Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191596 (6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191597 (3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191598 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191600 (2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191601 (3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191602 (3-((1-methyl-1Hpyrrolo[2,3-b]pyridin-3-yl)amino)is...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM50396019 (4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191603 (methyl 4'-(phenethylcarbamoyl)-[2,2'-bipyr...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 7.00E+3 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191599 (KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5A [1-588] (Homo sapiens (Human)) | BDBM191604 (8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobut...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a |
Emory University | Assay Description ITC experiments were carried out at an enzyme [E] concentration of 25-50 μM with 0.25-1 mM compound [I] concentration in the KDM5 storage buffer... | Cell Chem Biol 23: 769-81 (2016) Article DOI: 10.1016/j.chembiol.2016.06.006 BindingDB Entry DOI: 10.7270/Q2BZ64VH | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |