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Compile Data Set for Download or QSAR

Found 1682 hits of ic50 data for polymerid = 8880   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252685
PNG
(US9458176, 82)
Show SMILES CCOc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H26F3N3O2/c1-5-31-21-12-17(6-7-19(21)24(25,26)27)23-29-22(18-10-14(2)28-15(3)11-18)20-8-9-32-16(4)13-30(20)23/h6-7,10-12,16H,5,8-9,13H2,1-4H3/t16-/m1/s1
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n/an/a 1.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252846
PNG
(US9458176, 243)
Show SMILES CCOc1ccc(cc1C)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H28FN3O2/c1-5-29-22-7-6-18(10-15(22)2)24-27-23(19-11-16(3)26-17(4)12-19)21-8-9-30-20(13-25)14-28(21)24/h6-7,10-12,20H,5,8-9,13-14H2,1-4H3/t20-/m1/s1
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n/an/a 1.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252686
PNG
(US9458176, 83)
Show SMILES CCOc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C23H24F3N3O2/c1-4-30-20-12-17(5-6-18(20)23(24,25)26)22-28-21(16-7-9-27-14(2)11-16)19-8-10-31-15(3)13-29(19)22/h5-7,9,11-12,15H,4,8,10,13H2,1-3H3/t15-/m1/s1
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n/an/a 1.70n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252847
PNG
(US9458176, 244)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C25H30FN3O2/c1-15(2)31-23-7-6-19(10-16(23)3)25-28-24(20-11-17(4)27-18(5)12-20)22-8-9-30-21(13-26)14-29(22)25/h6-7,10-12,15,21H,8-9,13-14H2,1-5H3/t21-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252770
PNG
(US9458176, 167)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC3CC3)c(Cl)c2)n2C[C@@H](CF)OCCc12 |r|
Show InChI InChI=1S/C24H25ClFN3O2/c1-14-9-17(10-15(2)27-14)23-21-7-8-30-19(12-26)13-29(21)24(28-23)16-3-6-22(20(25)11-16)31-18-4-5-18/h3,6,9-11,18-19H,4-5,7-8,12-13H2,1-2H3/t19-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252612
PNG
(US9458176, 9)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(C)c1)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C22H22F3N3O2/c1-13-10-17(4-5-19(13)30-22(23,24)25)21-27-20(16-6-8-26-14(2)11-16)18-7-9-29-15(3)12-28(18)21/h4-6,8,10-11,15H,7,9,12H2,1-3H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252837
PNG
(US9458176, 234)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H24F3N3O2/c1-13-8-17(9-14(2)27-13)21-19-6-7-30-15(3)12-29(19)22(28-21)16-4-5-20(31-23(25)26)18(10-16)11-24/h4-5,8-10,15,23H,6-7,11-12H2,1-3H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16|
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332966
PNG
(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1 |t:15|
Show InChI InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332964
PNG
(4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...)
Show SMILES CCc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:17|
Show InChI InChI=1S/C25H22F3N3O/c1-4-19-11-18(9-15(3)29-19)16-6-5-7-17(10-16)21-13-24(32)31-23-12-20(25(26,27)28)14(2)8-22(23)30-21/h5-12H,4,13H2,1-3H3,(H,31,32)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332965
PNG
(4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...)
Show SMILES Cc1cc(cc(n1)C1CC1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:19|
Show InChI InChI=1S/C26H22F3N3O/c1-14-8-23-24(12-20(14)26(27,28)29)32-25(33)13-22(31-23)18-5-3-4-17(10-18)19-9-15(2)30-21(11-19)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,32,33)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252836
PNG
(US9458176, 233)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)F)c(Cl)c2)n2C[C@@H](CF)OCCc12 |r|
