Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM228656 (CAV (90-99) F92A | TTATVTKYWF) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 23 | n/a | n/a | n/a | 7.5 | 25 |
St. Paul's Hospital's Centre of Heart and Lung Innovation | Assay Description eNOS was diluted to varying concentrations in buffer containing 50 mM inorganic phosphate, 50 mM KCl, and 5 mM DTT, pH 7.5. A spectrophotometer was u... | J Biol Chem 289: 13273-83 (2014) Article DOI: 10.1074/jbc.M113.528695 BindingDB Entry DOI: 10.7270/Q2DJ5DJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM228655 (CAV (90-99) | TTFTVTKYWF) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 42 | n/a | n/a | n/a | 7.5 | 25 |
St. Paul's Hospital's Centre of Heart and Lung Innovation | Assay Description eNOS was diluted to varying concentrations in buffer containing 50 mM inorganic phosphate, 50 mM KCl, and 5 mM DTT, pH 7.5. A spectrophotometer was u... | J Biol Chem 289: 13273-83 (2014) Article DOI: 10.1074/jbc.M113.528695 BindingDB Entry DOI: 10.7270/Q2DJ5DJW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM130384 (6({[(2R,4S)4{[(6amino4methylpyridin2 yl)oxy]methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | 7.5 | 25 |
University of California at Irvine | Assay Description The buffer contained 50 mM HEPES (pH 7.5), 10% glycerol, and 100 mM NaCl, containing 1 mM imidazole. The spectral shift was monitored for a few minut... | Biochemistry 53: 5272-9 (2014) Article DOI: 10.1021/bi500561h BindingDB Entry DOI: 10.7270/Q2N01573 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM130385 (6(3amino2{5[2(6amino4methylpyridin2 yl)ethyl]pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | 7.5 | 25 |
University of California at Irvine | Assay Description The buffer contained 50 mM HEPES (pH 7.5), 10% glycerol, and 100 mM NaCl, containing 1 mM imidazole. The spectral shift was monitored for a few minut... | Biochemistry 53: 5272-9 (2014) Article DOI: 10.1021/bi500561h BindingDB Entry DOI: 10.7270/Q2N01573 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM130382 (4methyl6{[(3R,4R)4{[5(pyridin2 yl)pentyl]oxy}pyrro...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 4.13E+4 | n/a | n/a | n/a | 7.5 | 25 |
University of California at Irvine | Assay Description The buffer contained 50 mM HEPES (pH 7.5), 10% glycerol, and 100 mM NaCl, containing 1 mM imidazole. The spectral shift was monitored for a few minut... | Biochemistry 53: 5272-9 (2014) Article DOI: 10.1021/bi500561h BindingDB Entry DOI: 10.7270/Q2N01573 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Nitric oxide synthase, endothelial (Bos taurus (bovine)) | BDBM130383 (4methyl6{[(3R,4R)4{[5(4methylpyridin2 yl)pentyl]ox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 5.58E+4 | n/a | n/a | n/a | 7.5 | 25 |
University of California at Irvine | Assay Description The buffer contained 50 mM HEPES (pH 7.5), 10% glycerol, and 100 mM NaCl, containing 1 mM imidazole. The spectral shift was monitored for a few minut... | Biochemistry 53: 5272-9 (2014) Article DOI: 10.1021/bi500561h BindingDB Entry DOI: 10.7270/Q2N01573 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |