Found 58 hits of ic50 data for polymerid = 50001912,50005670 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075067
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H31N3O8S2/c1-15(2)12-19(27)25(32)29-39(33,34)35-13-21-22(30)23(31)24(37-21)26-28-20(14-38-26)16-8-10-18(11-9-16)36-17-6-4-3-5-7-17/h3-11,14-15,19,21-24,30-31H,12-13,27H2,1-2H3,(H,29,32)/t19-,21+,22+,23+,24+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075069
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(CCc2ccccc2)cs1 Show InChI InChI=1S/C22H31N3O7S2/c1-13(2)10-16(23)21(28)25-34(29,30)31-11-17-18(26)19(27)20(32-17)22-24-15(12-33-22)9-8-14-6-4-3-5-7-14/h3-7,12-13,16-20,26-27H,8-11,23H2,1-2H3,(H,25,28)/t16-,17+,18+,19+,20+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | <2 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075055
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(CCc2ccc(Oc3ccccc3)cc2)cs1 Show InChI InChI=1S/C28H35N3O8S2/c1-17(2)14-22(29)27(34)31-41(35,36)37-15-23-24(32)25(33)26(39-23)28-30-19(16-40-28)11-8-18-9-12-21(13-10-18)38-20-6-4-3-5-7-20/h3-7,9-10,12-13,16-17,22-26,32-33H,8,11,14-15,29H2,1-2H3,(H,31,34)/t22-,23+,24+,25+,26+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of human isoleucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50093005
((4aR,6S,7R,7aS)-7-[2-((S)-2-Amino-4-methyl-pentano...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)CC(=O)N[C@]1([C@@H](O)C[C@@H]2[C@H]1CN(C)C=C2C(N)=O)C(O)=O |c:26| Show InChI InChI=1S/C19H31N5O8S/c1-9(2)4-13(20)17(28)23-33(31,32)8-15(26)22-19(18(29)30)12-7-24(3)6-11(16(21)27)10(12)5-14(19)25/h6,9-10,12-14,25H,4-5,7-8,20H2,1-3H3,(H2,21,27)(H,22,26)(H,23,28)(H,29,30)/t10-,12+,13-,14-,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Australian National University
Curated by ChEMBL
| Assay Description Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29 |
Bioorg Med Chem Lett 10: 2263-6 (2001)
BindingDB Entry DOI: 10.7270/Q2PN94W3 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50458119
(Leusa)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C16H25N7O7S/c1-7(2)3-8(17)15(26)22-31(27,28)29-4-9-11(24)12(25)16(30-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,16,24-25H,3-4,17H2,1-2H3,(H,22,26)(H2,18,19,20)/t8-,9+,11+,12+,16+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2QR51RW |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286775
(CHEMBL4174152)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1cc(nc(N)n1)-c1ccccc1 |r| Show InChI InChI=1S/C22H25N5O3S/c1-14(2)11-18(23)21(28)27-31(29,30)17-10-6-9-16(12-17)20-13-19(25-22(24)26-20)15-7-4-3-5-8-15/h3-10,12-14,18H,11,23H2,1-2H3,(H,27,28)(H2,24,25,26)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50550346
(CHEMBL4558130)Show SMILES CC(C)[C@@H](O)[C@H](O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2QR51RW |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286766
(CHEMBL4163450)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1cc(C)nc(N)n1 |r| Show InChI InChI=1S/C17H23N5O3S/c1-10(2)7-14(18)16(23)22-26(24,25)13-6-4-5-12(9-13)15-8-11(3)20-17(19)21-15/h4-6,8-10,14H,7,18H2,1-3H3,(H,22,23)(H2,19,20,21)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286768
(CHEMBL4171458)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1ccc2ccccc2c1 |r| Show InChI InChI=1S/C16H20N2O3S/c1-11(2)9-15(17)16(19)18-22(20,21)14-8-7-12-5-3-4-6-13(12)10-14/h3-8,10-11,15H,9,17H2,1-2H3,(H,18,19)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50550345