Show InChI InChI=1S/C22H21ClF3N3O2/c1-12-7-15(8-13(2)27-12)20-18-5-6-30-16(10-24)11-29(18)21(28-20)14-3-4-19(17(23)9-14)31-22(25)26/h3-4,7-9,16,22H,5-6,10-11H2,1-2H3/t16-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332962
PNG
(7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...)
Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1cccnc1 |c:4|
Show InChI InChI=1S/C22H16F3N3O/c1-13-8-19-20(10-17(13)22(23,24)25)28-21(29)11-18(27-19)15-5-2-4-14(9-15)16-6-3-7-26-12-16/h2-10,12H,11H2,1H3,(H,28,29)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252834
PNG
(US9458176, 231)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-17(9-14(2)28-13)21-19-6-7-31-15(3)12-30(19)22(29-21)16-4-5-20(18(10-16)11-24)32-23(25,26)27/h4-5,8-10,15H,6-7,11-12H2,1-3H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252804
PNG
(US9458176, 201)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(CF)c1 |r|
Show InChI InChI=1S/C23H22F5N3O2/c1-13-7-15(8-16(10-24)29-13)21-19-5-6-33-17(11-25)12-31(19)22(30-21)14-3-4-18(23(26,27)28)20(9-14)32-2/h3-4,7-9,17H,5-6,10-12H2,1-2H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252845
PNG
(US9458176, 242)
Show SMILES CC(C)Oc1ccc(cc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C25H31N3O2/c1-15(2)30-23-8-7-20(11-16(23)3)25-27-24(21-12-17(4)26-18(5)13-21)22-9-10-29-19(6)14-28(22)25/h7-8,11-13,15,19H,9-10,14H2,1-6H3/t19-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252642
PNG
(US9458176, 39)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(CF)c1)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C22H21F4N3O2/c1-13-9-15(5-7-27-13)20-18-6-8-30-14(2)12-29(18)21(28-20)16-3-4-19(17(10-16)11-23)31-22(24,25)26/h3-5,7,9-10,14H,6,8,11-12H2,1-2H3/t14-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252619
PNG
(US9458176, 16)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H23F4N3O3/c1-13-8-16(9-14(2)28-13)21-18-6-7-32-17(11-24)12-30(18)22(29-21)15-4-5-19(20(10-15)31-3)33-23(25,26)27/h4-5,8-10,17H,6-7,11-12H2,1-3H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252638
PNG
(US9458176, 35)
Show SMILES CC(C)Oc1ccc(cc1Cl)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H28ClN3O2/c1-14(2)30-22-7-6-18(12-20(22)25)24-27-23(19-10-15(3)26-16(4)11-19)21-8-9-29-17(5)13-28(21)24/h6-7,10-12,14,17H,8-9,13H2,1-5H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252637
PNG
(US9458176, 34)
Show SMILES CCOc1ccc(cc1Cl)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H26ClN3O2/c1-5-28-21-7-6-17(12-19(21)24)23-26-22(18-10-14(2)25-15(3)11-18)20-8-9-29-16(4)13-27(20)23/h6-7,10-12,16H,5,8-9,13H2,1-4H3/t16-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252635
PNG
(US9458176, 32)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(Cl)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C22H22ClF2N3O2/c1-12-8-16(9-13(2)26-12)20-18-6-7-29-14(3)11-28(18)21(27-20)15-4-5-19(17(23)10-15)30-22(24)25/h4-5,8-10,14,22H,6-7,11H2,1-3H3/t14-/m1/s1
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n/an/a 2.80n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252839
PNG
(US9458176, 236)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)F)c(CF)c1)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C22H22F3N3O2/c1-13-9-15(5-7-26-13)20-18-6-8-29-14(2)12-28(18)21(27-20)16-3-4-19(30-22(24)25)17(10-16)11-23/h3-5,7,9-10,14,22H,6,8,11-12H2,1-2H3/t14-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50062522
PNG
((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c21-20(19(24)25,15-9-13(15)18(22)23)10-14-11-5-1-3-7-16(11)26-17-8-4-2-6-12(14)17/h1-8,13-15H,9-10,21H2,(H,22,23)(H,24,25)/t13-,15-,20-/m0/s1
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n/an/a 2.90n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells

