Found 65 hits of ic50 data for polymerid = 50000082 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459208
(CHEMBL4214342)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(nc3)N3CCN(CC3)C(C)=O)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C33H32F3N9O3/c1-20-7-8-25(39-30(47)22-5-4-6-24(15-22)33(34,35)36)16-27(20)45-19-23-17-38-31(41-29(23)42(3)32(45)48)40-26-9-10-28(37-18-26)44-13-11-43(12-14-44)21(2)46/h4-10,15-18H,11-14,19H2,1-3H3,(H,39,47)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459215
(CHEMBL4202685)Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C34H34F3N9O3/c1-4-44-12-14-45(15-13-44)31(48)27-11-10-26(19-38-27)41-32-39-18-23-20-46(33(49)43(3)29(23)42-32)28-17-25(9-8-21(28)2)40-30(47)22-6-5-7-24(16-22)34(35,36)37/h5-11,16-19H,4,12-15,20H2,1-3H3,(H,40,47)(H,39,41,42) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459203
(CHEMBL4207036)Show SMILES CN(C)C1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)N2Cc3cnc(Nc4ccc(C)nc4)nc3N(C)C2=O)C1 Show InChI InChI=1S/C35H38F3N9O2/c1-21-6-10-26(41-32(48)23-8-9-24(29(14-23)35(36,37)38)18-46-13-12-28(20-46)44(3)4)15-30(21)47-19-25-16-40-33(43-31(25)45(5)34(47)49)42-27-11-7-22(2)39-17-27/h6-11,14-17,28H,12-13,18-20H2,1-5H3,(H,41,48)(H,40,42,43) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459219
(CHEMBL4207100)Show SMILES CN1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)N2Cc3cnc(Nc4ccc(C)nc4)nc3N(C)C2=O)CC1 Show InChI InChI=1S/C34H36F3N9O2/c1-21-5-9-26(40-31(47)23-7-8-24(28(15-23)34(35,36)37)19-45-13-11-43(3)12-14-45)16-29(21)46-20-25-17-39-32(42-30(25)44(4)33(46)48)41-27-10-6-22(2)38-18-27/h5-10,15-18H,11-14,19-20H2,1-4H3,(H,40,47)(H,39,41,42) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459216
(CHEMBL4213673)Show SMILES CN1C(=O)N(Cc2cnc(Nc3cc(C)nn3C)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C27H25F3N8O2/c1-15-8-9-20(32-24(39)17-6-5-7-19(11-17)27(28,29)30)12-21(15)38-14-18-13-31-25(34-23(18)36(3)26(38)40)33-22-10-16(2)35-37(22)4/h5-13H,14H2,1-4H3,(H,32,39)(H,31,33,34) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459201
(CHEMBL4217421)Show SMILES CN1C(=O)N(Cc2cnc(Nc3cnn(C)c3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C26H23F3N8O2/c1-15-7-8-19(32-23(38)16-5-4-6-18(9-16)26(27,28)29)10-21(15)37-13-17-11-30-24(33-20-12-31-35(2)14-20)34-22(17)36(3)25(37)39/h4-12,14H,13H2,1-3H3,(H,32,38)(H,30,33,34) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459211
(CHEMBL4214863)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C33H34F3N9O2/c1-4-43-12-14-44(15-13-43)28-11-10-26(19-37-28)40-31-38-18-23-20-45(32(47)42(3)29(23)41-31)27-17-25(9-8-21(27)2)39-30(46)22-6-5-7-24(16-22)33(34,35)36/h5-11,16-19H,4,12-15,20H2,1-3H3,(H,39,46)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459212
(CHEMBL4207753)Show SMILES CN(C)C1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)N2Cc3cnc(Nc4cnn(C)c4)nc3N(C)C2=O)C1 Show InChI InChI=1S/C33H37F3N10O2/c1-20-6-9-24(39-30(47)21-7-8-22(27(12-21)33(34,35)36)16-45-11-10-26(19-45)42(2)3)13-28(20)46-17-23-14-37-31(40-25-15-38-43(4)18-25)41-29(23)44(5)32(46)48/h6-9,12-15,18,26H,10-11,16-17,19H2,1-5H3,(H,39,47)(H,37,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459209
