (4-(aminomethyl)benzene-1-sulfonamide | CHEMBL419 |...) Show SMILES NCc1ccc(cc1)S(N)(=O)=O Show InChI InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.40E+5	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM17638 (2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...) Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	9.70E+4	-22.9	1.95E+5	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50127140 ((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...) Show SMILES COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12 |r| Show InChI InChI=1S/C29H32O13/c1-11-36-9-20-27(40-11)24(31)25(32)29(41-20)42-26-14-7-17-16(38-10-39-17)6-13(14)21(22-15(26)8-37-28(22)33)12-4-18(34-2)23(30)19(5-12)35-3/h4-7,11,15,20-22,24-27,29-32H,8-10H2,1-3H3/t11-,15+,20-,21-,22+,24-,25-,26-,27-,29+/m1/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.31E+5	n/a	2.26E+5	n/a	n/a	n/a	n/a	10.5	n/a
Ahi Evran University					Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...				Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144690 (CHEMBL3759001) Show SMILES [Cl-].Cc1ccc2c(C[n+]3cn(Cn4nnc5ccccc45)c4ccccc34)cc(=O)oc2c1C Show InChI InChI=1S/C26H22N5O2.ClH/c1-17-11-12-20-19(13-25(32)33-26(20)18(17)2)14-29-15-30(24-10-6-5-9-23(24)29)16-31-22-8-4-3-7-21(22)27-28-31;/h3-13,15H,14,16H2,1-2H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.38E+5	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM82185 (Sulfosalazine, 3) Show SMILES OC(=O)c1ccc(cc1O)\N=N\c1ccc(cc1)S(=O)(=O)Nc1ccccn1 Show InChI InChI=1S/C18H14N4O5S/c23-16-11-13(6-9-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.70E+5	n/a	2.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50139136 (CHEMBL3759337) Show SMILES [Cl-].Cc1n(C)cc[n+]1Cc1cc(=O)oc2cc(C)cc(C)c12 Show InChI InChI=1S/C17H19N2O2.ClH/c1-11-7-12(2)17-14(9-16(20)21-15(17)8-11)10-19-6-5-18(4)13(19)3;/h5-9H,10H2,1-4H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM92332 (Tenoxicam) Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O |t:12| Show InChI InChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	3.06E+5	-20.1	3.40E+5	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM25902 (4-chloro-2-[(furan-2-ylmethyl)amino]-5-sulfamoylbe...) Show SMILES NS(=O)(=O)c1cc(C(O)=O)c(NCc2ccco2)cc1Cl Show InChI InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	7.02E+5	n/a	3.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144740 (CHEMBL3758357) Show SMILES C(n1cnc2ccccc12)n1nnc2ccccc12 Show InChI InChI=1S/C14H11N5/c1-3-7-13-11(5-1)15-9-18(13)10-19-14-8-4-2-6-12(14)16-17-19/h1-9H,10H2	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.64E+5	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144738 (CHEMBL3758838) Show SMILES [Cl-].Cc1n(C)cc[n+]1Cc1nc2ccccc2[nH]1 Show InChI InChI=1S/C13H15N4.ClH/c1-10-16(2)7-8-17(10)9-13-14-11-5-3-4-6-12(11)15-13;/h3-8H,9H2,1-2H3,(H,14,15);1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.26E+5	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144691 (CHEMBL3759697) Show SMILES [Cl-].CC(C)(C)c1ccc2oc(=O)cc(C[n+]3cn(Cn4nnc5ccccc45)c4ccccc34)c2c1 Show InChI InChI=1S/C28H26N5O2.ClH/c1-28(2,3)20-12-13-26-21(15-20)19(14-27(34)35-26)16-31-17-32(25-11-7-6-10-24(25)31)18-33-23-9-5-4-8-22(23)29-30-33;/h4-15,17H,16,18H2,1-3H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.27E+5	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM36351 (CID148124 | Docetaxel) Show SMILES [H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C |t:39| Show InChI InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	2.91E+5	n/a	6.65E+5	n/a	n/a	n/a	n/a	10.5	n/a
