BindingDB PrimarySearch

Found 105 hits of kd data for polymerid = 50006705,50006705
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein polybromo-1 (Homo sapiens (Human))	BDBM50539801 (CHEMBL4648912 \| US11840533, Compound 70) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to human partial length PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assay				J Med Chem 63: 7186-7210 (2020) Article DOI: 10.1021/acs.jmedchem.0c00456 BindingDB Entry DOI: 10.7270/Q2PK0KPP
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50539801 (CHEMBL4648912 \| US11840533, Compound 70) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago Curated by ChEMBL					Assay Description Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay				J Med Chem 63: 7186-7210 (2020) Article DOI: 10.1021/acs.jmedchem.0c00456 BindingDB Entry DOI: 10.7270/Q2PK0KPP
University of Illinois at Chicago Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM394399 (US10308614, Example 1 \| tert-butyl 4-(3-amino-6-(2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (5) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM394530 ((R)-1-(4-(3-amino-6-(2- \| US10308614, Example 131) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50158688 (CHEMBL3752911) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM394406 (2-(6-amino-5-(piperazin- \| US10308614, Example 7) Show SMILES Nc1nnc(cc1N1CCNCC1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (5) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50182280 (CHEMBL3819245) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human PB1 isoform 5 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetry				J Med Chem 59: 4800-11 (2016) Article DOI: 10.1021/acs.jmedchem.6b00012 BindingDB Entry DOI: 10.7270/Q2G44S62
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50198447 (CHEMBL3899245) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC method				J Med Chem 59: 8787-8803 (2016) Article DOI: 10.1021/acs.jmedchem.6b00355 BindingDB Entry DOI: 10.7270/Q2CV4KQM
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50158688 (CHEMBL3752911) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50158688 (CHEMBL3752911) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Binding affinity to PB1 bromodomain5 (unknown origin) by isothermal titration calorimetric analysis				J Med Chem 59: 1271-98 (2016) Article DOI: 10.1021/acs.jmedchem.5b01514 BindingDB Entry DOI: 10.7270/Q2X92D6H
Genentech Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50266286 (CHEMBL4650213) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Reverse ITC (compound as receptor). Domain start/stop: S613-D734				Sci Adv 1: (2015) Article DOI: 10.1126/sciadv.1500723 BindingDB Entry DOI: 10.7270/Q2S75KX6
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549126 (CHEMBL4793170) Show SMILES Nc1nnc(cc1N1CCC(O)CC1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (5) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM394583 (2-(6-amino-5-phenylpyridazin-3-yl)phenol \| US10308...) Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50158688 (CHEMBL3752911) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human PB1 isoform 5 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration calorimetry				J Med Chem 59: 4800-11 (2016) Article DOI: 10.1021/acs.jmedchem.6b00012 BindingDB Entry DOI: 10.7270/Q2G44S62
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184979 (CHEMBL3822689) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184978 (CHEMBL3823524) Show SMILES Clc1cccc2n3CC\C(=C/N4CCCCC4)c3nc(=O)c12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	127	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184977 (CHEMBL3823132) Show SMILES CN(C)\C=C1/CCn2c1nc(=O)c1c(Cl)cccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	137	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184980 (CHEMBL3824067) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	142	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50182280 (CHEMBL3819245) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	152	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to human PB1 isoform 2 expressed in BL21 (DE3)-R3-BirA cells by isothermal titration Calorimetry				J Med Chem 59: 4800-11 (2016) Article DOI: 10.1021/acs.jmedchem.6b00012 BindingDB Entry DOI: 10.7270/Q2G44S62
Pfizer Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50598934 (CHEMBL5183240) Show SMILES Nc1nnc2c3ccccc3[nH]c2c1-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184981 (CHEMBL3823055) Show SMILES CCC(CC)\C=C1/CCn2c1nc(=O)c1c(Cl)cccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549127 (CHEMBL4790365) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	238	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (5) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549127 (CHEMBL4790365) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	252	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (2) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50584925 (CHEMBL5079885) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	<316	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human PBRM1 bromodomain 5 assessed as dissociation constant by BROMOscan method				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01871 BindingDB Entry DOI: 10.7270/Q2280CH8
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549127 (CHEMBL4790365) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	328	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184981 (CHEMBL3823055) Show SMILES CCC(CC)\C=C1/CCn2c1nc(=O)c1c(Cl)cccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00864 BindingDB Entry DOI: 10.7270/Q2X06C18