(CHEMBL4209948)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2C)cc1 Show InChI InChI=1S/C34H35F3N8O2/c1-4-43-14-16-44(17-15-43)28-12-10-26(11-13-28)40-32-38-20-24-21-45(33(47)42(3)30(24)41-32)29-19-27(9-8-22(29)2)39-31(46)23-6-5-7-25(18-23)34(35,36)37/h5-13,18-20H,4,14-17,21H2,1-3H3,(H,39,46)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50323777
(CHEMBL1214141 | N-(4-Methyl-3-(1-methyl-7-(6-methy...)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C28H24F3N7O2/c1-16-7-9-21(34-25(39)18-5-4-6-20(11-18)28(29,30)31)12-23(16)38-15-19-13-33-26(36-24(19)37(3)27(38)40)35-22-10-8-17(2)32-14-22/h4-14H,15H2,1-3H3,(H,34,39)(H,33,35,36) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM4552
(4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-...)Show SMILES COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl Show InChI InChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Molecular Medicine of the Austrian Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 |
Leukemia 23: 477-85 (2009)
Article DOI: 10.1038/leu.2008.334 BindingDB Entry DOI: 10.7270/Q22Z15R6 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459218
(CHEMBL4211976)Show SMILES CN1CCN(CC1)c1ccc(cc1C(F)(F)F)C(=O)Nc1ccc(C)c(c1)N1Cc2cnc(Nc3ccc(C)nc3)nc2N(C)C1=O Show InChI InChI=1S/C33H34F3N9O2/c1-20-5-8-24(39-30(46)22-7-10-27(26(15-22)33(34,35)36)44-13-11-42(3)12-14-44)16-28(20)45-19-23-17-38-31(41-29(23)43(4)32(45)47)40-25-9-6-21(2)37-18-25/h5-10,15-18H,11-14,19H2,1-4H3,(H,39,46)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459200
(CHEMBL4213019)Show SMILES CCN1CCN(CC1)C(=O)c1ccc(Nc2ncc3CN(C(=O)N(C)c3n2)c2cc(NC(=O)c3ccc(CN4CCC(C4)N(C)C)c(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C41H48F3N11O3/c1-6-52-15-17-54(18-16-52)38(57)34-12-11-31(22-45-34)48-39-46-21-29-24-55(40(58)51(5)36(29)49-39)35-20-30(10-7-26(35)2)47-37(56)27-8-9-28(33(19-27)41(42,43)44)23-53-14-13-32(25-53)50(3)4/h7-12,19-22,32H,6,13-18,23-25H2,1-5H3,(H,47,56)(H,46,48,49) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459221
(CHEMBL4216786)Show SMILES CN(C)C1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)N2Cc3cnc(Nc4ccc(nc4)N4CCN(CC4)C(C)=O)nc3N(C)C2=O)C1 Show InChI InChI=1S/C40H46F3N11O3/c1-25-6-9-30(46-37(56)27-7-8-28(33(18-27)40(41,42)43)22-51-13-12-32(24-51)49(3)4)19-34(25)54-23-29-20-45-38(48-36(29)50(5)39(54)57)47-31-10-11-35(44-21-31)53-16-14-52(15-17-53)26(2)55/h6-11,18-21,32H,12-17,22-24H2,1-5H3,(H,46,56)(H,45,47,48) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459207
(CHEMBL4212663)Show SMILES CN(C)C1CCN(Cc2ccc(cc2C(F)(F)F)C(=O)Nc2ccc(C)c(c2)N2Cc3cnc(Nc4cc(C)nn4C)nc3N(C)C2=O)C1 Show InChI InChI=1S/C34H39F3N10O2/c1-20-7-10-25(39-31(48)22-8-9-23(27(14-22)34(35,36)37)17-46-12-11-26(19-46)43(3)4)15-28(20)47-18-24-16-38-32(41-30(24)44(5)33(47)49)40-29-13-21(2)42-45(29)6/h7-10,13-16,26H,11-12,17-19H2,1-6H3,(H,39,48)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50378568