Ahi Evran University					Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...				Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243048 ((3-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...) Show SMILES Oc1cc(Br)c(Br)c(C(=O)c2cc(O)c(O)c(Br)c2)c1O Show InChI InChI=1S/C13H7Br3O5/c14-5-3-8(18)13(21)9(10(5)16)11(19)4-1-6(15)12(20)7(17)2-4/h1-3,17-18,20-21H	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.01E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM10880 (AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...) Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	7.43E+5	n/a	8.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243046 ((2,3-Dibromo-5,6-dihydroxyphenyl)(3,4-dihydroxyphe...) Show SMILES Oc1ccc(cc1O)C(=O)c1c(O)c(O)cc(Br)c1Br Show InChI InChI=1S/C13H8Br2O5/c14-6-4-9(18)13(20)10(11(6)15)12(19)5-1-2-7(16)8(17)3-5/h1-4,16-18,20H	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.32E+5	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243047 ((2-Bromo-4,5-dihydroxyphenyl)(2,3-dibromo-5,6-dihy...) Show SMILES Oc1cc(Br)c(cc1O)C(=O)c1c(O)c(O)cc(Br)c1Br Show InChI InChI=1S/C13H7Br3O5/c14-5-2-8(18)7(17)1-4(5)12(20)10-11(16)6(15)3-9(19)13(10)21/h1-3,17-19,21H	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.11E+6	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM243042 ((2,3-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanon...) Show SMILES COc1ccc(cc1OC)C(=O)c1cccc(OC)c1OC Show InChI InChI=1S/C17H18O5/c1-19-13-9-8-11(10-15(13)21-3)16(18)12-6-5-7-14(20-2)17(12)22-4/h5-10H,1-4H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+6	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412 nm. Paraoxonase activity was determined spectrophotometrically using the same pr...				J Enzyme Inhib Med Chem 28: 1073-9 (2013) Article DOI: 10.3109/14756366.2012.715287 BindingDB Entry DOI: 10.7270/Q29W0DDQ
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM10868 (1,3,4-Thiadiazole-2-sulfonamide, 6 | 1,3,4-thiadia...) Show SMILES Nc1nnc(s1)S(N)(=O)=O Show InChI InChI=1S/C2H4N4O2S2/c3-1-5-6-2(9-1)10(4,7)8/h(H2,3,5)(H2,4,7,8)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents	Article PubMed	2.00E+6	n/a	1.24E+6	n/a	n/a	n/a	n/a	n/a	n/a
Atatürk University					Assay Description The inhibitory effects of six sulfonamide derivatives was examined against the purified enzyme hPON1 and were tested in a triplicate experiment in fi...				Chem Biol Drug Des 76: 552-8 (2010) Article DOI: 10.1111/j.1747-0285.2010.01036.x BindingDB Entry DOI: 10.7270/Q2Q52N3T
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50127646 (CHEMBL42577 | Phosphoric acid 4-amino-phenyl ester...) Show SMILES CCOP(=O)(OCC)Oc1ccc(N)cc1 Show InChI InChI=1S/C10H16NO4P/c1-3-13-16(12,14-4-2)15-10-7-5-9(11)6-8-10/h5-8H,3-4,11H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.28E+6	n/a	n/a	n/a	n/a	n/a	n/a
The University of Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against human serum paraoxonase (PON1)				Bioorg Med Chem Lett 13: 1623-6 (2003) BindingDB Entry DOI: 10.7270/Q23B60P7
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50174201 (ARTHROTEC | GP 45840 | SOLARAZE | Sodium; [2-(2,6-...) Show SMILES [O-]C(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl Show InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	8.05E+5	-17.7	1.64E+6	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144742 (CHEMBL3758332) Show SMILES [Cl-].C(n1c[n+](Cc2ccccc2)c2ccccc12)n1nnc2ccccc12 Show InChI InChI=1S/C21H18N5.ClH/c1-2-8-17(9-3-1)14-24-15-25(21-13-7-6-12-20(21)24)16-26-19-11-5-4-10-18(19)22-23-26;/h1-13,15H,14,16H2;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.06E+6	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM14675 (CHEMBL26128 | Fragment 5 | Phenylphosphate | pheno...) Show SMILES OP(O)(=O)Oc1ccccc1 Show InChI InChI=1S/C6H7O4P/c7-11(8,9)10-6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.25E+6	n/a	n/a	n/a	n/a	n/a	n/a
