Compile Data Set for Download or QSAR

Found 235 hits of ic50 data for polymerid = 50000071,50007006   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prolyl endopeptidase (Sus scrofa)	BDBM50051495 ((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1 Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 48: 7093-5 (2005) Article DOI: 10.1021/jm0509187 BindingDB Entry DOI: 10.7270/Q2RR1XTB
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50051495 ((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1 Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate				J Med Chem 47: 5605-7 (2004) Article DOI: 10.1021/jm049503w BindingDB Entry DOI: 10.7270/Q25D8R9G
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50155838 ((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate				J Med Chem 47: 5605-7 (2004) Article DOI: 10.1021/jm049503w BindingDB Entry DOI: 10.7270/Q25D8R9G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50155839 ((S)-1-[(R)-2-(4-Phenyl-butyryl)-cyclopent-2-enecar...) Show SMILES O=C(CCCc1ccccc1)C1=CCC[C@H]1C(=O)N1CCC[C@H]1C#N |t:12| Show InChI InChI=1S/C21H24N2O2/c22-15-17-10-6-14-23(17)21(25)19-12-5-11-18(19)20(24)13-4-9-16-7-2-1-3-8-16/h1-3,7-8,11,17,19H,4-6,9-10,12-14H2/t17-,19+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate				J Med Chem 47: 5605-7 (2004) Article DOI: 10.1021/jm049503w BindingDB Entry DOI: 10.7270/Q25D8R9G
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50051495 ((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)NCc1ccccc1 Show InChI InChI=1S/C19H25N3O4/c23-13-17(24)15-8-4-10-21(15)18(25)16-9-5-11-22(16)19(26)20-12-14-6-2-1-3-7-14/h1-3,6-7,15-16,23H,4-5,8-13H2,(H,20,26)/t15-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50155838 ((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant porcine PREP expressed in Escherichia coli using Suc-Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrat...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00399 BindingDB Entry DOI: 10.7270/Q20V8HK3
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50170689 (1-{(S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-c...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CCCc1ccccc1 Show InChI InChI=1S/C21H28N2O4/c24-15-19(25)17-10-5-14-23(17)21(27)18-11-6-13-22(18)20(26)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18,24H,4-6,9-15H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50155838 ((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.220	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50155836 ((R)-5-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCC=C1C(=O)NCc1ccccc1 |c:15| Show InChI InChI=1S/C20H24N2O4/c23-13-18(24)17-10-5-11-22(17)20(26)16-9-4-8-15(16)19(25)21-12-14-6-2-1-3-7-14/h1-3,6-8,16-17,23H,4-5,9-13H2,(H,21,25)/t16-,17+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate				J Med Chem 47: 5605-7 (2004) Article DOI: 10.1021/jm049503w BindingDB Entry DOI: 10.7270/Q25D8R9G
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134170 (1-((S)-2-Cyclopentanecarbonyl-pyrrolidin-1-yl)-5-{...) Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO Show InChI InChI=1S/C28H43N3O6/c1-28(2,16-24(34)29-13-6-11-21(29)26(36)19-8-3-4-9-19)17-25(35)30-14-7-12-22(30)27(37)31-15-5-10-20(31)23(33)18-32/h19-22,32H,3-18H2,1-2H3/t20-,21-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134170 (1-((S)-2-Cyclopentanecarbonyl-pyrrolidin-1-yl)-5-{...) Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO Show InChI InChI=1S/C28H43N3O6/c1-28(2,16-24(34)29-13-6-11-21(29)26(36)19-8-3-4-9-19)17-25(35)30-14-7-12-22(30)27(37)31-15-5-10-20(31)23(33)18-32/h19-22,32H,3-18H2,1-2H3/t20-,21-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.320	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50038879 ((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...) Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressed				J Med Chem 45: 4581-4 (2002) BindingDB Entry DOI: 10.7270/Q22R3R02
