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Compile Data Set for Download or QSAR

Found 136 hits of ic50 data for polymerid = 7877,8283   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116512
PNG
(CHEMBL3609741)
Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)
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n/an/a 3.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116512
PNG
(CHEMBL3609741)
Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)
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n/an/a 3.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116512
PNG
(CHEMBL3609741)
Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)
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n/an/a 3.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116512
PNG
(CHEMBL3609741)
Show SMILES FCOc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)
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n/an/a 3.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116513
PNG
(CHEMBL3609743)
Show SMILES [2H]C([2H])(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H11FN2O2/c14-9-18-11-5-3-4-10(8-11)16-13(17)12-6-1-2-7-15-12/h1-8H,9H2,(H,16,17)/i9D2
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n/an/a 3.70n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116513
PNG
(CHEMBL3609743)
Show SMILES [2H]C([2H])(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H11FN2O2/c14-9-18-11-5-3-4-10(8-11)16-13(17)12-6-1-2-7-15-12/h1-8H,9H2,(H,16,17)/i9D2
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n/an/a 3.70n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031313
PNG
(CHEMBL3357575)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C21H14ClN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)
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n/an/a 4.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031313
PNG
(CHEMBL3357575)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C21H14ClN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)
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n/an/a 4.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293720
PNG
(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)
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n/an/a 4.60n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293720
PNG
(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116520
PNG
(CHEMBL1300476)
Show SMILES CSc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H12N2OS/c1-17-11-6-4-5-10(9-11)15-13(16)12-7-2-3-8-14-12/h2-9H,1H3,(H,15,16)
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n/an/a 4.90n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116520
PNG
(CHEMBL1300476)
Show SMILES CSc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H12N2OS/c1-17-11-6-4-5-10(9-11)15-13(16)12-7-2-3-8-14-12/h2-9H,1H3,(H,15,16)
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n/an/a 4.90n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293721
PNG
(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/a 5.10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031312
PNG
(CHEMBL3357574)
Show SMILES Fc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C20H11ClFN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)
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n/an/a 5.10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031312
PNG
(CHEMBL3357574)
Show SMILES Fc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C20H11ClFN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)
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n/an/a 5.10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293721
PNG
(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116509
PNG
(CHEMBL3609738)
Show SMILES Clc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8ClN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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n/an/a 5.20n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116509
PNG
(CHEMBL3609738)
Show SMILES Clc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8ClN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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n/an/a 5.30n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116472
PNG
(CHEMBL3609734)
Show SMILES FC(F)Oc1cccc(NC(=O)c2cccc(F)n2)c1
Show InChI InChI=1S/C13H9F3N2O2/c14-11-6-2-5-10(18-11)12(19)17-8-3-1-4-9(7-8)20-13(15)16/h1-7,13H,(H,17,19)
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n/an/a 6.60n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116472
PNG
(CHEMBL3609734)
Show SMILES FC(F)Oc1cccc(NC(=O)c2cccc(F)n2)c1
Show InChI InChI=1S/C13H9F3N2O2/c14-11-6-2-5-10(18-11)12(19)17-8-3-1-4-9(7-8)20-13(15)16/h1-7,13H,(H,17,19)
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n/an/a 6.70n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116461
PNG
(CHEMBL3608323)
Show SMILES COc1cc(NC(=O)c2cccc(F)n2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c1-19-11-7-8(5-6-9(11)14)16-13(18)10-3-2-4-12(15)17-10/h2-7H,1H3,(H,16,18)
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n/an/a 7.30n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116461
PNG
(CHEMBL3608323)
Show SMILES COc1cc(NC(=O)c2cccc(F)n2)ccc1Cl
Show InChI InChI=1S/C13H10ClFN2O2/c1-19-11-7-8(5-6-9(11)14)16-13(18)10-3-2-4-12(15)17-10/h2-7H,1H3,(H,16,18)
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n/an/a 7.40n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116508
PNG
(CHEMBL3609737)
Show SMILES Fc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8FN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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n/an/a 7.40n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116508
PNG
(CHEMBL3609737)
Show SMILES Fc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8FN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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n/an/a 7.40n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50293720
PNG
(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)
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n/an/a 9.90n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116489
PNG
(CHEMBL3609736)
Show SMILES O=C(Nc1cccc(c1)C#N)c1ccccn1
Show InChI InChI=1S/C13H9N3O/c14-9-10-4-3-5-11(8-10)16-13(17)12-6-1-2-7-15-12/h1-8H,(H,16,17)
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n/an/a 10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50293720
PNG
(CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...)
Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)
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n/an/a 10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116489
PNG
(CHEMBL3609736)
Show SMILES O=C(Nc1cccc(c1)C#N)c1ccccn1
Show InChI InChI=1S/C13H9N3O/c14-9-10-4-3-5-11(8-10)16-13(17)12-6-1-2-7-15-12/h1-8H,(H,16,17)
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n/an/a 10n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50031313
PNG
(CHEMBL3357575)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C21H14ClN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)
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n/an/a 11n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(4-{[(2- Chlorophenyl)amino]sulfonyl} phenyl )pyridine-2-carboxamide from human mGlu4 receptor after 30 mins by scintillation ...


