Compile Data Set for Download or QSAR

Found 18 hits of ic50 data for polymerid = 8283   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031313 (CHEMBL3357575) Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl Show InChI InChI=1S/C21H14ClN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031313 (CHEMBL3357575) Show SMILES Cc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl Show InChI InChI=1S/C21H14ClN3O3/c1-12-5-4-6-14-18(12)21(28)25(20(14)27)17-9-8-13(11-15(17)22)24-19(26)16-7-2-3-10-23-16/h2-11H,1H3,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031312 (CHEMBL3357574) Show SMILES Fc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl Show InChI InChI=1S/C20H11ClFN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031312 (CHEMBL3357574) Show SMILES Fc1cccc2C(=O)N(C(=O)c12)c1ccc(NC(=O)c2ccccn2)cc1Cl Show InChI InChI=1S/C20H11ClFN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293720 (CHEMBL541754 | N-(3-(difluoromethoxy)phenyl)picoli...) Show SMILES FC(F)Oc1cccc(NC(=O)c2ccccn2)c1 Show InChI InChI=1S/C13H10F2N2O2/c14-13(15)19-10-5-3-4-9(8-10)17-12(18)11-6-1-2-7-16-11/h1-8,13H,(H,17,18)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031307 (CHEMBL3357576) Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(Br)c2C1=O Show InChI InChI=1S/C20H11BrClN3O3/c21-13-5-3-4-12-17(13)20(28)25(19(12)27)16-8-7-11(10-14(16)22)24-18(26)15-6-1-2-9-23-15/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031307 (CHEMBL3357576) Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(Br)c2C1=O Show InChI InChI=1S/C20H11BrClN3O3/c21-13-5-3-4-12-17(13)20(28)25(19(12)27)16-8-7-11(10-14(16)22)24-18(26)15-6-1-2-9-23-15/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293721 (CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...) Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50293721 (CHEMBL562551 | N-(4-chloro-3-methoxyphenyl)picolin...) Show SMILES COc1cc(NC(=O)c2ccccn2)ccc1Cl Show InChI InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031310 (CHEMBL3357577) Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(I)c2C1=O Show InChI InChI=1S/C20H11ClIN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50031310 (CHEMBL3357577) Show SMILES Clc1cc(NC(=O)c2ccccn2)ccc1N1C(=O)c2cccc(I)c2C1=O Show InChI InChI=1S/C20H11ClIN3O3/c21-13-10-11(24-18(26)15-6-1-2-9-23-15)7-8-16(13)25-19(27)12-4-3-5-14(22)17(12)20(25)28/h1-10H,(H,24,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26.3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Displacement of [3H]ML128 from rat mGlu4 receptor expressed in CHO cells after 30 mins by liquid scintillation counting analysis				J Med Chem 57: 9130-8 (2014) Article DOI: 10.1021/jm501245b BindingDB Entry DOI: 10.7270/Q2SX6FS1
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50151435 ((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...) Show SMILES N[C@@]1([C@H]2[C@@H](C[C@H]1OCc1ccc(Cl)c(Cl)c1)[C@]2(F)C(O)=O)C(O)=O Show InChI InChI=1S/C15H14Cl2FNO5/c16-8-2-1-6(3-9(8)17)5-24-10-4-7-11(14(7,18)12(20)21)15(10,19)13(22)23/h1-3,7,10-11H,4-5,19H2,(H,20,21)(H,22,23)/t7-,10-,11+,14-,15+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells				J Med Chem 47: 4570-87 (2004) Article DOI: 10.1021/jm0400294 BindingDB Entry DOI: 10.7270/Q2GH9HFK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Concentration required to inhibit metabotropic glutamate receptor 4 activity of rat expressed in CHO cells				J Med Chem 47: 4570-87 (2004) Article DOI: 10.1021/jm0400294 BindingDB Entry DOI: 10.7270/Q2GH9HFK
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50017264 (CHEMBL3287718) Show SMILES CCCC(=O)c1ccc(OCCCCOc2c(OC)cccc2C(O)=O)c(C)c1O Show InChI InChI=1S/C23H28O7/c1-4-8-18(24)16-11-12-19(15(2)21(16)25)29-13-5-6-14-30-22-17(23(26)27)9-7-10-20(22)28-3/h7,9-12,25H,4-6,8,13-14H2,1-3H3,(H,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Antagonist activity at rat mGlu4 receptor expressed in HEK293 cells				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50503456 (CHEMBL4435396) Show SMILES NC(=O)c1cc(-c2ccc(F)cc2)n2nc(COc3ccnc(c3)C(F)(F)F)cc2n1 Show InChI InChI=1S/C20H13F4N5O2/c21-12-3-1-11(2-4-12)16-9-15(19(25)30)27-18-7-13(28-29(16)18)10-31-14-5-6-26-17(8-14)20(22,23)24/h1-9H,10H2,(H2,25,30)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50503462 (CHEMBL4527834) Show SMILES C[C@H]1CN(Cc2cc3nc(cc(-c4ccc(F)cc4)c3s2)C(N)=O)C[C@@H](C)O1 |r| Show InChI InChI=1S/C21H22FN3O2S/c1-12-9-25(10-13(2)27-12)11-16-7-18-20(28-16)17(8-19(24-18)21(23)26)14-3-5-15(22)6-4-14/h3-8,12-13H,9-11H2,1-2H3,(H2,23,26)/t12-,13+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University School of Medicine Curated by ChEMBL					Assay Description Negative allosteric modulation of rat mGlu4 receptor expressed in HEK cells harboring GIRK assessed as reduction in glutamate-induced thallium flux p...				J Med Chem 62: 378-384 (2019) Article DOI: 10.1021/acs.jmedchem.8b01266 BindingDB Entry DOI: 10.7270/Q2125WWX
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Rattus norvegicus (Rat))	BDBM50288204 ((2S,3S)-3-Carboxymethyl-azetidine-2-carboxylic aci...) Show SMILES OC(=O)C[C@H]1CN[C@@H]1C(O)=O Show InChI InChI=1S/C6H9NO4/c8-4(9)1-3-2-7-5(3)6(10)11/h3,5,7H,1-2H2,(H,8,9)(H,10,11)/t3-,5-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	3.15E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested in vitro for binding affinity against mGluR4a metabotropic glutamate receptor, using [3H]-L-AP4 as the radioligand.				Bioorg Med Chem Lett 6: 2559-2564 (1996) Article DOI: 10.1016/0960-894X(96)00464-7 BindingDB Entry DOI: 10.7270/Q2HX1CN1
					More data for this Ligand-Target Pair