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Compile Data Set for Download or QSAR

Found 60 hits of ic50 data for polymerid = 50006480   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463844
PNG
(CHEMBL4247840)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H14F6N2O2/c22-20(23,24)14-7-3-12(4-8-14)17(18-16(21(25,26)27)2-1-11-28-18)29-19(31)13-5-9-15(30)10-6-13/h1-11,17,30H,(H,29,31)/t17-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463846
PNG
(CHEMBL4243837)
Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(OC(F)(F)F)c(F)c1 |r|
Show InChI InChI=1S/C19H12F5N3O3/c20-12-2-1-7-25-17(12)16(27-18(29)11-4-6-15(28)26-9-11)10-3-5-14(13(21)8-10)30-19(22,23)24/h1-9,16H,(H,26,28)(H,27,29)/t16-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463855
PNG
(CHEMBL4248077)
Show SMILES Fc1cccnc1[C@@H](NC(=O)c1ccc(=O)[nH]c1)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C19H13F4N3O2/c20-14-2-1-9-24-17(14)16(11-3-6-13(7-4-11)19(21,22)23)26-18(28)12-5-8-15(27)25-10-12/h1-10,16H,(H,25,27)(H,26,28)/t16-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463863
PNG
(CHEMBL4251467)
Show SMILES OC(=O)c1ccc(nc1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H13F6N3O3/c22-20(23,24)13-6-3-11(4-7-13)16(17-14(21(25,26)27)2-1-9-28-17)30-18(31)15-8-5-12(10-29-15)19(32)33/h1-10,16H,(H,30,31)(H,32,33)/t16-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463876
PNG
(CHEMBL4238921)
Show SMILES COc1ccc(cn1)C(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H15F6N3O2/c1-32-16-9-6-13(11-29-16)19(31)30-17(12-4-7-14(8-5-12)20(22,23)24)18-15(21(25,26)27)3-2-10-28-18/h2-11,17H,1H3,(H,30,31)/t17-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463854
PNG
(CHEMBL4251427)
Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc(=O)[nH]c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C20H13F6N3O2/c21-19(22,23)13-6-3-11(4-7-13)16(17-14(20(24,25)26)2-1-9-27-17)29-18(31)12-5-8-15(30)28-10-12/h1-10,16H,(H,28,30)(H,29,31)/t16-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463868
PNG
(CHEMBL4247268)
Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc(cc1)C#N)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C22H13F6N3O/c23-21(24,25)16-9-7-14(8-10-16)18(19-17(22(26,27)28)2-1-11-30-19)31-20(32)15-5-3-13(12-29)4-6-15/h1-11,18H,(H,31,32)/t18-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463856
PNG
(CHEMBL4247395)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccccc1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C21H13F7N2O/c22-16-11-13(8-9-14(16)20(23,24)25)17(30-19(31)12-5-2-1-3-6-12)18-15(21(26,27)28)7-4-10-29-18/h1-11,17H,(H,30,31)/t17-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463858
PNG
(CHEMBL4246904)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H14F7N3O/c25-18-11-14(7-8-16(18)23(26,27)28)20(21-17(24(29,30)31)4-2-10-33-21)34-22(35)15-6-5-13-3-1-9-32-19(13)12-15/h1-12,20H,(H,34,35)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463859
PNG
(CHEMBL4245257)
Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-9-7-15(8-10-17)20(21-18(24(28,29)30)4-2-12-32-21)33-22(34)16-6-5-14-3-1-11-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463867
PNG
(CHEMBL4249999)
Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1cccnc1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C20H13F6N3O/c21-19(22,23)14-7-5-12(6-8-14)16(29-18(30)13-3-1-9-27-11-13)17-15(20(24,25)26)4-2-10-28-17/h1-11,16H,(H,29,30)/t16-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463875
PNG
(CHEMBL4242867)
Show SMILES FC(F)(F)Oc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H15F6N3O2/c25-23(26,27)18-4-2-12-32-21(18)20(15-7-9-17(10-8-15)35-24(28,29)30)33-22(34)16-6-5-14-3-1-11-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463872
PNG
(CHEMBL4246304)
Show SMILES FC(F)(F)c1cccnc1[C@@H](NC(=O)c1ccc2cccnc2c1)c1cnc2ccccc2c1 |r|
Show InChI InChI=1S/C26H17F3N4O/c27-26(28,29)20-7-4-12-31-24(20)23(19-13-17-5-1-2-8-21(17)32-15-19)33-25(34)18-10-9-16-6-3-11-30-22(16)14-18/h1-15,23H,(H,33,34)/t23-/m0/s1
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n/an/a 119n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463848
PNG
(CHEMBL4245611)
Show SMILES Cc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H18F3N3O/c1-15-6-8-17(9-7-15)21(22-19(24(25,26)27)5-3-13-29-22)30-23(31)18-11-10-16-4-2-12-28-20(16)14-18/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1
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n/an/a 143n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463851
PNG
(CHEMBL4237740)
Show SMILES C[C@H](NC(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C18H14F9N3O/c1-9(16(19,20)21)29-15(31)30-13(10-4-6-11(7-5-10)17(22,23)24)14-12(18(25,26)27)3-2-8-28-14/h2-9,13H,1H3,(H2,29,30,31)/t9-,13-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463869
