Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252685 (US9458176, 82) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252846 (US9458176, 243) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252686 (US9458176, 83) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252847 (US9458176, 244) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252770 (US9458176, 167) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252612 (US9458176, 9) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252837 (US9458176, 234) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332966 (7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332964 (4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332965 (4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252836 (US9458176, 233) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332962 (7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252834 (US9458176, 231) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252804 (US9458176, 201) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252845 (US9458176, 242) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252642 (US9458176, 39) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252619 (US9458176, 16) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252638 (US9458176, 35) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252637 (US9458176, 34) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252635 (US9458176, 32) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252839 (US9458176, 236) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50062522 ((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells | Bioorg Med Chem 16: 4359-66 (2008) Article DOI: 10.1016/j.bmc.2008.02.066 BindingDB Entry DOI: 10.7270/Q2PG1SMM | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252844 (US9458176, 241) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252622 (US9458176, 19) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332967 (8-chloro-4-(3-(pyridin-4-yl)phenyl)-1H-benzo[b][1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332963 (4-(3-(2,6-dimethylpyridin-4-yl)phenyl)-7-methyl-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332962 (7-methyl-4-(3-(pyridin-3-yl)phenyl)-8-(trifluorome...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252756 (US9458176, 153) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252701 (US9458176, 98) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252628 (US9458176, 25) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252623 (US9458176, 20) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50376408 (CHEMBL409928) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.49 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd Curated by ChEMBL | Assay Description Displacement of [3H]-MGS0008 from mGluR2 expressed in CHO cells | Bioorg Med Chem 16: 4359-66 (2008) Article DOI: 10.1016/j.bmc.2008.02.066 BindingDB Entry DOI: 10.7270/Q2PG1SMM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252630 (US9458176, 27) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252798 (US9458176, 195) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252620 (US9458176, 17) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252681 (US9458176, 78) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252632 (US9458176, 29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252799 (US9458176, 196) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252828 (US9458176, 225) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM252807 (US9458176, 204) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | 25 |
Eisai R&D Management Co., Ltd. US Patent | Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ... | US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM213143 (US9278960, 8-50 | US9636337, 8-50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR... | US Patent US9663506 (2017) BindingDB Entry DOI: 10.7270/Q2PC34H4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM213143 (US9278960, 8-50 | US9636337, 8-50) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The utility of the compounds in accordance with the present invention as antagonists of metabotropic glutamate receptor activity, in particular mGluR... | US Patent US9636337 (2017) BindingDB Entry DOI: 10.7270/Q2F191TK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50376487 (CHEMBL261050) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd. Curated by ChEMBL | Assay Description Displacement of [3H]LY354740 from rat mGluR2 | Bioorg Med Chem Lett 18: 2725-9 (2008) Article DOI: 10.1016/j.bmcl.2008.02.076 BindingDB Entry DOI: 10.7270/Q2S75H7D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332965 (4-(3-(2-cyclopropyl-6-methylpyridin-4-yl)phenyl)-7...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332964 (4-(3-(2-ethyl-6-methylpyridin-4-yl)phenyl)-7-methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332970 (7-methyl-4-(3-(2-methylpyridin-4-yl)phenyl)-8-(tri...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Antagonist activity at recombinant rat mGluR2 expressed in forskolin-stimulated CHO cells assessed as inhibition of (1S,3R)-ACPD induced cAMP product... | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332966 (7,8-dichloro-4-(3-(2-methylpyridin-4-yl)phenyl)-1H...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332972 (7-ethoxy-4-(3-(pyridin-4-yl)phenyl)-8-(trifluorome...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM50332971 (4-(3-(2-isopropylpyridin-4-yl)phenyl)-7-methyl-8-(...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Partial displacement of [3H]LY354740 from recombinant rat mGluR2 | Bioorg Med Chem Lett 20: 6969-74 (2010) Article DOI: 10.1016/j.bmcl.2010.09.125 BindingDB Entry DOI: 10.7270/Q2X63N6R | |||||||||||
More data for this Ligand-Target Pair |
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