BindingDB PrimarySearch

Found 12 hits of kd data for polymerid = 6145
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50287585 (CHEMBL4169775) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a
University of California-Riverside Curated by ChEMBL					Assay Description Binding affinity to recombinant human MMP12 catalytic domain (Gly106 to Gly26 residues) expressed in Escherichia coli BL21 codon plus by 1D 1H alipha...				ACS Med Chem Lett 9: 137-142 (2018) Article DOI: 10.1021/acsmedchemlett.7b00483 BindingDB Entry DOI: 10.7270/Q29Z97F6
University of California-Riverside Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50287585 (CHEMBL4169775) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	<50	n/a	n/a	n/a	n/a	n/a
University of California-Riverside Curated by ChEMBL					Assay Description Binding affinity to recombinant human MMP12 catalytic domain (Gly106 to Gly26 residues) expressed in Escherichia coli BL21 codon plus by 2D [15N,1H] ...				ACS Med Chem Lett 9: 137-142 (2018) Article DOI: 10.1021/acsmedchemlett.7b00483 BindingDB Entry DOI: 10.7270/Q29Z97F6
University of California-Riverside Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29018 ((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	n/a	n/a	1.49E+5	1.54E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair				3D Structure (crystal)
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29017 ((1S,5S,7R)-N-hydroxy-3-[(4-phenylphenyl)methyl]-6,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.99E+5	>5.00E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29016 ((1R,5S,7R)-N-hydroxy-2-oxo-3-[(4-phenylphenyl)meth...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.25E+5	>5.00E+5	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM50246196 (CHEMBL4065195) Show SMILES [Na+].[O-]S(=O)(=O)CCCNC(=O)CCCCC1CCSS1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	8.75E+5	n/a	n/a	n/a	n/a	n/a
University of Florence Curated by ChEMBL					Assay Description Binding affinity to human 15N-labeled MMP-12 catalytic domain (G106 to G263 residues) expressed in Escherichia coli BL21 Gold by 1H NSQC NMR method				J Med Chem 60: 9003-9011 (2017) Article DOI: 10.1021/acs.jmedchem.7b01237 BindingDB Entry DOI: 10.7270/Q2KP84K3
University of Florence Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29014 ((1R,5S,7R)-2-oxo-3-[(4-phenylphenyl)methyl]-6,8-di...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.54E+5	>1.00E+6	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29015 ((1S,5S,7R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.35E+5	>1.00E+6	n/a	n/a	n/a	7.0	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29022 (ethyl 1-(hydroxycarbamoyl)piperidine-4-carboxylate...) Show SMILES CCOC(=O)C1CCN(CC1)C(=O)NO Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.40E+6	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29021 ((1R,5S,7R)-3-benzyl-N-hydroxy-2-oxo-6,8-dioxa-3-az...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29020 ((1S,5S,7R)-3-benzyl-6,8-dioxa-3-azabicyclo[3.2.1]o...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair
Macrophage metalloelastase (Homo sapiens (Human))	BDBM29019 ((1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+7	n/a	n/a	n/a	7.2	25
University of Florence					Assay Description The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...				Bioorg Med Chem 14: 7392-403 (2006) Article DOI: 10.1016/j.bmc.2006.07.028 BindingDB Entry DOI: 10.7270/Q2TD9VPX
University of Florence					More data for this Ligand-Target Pair