Found 17 hits of ic50 data for polymerid = 6211 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | Reactome pathway
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| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human MEK3 using p38alpha as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50134589
(CHEMBL3747095)Show InChI InChI=1S/C12H12N4O/c1-14-10-3-2-9(16-11(10)12(13)17)8-4-6-15-7-5-8/h2-7,14H,1H3,(H2,13,17) | Reactome pathway
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50134587
(CHEMBL3746157)Show InChI InChI=1S/C11H8N4OS/c12-10(16)11-14-9(8-4-5-13-17-8)7-3-1-2-6-15(7)11/h1-6H,(H2,12,16) | Reactome pathway
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | Reactome pathway
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| n/a | n/a | 17.2 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description
Inhibition of human MEK3 using p38alpha as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50134590
(CHEMBL3747443)Show InChI InChI=1S/C11H10N4O/c12-8-1-2-9(15-10(8)11(13)16)7-3-5-14-6-4-7/h1-6H,12H2,(H2,13,16) | Reactome pathway
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50134588
(CHEMBL3746484)Show InChI InChI=1S/C13H10N4O/c14-12(18)13-16-11(9-4-6-15-7-5-9)10-3-1-2-8-17(10)13/h1-8H,(H2,14,18) | Reactome pathway
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM103302
(SCH772984 | US8546404, 6)Show SMILES O=C(CN1CC[C@@H](C1)C(=O)Nc1ccc2[nH]nc(-c3ccncc3)c2c1)N1CCN(CC1)c1ccc(cc1)-c1ncccn1 |r| Show InChI InChI=1S/C33H33N9O2/c43-30(42-18-16-41(17-19-42)27-5-2-24(3-6-27)32-35-11-1-12-36-32)22-40-15-10-25(21-40)33(44)37-26-4-7-29-28(20-26)31(39-38-29)23-8-13-34-14-9-23/h1-9,11-14,20,25H,10,15-19,21-22H2,(H,37,44)(H,38,39)/t25-/m1/s1 | Reactome pathway
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| n/a | n/a | 304 | n/a | n/a | n/a | n/a | n/a | n/a |
George Washington University
| Assay Description
The IC50 values of selected kinases were determined using either Z'LYTE, Adapta or LanthaScreen assays. |
Nat Chem Biol 10: 853-860 (2014)
Article DOI: 10.1038/nchembio.1629
BindingDB Entry DOI: 10.7270/Q28G8JCH |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50141410
((Z)-3-Amino-3-(2-amino-phenylsulfanyl)-2-[3-(hydro...)Show SMILES Nc1ccccc1SC(=N)C(C#N)c1cccc(c1)C(O)c1ccncc1 Show InChI InChI=1S/C21H18N4OS/c22-13-17(21(24)27-19-7-2-1-6-18(19)23)15-4-3-5-16(12-15)20(26)14-8-10-25-11-9-14/h1-12,17,20,24,26H,23H2 | Reactome pathway
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Bristol-Myers Squibb Pharmaceuticals Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory potency against MAP kinase kinase 3 (MKK3) |
Bioorg Med Chem Lett 14: 1483-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.01.012
BindingDB Entry DOI: 10.7270/Q2H131F0 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50375668
(CHEMBL259526) | Reactome pathway
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University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50134591
(CHEMBL3745744)Show InChI InChI=1S/C12H11N3O/c13-9-6-7-10(15-11(9)12(14)16)8-4-2-1-3-5-8/h1-7H,13H2,(H2,14,16) | Reactome pathway
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| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50235816
(CHEMBL4069365)Show SMILES CC1(C)OCC(=O)Nc2cc(Nc3nc(NCC(F)(F)F)c4occc4n3)ccc12 Show InChI InChI=1S/C19H18F3N5O3/c1-18(2)11-4-3-10(7-13(11)25-14(28)8-30-18)24-17-26-12-5-6-29-15(12)16(27-17)23-9-19(20,21)22/h3-7H,8-9H2,1-2H3,(H,25,28)(H2,23,24,26,27) | Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Bioresearch Center
Curated by ChEMBL
| Assay Description
Inhibition of MAP2K3 (unknown origin) after 60 mins by TR-FRET assay |
Bioorg Med Chem Lett 26: 5562-5567 (2016)
Article DOI: 10.1016/j.bmcl.2016.09.077
BindingDB Entry DOI: 10.7270/Q2WQ061V |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50135286
(CHEMBL3745885)Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) | Reactome pathway
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Inhibition of human MEK3 using p38alpha as substrate |
Bioorg Med Chem 24: 521-44 (2016)
Article DOI: 10.1016/j.bmc.2015.11.045
BindingDB Entry DOI: 10.7270/Q24Q7WT8 |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50115298
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28) | Reactome pathway
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| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of MKK-3, Mitogen activated protein kinase kinase 3 |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50118831
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30) | Reactome pathway
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Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of Mitogen activated protein kinase kinase 3 |
J Med Chem 45: 4513-23 (2002)
BindingDB Entry DOI: 10.7270/Q2JH3MXF |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50115297
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29) | Reactome pathway
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Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of MKK-3, Mitogen activated protein kinase kinase 3 |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50115295
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28) | Reactome pathway
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Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of MKK-3, Mitogen activated protein kinase kinase 3 |
J Med Chem 45: 3057-66 (2002)
BindingDB Entry DOI: 10.7270/Q2RX9BDP |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 3
(Homo sapiens (Human)) | BDBM50097398
(CHEMBL449216 | HTS-9026)Show InChI InChI=1S/C9H8N4O/c10-7-5-3-1-2-4-6(5)12-13-8(7)9(11)14/h1-4H,(H2,10,12)(H2,11,14) | Reactome pathway
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| n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda California Inc.
Curated by ChEMBL
| Assay Description
Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assay |
Bioorg Med Chem Lett 26: 1086-9 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.054
BindingDB Entry DOI: 10.7270/Q28K7BXV |
More data for this
Ligand-Target Pair | |
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