(CHEMBL4104169)Show SMILES CC(C)C[C@H](O)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)nc(I)nc12 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | 337 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of catalytic activity of LRS (unknown origin) by aminoleucylation assay |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2QR51RW |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286767
(CHEMBL4172643)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1ccnc(N)c1 |r| Show InChI InChI=1S/C17H22N4O3S/c1-11(2)8-15(18)17(22)21-25(23,24)14-5-3-4-12(9-14)13-6-7-20-16(19)10-13/h3-7,9-11,15H,8,18H2,1-2H3,(H2,19,20)(H,21,22)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075067
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H31N3O8S2/c1-15(2)12-19(27)25(32)29-39(33,34)35-13-21-22(30)23(31)24(37-21)26-28-20(14-38-26)16-8-10-18(11-9-16)36-17-6-4-3-5-7-17/h3-11,14-15,19,21-24,30-31H,12-13,27H2,1-2H3,(H,29,32)/t19-,21+,22+,23+,24+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of human Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075069
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(CCc2ccccc2)cs1 Show InChI InChI=1S/C22H31N3O7S2/c1-13(2)10-16(23)21(28)25-34(29,30)31-11-17-18(26)19(27)20(32-17)22-24-15(12-33-22)9-8-14-6-4-3-5-7-14/h3-7,12-13,16-20,26-27H,8-11,23H2,1-2H3,(H,25,28)/t16-,17+,18+,19+,20+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of human Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286765
(CHEMBL4159778)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1cccc(N)n1 |r| Show InChI InChI=1S/C17H22N4O3S/c1-11(2)9-14(18)17(22)21-25(23,24)13-6-3-5-12(10-13)15-7-4-8-16(19)20-15/h3-8,10-11,14H,9,18H2,1-2H3,(H2,19,20)(H,21,22)/t14-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075068
(((2S,3S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid...)Show SMILES CC[C@H](C)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C20H27N3O7S2/c1-3-11(2)15(21)19(26)23-32(27,28)29-9-14-16(24)17(25)18(30-14)20-22-13(10-31-20)12-7-5-4-6-8-12/h4-8,10-11,14-18,24-25H,3,9,21H2,1-2H3,(H,23,26)/t11-,14+,15-,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286772
(CHEMBL4160841)Show InChI InChI=1S/C12H18N2O3S/c1-9(2)8-11(13)12(15)14-18(16,17)10-6-4-3-5-7-10/h3-7,9,11H,8,13H2,1-2H3,(H,14,15)/t11-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075055
(((S)-2-Amino-4-methyl-pentanoyl)-sulfamic acid (2R...)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(CCc2ccc(Oc3ccccc3)cc2)cs1 Show InChI InChI=1S/C28H35N3O8S2/c1-17(2)14-22(29)27(34)31-41(35,36)37-15-23-24(32)25(33)26(39-23)28-30-19(16-40-28)11-8-18-9-12-21(13-10-18)38-20-6-4-3-5-7-20/h3-7,9-10,12-13,16-17,22-26,32-33H,8,11,14-15,29H2,1-2H3,(H,31,34)/t22-,23+,24+,25+,26+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of human Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286774
(CHEMBL4163140)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1ccncc1 |r| Show InChI InChI=1S/C17H21N3O3S/c1-12(2)10-16(18)17(21)20-24(22,23)15-5-3-4-14(11-15)13-6-8-19-9-7-13/h3-9,11-12,16H,10,18H2,1-2H3,(H,20,21)/t16-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50111476
(1-[5-(4''-Chloro-biphenyl-4-yloxy)-pentyl]-3-pyrid...)Show SMILES Clc1ccc(cc1)-c1ccc(OCCCCCN2CCN(C2=O)c2ccncc2)cc1 Show InChI InChI=1S/C25H26ClN3O2/c26-22-8-4-20(5-9-22)21-6-10-24(11-7-21)31-19-3-1-2-16-28-17-18-29(25(28)30)23-12-14-27-15-13-23/h4-15H,1-3,16-19H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibitory activity against Echovirus 9 using plaque reduction assay |
