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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50480872 (CHEMBL582896) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 0.0314 | n/a | n/a | n/a | n/a | n/a |
Universita degli studi di Salerno Curated by ChEMBL | Assay Description Binding affinity to Bcl-XL BH3 domain | J Med Chem 52: 7856-67 (2009) Article DOI: 10.1021/jm9010687 BindingDB Entry DOI: 10.7270/Q23F4SGB | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM21447 (4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assay | J Med Chem 56: 5514-40 (2014) Article DOI: 10.1021/jm400556w BindingDB Entry DOI: 10.7270/Q2X92CQT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50436625 (CHEMBL2398169) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assay | J Med Chem 56: 5514-40 (2014) Article DOI: 10.1021/jm400556w BindingDB Entry DOI: 10.7270/Q2X92CQT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM21447 (4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 0.370 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to Bcl-Xl | J Med Chem 54: 1914-26 (2011) Article DOI: 10.1021/jm101596e BindingDB Entry DOI: 10.7270/Q27P8ZP8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM139041 (US8883784, 2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to N-terminal GST-tagged BCL-XL (unknown origin) assessed as equilibrium dissociation constant by SPR analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00162 BindingDB Entry DOI: 10.7270/Q2R78JW5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM139040 (US8883784, 1) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to N-terminal GST-tagged BCL-XL (unknown origin) assessed as equilibrium dissociation constant by SPR analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00162 BindingDB Entry DOI: 10.7270/Q2R78JW5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) (Homo sapiens (Human)) | BDBM109236 (WEHI-539) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.10 | 1.40 | n/a | n/a | n/a | 7.4 | n/a |
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia | Assay Description The protocols for tight and weak binders were described in Biacore S51 assay set-up with a flow rate of 30 µL/min. For His-Bcl-2 protein assays... | Nat Chem Biol 9: 390-7 (2013) Article DOI: 10.1038/nchembio.1246 BindingDB Entry DOI: 10.7270/Q2QJ7FZ7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50270877 ((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute Curated by ChEMBL | Assay Description Displacement of biotin-tagged LWAAQRYGRELRRMSDEFEGSFKGL from human BCL-XL expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay | J Med Chem 47: 5809-15 (2004) Article DOI: 10.1021/acs.jmedchem.1c00517 BindingDB Entry DOI: 10.7270/Q2NK3JX7 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50586598 (CHEMBL5077514) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute Curated by ChEMBL | Assay Description Displacement of biotin-tagged LWAAQRYGRELRRMSDEFEGSFKGL from human BCL-XL expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay | J Med Chem 47: 5809-15 (2004) Article DOI: 10.1021/acs.jmedchem.1c00517 BindingDB Entry DOI: 10.7270/Q2NK3JX7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50586597 (CHEMBL5073297) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute Curated by ChEMBL | Assay Description Displacement of biotin-tagged LWAAQRYGRELRRMSDEFEGSFKGL from human BCL-XL expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay | J Med Chem 47: 5809-15 (2004) Article DOI: 10.1021/acs.jmedchem.1c00517 BindingDB Entry DOI: 10.7270/Q2NK3JX7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50172738 (CHEMBL441321 | GQVGRQLAIIGDDINR) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a |
University of Washington Curated by ChEMBL | Assay Description Binding affinity for GST-tagged human wild type Bcl-2-like protein 1 expressed in Escherichia coli BL21 cells at 35 nM Bodipy-labelled compound after... | Bioorg Med Chem Lett 21: 4951-5 (2011) Article DOI: 10.1016/j.bmcl.2011.06.134 BindingDB Entry DOI: 10.7270/Q2DB8287 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM109232 (6-(8-(2-(Benzothiazol-2-yl)hydrazono)-5,6,7,8-tetr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assay | J Med Chem 56: 5514-40 (2014) Article DOI: 10.1021/jm400556w BindingDB Entry DOI: 10.7270/Q2X92CQT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50339777 ((R)-N-(7-(4-((4'-chlorobiphenyl-2-yl)methyl)pipera...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to Bcl-Xl | J Med Chem 54: 1914-26 (2011) Article DOI: 10.1021/jm101596e BindingDB Entry DOI: 10.7270/Q27P8ZP8 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50020938 (CHEMBL3287301) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | <5 | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assay | ACS Med Chem Lett 5: 662-7 (2014) Article DOI: 10.1021/ml500030p BindingDB Entry DOI: 10.7270/Q2KP83QG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50586596 (CHEMBL5087367) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a |
