Found 129 hits of ic50 data for polymerid = 50006845 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567363
(CHEMBL4876602)Show SMILES C[C@@H](Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1)c1ccccc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567386
(CHEMBL4861872)Show SMILES CC(Sc1nc2nn(cc2c(=O)n1-c1ccccc1)C1(C)COC1)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567382
(CHEMBL4859904)Show SMILES CC(Sc1nc2nn(CC3COC3)cc2c(=O)n1-c1ccccc1)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567362
(CHEMBL4848258) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567372
(CHEMBL4875157) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459603
(CHEMBL4213331)Show InChI InChI=1S/C19H15FN4OS/c1-23-17-16(11-21-23)18(25)24(15-8-3-2-4-9-15)19(22-17)26-12-13-6-5-7-14(20)10-13/h2-11H,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459603
(CHEMBL4213331)Show InChI InChI=1S/C19H15FN4OS/c1-23-17-16(11-21-23)18(25)24(15-8-3-2-4-9-15)19(22-17)26-12-13-6-5-7-14(20)10-13/h2-11H,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567376
(CHEMBL4848831)Show SMILES CC(Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1)c1cccc(O)c1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567373
(CHEMBL4855442) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567374
(CHEMBL4849624) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5274968
Show InChI InChI=1S/C8H8N2O2S/c9-13(11,12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H2,9,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Potency against histamine H1 receptor on guinea pig ileum |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5269320
Show SMILES COc1ccc2cc(n(c2c1)S(=O)(=O)c1ccccc1)S(N)(=O)=O Show InChI InChI=1S/C15H14N2O5S2/c1-22-12-8-7-11-9-15(23(16,18)19)17(14(11)10-12)24(20,21)13-5-3-2-4-6-13/h2-10H,1H3,(H2,16,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5283146
Show InChI InChI=1S/C8H7NO4S/c9-14(11,12)8-3-5-1-2-6(10)4-7(5)13-8/h1-4,10H,(H2,9,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description In vitro inhibition of human dihydrofolate reductase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5285815
Show InChI InChI=1S/C8H7NO3S/c9-13(10,11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H2,9,10,11) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of mevalonate kinase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5271934
Show InChI InChI=1S/C13H15NO5S/c1-13(2,3)12(15)18-9-4-5-10-8(6-9)7-11(19-10)20(14,16)17/h4-7H,1-3H3,(H2,14,16,17) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of squalene synthase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5278448
Show InChI InChI=1S/C9H8N2O4S/c10-16(12,13)9-2-5-1-7-8(15-4-14-7)3-6(5)11-9/h1-3,11H,4H2,(H2,10,12,13) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Potency against histamine H1 receptor on guinea pig ileum |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5286018
Show InChI InChI=1S/C10H9NO5S/c1-6(12)15-8-3-2-7-4-10(17(11,13)14)16-9(7)5-8/h2-5H,1H3,(H2,11,13,14) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Potency against histamine H1 receptor on guinea pig ileum |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5291299
Show InChI InChI=1S/C8H8N2O3S/c9-14(12,13)8-4-5-3-6(11)1-2-7(5)10-8/h1-4,10-11H,(H2,9,12,13) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Potency against histamine H1 receptor on guinea pig ileum |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5283146
Show InChI InChI=1S/C8H7NO4S/c9-14(11,12)8-3-5-1-2-6(10)4-7(5)13-8/h1-4,10H,(H2,9,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Potency against histamine H1 receptor on guinea pig ileum |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5269320