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50038879 ((S)-2-(2-Formyl-pyrrolidine-1-carbonyl)-pyrrolidin...) Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)OCc1ccccc1 |r| Show InChI InChI=1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.330	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50170712 ((S)-1-[(S)-1-(5-Azepan-1-yl-3,3-dimethyl-5-oxo-pen...) Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)CC(=O)N1CCCCCC1 Show InChI InChI=1S/C23H36N4O3/c1-23(2,15-20(28)25-11-5-3-4-6-12-25)16-21(29)27-14-8-10-19(27)22(30)26-13-7-9-18(26)17-24/h18-19H,3-16H2,1-2H3/t18-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134160 (2-Hydroxy-1-[(S)-1-((S)-1-{3-[(S)-2-(pyrrolidine-1...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1 Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134160 (2-Hydroxy-1-[(S)-1-((S)-1-{3-[(S)-2-(pyrrolidine-1...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1 Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50118910 (2-Hydroxy-1-[1-(1-{3-[2-(pyrrolidine-1-carbonyl)-p...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCCC1C(=O)N1CCCC1 Show InChI InChI=1S/C28H36N4O6/c33-18-24(34)21-9-4-14-30(21)28(38)23-11-6-16-32(23)26(36)20-8-3-7-19(17-20)25(35)31-15-5-10-22(31)27(37)29-12-1-2-13-29/h3,7-8,17,21-23,33H,1-2,4-6,9-16,18H2/t21-,22?,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.390	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pig brain ;value ranges from (1.1-2.2)				J Med Chem 45: 4581-4 (2002) BindingDB Entry DOI: 10.7270/Q22R3R02
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134150 ((S)-1-{(S)-1-[5-((S)-2-Cyclopentanecarbonyl-pyrrol...) Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C27H40N4O4/c1-27(2,16-23(32)30-14-6-11-21(30)25(34)19-8-3-4-9-19)17-24(33)31-15-7-12-22(31)26(35)29-13-5-10-20(29)18-28/h19-22H,3-17H2,1-2H3/t20-,21-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134150 ((S)-1-{(S)-1-[5-((S)-2-Cyclopentanecarbonyl-pyrrol...) Show SMILES CC(C)(CC(=O)N1CCC[C@H]1C(=O)C1CCCC1)CC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C27H40N4O4/c1-27(2,16-23(32)30-14-6-11-21(30)25(34)19-8-3-4-9-19)17-24(33)31-15-7-12-22(31)26(35)29-13-5-10-20(29)18-28/h19-22H,3-17H2,1-2H3/t20-,21-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170693 (1-((S)-1-{(S)-1-[3-((S)-2-Cyclopentanecarbonyl-pyr...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)C1CCCC1 Show InChI InChI=1S/C29H37N3O6/c33-18-25(34)22-11-4-14-30(22)29(38)24-13-6-16-32(24)28(37)21-10-3-9-20(17-21)27(36)31-15-5-12-23(31)26(35)19-7-1-2-8-19/h3,9-10,17,19,22-24,33H,1-2,4-8,11-16,18H2/t22-,23-,24-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134168 (1-((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyr...) Show SMILES OCC(=O)[C@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)C1CCCC1 Show InChI InChI=1S/C29H37N3O6/c33-18-25(34)22-11-4-14-30(22)29(38)24-13-6-16-32(24)28(37)21-10-3-9-20(17-21)27(36)31-15-5-12-23(31)26(35)19-7-1-2-8-19/h3,9-10,17,19,22-24,33H,1-2,4-8,11-16,18H2/t22-,23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.610	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170686 ((S)-1-{(S)-1-[3-((S)-2-Cyclohexanecarbonyl-pyrroli...) Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)C1CCCCC1 Show InChI InChI=1S/C29H36N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h4,10-11,18,20,23-25H,1-3,5-9,12-17H2/t23-,24-,25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134161 ((R)-1-{(S)-1-[3-((R)-2-Cyclohexanecarbonyl-pyrroli...) Show SMILES O=C([C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N)C1CCCCC1 Show InChI InChI=1S/C29H36N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h4,10-11,18,20,23-25H,1-3,5-9,12-17H2/t23-,24-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170705 ((S)-1-[(S)-1-(4-Azepan-1-yl-4-oxo-butyryl)-pyrroli...) Show SMILES O=C(CCC(=O)N1CCCCCC1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C20H30N4O3/c21-15-16-7-5-13-23(16)20(27)17-8-6-14-24(17)19(26)10-9-18(25)22-11-3-1-2-4-12-22/h16-17H,1-14H2/t16-,17-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.760	