Bioorg Med Chem Lett 15: 4206-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.069 BindingDB Entry DOI: 10.7270/Q27080ZC |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50093003
((4aR,6S,7R,7aS)-7-[2-((2S,3S)-2-Amino-3-methyl-pen...)Show SMILES CC[C@H](C)[C@H](N)C(=O)NS(=O)(=O)CC(=O)N[C@]1([C@@H](O)C[C@@H]2[C@H]1CN(C)C=C2C(N)=O)C(O)=O |c:26| Show InChI InChI=1S/C19H31N5O8S/c1-4-9(2)15(20)17(28)23-33(31,32)8-14(26)22-19(18(29)30)12-7-24(3)6-11(16(21)27)10(12)5-13(19)25/h6,9-10,12-13,15,25H,4-5,7-8,20H2,1-3H3,(H2,21,27)(H,22,26)(H,23,28)(H,29,30)/t9-,10-,12+,13-,15-,19+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Australian National University
Curated by ChEMBL
| Assay Description Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29 |
Bioorg Med Chem Lett 10: 2263-6 (2001)
BindingDB Entry DOI: 10.7270/Q2PN94W3 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286771
(CHEMBL4167692)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1cc(C)ncn1 |r| Show InChI InChI=1S/C17H22N4O3S/c1-11(2)7-15(18)17(22)21-25(23,24)14-6-4-5-13(9-14)16-8-12(3)19-10-20-16/h4-6,8-11,15H,7,18H2,1-3H3,(H,21,22)/t15-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370987
(TAVABOROLE)Show InChI InChI=1S/C7H6BFO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50093001
((4aR,6S,7R,7aS)-7-[2-((S)-2-Amino-3-methyl-butyryl...)Show SMILES CC(C)[C@H](N)C(=O)NS(=O)(=O)CC(=O)N[C@]1([C@@H](O)C[C@@H]2[C@H]1CN(C)C=C2C(N)=O)C(O)=O |c:25| Show InChI InChI=1S/C18H29N5O8S/c1-8(2)14(19)16(27)22-32(30,31)7-13(25)21-18(17(28)29)11-6-23(3)5-10(15(20)26)9(11)4-12(18)24/h5,8-9,11-12,14,24H,4,6-7,19H2,1-3H3,(H2,20,26)(H,21,25)(H,22,27)(H,28,29)/t9-,11+,12-,14-,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Australian National University
Curated by ChEMBL
| Assay Description Compound was evaluated for its inhibitory activity against Leucyl-tRNA synthetase from staphylococcus aureus WCUH29 |
Bioorg Med Chem Lett 10: 2263-6 (2001)
BindingDB Entry DOI: 10.7270/Q2PN94W3 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286770
(CHEMBL4171058)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1ccccc1 |r| Show InChI InChI=1S/C18H22N2O3S/c1-13(2)11-17(19)18(21)20-24(22,23)16-10-6-9-15(12-16)14-7-4-3-5-8-14/h3-10,12-13,17H,11,19H2,1-2H3,(H,20,21)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286769
(CHEMBL4161986)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(c1)-c1ccnc(N)n1 |r| Show InChI InChI=1S/C16H21N5O3S/c1-10(2)8-13(17)15(22)21-25(23,24)12-5-3-4-11(9-12)14-6-7-19-16(18)20-14/h3-7,9-10,13H,8,17H2,1-2H3,(H,21,22)(H2,18,19,20)/t13-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human LeuRS assessed as reduction in ATP consumption |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50286773
(CHEMBL4174897)Show SMILES CC(C)C[C@H](N)C(=O)NS(=O)(=O)c1cccc(NC(=S)NC(=O)COc2ccc(Br)cc2Cl)c1 |r| Show InChI InChI=1S/C21H24BrClN4O5S2/c1-12(2)8-17(24)20(29)27-34(30,31)15-5-3-4-14(10-15)25-21(33)26-19(28)11-32-18-7-6-13(22)9-16(18)23/h3-7,9-10,12,17H,8,11,24H2,1-2H3,(H,27,29)(H2,25,26,28,33)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Oxford Drug Design Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human cytoplasmic LeuRS assessed as reduction in protein synthesis measured after 10 mins in presence of [3H]Leu by scintillation count... |