PNG
(CHEMBL4237383)
Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cccnc2c1)c1ccccc1C(F)(F)F |r|
Show InChI InChI=1S/C25H15F7N2O/c26-20-12-15(9-10-19(20)25(30,31)32)22(17-5-1-2-6-18(17)24(27,28)29)34-23(35)16-8-7-14-4-3-11-33-21(14)13-16/h1-13,22H,(H,34,35)/t22-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463845
PNG
(CHEMBL4242403)
Show SMILES FC(F)(F)c1cccc(c1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-6-1-4-15(12-17)20(21-18(24(28,29)30)7-3-11-32-21)33-22(34)16-9-8-14-5-2-10-31-19(14)13-16/h1-13,20H,(H,33,34)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463877
PNG
(CHEMBL4238688)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H18F3N3O2/c1-32-18-10-8-16(9-11-18)21(22-19(24(25,26)27)5-3-13-29-22)30-23(31)17-7-6-15-4-2-12-28-20(15)14-17/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1
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n/an/a 224n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463861
PNG
(CHEMBL4247089)
Show SMILES Fc1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C23H15F4N3O/c24-17-9-7-15(8-10-17)20(21-18(23(25,26)27)4-2-12-29-21)30-22(31)16-6-5-14-3-1-11-28-19(14)13-16/h1-13,20H,(H,30,31)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463866
PNG
(CHEMBL4247847)
Show SMILES C[C@H](NC(=O)N[C@@H](c1ccc(cc1)C(F)(F)F)c1ncccc1F)C(F)(F)F |r|
Show InChI InChI=1S/C17H14F7N3O/c1-9(16(19,20)21)26-15(28)27-13(14-12(18)3-2-8-25-14)10-4-6-11(7-5-10)17(22,23)24/h2-9,13H,1H3,(H2,26,27,28)/t9-,13-/m0/s1
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n/an/a 234n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463874
PNG
(CHEMBL4239691)
Show SMILES Cc1cccc(c1)[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H18F3N3O/c1-15-5-2-6-17(13-15)21(22-19(24(25,26)27)8-4-12-29-22)30-23(31)18-10-9-16-7-3-11-28-20(16)14-18/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1
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n/an/a 321n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 350n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463871
PNG
(CHEMBL4245270)
Show SMILES FC(F)(F)c1cccnc1[C@@H](NC(=O)c1ccc2cccnc2c1)C1CCCCC1 |r|
Show InChI InChI=1S/C23H22F3N3O/c24-23(25,26)18-9-5-13-28-21(18)20(16-6-2-1-3-7-16)29-22(30)17-11-10-15-8-4-12-27-19(15)14-17/h4-5,8-14,16,20H,1-3,6-7H2,(H,29,30)/t20-/m0/s1
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n/an/a 373n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 400n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 400n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellula...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50133817
PNG
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)
Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1
Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26)
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n/an/a 400n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50044106
PNG
(CHEMBL3325770)
Show SMILES [H][C@@]12C[C@H](CC)[C@@]3([H])N(C1)CCc1c([nH]c4ccccc14)[C@]3(C2)C(=O)OC |r,TLB:4:3:21.22:8.9,23:21:3.2:8.9,THB:10:8:3.2:21.22,3:6:1.22.9:13.10.12.11,13:21:3.2:8.9|
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n/an/a 600n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50044106
PNG
(CHEMBL3325770)
Show SMILES [H][C@@]12C[C@H](CC)[C@@]3([H])N(C1)CCc1c([nH]c4ccccc14)[C@]3(C2)C(=O)OC |r,TLB:4:3:21.22:8.9,23:21:3.2:8.9,THB:10:8:3.2:21.22,3:6:1.22.9:13.10.12.11,13:21:3.2:8.9|
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n/an/a 600n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463870
PNG
(CHEMBL4245344)
Show SMILES FC(F)(F)c1ccc(cc1)[C@H](NC(=O)c1ccc2cccnc2c1)c1cnccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H15F6N3O/c25-23(26,27)17-7-5-15(6-8-17)21(18-13-31-11-9-19(18)24(28,29)30)33-22(34)16-4-3-14-2-1-10-32-20(14)12-16/h1-13,21H,(H,33,34)/t21-/m0/s1
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n/an/a 663n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50396009
PNG
(CHEMBL2163793)
Show SMILES CCC1=C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@](C2)([C@@H]13)C(=O)OC |r,t:2,THB:2:20:5.4.19:7.8.9.10|
Show InChI InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
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n/an/a 700n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50396009
PNG
(CHEMBL2163793)
Show SMILES CCC1=C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@](C2)([C@@H]13)C(=O)OC |r,t:2,THB:2:20:5.4.19:7.8.9.10|
Show InChI InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3/t13-,19+,21-/m0/s1
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n/an/a 900n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463852
PNG
(CHEMBL4246078)
Show SMILES FC(F)(F)c1cccnc1[C@@H](NC(=O)c1ccc2cccnc2c1)c1ccccc1 |r|
