Found 17 hits of kd data for polymerid = 7499 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50400616
(CHEMBL2203439)Show InChI InChI=1S/C17H16F3N3O2S/c1-11-13(21-8-7-15(11)25-10-17(18,19)20)9-26(24)16-22-12-5-3-4-6-14(12)23(16)2/h3-8H,9-10H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to heparin induced human Tau 441 at 50 pM to 500 nM after 30 mins |
ACS Med Chem Lett 3: 936-941 (2012)
Article DOI: 10.1021/ml300216t BindingDB Entry DOI: 10.7270/Q2Z320TV |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50384538
(CHEMBL2036419 | CHEMBL2036420)Show SMILES CN(C)c1ccc(cc1)\N=N\c1nc2ccc(OCCOCCOCCF)cc2s1 Show InChI InChI=1S/C21H25FN4O3S/c1-26(2)17-5-3-16(4-6-17)24-25-21-23-19-8-7-18(15-20(19)30-21)29-14-13-28-12-11-27-10-9-22/h3-8,15H,9-14H2,1-2H3/b25-24+ | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 44.8 | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human tau expressed in Escherichia coli after 30 mins by fluorescence assay |
ACS Med Chem Lett 3: 58-62 (2012)
Article DOI: 10.1021/ml200230e BindingDB Entry DOI: 10.7270/Q2PR7X1P |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50103964
(CHEMBL3593932)Show SMILES [O-][N+](=O)c1ccc(\C=C\C=C2/C(=O)N(Cc3ccc(OCCF)cc3)c3ccccc23)cc1 Show InChI InChI=1S/C26H21FN2O4/c27-16-17-33-22-14-10-20(11-15-22)18-28-25-7-2-1-5-23(25)24(26(28)30)6-3-4-19-8-12-21(13-9-19)29(31)32/h1-15H,16-18H2/b4-3+,24-6- | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
Washington University School of Medicine
Curated by ChEMBL
| Assay Description Binding affinity human recombinant tau (243 to 375) expressed in Escherichia coli BL21(DE3)RIL after 1 hr by scintillation counting |
J Med Chem 58: 6002-17 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00571 BindingDB Entry DOI: 10.7270/Q24Q7WRC |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601751
(US11642413, Compound 160313)Show SMILES CN(C)c1ccc(cn1)-c1ccc(cc1)-c1nc2ccc(NCCOCCOc3ccc4C(=O)N(Cc4c3)C3CCC(=O)NC3=O)cc2s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601742
(US11642413, Compound 159985)Show SMILES CN(C)c1ccc(cn1)-c1ccc(cc1)-c1nc2ccc(NCCOCCOCCOCCOCCOCCOc3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)cc2s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601749
(US11642413, Compound 160219)Show SMILES CN(C)c1ccc(cn1)-c1ccc(cc1)-c1nc2ccc(NCCOCCOc3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)cc2s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601754
(US11642413, Compound 160624)Show SMILES CN(C)c1ccc(cn1)-c1ccc(cc1)-c1nc2ccc(NCCOCCN3C(=O)CCC(N4Cc5cc(O)ccc5C4=O)C3=O)cc2s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601755
(US11642413, Compound 160744)Show SMILES CN(C)c1ccc(c(F)n1)-c1ccc(cc1)-c1cn2cc(OCCOCCOCCOCCOCCOCCOc3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)ccc2n1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601752
(US11642413, Compound 160275)Show SMILES CN(C)c1ccc2nc(sc2c1)-c1ccc(cc1)-c1ccc(NCCOCCOCCOCCOCCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)nc1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50434484
(CHEMBL2385165)Show SMILES CN(C)c1ccc(C=Cc2nc3ccc(I)cc3[nH]2)cc1 |w:8.8| Show InChI InChI=1S/C17H16IN3/c1-21(2)14-7-3-12(4-8-14)5-10-17-19-15-9-6-13(18)11-16(15)20-17/h3-11H,1-2H3,(H,19,20) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta... |
Bioorg Med Chem 21: 3356-62 (2013)
Article DOI: 10.1016/j.bmc.2013.02.054 BindingDB Entry DOI: 10.7270/Q23J3FB2 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50606489
(CHEMBL5220063)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(O)=O |r| | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 394 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112993 BindingDB Entry DOI: 10.7270/Q2P55SM1 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50434483
(CHEMBL2385164)Show InChI InChI=1S/C16H14IN3/c1-18-13-6-2-11(3-7-13)4-9-16-19-14-8-5-12(17)10-15(14)20-16/h2-10,18H,1H3,(H,19,20) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta... |
Bioorg Med Chem 21: 3356-62 (2013)