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50176777 (4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl...) Show SMILES OCC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc12 |r| Show InChI InChI=1S/C38H40N4O9S/c43-21-31(46)29-6-4-17-42(29)35(48)30-7-5-16-41(30)34(47)8-2-1-3-15-39-37(52)40-22-9-12-26-25(18-22)36(49)51-38(26)27-13-10-23(44)19-32(27)50-33-20-24(45)11-14-28(33)38/h9-14,18-20,29-30,43-45H,1-8,15-17,21H2,(H2,39,40,52)/t29-,30-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.830	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 48: 7093-5 (2005) Article DOI: 10.1021/jm0509187 BindingDB Entry DOI: 10.7270/Q2RR1XTB
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50155838 ((S)-1-((S)-1-(4-phenylbutanoyl)pyrrolidine-2-carbo...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C20H25N3O2/c21-15-17-10-5-13-22(17)20(25)18-11-6-14-23(18)19(24)12-4-9-16-7-2-1-3-8-16/h1-3,7-8,17-18H,4-6,9-14H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	0.860	n/a	n/a	n/a	n/a	n/a	n/a
University of Helsinki Curated by ChEMBL					Assay Description Inhibition of recombinant porcine brain PREP expressed in Escherichia coli assessed as formation of 7-amido-4-methylcoumarin using Suc-Gly-Pro-amido-...				ACS Med Chem Lett 10: 1635-1640 (2019) Article DOI: 10.1021/acsmedchemlett.9b00394 BindingDB Entry DOI: 10.7270/Q2542S18
					More data for this Ligand-Target Pair				3D Structure (crystal)
Prolyl endopeptidase (Sus scrofa)	BDBM50572234 (CHEMBL4861124) Show SMILES O=C(CCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1c1ncc[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant porcine PREP expressed in Escherichia coli using Suc-Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrat...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00399 BindingDB Entry DOI: 10.7270/Q20V8HK3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50572235 (CHEMBL4873431) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1c1ncc[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant porcine PREP expressed in Escherichia coli using Suc-Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrat...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00399 BindingDB Entry DOI: 10.7270/Q20V8HK3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50572237 (CHEMBL4862396) Show SMILES O=C(CCCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1c1ncc[nH]1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant porcine PREP expressed in Escherichia coli using Suc-Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrat...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00399 BindingDB Entry DOI: 10.7270/Q20V8HK3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50037604 (1-{(S)-2-[(S)-2-(1H-Imidazole-2-carbonyl)-pyrrolid...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)c1ncc[nH]1 Show InChI InChI=1S/C23H28N4O3/c28-20(12-4-9-17-7-2-1-3-8-17)26-15-6-11-19(26)23(30)27-16-5-10-18(27)21(29)22-24-13-14-25-22/h1-3,7-8,13-14,18-19H,4-6,9-12,15-16H2,(H,24,25)/t18-,19-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant porcine PREP expressed in Escherichia coli using Suc-Gly-Pro-AMC as substrate preincubated for 30 mins followed by substrat...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00399 BindingDB Entry DOI: 10.7270/Q20V8HK3
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50316822 (3-cyclohexyl-N-((S)-1-oxo-3-phenyl-1-((S)-2-(piper...) Show SMILES O=C(CCC1CCCCC1)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C28H41N3O3/c32-26(17-16-22-11-4-1-5-12-22)29-24(21-23-13-6-2-7-14-23)27(33)31-20-10-15-25(31)28(34)30-18-8-3-9-19-30/h2,6-7,13-14,22,24-25H,1,3-5,8-12,15-21H2,(H,29,32)/t24-,25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 53: 3423-38 (2010) Article DOI: 10.1021/jm901104g BindingDB Entry DOI: 10.7270/Q261119N