(CHEMBL1163016)Show SMILES CC1(C)CC(CC(C)(C)N1[O])NC(=O)c1cccc(c1)-c1cc2nccc(Nc3cccc(O)c3)n2n1 |^1:10| Show InChI InChI=1S/C28H31N6O3/c1-27(2)16-21(17-28(3,4)34(27)37)31-26(36)19-8-5-7-18(13-19)23-15-25-29-12-11-24(33(25)32-23)30-20-9-6-10-22(35)14-20/h5-15,21,30,35H,16-17H2,1-4H3,(H,31,36) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of GCK |
J Med Chem 53: 1238-49 (2010)
Article DOI: 10.1021/jm901525b BindingDB Entry DOI: 10.7270/Q2QJ7J72 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459198
(CHEMBL4212150)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2ccc(c(c2)C(F)(F)F)-n2cccc2)ccc1C Show InChI InChI=1S/C32H27F3N8O2/c1-19-6-9-23(38-29(44)21-8-11-26(42-12-4-5-13-42)25(14-21)32(33,34)35)15-27(19)43-18-22-16-37-30(40-28(22)41(3)31(43)45)39-24-10-7-20(2)36-17-24/h4-17H,18H2,1-3H3,(H,38,44)(H,37,39,40) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459202
(CHEMBL4211880)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cc(cc(c2)C(F)(F)F)-n2cnc(C)c2)ccc1C Show InChI InChI=1S/C32H28F3N9O2/c1-18-5-7-24(39-29(45)21-9-23(32(33,34)35)11-26(10-21)43-15-20(3)38-17-43)12-27(18)44-16-22-13-37-30(41-28(22)42(4)31(44)46)40-25-8-6-19(2)36-14-25/h5-15,17H,16H2,1-4H3,(H,39,45)(H,37,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50242740
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459214
(CHEMBL4215989)Show SMILES CN1C(=O)N(Cc2cnc(NCCO)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C24H23F3N6O3/c1-14-6-7-18(30-21(35)15-4-3-5-17(10-15)24(25,26)27)11-19(14)33-13-16-12-29-22(28-8-9-34)31-20(16)32(2)23(33)36/h3-7,10-12,34H,8-9,13H2,1-2H3,(H,30,35)(H,28,29,31) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459220
(CHEMBL4203337)Show SMILES CCN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C30H28F3N7O2/c1-5-39-26-21(14-35-28(38-26)37-23-11-8-19(4)34-15-23)16-40(29(39)42)25-13-22(10-7-18(25)3)36-27(41)20-9-6-17(2)24(12-20)30(31,32)33/h6-15H,5,16H2,1-4H3,(H,36,41)(H,35,37,38) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459213
(CHEMBL4212809)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2ccc(C)c(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C29H26F3N7O2/c1-16-5-8-19(11-23(16)29(30,31)32)26(40)35-21-9-6-17(2)24(12-21)39-15-20-13-34-27(37-25(20)38(4)28(39)41)36-22-10-7-18(3)33-14-22/h5-14H,15H2,1-4H3,(H,35,40)(H,34,36,37) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459205
(CHEMBL4210482)Show SMILES CN1C(=O)N(Cc2cnc(NC3CC3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C25H23F3N6O2/c1-14-6-7-19(30-22(35)15-4-3-5-17(10-15)25(26,27)28)11-20(14)34-13-16-12-29-23(31-18-8-9-18)32-21(16)33(2)24(34)36/h3-7,10-12,18H,8-9,13H2,1-2H3,(H,30,35)(H,29,31,32) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459217
(CHEMBL4218831)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cc(cc(c2)C(F)(F)F)N2CCOCC2)ccc1C Show InChI InChI=1S/C32H31F3N8O3/c1-19-4-6-24(38-29(44)21-12-23(32(33,34)35)14-26(13-21)42-8-10-46-11-9-42)15-27(19)43-18-22-16-37-30(40-28(22)41(3)31(43)45)39-25-7-5-20(2)36-17-25/h4-7,12-17H,8-11,18H2,1-3H3,(H,38,44)(H,37,39,40) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50323778