Show SMILES COc1ccc2cc(n(c2c1)S(=O)(=O)c1ccccc1)S(N)(=O)=O Show InChI InChI=1S/C15H14N2O5S2/c1-22-12-8-7-11-9-15(23(16,18)19)17(14(11)10-12)24(20,21)13-5-3-2-4-6-13/h2-10H,1H3,(H2,16,18,19) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description In vitro inhibition of human dihydrofolate reductase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5285815
Show InChI InChI=1S/C8H7NO3S/c9-13(10,11)8-5-6-3-1-2-4-7(6)12-8/h1-5H,(H2,9,10,11) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5271934
Show InChI InChI=1S/C13H15NO5S/c1-13(2,3)12(15)18-9-4-5-10-8(6-9)7-11(19-10)20(14,16)17/h4-7H,1-3H3,(H2,14,16,17) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description In vitro inhibition of human dihydrofolate reductase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5274968
Show InChI InChI=1S/C8H8N2O2S/c9-13(11,12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H2,9,11,12) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5278448
Show InChI InChI=1S/C9H8N2O4S/c10-16(12,13)9-2-5-1-7-8(15-4-14-7)3-6(5)11-9/h1-3,11H,4H2,(H2,10,12,13) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL CHEMBL PC cid PC sid UniChem
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5286018
Show InChI InChI=1S/C10H9NO5S/c1-6(12)15-8-3-2-7-4-10(17(11,13)14)16-9(7)5-8/h2-5H,1H3,(H2,11,13,14) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of dihydrofolate reductase in Candida albicans (in vitro). |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | CHEMBL5291299
Show InChI InChI=1S/C8H8N2O3S/c9-14(12,13)8-4-5-3-6(11)1-2-7(5)10-8/h1-4,10-11H,(H2,9,12,13) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description In vitro inhibition of human dihydrofolate reductase |
Citation and Details
|
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567383
(CHEMBL4847114)Show SMILES CC(Sc1nc2nn(cc2c(=O)n1-c1ccccc1)C1COC1)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 109 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567377
(CHEMBL4874309)Show SMILES COc1ccccc1C(C)Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567366
(CHEMBL4876076)Show SMILES CCC(Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459588
(CHEMBL4210115)Show SMILES Fc1cccc(CSc2nc3nn(cc3c(=O)n2-c2ccccc2)C2COC2)c1 Show InChI InChI=1S/C21H17FN4O2S/c22-15-6-4-5-14(9-15)13-29-21-23-19-18(10-25(24-19)17-11-28-12-17)20(27)26(21)16-7-2-1-3-8-16/h1-10,17H,11-13H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459588
(CHEMBL4210115)Show SMILES Fc1cccc(CSc2nc3nn(cc3c(=O)n2-c2ccccc2)C2COC2)c1 Show InChI InChI=1S/C21H17FN4O2S/c22-15-6-4-5-14(9-15)13-29-21-23-19-18(10-25(24-19)17-11-28-12-17)20(27)26(21)16-7-2-1-3-8-16/h1-10,17H,11-13H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567361
(CHEMBL4862833)Show SMILES CC(Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1)c1cccc(F)c1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459613
(CHEMBL4214509)Show SMILES Cn1cc2c(n1)nc(SCc1cccc(F)c1)n(-c1ccccc1)c2=O Show InChI InChI=1S/C19H15FN4OS/c1-23-11-16-17(22-23)21-19(26-12-13-6-5-7-14(20)10-13)24(18(16)25)15-8-3-2-4-9-15/h2-11H,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459593
(CHEMBL4217452)Show SMILES Fc1cccc(CSc2nc3nn(CC4COC4)cc3c(=O)n2-c2ccccc2)c1 Show InChI InChI=1S/C22H19FN4O2S/c23-17-6-4-5-15(9-17)14-30-22-24-20-19(11-26(25-20)10-16-12-29-13-16)21(28)27(22)18-7-2-1-3-8-18/h1-9,11,16H,10,12-14H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567367
(CHEMBL4863668)Show SMILES CC(C)C(Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567352
(CHEMBL4873315) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567369
(CHEMBL4873090)Show SMILES Cn1ncc2c1c1C(=O)C(Sc1n(-c1ccccc1)c2=O)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459602