Show InChI InChI=1S/C23H16F3N3O/c24-23(25,26)18-9-5-13-28-21(18)20(16-6-2-1-3-7-16)29-22(30)17-11-10-15-8-4-12-27-19(15)14-17/h1-14,20H,(H,29,30)/t20-/m0/s1
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n/an/a 1.26E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463847
PNG
(CHEMBL4246499)
Show SMILES FC(F)(F)c1cccnc1[C@H](Cc1ccccc1)NC(=O)c1ccc2cccnc2c1 |r|
Show InChI InChI=1S/C24H18F3N3O/c25-24(26,27)19-9-5-13-29-22(19)21(14-16-6-2-1-3-7-16)30-23(31)18-11-10-17-8-4-12-28-20(17)15-18/h1-13,15,21H,14H2,(H,30,31)/t21-/m0/s1
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n/an/a 2.05E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50329102
PNG
(CHEMBL364613 | Indole alkaloid derivative | corona...)
Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@](C2)([C@H]13)C(=O)OC |r,TLB:1:2:19.18:6.5,21:18:2.3:6.5,THB:7:6:2.3:19.18,10:18:2.3:6.5|
Show InChI InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14-,19-,21+/m0/s1
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n/an/a 3.00E+3n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50044107
PNG
(CHEMBL3325769)
Show SMILES [H][C@@]12C[C@H](CC)[C@]3([H])N(Cn4c(c(COC)c5ccc(OC)cc45)[C@@]3(C1)C(=O)OC)C2 |r,TLB:26:24:2.3:8.30,THB:3:6:10.11.9:25.1.30,4:3:24.25:8.30,11:24:2.3:8.30,9:8:24.25:2.3|
Show InChI InChI=1S/C23H30N2O4/c1-5-15-8-14-10-23(22(26)29-4)20(15)24(11-14)13-25-19-9-16(28-3)6-7-17(19)18(12-27-2)21(23)25/h6-7,9,14-15,20H,5,8,10-13H2,1-4H3/t14-,15+,20+,23+/m1/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50329104
PNG
(CHEMBL182120 | Indole alkaloid derivative | voacan...)
Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccc(OC)cc45)[C@](C2)([C@H]13)C(=O)OC |r,THB:2:22:10.9.8.7:21.4.5,1:2:20.21:6.5|
Show InChI InChI=1S/C22H28N2O3/c1-4-14-9-13-11-22(21(25)27-3)19-16(7-8-24(12-13)20(14)22)17-10-15(26-2)5-6-18(17)23-19/h5-6,10,13-14,20,23H,4,7-9,11-12H2,1-3H3/t13-,14-,20-,22+/m0/s1
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n/an/a 7.00E+3n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50329104
PNG
(CHEMBL182120 | Indole alkaloid derivative | voacan...)
Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccc(OC)cc45)[C@](C2)([C@H]13)C(=O)OC |r,THB:2:22:10.9.8.7:21.4.5,1:2:20.21:6.5|
Show InChI InChI=1S/C22H28N2O3/c1-4-14-9-13-11-22(21(25)27-3)19-16(7-8-24(12-13)20(14)22)17-10-15(26-2)5-6-18(17)23-19/h5-6,10,13-14,20,23H,4,7-9,11-12H2,1-3H3/t13-,14-,20-,22+/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50329104
PNG
(CHEMBL182120 | Indole alkaloid derivative | voacan...)
Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccc(OC)cc45)[C@](C2)([C@H]13)C(=O)OC |r,THB:2:22:10.9.8.7:21.4.5,1:2:20.21:6.5|
Show InChI InChI=1S/C22H28N2O3/c1-4-14-9-13-11-22(21(25)27-3)19-16(7-8-24(12-13)20(14)22)17-10-15(26-2)5-6-18(17)23-19/h5-6,10,13-14,20,23H,4,7-9,11-12H2,1-3H3/t13-,14-,20-,22+/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463857
PNG
(CHEMBL4248352)
Show SMILES FC(F)(F)c1cccnc1[C@@H](NC(=O)c1ccc2cccnc2c1)c1ccccn1 |r|
Show InChI InChI=1S/C22H15F3N4O/c23-22(24,25)16-6-4-12-28-19(16)20(17-7-1-2-10-26-17)29-21(30)15-9-8-14-5-3-11-27-18(14)13-15/h1-13,20H,(H,29,30)/t20-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463860
PNG
(CHEMBL4238340)
Show SMILES FC(F)(F)c1cccnc1[C@@H](NC(=O)c1ccc2cccnc2c1)c1nccs1 |r|
Show InChI InChI=1S/C20H13F3N4OS/c21-20(22,23)14-4-2-8-25-16(14)17(19-26-9-10-29-19)27-18(28)13-6-5-12-3-1-7-24-15(12)11-13/h1-11,17H,(H,27,28)/t17-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50329102
PNG
(CHEMBL364613 | Indole alkaloid derivative | corona...)
Show SMILES CC[C@H]1C[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@](C2)([C@H]13)C(=O)OC |r,TLB:1:2:19.18:6.5,21:18:2.3:6.5,THB:7:6:2.3:19.18,10:18:2.3:6.5|
Show InChI InChI=1S/C21H26N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,13-14,19,22H,3,8-12H2,1-2H3/t13-,14-,19-,21+/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50044108
PNG
(CHEMBL3325768)
Show SMILES [H][C@]12C[C@H](CC)[C@]3([H])N(C1)CCc1c([nH]c4ccc(OC)cc14)[C@]3(CO)C2 |r,TLB:4:3:23.26:8.9,24:23:8.9:3.2,THB:13:23:8.9:3.2,3:6:26.9.1:13.12.11.10,10:8:23.26:3.2|
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n/an/a 1.90E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50463873
PNG
(CHEMBL4242496)
Show SMILES Cc1ccccc1[C@H](NC(=O)c1ccc2cccnc2c1)c1ncccc1C(F)(F)F |r|
Show InChI InChI=1S/C24H18F3N3O/c1-15-6-2-3-8-18(15)21(22-19(24(25,26)27)9-5-13-29-22)30-23(31)17-11-10-16-7-4-12-28-20(16)14-17/h2-14,21H,1H3,(H,30,31)/t21-/m0/s1
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n/an/a>2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonist activity at mouse TRPM8 expressed in CHO cells assessed as inhibition of icilin-induced intracellular calcium levels preincubated for 2.5 ...

