Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM223981 (6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthala...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 144 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM223980 (6,7-Dichloro-N-cyclopentylquinolin-4-amine (2)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM223979 (7-Chloro-N-cyclopentylquinolin-4-amine (1)) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of SUV420H2 (unknown origin) by HMT assay | Bioorg Med Chem Lett 25: 1532-7 (2015) Article DOI: 10.1016/j.bmcl.2015.02.017 BindingDB Entry DOI: 10.7270/Q2TM7CSS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM223982 ((6,7-Dichloro-4-(cyclopentylamino)phthalazin-1-yl)...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 8.0 | 25 |
AbbVie | Assay Description Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ... | Nat Chem Biol 13: 317-324 (2017) Article DOI: 10.1038/nchembio.2282 BindingDB Entry DOI: 10.7270/Q2X065XF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM50063670 (CHEMBL3397332) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of SUV420H2 (unknown origin) by HMT assay | Bioorg Med Chem Lett 25: 1532-7 (2015) Article DOI: 10.1016/j.bmcl.2015.02.017 BindingDB Entry DOI: 10.7270/Q2TM7CSS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase KMT5C (Homo sapiens (Human)) | BDBM50051117 (CHEMBL3318285) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of North Carolina at Chapel Hill Curated by ChEMBL | Assay Description Inhibition of SUV420H2 (unknown origin) assessed as incorporation of tritium-labeled methyl group to lysine or arginine residues of peptide substrate... | J Med Chem 57: 6822-33 (2014) Article DOI: 10.1021/jm500871s BindingDB Entry DOI: 10.7270/Q2J9681Q | |||||||||||
More data for this Ligand-Target Pair |