(CHEMBL1214142 | N-(4-Methyl-3-(1-methyl-2-oxo-7-(p...)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccccc3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C28H23F3N6O2/c1-17-11-12-22(33-25(38)18-7-6-8-20(13-18)28(29,30)31)14-23(17)37-16-19-15-32-26(34-21-9-4-3-5-10-21)35-24(19)36(2)27(37)39/h3-15H,16H2,1-2H3,(H,33,38)(H,32,34,35) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459199
(CHEMBL4215916)Show SMILES Cc1ccc(Nc2ncc3CN(C(=O)N(c4ccccc4)c3n2)c2cc(NC(=O)c3ccc(C)c(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C34H28F3N7O2/c1-20-9-12-23(15-28(20)34(35,36)37)31(45)40-25-13-10-21(2)29(16-25)43-19-24-17-39-32(41-26-14-11-22(3)38-18-26)42-30(24)44(33(43)46)27-7-5-4-6-8-27/h4-18H,19H2,1-3H3,(H,40,45)(H,39,41,42) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50389154
(CHEMBL2064666)Show SMILES COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1 |r,c:16| Show InChI InChI=1S/C28H35ClN6O3/c1-37-25-20-8-7-19(35-10-12-38-13-11-35)6-4-16(20)5-9-22(25)32-28-31-15-21(29)27(34-28)33-24-18-3-2-17(14-18)23(24)26(30)36/h2-3,5,9,15,17-19,23-24H,4,6-8,10-14H2,1H3,(H2,30,36)(H2,31,32,33,34)/t17-,18+,19+,23+,24-/m1/s1 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Cephalon, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human GCK |
J Med Chem 55: 4580-93 (2012)
Article DOI: 10.1021/jm201550q BindingDB Entry DOI: 10.7270/Q23F4QQN |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459222
(CHEMBL4213945)Show SMILES Cc1ccc(Nc2ncc3CN(C(=O)N(C4CC4)c3n2)c2cc(NC(=O)c3ccc(C)c(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C31H28F3N7O2/c1-17-4-7-20(12-25(17)31(32,33)34)28(42)37-22-8-5-18(2)26(13-22)40-16-21-14-36-29(38-23-9-6-19(3)35-15-23)39-27(21)41(30(40)43)24-10-11-24/h4-9,12-15,24H,10-11,16H2,1-3H3,(H,37,42)(H,36,38,39) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459206
(CHEMBL4205942)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2cc(cc(c2)C(F)(F)F)N2CCC(O)CC2)ccc1C Show InChI InChI=1S/C33H33F3N8O3/c1-19-4-6-24(39-30(46)21-12-23(33(34,35)36)14-26(13-21)43-10-8-27(45)9-11-43)15-28(19)44-18-22-16-38-31(41-29(22)42(3)32(44)47)40-25-7-5-20(2)37-17-25/h4-7,12-17,27,45H,8-11,18H2,1-3H3,(H,39,46)(H,38,40,41) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50235830
(CHEMBL2006765)Show SMILES CCCNC(=O)c1ccc(Nc2nc(NCC(F)(F)F)c3cc[nH]c3n2)cc1 Show InChI InChI=1S/C18H19F3N6O/c1-2-8-23-16(28)11-3-5-12(6-4-11)25-17-26-14-13(7-9-22-14)15(27-17)24-10-18(19,20)21/h3-7,9H,2,8,10H2,1H3,(H,23,28)(H3,22,24,25,26,27) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 115 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459204
(CHEMBL4206139)Show SMILES Cc1ccc(Nc2ncc3CN(C(=O)N(Cc4ccccc4)c3n2)c2cc(NC(=O)c3ccc(C)c(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C35H30F3N7O2/c1-21-9-12-25(15-29(21)35(36,37)38)32(46)41-27-13-10-22(2)30(16-27)44-20-26-17-40-33(42-28-14-11-23(3)39-18-28)43-31(26)45(34(44)47)19-24-7-5-4-6-8-24/h4-18H,19-20H2,1-3H3,(H,41,46)(H,40,42,43) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 165 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50466038