The University of Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against human serum paraoxonase (PON1)				Bioorg Med Chem Lett 13: 1623-6 (2003) BindingDB Entry DOI: 10.7270/Q23B60P7
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50127647 (CHEMBL296745 | Phosphoric acid diethyl ester pheny...) Show SMILES CCOP(=O)(OCC)Oc1ccccc1 Show InChI InChI=1S/C10H15O4P/c1-3-12-15(11,13-4-2)14-10-8-6-5-7-9-10/h5-9H,3-4H2,1-2H3	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents	PubMed	n/a	n/a	3.27E+6	n/a	n/a	n/a	n/a	n/a	n/a
The University of Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against human serum paraoxonase (PON1)				Bioorg Med Chem Lett 13: 1623-6 (2003) BindingDB Entry DOI: 10.7270/Q23B60P7
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50144741 (CHEMBL3760112) Show SMILES [Cl-].CCCC[n+]1cn(Cn2nnc3ccccc23)c2ccccc12 Show InChI InChI=1S/C18H20N5.ClH/c1-2-3-12-21-13-22(18-11-7-6-10-17(18)21)14-23-16-9-5-4-8-15(16)19-20-23;/h4-11,13H,2-3,12,14H2,1H3;1H/q+1;/p-1	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.33E+6	n/a	n/a	n/a	n/a	n/a	n/a
In£n£ University Curated by ChEMBL					Assay Description Inhibition of human serum PON1 using paraoxon as substrate by spectrophotometric analysis				Bioorg Med Chem 24: 1392-401 (2016) Article DOI: 10.1016/j.bmc.2016.02.012 BindingDB Entry DOI: 10.7270/Q2FT8NWG
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM50022271 (2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...) Show SMILES CC(C(O)=O)c1cccc(c1)C(=O)c1ccccc1 Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.30E+7	-10.8	6.23E+6	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM92333 (Lincomycine) Show SMILES CCCC1CC(N(C)C1)C(=O)NC(C(C)O)C1OC(SC)C(O)C(O)C1O Show InChI InChI=1S/C18H34N2O6S/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	1.11E+7	-11.2	1.30E+7	n/a	n/a	n/a	n/a	10.5	25
Atatürk University					Assay Description The enzyme assay was based on the estimation of p-nitrophenol at 412nm. The molar extinction coefficient of p-nitrophenol was used to calculate enzy...				J Enzyme Inhib Med Chem 24: 1034-9 (2009) Article DOI: 10.1080/14756360802608351 BindingDB Entry DOI: 10.7270/Q2TT4PKR
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM24514 (4-nitrophenoxyphosphonic acid | 4-nitrophenyl phos...) Show SMILES OP(O)(=O)Oc1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C6H6NO6P/c8-7(9)5-1-3-6(4-2-5)13-14(10,11)12/h1-4H,(H2,10,11,12)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.85E+7	n/a	n/a	n/a	n/a	n/a	n/a
The University of Birmingham Curated by ChEMBL					Assay Description Inhibitory activity against human serum paraoxonase (PON1)				Bioorg Med Chem Lett 13: 1623-6 (2003) BindingDB Entry DOI: 10.7270/Q23B60P7
					More data for this Ligand-Target Pair
Serum paraoxonase/arylesterase 1 (Homo sapiens (Human))	BDBM189358 (Asta Z 4942 | Ifosfamide | Iphosphamide | N,3-bis(...) Show SMILES ClCCNP1(=O)OCCCN1CCCl Show InChI InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid UniChem	Article PubMed	8.97E+6	n/a	2.33E+7	n/a	n/a	n/a	n/a	10.5	n/a
Ahi Evran University					Assay Description Paraoxonase enzyme activity was determined at 25 °C with paraoxon (1 mM) in 50 mM glycine-NaOH (pH 10.5) containing 1 mM CaCl2. The enzyme assay was ...				Chem Biol Drug Des 88: 188-96 (2016) Article DOI: 10.1111/cbdd.12746 BindingDB Entry DOI: 10.7270/Q2SB44JJ
					More data for this Ligand-Target Pair