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Compile Data Set for Download or QSAR

Found 8 hits of ic50 data for polymerid = 50000960   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50029495
PNG
(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Show SMILES Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
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n/an/a 200n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


J Med Chem 38: 4439-45 (1995)


BindingDB Entry DOI: 10.7270/Q2W37V9R
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50029497
PNG
(2-Methyl-7-oxo-5-(tetrazol-1-ylcarbamoyl)-4,7-dihy...)
Show SMILES COC(=O)c1c(C)sc2c(O)cc(nc12)C(=O)Nn1cnnn1
Show InChI InChI=1S/C12H10N6O4S/c1-5-8(12(21)22-2)9-10(23-5)7(19)3-6(14-9)11(20)15-18-4-13-16-17-18/h3-4H,1-2H3,(H,14,19)(H,15,20)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


J Med Chem 38: 4439-45 (1995)


BindingDB Entry DOI: 10.7270/Q2W37V9R
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50029494
PNG
(2-Methyl-7-oxo-4,7-dihydro-thieno[3,2-b]pyridine-3...)
Show SMILES COC(=O)c1c(C)sc2c(O)cc(nc12)C(O)=O
Show InChI InChI=1S/C11H9NO5S/c1-4-7(11(16)17-2)8-9(18-4)6(13)3-5(12-8)10(14)15/h3H,1-2H3,(H,12,13)(H,14,15)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


J Med Chem 38: 4439-45 (1995)


BindingDB Entry DOI: 10.7270/Q2W37V9R
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50029496
PNG
(6-Amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic a...)
Show SMILES Nc1ccc2nc(cc(O)c2c1)C(O)=O
Show InChI InChI=1S/C10H8N2O3/c11-5-1-2-7-6(3-5)9(13)4-8(12-7)10(14)15/h1-4H,11H2,(H,12,13)(H,14,15)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


J Med Chem 38: 4439-45 (1995)


BindingDB Entry DOI: 10.7270/Q2W37V9R
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50111443
PNG
(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
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n/an/a 3.72E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells


J Med Chem 45: 1543-58 (2002)


BindingDB Entry DOI: 10.7270/Q2CN74ND
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50029495
PNG
(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Show SMILES Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
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n/an/a 1.10E+5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method


J Med Chem 60: 66-88 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00964
BindingDB Entry DOI: 10.7270/Q2C24ZCR
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50396070
PNG
(CHEMBL1397270)
Show SMILES Cc1cc2nc3c(nc(=O)[nH]c3=O)n(C)c2cc1C=O
Show InChI InChI=1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20)
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n/an/a 2.44E+5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method


J Med Chem 60: 66-88 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00964
BindingDB Entry DOI: 10.7270/Q2C24ZCR
More data for this
Ligand-Target Pair
Tumor necrosis factor receptor superfamily member 16


(Homo sapiens (Human))
BDBM50111443
PNG
(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
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n/an/a>3.00E+5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method


J Med Chem 60: 66-88 (2017)


Article DOI: 10.1021/acs.jmedchem.6b00964
BindingDB Entry DOI: 10.7270/Q2C24ZCR
More data for this
Ligand-Target Pair