(CHEMBL4281823)Show SMILES CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12 Show InChI InChI=1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 387 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University/Collaborative Innovation Center of Biotherapy
Curated by ChEMBL
| Assay Description Inhibition of recombinant human GCK (1 to 473 residues) using myelin basic protein as substrate after 40 mins in presence of [gamma-33P]-ATP by scint... |
J Med Chem 61: 11398-11414 (2018)
Article DOI: 10.1021/acs.jmedchem.8b01652 BindingDB Entry DOI: 10.7270/Q2377CDJ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459210
(CHEMBL4210185)Show SMILES Cc1ccc(Nc2ncc3CN(C(=O)N(C4CCCCC4)c3n2)c2cc(NC(=O)c3ccc(C)c(c3)C(F)(F)F)ccc2C)cn1 Show InChI InChI=1S/C34H34F3N7O2/c1-20-9-12-23(15-28(20)34(35,36)37)31(45)40-25-13-10-21(2)29(16-25)43-19-24-17-39-32(41-26-14-11-22(3)38-18-26)42-30(24)44(33(43)46)27-7-5-4-6-8-27/h9-18,27H,4-8,19H2,1-3H3,(H,40,45)(H,39,41,42) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 497 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50509365
(CHEMBL4564337)Show SMILES COc1cc2c(c[nH]c2cc1Br)-c1cnc(o1)-c1ccc[nH]1 Show InChI InChI=1S/C16H12BrN3O2/c1-21-14-5-9-10(7-19-13(9)6-11(14)17)15-8-20-16(22-15)12-3-2-4-18-12/h2-8,18-19H,1H3 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006 BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459196
(CHEMBL4211395)Show SMILES CN1C(=O)N(Cc2cnc(NC3CCCCC3)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C28H29F3N6O2/c1-17-11-12-22(33-25(38)18-7-6-8-20(13-18)28(29,30)31)14-23(17)37-16-19-15-32-26(34-21-9-4-3-5-10-21)35-24(19)36(2)27(37)39/h6-8,11-15,21H,3-5,9-10,16H2,1-2H3,(H,33,38)(H,32,34,35) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 925 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50571440
(CHEMBL4873571)Show SMILES CC(C)n1cc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c(=O)n(-c2ccc(F)cc2)c1=O | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human GCK (1 to 473 residues) using myelin basic protein as substrate incubated for 40 mins in presence of [gamma-33ATP] by... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02093 BindingDB Entry DOI: 10.7270/Q2PR80SR |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50459197
(CHEMBL4209082)Show SMILES CN1C(=O)N(Cc2cnc(Nc3ccc(C)nc3)nc12)c1cc(NC(=O)c2ccccc2)ccc1C Show InChI InChI=1S/C27H25N7O2/c1-17-9-11-21(30-25(35)19-7-5-4-6-8-19)13-23(17)34-16-20-14-29-26(32-24(20)33(3)27(34)36)31-22-12-10-18(2)28-15-22/h4-15H,16H2,1-3H3,(H,30,35)(H,29,31,32) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by radiometric biochemical kinase assay |
J Med Chem 61: 8353-8373 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00882 BindingDB Entry DOI: 10.7270/Q2T72M31 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50509370
