Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 8.30 | 5.20 | n/a | n/a | n/a | 7.5 | 25 |
Hebrew University of Jerusalem | Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH... | J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Homo sapiens (Human)) | BDBM50017712 ((-)-reserpine | (3beta,16beta,17alpha,18beta,20alp...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | DrugBank PDB Article PubMed | n/a | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a |
Organix Inc Curated by ChEMBL | Assay Description Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assay | J Med Chem 61: 9121-9131 (2018) Article DOI: 10.1021/acs.jmedchem.8b00542 BindingDB Entry DOI: 10.7270/Q2KH0QZ9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Synaptic vesicular amine transporter (Homo sapiens (Human)) | BDBM50459619 (CHEMBL4206824) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 71 | n/a | n/a | n/a | n/a | n/a |
Organix Inc Curated by ChEMBL | Assay Description Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assay | J Med Chem 61: 9121-9131 (2018) Article DOI: 10.1021/acs.jmedchem.8b00542 BindingDB Entry DOI: 10.7270/Q2KH0QZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Homo sapiens (Human)) | BDBM50459625 (CHEMBL4205254) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a |
Organix Inc Curated by ChEMBL | Assay Description Displacement of [3H](+)-syn-Ethyl 1-(2-(2,4-Dioxo-1,2-dihydroquinazolin-3(4H)-yl)ethyl)-4-(4-fluorophenyl)piperidine-3-carboxylate from human VMAT2 e... | J Med Chem 61: 9121-9131 (2018) Article DOI: 10.1021/acs.jmedchem.8b00542 BindingDB Entry DOI: 10.7270/Q2KH0QZ9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Homo sapiens (Human)) | BDBM50459629 (CHEMBL4207838) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a |
Organix Inc Curated by ChEMBL | Assay Description Binding affinity to human VMAT2 expressed in HEK293 cell membranes by scintillation counting method based saturation binding assay | J Med Chem 61: 9121-9131 (2018) Article DOI: 10.1021/acs.jmedchem.8b00542 BindingDB Entry DOI: 10.7270/Q2KH0QZ9 | |||||||||||
More data for this Ligand-Target Pair |