Bioorg Med Chem 16: 4359-66 (2008)


Article DOI: 10.1016/j.bmc.2008.02.066
BindingDB Entry DOI: 10.7270/Q2PG1SMM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252844
PNG
(US9458176, 241)
Show SMILES CCOc1ccc(cc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H29N3O2/c1-6-28-22-8-7-19(11-15(22)2)24-26-23(20-12-16(3)25-17(4)13-20)21-9-10-29-18(5)14-27(21)24/h7-8,11-13,18H,6,9-10,14H2,1-5H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252622
PNG
(US9458176, 19)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC2CC2)c(Cl)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H26ClN3O2/c1-14-10-18(11-15(2)26-14)23-21-8-9-29-16(3)13-28(21)24(27-23)17-4-7-22(20(25)12-17)30-19-5-6-19/h4,7,10-12,16,19H,5-6,8-9,13H2,1-3H3/t16-/m1/s1
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n/an/a 3n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332967
PNG
(8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...)
Show SMILES Clc1ccc2N=C(CC(=O)Nc2c1)c1cccc(c1)-c1ccncc1 |c:5|
Show InChI InChI=1S/C20H14ClN3O/c21-16-4-5-17-19(11-16)24-20(25)12-18(23-17)15-3-1-2-14(10-15)13-6-8-22-9-7-13/h1-11H,12H2,(H,24,25)
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n/an/a 3n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332963
PNG
(4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...)
Show SMILES Cc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:16|
Show InChI InChI=1S/C24H20F3N3O/c1-13-7-21-22(11-19(13)24(25,26)27)30-23(31)12-20(29-21)17-6-4-5-16(10-17)18-8-14(2)28-15(3)9-18/h4-11H,12H2,1-3H3,(H,30,31)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332962
PNG
(7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...)
Show SMILES Cc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1cccnc1 |c:4|
Show InChI InChI=1S/C22H16F3N3O/c1-13-8-19-20(10-17(13)22(23,24)25)28-21(29)11-18(27-19)15-5-2-4-14(9-15)16-6-3-7-26-12-16/h2-10,12H,11H2,1H3,(H,28,29)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252756
PNG
(US9458176, 153)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(Cl)c1)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C21H19ClF3N3O2/c1-12-9-14(5-7-26-12)19-17-6-8-29-13(2)11-28(17)20(27-19)15-3-4-18(16(22)10-15)30-21(23,24)25/h3-5,7,9-10,13H,6,8,11H2,1-2H3/t13-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252701
PNG
(US9458176, 98)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(F)c(OCC2CCC2)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C26H30FN3O2/c1-16-11-21(12-17(2)28-16)25-23-9-10-31-18(3)14-30(23)26(29-25)20-7-8-22(27)24(13-20)32-15-19-5-4-6-19/h7-8,11-13,18-19H,4-6,9-10,14-15H2,1-3H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252628
PNG
(US9458176, 25)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H24F3N3O3/c1-13-9-17(10-14(2)27-13)21-18-7-8-31-15(3)12-29(18)22(28-21)16-5-6-19(20(11-16)30-4)32-23(24,25)26/h5-6,9-11,15H,7-8,12H2,1-4H3/t15-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252623
PNG
(US9458176, 20)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC2CC2)c(C)c1)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C25H29N3O2/c1-15-11-19(5-8-23(15)30-21-6-7-21)25-27-24(20-12-16(2)26-17(3)13-20)22-9-10-29-18(4)14-28(22)25/h5,8,11-13,18,21H,6-7,9-10,14H2,1-4H3/t18-/m1/s1
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n/an/a 3.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50376408
PNG
(CHEMBL409928)
Show SMILES N[C@@](CC1c2ccccc2Oc2ccccc12)([C@H]1C[C@]1(F)C(O)=O)C(O)=O
Show InChI InChI=1S/C20H18FNO5/c21-19(17(23)24)10-16(19)20(22,18(25)26)9-13-11-5-1-3-7-14(11)27-15-8-4-2-6-12(13)15/h1-8,13,16H,9-10,22H2,(H,23,24)(H,25,26)/t16-,19+,20-/m0/s1
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n/an/a 3.49n/an/an/an/an/an/a



Taisho Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells

Bioorg Med Chem 16: 4359-66 (2008)