(CHEMBL4446434)Show SMILES COc1cc(Br)cc2[nH]cc(-c3cnc(o3)-c3ccc[nH]3)c12 Show InChI InChI=1S/C16H12BrN3O2/c1-21-13-6-9(17)5-12-15(13)10(7-19-12)14-8-20-16(22-14)11-3-2-4-18-11/h2-8,18-19H,1H3 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
UiT - The Arctic University of Norway
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) by [33P]-ATP filter binding kinase assay |
J Med Chem 62: 10167-10181 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01006 BindingDB Entry DOI: 10.7270/Q26M3B4R |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50311953
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1 Show InChI InChI=1S/C28H28N6O2S/c1-20-25-10-11-31-27(25)9-8-26(20)32-28-22(18-30-19-23(28)17-29)7-6-21-4-3-5-24(16-21)37(35,36)34-14-12-33(2)13-15-34/h3-11,16,18-19,31H,12-15H2,1-2H3,(H,30,32)/b7-6+ | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of GCK |
Bioorg Med Chem Lett 19: 6575-7 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.031 BindingDB Entry DOI: 10.7270/Q2KD1Z1F |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50235817
(CHEMBL4078893)Show SMILES FC(F)(F)CNc1nc(Nc2ccc(N3CCOCC3)c(Cl)c2)nc2ccoc12 Show InChI InChI=1S/C18H17ClF3N5O2/c19-12-9-11(1-2-14(12)27-4-7-28-8-5-27)24-17-25-13-3-6-29-15(13)16(26-17)23-10-18(20,21)22/h1-3,6,9H,4-5,7-8,10H2,(H2,23,24,25,26) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50462709
(CHEMBL4245507)Show SMILES O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C23H27N5O2S/c29-22(27-23-26-21(17-31-23)19-5-7-24-8-6-19)16-18-3-1-4-20(15-18)30-14-2-11-28-12-9-25-10-13-28/h1,3-8,15,17,25H,2,9-14,16H2,(H,26,27,29) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) |
Bioorg Med Chem Lett 28: 2616-2621 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.043 BindingDB Entry DOI: 10.7270/Q2XP77MH |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50235816
(CHEMBL4069365)Show SMILES CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 Show InChI InChI=1S/C19H18F3N5O3/c1-18(2)11-4-3-10(7-13(11)25-14(28)8-30-18)24-17-26-12-5-6-29-15(12)16(27-17)23-9-19(20,21)22/h3-7H,8-9H2,1-2H3,(H,25,28)(H2,23,24,26,27) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50430289
(CHEMBL2333445)Show SMILES CCc1ccc(cc1)-c1ccc2N(C)S(=O)(=O)c3c[nH]nc3-c2c1 Show InChI InChI=1S/C18H17N3O2S/c1-3-12-4-6-13(7-5-12)14-8-9-16-15(10-14)18-17(11-19-20-18)24(22,23)21(16)2/h4-11H,3H2,1-2H3,(H,19,20) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) using [gamma-33P]ATP |
Eur J Med Chem 61: 49-60 (2013)
Article DOI: 10.1016/j.ejmech.2012.06.035 BindingDB Entry DOI: 10.7270/Q2KP83HS |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50311985
(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1 |r| Show InChI InChI=1S/C29H26N6O/c1-33-17-24-16-23(33)18-34(24)22-7-5-19(6-8-22)26-11-14-31-29-27(21-3-2-4-25(36)15-21)28(32-35(26)29)20-9-12-30-13-10-20/h2-15,23-24,36H,16-18H2,1H3/t23-,24-/m0/s1 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Inhibition of GCK |