ACS Med Chem Lett 9: 84-88 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00374 BindingDB Entry DOI: 10.7270/Q2BZ68KK |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075064
(((S)-2-Amino-3-methyl-butyryl)-sulfamic acid (2R,3...)Show SMILES CC(C)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C19H25N3O7S2/c1-10(2)14(20)18(25)22-31(26,27)28-8-13-15(23)16(24)17(29-13)19-21-12(9-30-19)11-6-4-3-5-7-11/h3-7,9-10,13-17,23-24H,8,20H2,1-2H3,(H,22,25)/t13-,14+,15-,16-,17-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50145676
(CHEMBL3764310)Show SMILES Oc1c(Br)cc(\C=N\Nc2nc(cs2)-c2ccc(cc2)[N+]([O-])=O)cc1Br Show InChI InChI=1S/C16H10Br2N4O3S/c17-12-5-9(6-13(18)15(12)23)7-19-21-16-20-14(8-26-16)10-1-3-11(4-2-10)22(24)25/h1-8,23H,(H,20,21)/b19-7+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.87E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m... |
Bioorg Med Chem 24: 1023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.01.028 BindingDB Entry DOI: 10.7270/Q2RN39Q8 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075068
(((2S,3S)-2-Amino-3-methyl-pentanoyl)-sulfamic acid...)Show SMILES CC[C@H](C)[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C20H27N3O7S2/c1-3-11(2)15(21)19(26)23-32(27,28)29-9-14-16(24)17(25)18(30-14)20-22-13(10-31-20)12-7-5-4-6-8-12/h4-8,10-11,14-18,24-25H,3,9,21H2,1-2H3,(H,23,26)/t11-,14+,15-,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of human isoleucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50171203
(1-[(S)-5-(4'-Chloro-biphenyl-4-yloxy)-3-methyl-pen...)Show SMILES C[C@H](CCOc1ccc(cc1)-c1ccc(Cl)cc1)CCN1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C26H28ClN3O2/c1-20(12-16-29-17-18-30(26(29)31)24-10-14-28-15-11-24)13-19-32-25-8-4-22(5-9-25)21-2-6-23(27)7-3-21/h2-11,14-15,20H,12-13,16-19H2,1H3/t20-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibitory activity against Echovirus 9 using plaque reduction assay |
Bioorg Med Chem Lett 15: 4206-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.069 BindingDB Entry DOI: 10.7270/Q27080ZC |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50171204
(1-[(R)-5-(4'-Chloro-biphenyl-4-yloxy)-3-methyl-pen...)Show SMILES C[C@@H](CCOc1ccc(cc1)-c1ccc(Cl)cc1)CCN1CCN(C1=O)c1ccncc1 Show InChI InChI=1S/C26H28ClN3O2/c1-20(12-16-29-17-18-30(26(29)31)24-10-14-28-15-11-24)13-19-32-25-8-4-22(5-9-25)21-2-6-23(27)7-3-21/h2-11,14-15,20H,12-13,16-19H2,1H3/t20-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
National Health Research Institutes
Curated by ChEMBL
| Assay Description Inhibitory activity against Echovirus 9 using plaque reduction assay |
Bioorg Med Chem Lett 15: 4206-11 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.069 BindingDB Entry DOI: 10.7270/Q27080ZC |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50268308
(CHEMBL4061292)Show SMILES COc1ccc(CNS(=O)(=O)c2ccc(cc2)N2C(=O)N[C@@H](CC(C)C)C2=O)cc1OC |r| Show InChI InChI=1S/C22H27N3O6S/c1-14(2)11-18-21(26)25(22(27)24-18)16-6-8-17(9-7-16)32(28,29)23-13-15-5-10-19(30-3)20(12-15)31-4/h5-10,12,14,18,23H,11,13H2,1-4H3,(H,24,27)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Curated by ChEMBL
| Assay Description Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret... |
Bioorg Med Chem 25: 4145-4152 (2017)
Article DOI: 10.1016/j.bmc.2017.06.002 BindingDB Entry DOI: 10.7270/Q2RJ4MZG |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50145675
(CHEMBL3764493)Show SMILES COc1cc(\C=N\Nc2nc(cs2)-c2ccc(Cl)cc2)cc(Br)c1O Show InChI InChI=1S/C17H13BrClN3O2S/c1-24-15-7-10(6-13(18)16(15)23)8-20-22-17-21-14(9-25-17)11-2-4-12(19)5-3-11/h2-9,23H,1H3,(H,21,22)/b20-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m... |
