Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50427294 (CHEMBL2325429 | SB-743921) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a |
The Beatson Institute for Cancer Research Curated by ChEMBL | Assay Description Binding affinity to human wild type Eg5 at 250 uM by isothermal calorimetric analysis | J Med Chem 56: 6317-29 (2013) Article DOI: 10.1021/jm4006274 BindingDB Entry DOI: 10.7270/Q2M32X5D | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50468755 (CHEMBL4283764) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titratio... | Eur J Med Chem 156: 641-651 (2018) Article DOI: 10.1016/j.ejmech.2018.07.006 BindingDB Entry DOI: 10.7270/Q2445Q52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50293744 (2-(4-sulfamoylphenylamino)-1-(2-(trifluoromethyl)b...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50431886 (CHEMBL1413473) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 665 | n/a | n/a | n/a | n/a | n/a |
University College London Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-tagged human Eg5 motor domain (1 to 368 residues) expressed in Escherichia coli BL21 (DE3) by isothermal titratio... | Eur J Med Chem 156: 641-651 (2018) Article DOI: 10.1016/j.ejmech.2018.07.006 BindingDB Entry DOI: 10.7270/Q2445Q52 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50293759 (2-(4-methoxyphenylamino)-1-(2-(trifluoromethyl)ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50293756 (2-(4-(methylthio)phenylamino)-1-(2-(trifluoromethy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM50293753 (2-(4-(methylsulfonyl)phenylamino)-1-(2-(trifluorom...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM92866 (KSP Inhibitor, 4g) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM92865 (KSP Inhibitor, 4d) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kinesin-like protein KIF11 (Homo sapiens (Human)) | BDBM92864 (KSP Inhibitor, 4c) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Binding assay using temperature-dependent circular dichroism (TdCD). In TdCD, the loss of protein secondary structure was monitored as a function of... | Biochemistry 49: 8350-8 (2010) Article DOI: 10.1021/bi1005283 BindingDB Entry DOI: 10.7270/Q22V2DQ0 | |||||||||||
More data for this Ligand-Target Pair |