Bioorg Med Chem Lett 19: 6571-4 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.030 BindingDB Entry DOI: 10.7270/Q29Z9510 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50235820
(CHEMBL4066664)Show InChI InChI=1S/C15H11F3N6O/c16-15(17,18)7-19-13-12-10(3-4-25-12)22-14(23-13)21-9-2-1-8-6-20-24-11(8)5-9/h1-6H,7H2,(H,20,24)(H2,19,21,22,23) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50462710
(CHEMBL4251324)Show SMILES O=C(Cc1cccc(OCCCC2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1 Show InChI InChI=1S/C24H28N4O2S/c29-23(28-24-27-22(17-31-24)20-8-12-26-13-9-20)16-19-3-1-5-21(15-19)30-14-2-4-18-6-10-25-11-7-18/h1,3,5,8-9,12-13,15,17-18,25H,2,4,6-7,10-11,14,16H2,(H,27,28,29) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) |
Bioorg Med Chem Lett 28: 2616-2621 (2018)
Article DOI: 10.1016/j.bmcl.2018.06.043 BindingDB Entry DOI: 10.7270/Q2XP77MH |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50235833
(CHEMBL4062803)Show InChI InChI=1S/C17H16N6O/c1-9-12-5-4-11(8-14(12)23-22-9)19-17-20-13-6-7-24-15(13)16(21-17)18-10-2-3-10/h4-8,10H,2-3H2,1H3,(H,22,23)(H2,18,19,20,21) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 6.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 (unknown origin) after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077 BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50436478
(CHEMBL2397314)Show SMILES C[C@H](CC(F)(F)F)C(=O)Nc1nc(C)c(s1)-c1ccc(N)nc1 |r| Show InChI InChI=1S/C14H15F3N4OS/c1-7(5-14(15,16)17)12(22)21-13-20-8(2)11(23-13)9-3-4-10(18)19-6-9/h3-4,6-7H,5H2,1-2H3,(H2,18,19)(H,20,21,22)/t7-/m1/s1 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd.
Curated by ChEMBL
| Assay Description Inhibition of MAP4K2 (unknown origin) |
Bioorg Med Chem Lett 23: 3841-7 (2013)
Article DOI: 10.1016/j.bmcl.2013.04.077 BindingDB Entry DOI: 10.7270/Q2BG2QCX |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50430297
(CHEMBL2333436)Show SMILES CCc1ccc(cc1)-c1ccc2N(C)S(=O)(=O)c3cnn(CC)c3-c2c1 Show InChI InChI=1S/C20H21N3O2S/c1-4-14-6-8-15(9-7-14)16-10-11-18-17(12-16)20-19(13-21-23(20)5-2)26(24,25)22(18)3/h6-13H,4-5H2,1-3H3 | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company, Ltd.
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) using [gamma-33P]ATP |
Eur J Med Chem 61: 49-60 (2013)
Article DOI: 10.1016/j.ejmech.2012.06.035 BindingDB Entry DOI: 10.7270/Q2KP83HS |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase kinase 2
(Homo sapiens (Human)) | BDBM50429867
(CHEMBL2333365)Show SMILES Cc1c(F)c(ccc1C(=O)N1CCOc2ccc(cc2C1)-c1ccc(N)nc1)S(C)(=O)=O Show InChI InChI=1S/C23H22FN3O4S/c1-14-18(5-7-20(22(14)24)32(2,29)30)23(28)27-9-10-31-19-6-3-15(11-17(19)13-27)16-4-8-21(25)26-12-16/h3-8,11-12H,9-10,13H2,1-2H3,(H2,25,26) | MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Exelixis
Curated by ChEMBL
| Assay Description Inhibition of GCK (unknown origin) |
J Med Chem 56: 2218-34 (2013)
Article DOI: 10.1021/jm3007933 BindingDB Entry DOI: 10.7270/Q2ZC847X |
More data for this Ligand-Target Pair | |