Found 6 hits of kd data for polymerid = 3592 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50425824
(CHEMBL2312289)Show InChI InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17)/t9-/m1/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
Lilly Biotechnology Center San Diego
Curated by ChEMBL
| Assay Description Binding affinity to C-terminally His-tagged SIRT1 catalytic domain (241 to 516 amino acid residues plus EGHHHHHH) (unknown origin) expressed in bacul... |
J Med Chem 56: 963-9 (2013)
Article DOI: 10.1021/jm301431y BindingDB Entry DOI: 10.7270/Q2B56M22 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50228364
(3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1 Show InChI InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity to SIRT1 |
J Med Chem 52: 1275-83 (2010)
Article DOI: 10.1021/jm8012954 BindingDB Entry DOI: 10.7270/Q2ZC82V5 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50228364
(3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imi...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1 Show InChI InChI=1S/C26H29N5O4S/c1-33-22-12-17(13-23(34-2)24(22)35-3)25(32)28-20-7-5-4-6-19(20)21-15-31-18(16-36-26(31)29-21)14-30-10-8-27-9-11-30/h4-7,12-13,15-16,27H,8-11,14H2,1-3H3,(H,28,32) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a |
Sirtris Pharmaceuticals Inc.
Curated by ChEMBL
| Assay Description Binding affinity to human SIRT1 by isothermal titration calorimetry |
Nature 450: 712-716 (2007)
Article DOI: 10.1038/nature06261 BindingDB Entry DOI: 10.7270/Q2765G67 |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576690
(CHEMBL4873772)Show SMILES O=C(NCCOCCOCCOCCNC(=O)c1cccc(c1)-c1cccnc1)c1cccc(c1)-c1cccnc1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to chip-immobilized recombinant human SIRT1 measured after 300 secs by surface plasmon resonance method |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576701
(CHEMBL4867959)Show SMILES O=C(NCCCCCCNC(=O)c1cccc(c1)-c1cccnc1)c1cccc(c1)-c1cccnc1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to chip-immobilized recombinant human SIRT1 measured after 300 secs by surface plasmon resonance method |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |
NAD-dependent protein deacetylase sirtuin-1
(Homo sapiens (Human)) | BDBM50576689
(CHEMBL4872893)Show SMILES COc1cc(CC(=O)NCCCCCCNC(=O)c2cccc(c2)-c2cccnc2)cc(OC)c1OC | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.39E+5 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to chip-immobilized recombinant human SIRT1 measured after 300 secs by surface plasmon resonance method |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116328 BindingDB Entry DOI: 10.7270/Q23F4TGR |
More data for this Ligand-Target Pair | |