Article DOI: 10.1016/j.bmc.2013.02.054 BindingDB Entry DOI: 10.7270/Q23J3FB2 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601750
(US11642413, Compound 160273)Show SMILES CN(C)c1ccc(cn1)-c1ccc(cc1)-c1nc2ccc(NCCOCCOCCOCCOCCOCCOc3ccc4C(=O)N(Cc4c3)C3CCC(=O)NC3=O)cc2s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM601753
(US11642413, Compound 160383)Show SMILES CN(C)c1ccc2nc(sc2c1)-c1ccc(cc1)-c1ccc(NCCOCCOCCOCCOCCOCCOc2ccc3C(=O)N(Cc3c2)C2CCC(=O)NC2=O)nc1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2HM5DC8 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50295169
(CHEMBL4177337)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(=O)N[C@H](CCCNC(N)=N)C(O)=O |r| Show InChI InChI=1S/C169H270N62O59/c1-77(2)63-105(150(278)214-95(24-15-59-195-167(184)185)141(269)212-93(22-13-57-193-165(180)181)139(267)210-91(20-11-55-191-163(176)177)137(265)208-90(19-10-54-190-162(174)175)136(264)209-92(21-12-56-192-164(178)179)138(266)211-94(23-14-58-194-166(182)183)140(268)213-96(25-16-60-196-168(186)187)142(270)221-104(161(289)290)26-17-61-197-169(188)189)223-154(282)109(67-86-32-38-89(239)39-33-86)225-143(271)98(44-51-124(248)249)205-122(246)74-201-158(286)130(81(7)234)230-148(276)103(46-53-126(252)253)220-157(285)115-27-18-62-231(115)160(288)112(70-129(258)259)228-151(279)106(64-78(3)4)224-156(284)114(76-233)207-123(247)73-200-135(263)113(75-232)206-121(245)72-198-120(244)71-199-134(262)97(40-47-116(170)240)215-145(273)102(45-52-125(250)251)219-155(283)111(69-128(256)257)222-132(260)79(5)203-159(287)131(82(8)235)229-133(261)80(6)202-149(277)110(68-127(254)255)227-147(275)101(43-50-119(173)243)218-153(281)108(66-85-30-36-88(238)37-31-85)226-146(274)100(42-49-118(172)242)216-144(272)99(41-48-117(171)241)217-152(280)107(204-83(9)236)65-84-28-34-87(237)35-29-84/h28-39,77-82,90-115,130-131,232-235,237-239H,10-27,40-76H2,1-9H3,(H2,170,240)(H2,171,241)(H2,172,242)(H2,173,243)(H,198,244)(H,199,262)(H,200,263)(H,201,286)(H,202,277)(H,203,287)(H,204,236)(H,205,246)(H,206,245)(H,207,247)(H,208,265)(H,209,264)(H,210,267)(H,211,266)(H,212,269)(H,213,268)(H,214,278)(H,215,273)(H,216,272)(H,217,280)(H,218,281)(H,219,283)(H,220,285)(H,221,270)(H,222,260)(H,223,282)(H,224,284)(H,225,271)(H,226,274)(H,227,275)(H,228,279)(H,229,261)(H,230,276)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H,289,290)(H4,174,175,190)(H4,176,177,191)(H4,178,179,192)(H4,180,181,193)(H4,182,183,194)(H4,184,185,195)(H4,186,187,196)(H4,188,189,197)/t79-,80-,81+,82+,90+,91+,92+,93+,94+,95+,96+,97-,98-,99-,100-,101-,102-,103-,104+,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,130-,131-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 763 | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Binding affinity to human Tau (1 to 441 residues) by ITC method |
Eur J Med Chem 146: 251-259 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.063 BindingDB Entry DOI: 10.7270/Q2QZ2DH7 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | BDBM50434482
(CHEMBL2385163)Show InChI InChI=1S/C15H12IN3/c16-11-4-7-13-14(9-11)19-15(18-13)8-3-10-1-5-12(17)6-2-10/h1-9H,17H2,(H,18,19) | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 2.36E+3 | n/a | n/a | n/a | n/a | n/a |
Kyoto University
Curated by ChEMBL
| Assay Description Binding affinity to recombinant human tau (441 amino acid residues) aggregates expressed in Escherichia coli assessed as apparent dissociation consta... |
Bioorg Med Chem 21: 3356-62 (2013)
Article DOI: 10.1016/j.bmc.2013.02.054 BindingDB Entry DOI: 10.7270/Q23J3FB2 |
More data for this Ligand-Target Pair | |
Microtubule-associated protein tau
(Homo sapiens (Human)) | CHEMBL5290786
Show InChI InChI=1S/C16H14ClNOS/c1-2-5-16(19)18-12-6-3-4-7-14(12)20-15-9-8-11(17)10-13(15)18/h3-4,6-10H,2,5H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL CHEMBL PC cid PC sid UniChem
Similars
| | n/a | n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Antagonist activity at human muscarinic acetylcholine M3 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobi... |
Citation and Details
|
More data for this Ligand-Target Pair | |