Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50496629 (CHEMBL3133031) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of APT2 (unknown origin) | Medchemcomm 5: 268-276 (2014) Article DOI: 10.1039/c3md00333g BindingDB Entry DOI: 10.7270/Q2TX3JBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50496626 (CHEMBL1903566) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human APT2 | Medchemcomm 5: 268-276 (2014) Article DOI: 10.1039/c3md00333g BindingDB Entry DOI: 10.7270/Q2TX3JBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50336546 (CHEMBL1673415 | Palmostatin B) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of APT2 (unknown origin) | Medchemcomm 5: 268-276 (2014) Article DOI: 10.1039/c3md00333g BindingDB Entry DOI: 10.7270/Q2TX3JBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50282567 (3,4-Dichlorophenyl boronic acid | 3,4-dichloro ben...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50496625 (CHEMBL3133033) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human APT2 | Medchemcomm 5: 268-276 (2014) Article DOI: 10.1039/c3md00333g BindingDB Entry DOI: 10.7270/Q2TX3JBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92722 (Phenylboronic acid, 15) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92718 (Phenylboronic acid, 10) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26139 (1-benzothiophen-2-ylboranediol | 1-benzothiophen-2...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 529 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM207992 (ML349) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by flu... | ACS Med Chem Lett 8: 215-220 (2017) Article DOI: 10.1021/acsmedchemlett.6b00441 BindingDB Entry DOI: 10.7270/Q2V98B7S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM207992 (ML349) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.10E+3 | 240 | n/a | n/a | n/a | n/a | 25 |
University of Michigan | Assay Description Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe... | ACS Chem Biol 11: 3374-3382 (2016) Article DOI: 10.1021/acschembio.6b00720 BindingDB Entry DOI: 10.7270/Q29K492D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92719 (Phenylboronic acid, 12) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92721 (Phenylboronic acid, 14) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92717 (Phenylboronic acid, 8) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92727 (Phenylboronic acid, 20) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92726 (Phenylboronic acid, 19) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92724 (Phenylboronic acid, 17) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92723 (Phenylboronic acid, 16) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26132 ((4-phenylphenyl)boranediol | Phenylboronic Acid, 1...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92720 (Phenylboronic acid, 13) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92725 (Phenylboronic acid, 18) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50212216 (CHEMBL3944678) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of fluorescein-labeled ML349 binding to HEK293T cells-derived His-tagged APT2 expressed in Escherichia coli BL21(DE3) after 30 mins by flu... | ACS Med Chem Lett 8: 215-220 (2017) Article DOI: 10.1021/acsmedchemlett.6b00441 BindingDB Entry DOI: 10.7270/Q2V98B7S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM50211276 (CHEMBL1891894) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Michigan Curated by ChEMBL | Assay Description Inhibition of human APT2 | Medchemcomm 5: 268-276 (2014) Article DOI: 10.1039/c3md00333g BindingDB Entry DOI: 10.7270/Q2TX3JBM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26140 (1-benzofuran-2-ylboranediol | 1-benzofuran-2-ylbor...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM207994 (ML349-sulfoxide) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+4 | 5.20E+3 | n/a | n/a | n/a | n/a | 25 |
University of Michigan | Assay Description Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe... | ACS Chem Biol 11: 3374-3382 (2016) Article DOI: 10.1021/acschembio.6b00720 BindingDB Entry DOI: 10.7270/Q29K492D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26996 (CHEMBL21485 | PhB(OH)2 | Phenyl-boronic acid | Phe...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM92728 (Phenylboronic acid, 7) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM26137 ((2-phenylphenyl)boranediol | Phenylboronic Acid, 1...) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University of Dortmund | Assay Description The enzyme activities were determined by measuring the release of fluorescent 6,8-difluoro-4-methylumbelliferone (DiFMU) by the APT hydrolysis of DiF... | Chembiochem 14: 115-22 (2013) Article DOI: 10.1002/cbic.201200571 BindingDB Entry DOI: 10.7270/Q2NS0SG7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Acyl-protein thioesterase 2 (Homo sapiens (Human)) | BDBM207995 (ML349-thioether) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | >1.00E+4 | n/a | n/a | n/a | n/a | 25 |
University of Michigan | Assay Description Varying amounts of enzyme were diluted in PBS supplemented with 0.5 g/L pluronic F127 and incubated with 500 nM ML349-FL for 30 minutes at room tempe... | ACS Chem Biol 11: 3374-3382 (2016) Article DOI: 10.1021/acschembio.6b00720 BindingDB Entry DOI: 10.7270/Q29K492D | |||||||||||
More data for this Ligand-Target Pair |