Human BioMolecular Research Institute Curated by ChEMBL | Assay Description Displacement of biotin-tagged LWAAQRYGRELRRMSDEFEGSFKGL from human BCL-XL expressed in Escherichia coli measured after 2 hrs by AlphaScreen assay | J Med Chem 47: 5809-15 (2004) Article DOI: 10.1021/acs.jmedchem.1c00517 BindingDB Entry DOI: 10.7270/Q2NK3JX7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50020930 (CHEMBL3287293) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assay | ACS Med Chem Lett 5: 662-7 (2014) Article DOI: 10.1021/ml500030p BindingDB Entry DOI: 10.7270/Q2KP83QG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Isoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL) (Homo sapiens (Human)) | BDBM218795 (130E7 | Ac-λIAQELRRIGDEFNAYYARR-NH2) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 25.5 | n/a | n/a | n/a | 7.4 | 298.15 |
University of California, Riverside | Assay Description One hundred microliters of a 600 ng/mL solution of biotin-BID (Biotin-lc-EDIIRNIARHLAQVGDSMDR-NH2, where lc indicates a hydrocarbon chain of six meth... | ACS Chem Biol 12: 444-455 (2017) Article DOI: 10.1021/acschembio.6b00962 BindingDB Entry DOI: 10.7270/Q2P26WZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50020929 (CHEMBL3287292) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a |
Genentech Curated by ChEMBL | Assay Description Binding affinity to GST-tagged Bcl-Xl (unknown origin) by surface plasmon resonance assay | ACS Med Chem Lett 5: 662-7 (2014) Article DOI: 10.1021/ml500030p BindingDB Entry DOI: 10.7270/Q2KP83QG | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM174845 (US9115061, XII) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | n/a | 40 | n/a | n/a | n/a | 7.4 | n/a |
BURNHAM INSTITUTE FOR MEDICAL RESEARCH US Patent | Assay Description Titrations were performed using a VP-ITC or ITC200 calorimeter from Microcal (Northampton, Mass.). BCL-XL was used at concentrations between 25 and 1... | US Patent US9115061 (2015) BindingDB Entry DOI: 10.7270/Q2TB15PX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552927 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552926 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552931 ((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM60828 (ABT-199 | BDBM189459 | US10213433, Compound 5 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50270877 ((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552930 ((R)-4-(4-((5,5-Dimethyl-2-(3-methylbicyclo[1.1.1]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552913 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50270877 ((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552913 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552926 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552927 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552930 ((R)-4-(4-((5,5-Dimethyl-2-(3-methylbicyclo[1.1.1]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552931 ((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM60828 (ABT-199 | BDBM189459 | US10213433, Compound 5 | US...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50436648 (CHEMBL2398286) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 61 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to human GST-tagged Bcl-Xl assessed as direct binding constant at steady state by surface plasmon resonance assay | J Med Chem 56: 5514-40 (2014) Article DOI: 10.1021/jm400556w BindingDB Entry DOI: 10.7270/Q2X92CQT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50436648 (CHEMBL2398286) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a |
The Walter and Eliza Hall Institute of Medical Research Curated by ChEMBL | Assay Description Binding affinity to human GST-tagged Bcl-Xl assessed as dissociation rate by surface plasmon resonance assay | J Med Chem 56: 5514-40 (2014) Article DOI: 10.1021/jm400556w BindingDB Entry DOI: 10.7270/Q2X92CQT | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM50566652 (CHEMBL4871228) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to Bcl-xl (unknown origin) measured by surface plasmon resonance based pull down assay | Citation and Details Article DOI: 10.1016/j.bmc.2021.116282 BindingDB Entry DOI: 10.7270/Q2T157DK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552919 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall... | Citation and Details BindingDB Entry DOI: 10.7270/Q29K4G5T | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552928 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552925 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552924 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552923 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552922 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552921 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552920 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552919 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4,4-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552918 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552917 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552916 (2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552915 (2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((2-(3-e...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bcl-2-like protein 1 (Homo sapiens (Human)) | BDBM552914 (2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((4,4-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HD7ZW9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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