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50316821 (CHEMBL1096175 | N-((S)-3-methyl-1-oxo-1-((S)-2-(pi...) Show SMILES CC(C)[C@H](NC(=O)c1cccc(Oc2ccccc2)c1)C(=O)N1CCC[C@H]1C(=O)N1CCCCC1 |r| Show InChI InChI=1S/C28H35N3O4/c1-20(2)25(28(34)31-18-10-15-24(31)27(33)30-16-7-4-8-17-30)29-26(32)21-11-9-14-23(19-21)35-22-12-5-3-6-13-22/h3,5-6,9,11-14,19-20,24-25H,4,7-8,10,15-18H2,1-2H3,(H,29,32)/t24-,25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.05	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 53: 3423-38 (2010) Article DOI: 10.1021/jm901104g BindingDB Entry DOI: 10.7270/Q261119N
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170682 ((S)-1-((S)-1-(3-((S)-2-(cyclopentanecarbonyl)pyrro...) Show SMILES O=C(C1CCCC1)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134175 ((R)-1-{(S)-1-[3-((R)-2-Cyclopentanecarbonyl-pyrrol...) Show SMILES O=C(C1CCCC1)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N Show InChI InChI=1S/C28H34N4O4/c29-18-22-11-4-14-30(22)28(36)24-13-6-16-32(24)27(35)21-10-3-9-20(17-21)26(34)31-15-5-12-23(31)25(33)19-7-1-2-8-19/h3,9-10,17,19,22-24H,1-2,4-8,11-16H2/t22-,23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170707 (1-((S)-1-{(S)-1-[3-((S)-2-Acetyl-pyrrolidine-1-car...) Show SMILES CC(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)CO Show InChI InChI=1S/C25H31N3O6/c1-16(30)19-8-3-11-26(19)23(32)17-6-2-7-18(14-17)24(33)28-13-5-10-21(28)25(34)27-12-4-9-20(27)22(31)15-29/h2,6-7,14,19-21,29H,3-5,8-13,15H2,1H3/t19-,20-,21-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50193665 (1-((2R,5S)-2-tert-butyl-5-(pyrrolidine-1-carbonyl)...) Show SMILES CC(C)(C)[C@H]1CC[C@H](N1C(=O)CCCc1ccccc1)C(=O)N1CCCC1 Show InChI InChI=1S/C23H34N2O2/c1-23(2,3)20-15-14-19(22(27)24-16-7-8-17-24)25(20)21(26)13-9-12-18-10-5-4-6-11-18/h4-6,10-11,19-20H,7-9,12-17H2,1-3H3/t19-,20+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 53: 3423-38 (2010) Article DOI: 10.1021/jm901104g BindingDB Entry DOI: 10.7270/Q261119N
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134164 (1-((R)-1-{(S)-1-[3-((R)-2-Acetyl-pyrrolidine-1-car...) Show SMILES CC(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C(=O)CO Show InChI InChI=1S/C25H31N3O6/c1-16(30)19-8-3-11-26(19)23(32)17-6-2-7-18(14-17)24(33)28-13-5-10-21(28)25(34)27-12-4-9-20(27)22(31)15-29/h2,6-7,14,19-21,29H,3-5,8-13,15H2,1H3/t19-,20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170683 ((S)-1-[(S)-1-(5-Azepan-1-yl-5-oxo-pentanoyl)-pyrro...) Show SMILES O=C(CCCC(=O)N1CCCCCC1)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C21H32N4O3/c22-16-17-8-6-14-24(17)21(28)18-9-7-15-25(18)20(27)11-5-10-19(26)23-12-3-1-2-4-13-23/h17-18H,1-15H2/t17-,18-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50155834 (4-Phenyl-1-[5-(pyrrolidine-1-carbonyl)-cyclopent-1...) Show SMILES O=C(CCCc1ccccc1)C1=CCCC1C(=O)N1CCCC1 |t:12| Show InChI InChI=1S/C20H25NO2/c22-19(13-6-10-16-8-2-1-3-9-16)17-11-7-12-18(17)20(23)21-14-4-5-15-21/h1-3,8-9,11,18H,4-7,10,12-15H2	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description Inhibitory activity against prolyl oligopeptidase of porcine brain homogenate				J Med Chem 47: 5605-7 (2004) Article DOI: 10.1021/jm049503w BindingDB Entry DOI: 10.7270/Q25D8R9G
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134167 ((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...) Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1 Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134167 ((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...) Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCCC1 Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50118908 (1-(1-{3-[2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-...) Show SMILES O=C[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCCC1C(=O)N1CCCC1 Show InChI InChI=1S/C27H34N4O5/c32-18-21-9-4-14-29(21)27(36)23-11-6-16-31(23)25(34)20-8-3-7-19(17-20)24(33)30-15-5-10-22(30)26(35)28-12-1-2-13-28/h3,7-8,17-18,21-23H,1-2,4-6,9-16H2/t21-,22?,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pigbrain expressed				J Med Chem 45: 4581-4 (2002) BindingDB Entry DOI: 10.7270/Q22R3R02