Bioorg Med Chem 24: 1023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.01.028 BindingDB Entry DOI: 10.7270/Q2RN39Q8 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50241754
(CHEMBL4077894)Show InChI InChI=1S/C10H13BClNO3.ClH/c1-2-15-7-4-3-6(12)9-8(5-13)16-11(14)10(7)9;/h3-4,8,14H,2,5,13H2,1H3;1H/t8-;/m1./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E... |
J Med Chem 60: 8011-8026 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50268307
(CHEMBL4074495)Show SMILES COc1ccc(CNS(=O)(=O)c2ccc(NC(=O)[C@@H](N)CC(C)C)cc2)cc1OC |r| Show InChI InChI=1S/C21H29N3O5S/c1-14(2)11-18(22)21(25)24-16-6-8-17(9-7-16)30(26,27)23-13-15-5-10-19(28-3)20(12-15)29-4/h5-10,12,14,18,23H,11,13,22H2,1-4H3,(H,24,25)/t18-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratory of Medicinal Chemistry, Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Curated by ChEMBL
| Assay Description Inhibition of LRS-dependent mTORC1 activation in HEK293 cells assessed as reduction in leucine-induced mTORC1-mediated S6 Kinase phosphorylation pret... |
Bioorg Med Chem 25: 4145-4152 (2017)
Article DOI: 10.1016/j.bmc.2017.06.002 BindingDB Entry DOI: 10.7270/Q2RJ4MZG |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50145677
(CHEMBL3765025)Show SMILES COc1cc(\C=N/Nc2nc(cs2)-c2ccc(cc2)[N+]([O-])=O)cc(c1O)[N+]([O-])=O Show InChI InChI=1S/C17H13N5O6S/c1-28-15-7-10(6-14(16(15)23)22(26)27)8-18-20-17-19-13(9-29-17)11-2-4-12(5-3-11)21(24)25/h2-9,23H,1H3,(H,19,20)/b18-8- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m... |
Bioorg Med Chem 24: 1023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.01.028 BindingDB Entry DOI: 10.7270/Q2RN39Q8 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50241756
(CHEMBL4075879)Show InChI InChI=1S/C10H13BBrNO3/c1-2-15-7-4-3-6(12)9-8(5-13)16-11(14)10(7)9/h3-4,8,14H,2,5,13H2,1H3/t8-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.69E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E... |
J Med Chem 60: 8011-8026 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370990
(CHEMBL214011)Show InChI InChI=1S/C8H8BFO2/c10-7-1-2-8-6(5-7)3-4-12-9(8)11/h1-2,5,11H,3-4H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50241780
(CHEMBL4105269)Show InChI InChI=1S/C10H11BClNO4.ClH/c12-5-3-6-10(16-2-1-15-6)9-8(5)7(4-13)17-11(9)14;/h3,7,14H,1-2,4,13H2;1H/t7-;/m1./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E... |
J Med Chem 60: 8011-8026 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370991
(CHEMBL388368)Show InChI InChI=1S/C8H10BFO3/c1-13-5-6-4-7(10)2-3-8(6)9(11)12/h2-4,11-12H,5H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075060
(((S)-2-Amino-3-phenyl-propionyl)-sulfamic acid (2R...)Show SMILES N[C@@H](Cc1ccccc1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C23H25N3O7S2/c24-16(11-14-7-3-1-4-8-14)22(29)26-35(30,31)32-12-18-19(27)20(28)21(33-18)23-25-17(13-34-23)15-9-5-2-6-10-15/h1-10,13,16,18-21,27-28H,11-12,24H2,(H,26,29)/t16-,18+,19+,20+,21+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075057
(CHEMBL126919 | [(S)-2-Amino-3-(3H-imidazol-4-yl)-p...)Show SMILES N[C@@H](Cc1cnc[nH]1)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C20H23N5O7S2/c21-13(6-12-7-22-10-23-12)19(28)25-34(29,30)31-8-15-16(26)17(27)18(32-15)20-24-14(9-33-20)11-4-2-1-3-5-11/h1-5,7,9-10,13,15-18,26-27H,6,8,21H2,(H,22,23)(H,25,28)/t13-,15+,16+,17+,18+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50075066