Article DOI: 10.1016/j.bmc.2008.02.066
BindingDB Entry DOI: 10.7270/Q2PG1SMM
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252630
PNG
(US9458176, 27)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)F)c(C)c2)n2C[C@@H](CF)OCCc12 |r|
Show InChI InChI=1S/C23H24F3N3O2/c1-13-8-16(4-5-20(13)31-23(25)26)22-28-21(17-9-14(2)27-15(3)10-17)19-6-7-30-18(11-24)12-29(19)22/h4-5,8-10,18,23H,6-7,11-12H2,1-3H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252798
PNG
(US9458176, 195)
Show SMILES Cc1cc(cc(C)n1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12 |r|
Show InChI InChI=1S/C23H20F4N4O2/c1-13-7-16(8-14(2)29-13)21-19-5-6-32-18(10-24)12-31(19)22(30-21)15-3-4-20(17(9-15)11-28)33-23(25,26)27/h3-4,7-9,18H,5-6,10,12H2,1-2H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252620
PNG
(US9458176, 17)
Show SMILES COc1cc(ccc1OC(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C22H21F4N3O3/c1-13-9-14(5-7-27-13)20-17-6-8-31-16(11-23)12-29(17)21(28-20)15-3-4-18(19(10-15)30-2)32-22(24,25)26/h3-5,7,9-10,16H,6,8,11-12H2,1-2H3/t16-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252681
PNG
(US9458176, 78)
Show SMILES CC[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(Cl)c(OC)c1)-c1ccnc(C)c1 |r|
Show InChI InChI=1S/C22H24ClN3O2/c1-4-17-13-26-19(8-10-28-17)21(15-7-9-24-14(2)11-15)25-22(26)16-5-6-18(23)20(12-16)27-3/h5-7,9,11-12,17H,4,8,10,13H2,1-3H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252632
PNG
(US9458176, 29)
Show SMILES COc1cc(ccc1C(F)(F)F)-c1nc(c2CCO[C@H](CF)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-16(9-14(2)28-13)21-19-6-7-32-17(11-24)12-30(19)22(29-21)15-4-5-18(23(25,26)27)20(10-15)31-3/h4-5,8-10,17H,6-7,11-12H2,1-3H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252799
PNG
(US9458176, 196)
Show SMILES Cc1cc(ccn1)-c1nc(-c2ccc(OC(F)(F)F)c(c2)C#N)n2C[C@@H](CF)OCCc12 |r|
Show InChI InChI=1S/C22H18F4N4O2/c1-13-8-14(4-6-28-13)20-18-5-7-31-17(10-23)12-30(18)21(29-20)15-2-3-19(16(9-15)11-27)32-22(24,25)26/h2-4,6,8-9,17H,5,7,10,12H2,1H3/t17-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252828
PNG
(US9458176, 225)
Show SMILES CCOc1cc(ccc1C)-c1nc(c2CCO[C@H](C)Cn12)-c1cc(C)nc(C)c1 |r|
Show InChI InChI=1S/C24H29N3O2/c1-6-28-22-13-19(8-7-15(22)2)24-26-23(20-11-16(3)25-17(4)12-20)21-9-10-29-18(5)14-27(21)24/h7-8,11-13,18H,6,9-10,14H2,1-5H3/t18-/m1/s1
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Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM252807
PNG
(US9458176, 204)
Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(OC(F)(F)F)c(C)c1)-c1cc(C)nc(CF)c1 |r|
Show InChI InChI=1S/C23H23F4N3O2/c1-13-8-16(4-5-20(13)32-23(25,26)27)22-29-21(17-9-14(2)28-18(10-17)11-24)19-6-7-31-15(3)12-30(19)22/h4-5,8-10,15H,6-7,11-12H2,1-3H3/t15-/m1/s1
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n/an/a 4n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...

US Patent US9458176 (2016)


BindingDB Entry DOI: 10.7270/Q2PK0F3D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM213143
PNG
(US9278960, 8-50 | US9636337, 8-50)
Show SMILES COc1ccc(cc1F)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O
Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-18-19(11-22(24(26)30)29-21(18)9-15)17-6-8-23(31-2)20(25)10-17/h5-13H,3-4H2,1-2H3,(H2,26,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...