J Med Chem 61: 8186-8201 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00518
BindingDB Entry DOI: 10.7270/Q2TH8QCW
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM20461
PNG
((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Show SMILES COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
Show InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50044107
PNG
(CHEMBL3325769)
Show SMILES [H][C@@]12C[C@H](CC)[C@]3([H])N(Cn4c(c(COC)c5ccc(OC)cc45)[C@@]3(C1)C(=O)OC)C2 |r,TLB:26:24:2.3:8.30,THB:3:6:10.11.9:25.1.30,4:3:24.25:8.30,11:24:2.3:8.30,9:8:24.25:2.3|
Show InChI InChI=1S/C23H30N2O4/c1-5-15-8-14-10-23(22(26)29-4)20(15)24(11-14)13-25-19-9-16(28-3)6-7-17(19)18(12-27-2)21(23)25/h6-7,9,14-15,20H,5,8,10-13H2,1-4H3/t14-,15+,20+,23+/m1/s1
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n/an/a 3.90E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of menthol-induced intracellul...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellula...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of menthol-induced increase in intracellular Ca2+ accumul...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM20284
PNG
(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Show SMILES Oc1cc2CCCN(Cc2cc1O)C(=S)NCCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist activity against mouse TRPM8 expressed in T-REx HEK cells assessed as inhibition of icilin-induced increase in intracellular Ca2+ accumula...

J. Nat. Prod. 77: 1831-8 (2014)


Article DOI: 10.1021/np500235b
BindingDB Entry DOI: 10.7270/Q27S7QDF
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily M member 8


(Mus musculus)		BDBM50366620
PNG
(RESINIFERATOXIN)
Show SMILES COc1cc(CC(=O)OCC2=C[C@H]3[C@H]4OC5(Cc6ccccc6)O[C@@]4(C[C@@H](C)[C@]3(O5)[C@@H]3C=C(C)C(=O)[C@@]3(O)C2)C(C)=C)ccc1O |r,t:10,35,TLB:23:15:12:24.25.26,THB:16:15:12:24.25.26|
Show InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35+,36?,37-/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Shizuoka

Curated by ChEMBL


Assay Description
Antagonist at TRPM8 isolated from mouse dorsal root ganglion cells expressed in HEK T-REx cells assessed as inhibition of icilin-induced intracellula...

J Nat Prod 77: 285-97 (2014)


Article DOI: 10.1021/np400885u
BindingDB Entry DOI: 10.7270/Q20P11H1
More data for this
Ligand-Target Pair
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