(((S)-2-Amino-propionyl)-sulfamic acid (2R,3S,4R,5R...)Show SMILES C[C@H](N)C(=O)NS(=O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)c1nc(cs1)-c1ccccc1 Show InChI InChI=1S/C17H21N3O7S2/c1-9(18)16(23)20-29(24,25)26-7-12-13(21)14(22)15(27-12)17-19-11(8-28-17)10-5-3-2-4-6-10/h2-6,8-9,12-15,21-22H,7,18H2,1H3,(H,20,23)/t9-,12+,13+,14+,15+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Compound tested for the inhibition of E. coli Leucyl-tRNA synthetase |
Bioorg Med Chem Lett 9: 375-80 (1999)
BindingDB Entry DOI: 10.7270/Q2M32TX1 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370988
(CHEMBL225804)Show InChI InChI=1S/C7H8BFO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4,10-11H,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370989
(CHEMBL226398)Show InChI InChI=1S/C8H5FO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3H,4H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM26128
((4-fluorophenyl)boranediol | CHEMBL344890 | Phenyl...)Show InChI InChI=1S/C6H6BFO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4,9-10H | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Saccharomyces cerevisiae S288c) | BDBM50370992
(CHEMBL226509)Show InChI InChI=1S/C8H7FO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,8,10H,4H2 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae cytoplasmic leucyl-tRNA synthetase assessed as tRNA amino-acylation |
Science 316: 1759-1761 (2007)
Article DOI: 10.1126/science.1142189 BindingDB Entry DOI: 10.7270/Q2P84CQ2 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50145678
(CHEMBL3763921)Show SMILES COc1cc(\C=N/Nc2nc(cs2)-c2ccc(Br)cc2)cc(c1O)[N+]([O-])=O Show InChI InChI=1S/C17H13BrN4O4S/c1-26-15-7-10(6-14(16(15)23)22(24)25)8-19-21-17-20-13(9-27-17)11-2-4-12(18)5-3-11/h2-9,23H,1H3,(H,20,21)/b19-8- | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.16E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m... |
Bioorg Med Chem 24: 1023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.01.028 BindingDB Entry DOI: 10.7270/Q2RN39Q8 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50145674
(CHEMBL2436531)Show InChI InChI=1S/C15H17N3O4S/c1-4-22-14(20)13-9(2)17-15(23-13)18-16-8-10-5-6-11(19)12(7-10)21-3/h5-8,19H,4H2,1-3H3,(H,17,18)/b16-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.16E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
NAS of Ukraine
Curated by ChEMBL
| Assay Description Inhibition of human leucyl-tRNA synthetase assessed as reduction of [14C]-L-leucine ligation to tRNA incubated for 5 mins by scintillation counting m... |
Bioorg Med Chem 24: 1023-31 (2016)
Article DOI: 10.1016/j.bmc.2016.01.028 BindingDB Entry DOI: 10.7270/Q2RN39Q8 |
More data for this Ligand-Target Pair | |
Leucine--tRNA ligase, cytoplasmic
(Homo sapiens (Human)) | BDBM50241782
(CHEMBL4081207)Show InChI InChI=1S/C10H13BBrNO4.ClH/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15;/h1-2,8,14-15H,3-5,13H2;1H/t8-;/m1./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Anacor Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description Inhibition of human N-terminal 6His-tagged cytoplasmic LeuRS expressed in Escherichia coli BL21(DE3) assessed as L-[14C]leucine incorporation in to E... |
J Med Chem 60: 8011-8026 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00631 BindingDB Entry DOI: 10.7270/Q2XD13TH |
More data for this Ligand-Target Pair | |