US Patent US9663506 (2017)


BindingDB Entry DOI: 10.7270/Q2PC34H4
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM213143
PNG
(US9278960, 8-50 | US9636337, 8-50)
Show SMILES COc1ccc(cc1F)-c1cc(nc2cc(CCc3cnc(C)nc3)ccc12)C(N)=O
Show InChI InChI=1S/C24H21FN4O2/c1-14-27-12-16(13-28-14)4-3-15-5-7-18-19(11-22(24(26)30)29-21(18)9-15)17-6-8-23(31-2)20(25)10-17/h5-13H,3-4H2,1-2H3,(H2,26,30)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR...

US Patent US9636337 (2017)


BindingDB Entry DOI: 10.7270/Q2F191TK
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50376487
PNG
(CHEMBL261050)
Show SMILES CCc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-n1ccnc1 |c:5|
Show InChI InChI=1S/C21H17F3N4O/c1-2-13-9-18-19(10-16(13)21(22,23)24)27-20(29)11-17(26-18)14-4-3-5-15(8-14)28-7-6-25-12-28/h3-10,12H,2,11H2,1H3,(H,27,29)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]LY354740 from rat mGluR2

Bioorg Med Chem Lett 18: 2725-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.076
BindingDB Entry DOI: 10.7270/Q2S75H7D
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332965
PNG
(4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...)
Show SMILES Cc1cc(cc(n1)C1CC1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:19|
Show InChI InChI=1S/C26H22F3N3O/c1-14-8-23-24(12-20(14)26(27,28)29)32-25(33)13-22(31-23)18-5-3-4-17(10-18)19-9-15(2)30-21(11-19)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,32,33)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332964
PNG
(4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...)
Show SMILES CCc1cc(cc(C)n1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:17|
Show InChI InChI=1S/C25H22F3N3O/c1-4-19-11-18(9-15(3)29-19)16-6-5-7-17(10-16)21-13-24(32)31-23-12-20(25(26,27)28)14(2)8-22(23)30-21/h5-12H,4,13H2,1-3H3,(H,31,32)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332970
PNG
(7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:15|
Show InChI InChI=1S/C23H18F3N3O/c1-13-8-20-21(11-18(13)23(24,25)26)29-22(30)12-19(28-20)17-5-3-4-15(10-17)16-6-7-27-14(2)9-16/h3-11H,12H2,1-2H3,(H,29,30)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product...

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332966
PNG
(7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...)
Show SMILES Cc1cc(ccn1)-c1cccc(c1)C1=Nc2cc(Cl)c(Cl)cc2NC(=O)C1 |t:15|
Show InChI InChI=1S/C21H15Cl2N3O/c1-12-7-14(5-6-24-12)13-3-2-4-15(8-13)18-11-21(27)26-20-10-17(23)16(22)9-19(20)25-18/h2-10H,11H2,1H3,(H,26,27)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332972
PNG
(7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...)
Show SMILES CCOc1cc2N=C(CC(=O)Nc2cc1C(F)(F)F)c1cccc(c1)-c1ccncc1 |c:6|
Show InChI InChI=1S/C23H18F3N3O2/c1-2-31-21-12-20-19(11-17(21)23(24,25)26)29-22(30)13-18(28-20)16-5-3-4-15(10-16)14-6-8-27-9-7-14/h3-12H,2,13H2,1H3,(H,29,30)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50332971
PNG
(4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(...)
Show SMILES CC(C)c1cc(ccn1)-c1cccc(c1)C1=Nc2cc(C)c(cc2NC(=O)C1)C(F)(F)F |t:17|
Show InChI InChI=1S/C25H22F3N3O/c1-14(2)20-11-17(7-8-29-20)16-5-4-6-18(10-16)21-13-24(32)31-23-12-19(25(26,27)28)15(3)9-22(23)30-21/h4-12,14H,13H2,1-3H3,(H,31,32)
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F. Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Partial displacement of [3H]LY354740 from recombinant rat mGluR2

Bioorg Med Chem Lett 20: 6969-74 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.125
BindingDB Entry DOI: 10.7270/Q2X63N6R
More data for this
Ligand-Target Pair
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