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170692 ((S)-1-{(S)-1-[3-((S)-2-Benzoyl-pyrrolidine-1-carbo...) Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)c1ccccc1)N1CCC[C@H]1C#N Show InChI InChI=1S/C29H30N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h1-4,8-11,18,23-25H,5-7,12-17H2/t23-,24-,25-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50051539 ((S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolid...) Show SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1 |r| Show InChI InChI=1S/C19H26N2O2/c22-18(12-6-10-16-8-2-1-3-9-16)21-15-7-11-17(21)19(23)20-13-4-5-14-20/h1-3,8-9,17H,4-7,10-15H2/t17-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Inhibition of pig brain POP				J Med Chem 53: 3423-38 (2010) Article DOI: 10.1021/jm901104g BindingDB Entry DOI: 10.7270/Q261119N
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134159 ((R)-1-{(S)-1-[3-((R)-2-Benzoyl-pyrrolidine-1-carbo...) Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@@H]1C(=O)c1ccccc1)N1CCC[C@@H]1C#N Show InChI InChI=1S/C29H30N4O4/c30-19-23-12-5-15-31(23)29(37)25-14-7-17-33(25)28(36)22-11-4-10-21(18-22)27(35)32-16-6-13-24(32)26(34)20-8-2-1-3-9-20/h1-4,8-11,18,23-25H,5-7,12-17H2/t23-,24-,25+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50118912 (1-(1-{3-[2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-...) Show SMILES O=C(C1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)N1CCCC1 Show InChI InChI=1S/C27H33N5O4/c28-18-21-9-4-14-30(21)27(36)23-11-6-16-32(23)25(34)20-8-3-7-19(17-20)24(33)31-15-5-10-22(31)26(35)29-12-1-2-13-29/h3,7-8,17,21-23H,1-2,4-6,9-16H2/t21-,22?,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against prolyl oligopeptidase (POP) from pig brain ;value ranges from (1.1-2.2)				J Med Chem 45: 4581-4 (2002) BindingDB Entry DOI: 10.7270/Q22R3R02
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134163 ((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...) Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)N1CCCC1 Show InChI InChI=1S/C27H33N5O4/c28-18-21-9-4-14-30(21)27(36)23-11-6-16-32(23)25(34)20-8-3-7-19(17-20)24(33)31-15-5-10-22(31)26(35)29-12-1-2-13-29/h3,7-8,17,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134163 ((S)-1-((S)-1-{3-[(S)-2-(Pyrrolidine-1-carbonyl)-py...) Show SMILES O=C([C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N)N1CCCC1 Show InChI InChI=1S/C27H33N5O4/c28-18-21-9-4-14-30(21)27(36)23-11-6-16-32(23)25(34)20-8-3-7-19(17-20)24(33)31-15-5-10-22(31)26(35)29-12-1-2-13-29/h3,7-8,17,21-23H,1-2,4-6,9-16H2/t21-,22-,23-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50170690 ((S)-1-{(S)-1-[3-((S)-2-Isobutyryl-pyrrolidine-1-ca...) Show SMILES CC(C)C(=O)[C@@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C#N Show InChI InChI=1S/C26H32N4O4/c1-17(2)23(31)21-10-5-13-29(21)24(32)18-7-3-8-19(15-18)25(33)30-14-6-11-22(30)26(34)28-12-4-9-20(28)16-27/h3,7-8,15,17,20-22H,4-6,9-14H2,1-2H3/t20-,21-,22-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.0	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...				J Med Chem 48: 4772-82 (2005) Article DOI: 10.1021/jm0500020 BindingDB Entry DOI: 10.7270/Q22B8ZT2
					More data for this Ligand-Target Pair
Prolyl endopeptidase (Sus scrofa)	BDBM50134174 ((R)-1-{(S)-1-[3-((R)-2-Isobutyryl-pyrrolidine-1-ca...) Show SMILES CC(C)C(=O)[C@H]1CCCN1C(=O)c1cccc(c1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@@H]1C#N Show InChI InChI=1S/C26H32N4O4/c1-17(2)23(31)21-10-5-13-29(21)24(32)18-7-3-8-19(15-18)25(33)30-14-6-11-22(30)26(34)28-12-4-9-20(28)16-27/h3,7-8,15,17,20-22H,4-6,9-14H2,1-2H3/t20-,21-,22+/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Kuopio Curated by ChEMBL					Assay Description In vitro inhibition of prolyl oligopeptidase (POP) from pig brain				J Med Chem 46: 4543-51 (2003) Article DOI: 10.1021/jm030811o BindingDB Entry DOI: 10.7270/Q2H70F6R
					More data for this Ligand-Target Pair

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