Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085553 (CHEMBL214603 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50421415 (CHEMBL414948) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50421415 (CHEMBL414948) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370219 (CHEMBL610868) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370220 (CHEMBL1163094) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025002 (CHEMBL404038 | ppp'A2'p5'A2'p5'A | ppp5'A2'p5'A2'p...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085558 (CHEMBL402676 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50373177 (CHEMBL404038) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50421415 (CHEMBL414948) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085554 (5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5'...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid UniChem Similars | MMDB PubMed | n/a | n/a | 7.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of [32P]-pC11U2C7 | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50421415 (CHEMBL414948) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes and Digestive antd Kidney Diseases Curated by ChEMBL | Assay Description Displacement of the probe bound to Ribonuclease L by compound in radiobinding assay was evaluated | Bioorg Med Chem Lett 10: 1357-60 (2000) BindingDB Entry DOI: 10.7270/Q2TT4Q67 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50421415 (CHEMBL414948) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085556 (CHEMBL405496 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025005 (CHEMBL3143469 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A)) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50366437 (CHEMBL608874) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370222 (CHEMBL610866) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085555 (CHEMBL384725 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Activation of purified recombinant human Ribonuclease L by the compound was measured as degradation of poly (U) 3'[32P]p5'C3'p | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370227 (CHEMBL610609) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085559 (CHEMBL410213 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025001 (CHEMBL3143411 | pp5'(br8A)2'p5'(br8A)2'p5'(br8A)2'...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50021104 ((2'-5'(pAris)3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in human Daudi lymphoblastoid cells | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025000 (CHEMBL3143409 | ppp5'(br8A)2'p5'(br8A)2'p5'(br8A)) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50021104 ((2'-5'(pAris)3) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in mouse L cells | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370221 (CHEMBL610855) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50024997 (CHEMBL3143462 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025003 ((br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL3143413) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370224 (CHEMBL610867) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50366437 (CHEMBL608874) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50085557 (CHEMBL407239 | Oligoadenylate analogue) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gifu University Curated by ChEMBL | Assay Description Compound was tested for its binding ability, by displacement of p(A2'p)3A3'[32p]p5'Cp from recombinant human ribonuclease L | Bioorg Med Chem Lett 10: 329-31 (2000) BindingDB Entry DOI: 10.7270/Q2TM79B4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50241367 (2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 5 nM 2-... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50241367 (2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 1 nM 2-... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50241367 (2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of full length H-RNAase L expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate incubated for 15 min in presence of 20 nM 2... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50241367 (2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50021104 ((2'-5'(pAris)3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibitory activity to prevent binding of added ppp5'A2'p5'A2'pA2'p5'A3'[32P]p5' (c3 label) to RNase L in rabbit reticulocytes | J Med Chem 28: 1376-80 (1985) BindingDB Entry DOI: 10.7270/Q26W9BNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370229 (CHEMBL607600) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025006 ((br8A)2'p5'(br8A)2'p5'(br8A)2'p5'(br8A) | CHEMBL31...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50366438 (CHEMBL608875) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50025004 (CHEMBL3143467 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50366436 (CHEMBL605454) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50366438 (CHEMBL608875) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from rabbit reticulocyte lysate | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50366436 (CHEMBL605454) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound concentration which displaces 50% of [125I]-labeled 2-5A probe bound to RNase L from mouse L cell extract | Bioorg Med Chem Lett 6: 1785-1790 (1996) Checked by Author Article DOI: 10.1016/0960-894X(96)00314-9 BindingDB Entry DOI: 10.7270/Q2XS5VWT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370226 (CHEMBL607595) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370223 (CHEMBL607888) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370225 (CHEMBL608161) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370230 (CHEMBL610610) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50370228 (CHEMBL607882) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gunma University Curated by ChEMBL | Assay Description Displacement of [125I]-labeled 2-5A from 2-5A dependent Ribonuclease L (RNase L) of mouse liver | J Med Chem 46: 4926-32 (2003) Article DOI: 10.1021/jm030035k BindingDB Entry DOI: 10.7270/Q2QR4XVM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM50362886 (VITEXIN) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.90E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50024999 (CHEMBL414948 | Sulfuric acid mono-{5-(6-amino-puri...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Mus musculus) | BDBM50024998 (CHEMBL3143412 | p5'(br8A)2'p5'(br8A)2'p5'(br8A)2'p...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts | J Med Chem 29: 1015-22 (1986) BindingDB Entry DOI: 10.7270/Q2SX6C6K | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
2-5A-dependent ribonuclease (Homo sapiens (Human)) | BDBM15236 (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.64E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant full length H-RNAase L (1 to 741 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition rate in presence... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01156 BindingDB Entry DOI: 10.7270/Q2KD22SX | |||||||||||
More data for this Ligand-Target Pair |
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