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549129 (CHEMBL4788561) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (2) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549126 (CHEMBL4793170) Show SMILES Nc1nnc(cc1N1CCC(O)CC1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	448	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549126 (CHEMBL4793170) Show SMILES Nc1nnc(cc1N1CCC(O)CC1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	464	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (2) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM394530 ((R)-1-(4-(3-amino-6-(2- \| US10308614, Example 131) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM394583 (2-(6-amino-5-phenylpyridazin-3-yl)phenol \| US10308...) Show SMILES Nc1nnc(cc1-c1ccccc1)-c1ccccc1O Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50598934 (CHEMBL5183240) Show SMILES Nc1nnc2c3ccccc3[nH]c2c1-c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00662 BindingDB Entry DOI: 10.7270/Q2TB1BX4
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184981 (CHEMBL3823055) Show SMILES CCC(CC)\C=C1/CCn2c1nc(=O)c1c(Cl)cccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00864 BindingDB Entry DOI: 10.7270/Q2X06C18
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549129 (CHEMBL4788561) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549131 (CHEMBL4742007) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	892	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (2) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549128 (CHEMBL4753080) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	911	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM220447 (US10633379, Compound X \| US9296741, 36) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Inhibition of ADP-induced platelet aggregation in human platelet-rich plasma				J Med Chem 60: 8369-8384 (2017) Article DOI: 10.1021/acs.jmedchem.7b00746 BindingDB Entry DOI: 10.7270/Q2251MB8
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM220447 (US10633379, Compound X \| US9296741, 36) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Binding affinity to human PBRM1 bromodamian-5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay				J Med Chem 60: 8369-8384 (2017) Article DOI: 10.1021/acs.jmedchem.7b00746 BindingDB Entry DOI: 10.7270/Q2251MB8
AbbVie Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184973 (CHEMBL3822828) Show SMILES O=c1nc2\C(CCn2c2ccccc12)=C\N1CCCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50591363 (CHEMBL5170275) Show SMILES Cc1cccc(c1)C1NC(=O)c2c(Cl)cccc2N1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00864 BindingDB Entry DOI: 10.7270/Q2X06C18
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549130 (CHEMBL4750084) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.87E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM394399 (US10308614, Example 1 \| tert-butyl 4-(3-amino-6-(2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.96E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (3) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein polybromo-1 (Homo sapiens (Human))	BDBM50184972 (CHEMBL3823525) Show SMILES O=c1nc2\C(CCn2c2ccccc12)=C\N1CCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a
University of Cambridge Curated by ChEMBL					Assay Description Binding affinity to His6-tagged human recombinant PB1 bromodomain isoform 5 expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by VP-ITC microca...				J Med Chem 59: 5095-101 (2016) Article DOI: 10.1021/acs.jmedchem.5b01997 BindingDB Entry DOI: 10.7270/Q22R3TKH
University of Cambridge Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50098305 (CHEMBL3590405) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	2.51E+3	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Binding affinity to PBRM1 in human HUT78 cells incubated for 45 mins by mass spectrometry based bromosphere chemoproteomic assay				J Med Chem 58: 6151-78 (2015) Article DOI: 10.1021/acs.jmedchem.5b00773 BindingDB Entry DOI: 10.7270/Q2FN17Z1
GlaxoSmithKline Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549128 (CHEMBL4753080) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	2.94E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (4) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50366670 (CHEMBL4173488) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by BROMOScan assay				J Med Chem 61: 6110-6120 (2018) Article DOI: 10.1021/acs.jmedchem.8b00483 BindingDB Entry DOI: 10.7270/Q26M39B1
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50549127 (CHEMBL4790365) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.11E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to polybromo-1 (4) (unknown origin) by ITC analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01242 BindingDB Entry DOI: 10.7270/Q2FR017S
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50198449 (CHEMBL3936967) Show SMILES Cc1[nH]nc2oc(=O)c3ccccc3c12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC method				J Med Chem 59: 8787-8803 (2016) Article DOI: 10.1021/acs.jmedchem.6b00355 BindingDB Entry DOI: 10.7270/Q2CV4KQM
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50591357 (CHEMBL5205514) Show SMILES CCC(CC)\C=C1/CCn2c1nc(=O)c1ccccc21 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00864 BindingDB Entry DOI: 10.7270/Q2X06C18
TBA					More data for this Ligand-Target Pair
Protein polybromo-1 (Homo sapiens (Human))	BDBM50198438 (CHEMBL3904183) Show SMILES CCCc1[nH]nc2oc(=O)c3ccccc3c12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Binding affinity to N-terminal his6-tagged human PB1 bromodomain 5 expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 at 15 uM by ITC method				J Med Chem 59: 8787-8803 (2016) Article DOI: 10.1021/acs.jmedchem.6b00355 BindingDB Entry DOI: 10.7270/Q2CV4KQM
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair

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