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031307
PNG
(CHEMBL3357576)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(Br)c2C1=O
Show InChI InChI=1S/C20H11BrClN3O3/c21-13-5-3-4-12-17(13)20(28)25(19(12)27)16-8-7-11(10-14(16)22)24-18(26)15-6-1-2-9-23-15/h1-10H,(H,24,26)
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n/an/a 12n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031307
PNG
(CHEMBL3357576)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(Br)c2C1=O
Show InChI InChI=1S/C20H11BrClN3O3/c21-13-5-3-4-12-17(13)20(28)25(19(12)27)16-8-7-11(10-14(16)22)24-18(26)15-6-1-2-9-23-15/h1-10H,(H,24,26)
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n/an/a 12n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50031309
PNG
(CHEMBL3357578)
Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Br
Show InChI InChI=1S/C21H14BrN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)
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n/an/a 12n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(4-{[(2- Chlorophenyl)amino]sulfonyl} phenyl )pyridine-2-carboxamide from human mGlu4 receptor after 30 mins by scintillation ...


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50293721
PNG
(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/a 13n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50293721
PNG
(CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl
Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/a 13n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116519
PNG
(CHEMBL3609733)
Show SMILES COc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H12N2O2/c1-17-11-6-4-5-10(9-11)15-13(16)12-7-2-3-8-14-12/h2-9H,1H3,(H,15,16)
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n/an/a 14n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116519
PNG
(CHEMBL3609733)
Show SMILES COc1cccc(NC(=O)c2ccccn2)c1
Show InChI InChI=1S/C13H12N2O2/c1-17-11-6-4-5-10(9-11)15-13(16)12-7-2-3-8-14-12/h2-9H,1H3,(H,15,16)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031310
PNG
(CHEMBL3357577)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(I)c2C1=O
Show InChI InChI=1S/C20H11ClIN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)
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n/an/a 26n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))
BDBM50031310
PNG
(CHEMBL3357577)
Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(I)c2C1=O
Show InChI InChI=1S/C20H11ClIN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)
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n/an/a 26.3n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293714
PNG
(CHEMBL551635 | N-(4-fluoro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1F
Show InChI InChI=1S/C13H11FN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/a 32n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50293714
PNG
(CHEMBL551635 | N-(4-fluoro-3-methoxyphenyl)picolin...)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1F
Show InChI InChI=1S/C13H11FN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50031312
PNG
(CHEMBL3357574)
Show SMILES Fc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl
Show InChI InChI=1S/C20H11ClFN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)
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n/an/a 36n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]-N-(4-{[(2- Chlorophenyl)amino]sulfonyl} phenyl )pyridine-2-carboxamide from human mGlu4 receptor after 30 mins by scintillation ...


J Med Chem 57: 9130-8 (2014)


Article DOI: 10.1021/jm501245b
BindingDB Entry DOI: 10.7270/Q2SX6FS1
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116510
PNG
(CHEMBL3609739)
Show SMILES Brc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8BrN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116510
PNG
(CHEMBL3609739)
Show SMILES Brc1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8BrN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
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Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116482
PNG
(CHEMBL3609735)
Show SMILES COc1cc(NC(=O)c2cccc(F)n2)ccc1F
Show InChI InChI=1S/C13H10F2N2O2/c1-19-11-7-8(5-6-9(11)14)16-13(18)10-3-2-4-12(15)17-10/h2-7H,1H3,(H,16,18)
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n/an/a 89n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116482
PNG
(CHEMBL3609735)
Show SMILES COc1cc(NC(=O)c2cccc(F)n2)ccc1F
Show InChI InChI=1S/C13H10F2N2O2/c1-19-11-7-8(5-6-9(11)14)16-13(18)10-3-2-4-12(15)17-10/h2-7H,1H3,(H,16,18)
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n/an/a 89n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116518
PNG
(CHEMBL3609732)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1I
Show InChI InChI=1S/C13H11IN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
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n/an/a 145n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116518
PNG
(CHEMBL3609732)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1I
Show InChI InChI=1S/C13H11IN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
PDB

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n/an/a 146n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116511
PNG
(CHEMBL3609740)
Show SMILES Ic1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8IN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
PDB

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n/an/a 170n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116511
PNG
(CHEMBL3609740)
Show SMILES Ic1ccc(NC(=O)c2ccccn2)cc1C#N
Show InChI InChI=1S/C13H8IN3O/c14-11-5-4-10(7-9(11)8-15)17-13(18)12-3-1-2-6-16-12/h1-7H,(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
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PC sid
UniChem

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PubMed
n/an/a 172n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM50116517
PNG
(CHEMBL3609731)
Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Br
Show InChI InChI=1S/C13H11BrN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
PDB

UniProtKB/SwissProt

antibodypedia
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Purchase

CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
n/an/a 322n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Displacement of [3H]N-(4-chloro-3-methoxyphenyl)picolinamide from human mGlu4 receptor expressed in CHO cell membranes incubated for 30 mins by liqui...


Bioorg Med Chem Lett 25: 3956-60 (2015)


Article DOI: 10.1016/j.bmcl.2015.07.031
BindingDB Entry DOI: 10.7270/Q28C9Z1B
More data for this
Ligand-Target Pair
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