Compile Data Set for Download or QSAR

Found 13 hits of ic50 data for polymerid = 50007046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50135174 (CHEMBL3747431) Show SMILES Cl.CN(C)c1ccc2nc3c(cc(=O)c(O)c3oc2c1)C(O)=O Show InChI InChI=1S/C15H12N2O5.ClH/c1-17(2)7-3-4-9-11(5-7)22-14-12(16-9)8(15(20)21)6-10(18)13(14)19;/h3-6,19H,1-2H3,(H,20,21);1H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145410 (CHEMBL3764819) Show SMILES CCCCOC(=O)c1c(NCc2ccc(OC)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C27H29N3O6/c1-5-6-13-35-27(33)21-22(28-15-16-7-10-18(34-4)11-8-16)24(31)25(32)26-23(21)29-19-12-9-17(30(2)3)14-20(19)36-26/h7-12,14,28,32H,5-6,13,15H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145403 (CHEMBL3764323) Show SMILES COC(=O)c1c(N2CCOCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C20H21N3O6/c1-22(2)11-4-5-12-13(10-11)29-19-15(21-12)14(20(26)27-3)16(17(24)18(19)25)23-6-8-28-9-7-23/h4-5,10,25H,6-9H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145379 (CHEMBL3765769) Show SMILES COC(=O)c1c(Nc2ccc(C)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C23H21N3O5/c1-12-5-7-13(8-6-12)24-18-17(23(29)30-4)19-22(21(28)20(18)27)31-16-11-14(26(2)3)9-10-15(16)25-19/h5-11,24,28H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.77E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145384 (CHEMBL3764205) Show SMILES COC(=O)c1c(NC2CCCCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C22H25N3O5/c1-25(2)13-9-10-14-15(11-13)30-21-18(24-14)16(22(28)29-3)17(19(26)20(21)27)23-12-7-5-4-6-8-12/h9-12,23,27H,4-8H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.06E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145382 (CHEMBL3765415) Show SMILES COC(=O)c1c(NCc2ccc(OC)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C24H23N3O6/c1-27(2)14-7-10-16-17(11-14)33-23-20(26-16)18(24(30)32-4)19(21(28)22(23)29)25-12-13-5-8-15(31-3)9-6-13/h5-11,25,29H,12H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.33E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145409 (CHEMBL3765394) Show SMILES COC(=O)c1c(NC2CCCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C21H23N3O5/c1-24(2)12-8-9-13-14(10-12)29-20-17(23-13)15(21(27)28-3)16(18(25)19(20)26)22-11-6-4-5-7-11/h8-11,22,26H,4-7H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.61E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145380 (CHEMBL3765591) Show SMILES COC(=O)c1c(Nc2ccc(OC)cc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C23H21N3O6/c1-26(2)13-7-10-15-16(11-13)32-22-19(25-15)17(23(29)31-4)18(20(27)21(22)28)24-12-5-8-14(30-3)9-6-12/h5-11,24,28H,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145381 (CHEMBL3763214) Show SMILES COC(=O)c1c(Nc2ccc(Cl)c(Cl)c2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C22H17Cl2N3O5/c1-27(2)11-5-7-14-15(9-11)32-21-18(26-14)16(22(30)31-3)17(19(28)20(21)29)25-10-4-6-12(23)13(24)8-10/h4-9,25,29H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.87E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145377 (CHEMBL3764713) Show SMILES COC(=O)c1c(N)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C16H15N3O5/c1-19(2)7-4-5-8-9(6-7)24-15-12(18-8)10(16(22)23-3)11(17)13(20)14(15)21/h4-6,21H,17H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145383 (CHEMBL3763953) Show SMILES COC(=O)c1c(N2CCCCC2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C21H23N3O5/c1-23(2)12-7-8-13-14(11-12)29-20-16(22-13)15(21(27)28-3)17(18(25)19(20)26)24-9-5-4-6-10-24/h7-8,11,26H,4-6,9-10H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50145378 (CHEMBL3764972) Show SMILES COC(=O)c1c(Nc2ccccc2)c(=O)c(O)c2oc3cc(ccc3nc12)N(C)C Show InChI InChI=1S/C22H19N3O5/c1-25(2)13-9-10-14-15(11-13)30-21-18(24-14)16(22(28)29-3)17(19(26)20(21)27)23-12-7-5-4-6-8-12/h4-11,23,27H,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair
Low-density lipoprotein receptor-related protein 6 (Homo sapiens (Human))	BDBM50135174 (CHEMBL3747431) Show SMILES Cl.CN(C)c1ccc2nc3c(cc(=O)c(O)c3oc2c1)C(O)=O Show InChI InChI=1S/C15H12N2O5.ClH/c1-17(2)7-3-4-9-11(5-7)22-14-12(16-9)8(15(20)21)6-10(18)13(14)19;/h3-6,19H,1-2H3,(H,20,21);1H	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Aristotle University of Thessaloniki Curated by ChEMBL					Assay Description Binding affinity to human LRP6 expressed in HEK293 cells assessed as inhibition of DKK1/LRP6 interaction using compound pre-treated DKK1 conditioned ...				Bioorg Med Chem 24: 1014-22 (2016) Article DOI: 10.1016/j.bmc.2016.01.025 BindingDB Entry DOI: 10.7270/Q2J67JRS
					More data for this Ligand-Target Pair