(CHEMBL4216790)Show SMILES Fc1cccc(CSc2nc3n(ncc3c(=O)n2-c2ccccc2)C2COC2)c1 Show InChI InChI=1S/C21H17FN4O2S/c22-15-6-4-5-14(9-15)13-29-21-24-19-18(10-23-26(19)17-11-28-12-17)20(27)25(21)16-7-2-1-3-8-16/h1-10,17H,11-13H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459612
(CHEMBL4205216)Show SMILES Fc1cccc(CSc2nc3nn(CC4CC4)cc3c(=O)n2-c2ccccc2)c1 Show InChI InChI=1S/C22H19FN4OS/c23-17-6-4-5-16(11-17)14-29-22-24-20-19(13-26(25-20)12-15-9-10-15)21(28)27(22)18-7-2-1-3-8-18/h1-8,11,13,15H,9-10,12,14H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50236905
(CHEMBL1349972)Show InChI InChI=1S/C16H14O3/c1-8-9(2)18-14-7-15-13(6-12(8)14)10-4-3-5-11(10)16(17)19-15/h6-7H,3-5H2,1-2H3 | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of full length recombinant human ALDH1A3 expressed in Escherichia coli BL21(DE3) assessed as reduction in dehydrogenase activity by measur... |
J Med Chem 60: 2439-2455 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01825 BindingDB Entry DOI: 10.7270/Q2M32Z11 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567378
(CHEMBL4846491)Show SMILES COc1cccc(c1)C(C)Sc1nc2n(C)ncc2c(=O)n1-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 174 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50459599
(CHEMBL4213859)Show SMILES Cn1ncc2c1nc(SCc1cccc(F)c1)n(CCc1ccccc1)c2=O Show InChI InChI=1S/C21H19FN4OS/c1-25-19-18(13-23-25)20(27)26(11-10-15-6-3-2-4-7-15)21(24-19)28-14-16-8-5-9-17(22)12-16/h2-9,12-13H,10-11,14H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of human recombinant ALDH1A3 assessed as reduction in of NAD(P)H formation incubated for 2 mins by spectrophotometry |
J Med Chem 61: 8754-8773 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00930 BindingDB Entry DOI: 10.7270/Q2V127F6 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567387
(CHEMBL4852411)Show SMILES CC(Sc1nc2n(C)ncc2c(=O)n1-c1ccc(cc1)C#N)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567371
(CHEMBL4868666)Show SMILES Cn1ncc2c1c1C=CC(Sc1n(-c1ccccc1)c2=O)c1ccccc1 |c:8| | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50567385
(CHEMBL4846203)Show SMILES CC(Sc1nc2nn(cc2c(=O)n1-c1ccccc1)C1COC1)c1cccnc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human ALDH1A3 assessed as NADH formation using propionaldehyde as substrate by spectrophotometery |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.113060 BindingDB Entry DOI: 10.7270/Q2N58R5M |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50585950
(CHEMBL5075900) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01367 BindingDB Entry DOI: 10.7270/Q22Z19FT |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50236900
(CHEMBL4072941)Show InChI InChI=1S/C15H14O3/c1-7-8(2)15(16)18-14-6-13-12(5-11(7)14)9(3)10(4)17-13/h5-6H,1-4H3 | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells |
J Med Chem 60: 2439-2455 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01825 BindingDB Entry DOI: 10.7270/Q2M32Z11 |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM69358
(3-nitro-4-(1-pyrrolidinyl)benzaldehyde | 3-nitro-4...)Show InChI InChI=1S/C11H12N2O3/c14-8-9-3-4-10(11(7-9)13(15)16)12-5-1-2-6-12/h3-4,7-8H,1-2,5-6H2 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01367 BindingDB Entry DOI: 10.7270/Q22Z19FT |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50585951
(CHEMBL5086460) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01367 BindingDB Entry DOI: 10.7270/Q22Z19FT |
More data for this Ligand-Target Pair | |
Aldehyde dehydrogenase family 1 member A3
(Homo sapiens (Human)) | BDBM50585952
(CHEMBL5090970) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal-His6 tagged recombinant human ALDH1A3 assessed as reduction in NADH production using hexanal and NAD+ as substrate by fluori... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01367 BindingDB Entry DOI: 10.7270/Q22Z19FT |
More data for this Ligand-Target Pair | |