Found 16 hits of kd data for polymerid = 8407 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50460988
(CHEMBL4226482)Show SMILES O=S(=O)(Cc1cccc(c1)C#N)Nc1ccccc1-c1cccc2c1[nH]c1ccccc21 Show InChI InChI=1S/C26H19N3O2S/c27-16-18-7-5-8-19(15-18)17-32(30,31)29-25-14-4-2-10-21(25)23-12-6-11-22-20-9-1-3-13-24(20)28-26(22)23/h1-15,28-29H,17H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461016
(CHEMBL4226393)Show InChI InChI=1S/C20H16N2O/c1-13(23)21-18-11-4-2-7-14(18)16-9-6-10-17-15-8-3-5-12-19(15)22-20(16)17/h2-12,22H,1H3,(H,21,23) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461036
(CHEMBL4225366)Show SMILES Fc1ccc(cc1CS(=O)(=O)Nc1ccccc1-c1cccc2c1[nH]c1ccccc21)C#N Show InChI InChI=1S/C26H18FN3O2S/c27-23-13-12-17(15-28)14-18(23)16-33(31,32)30-25-11-4-2-7-20(25)22-9-5-8-21-19-6-1-3-10-24(19)29-26(21)22/h1-14,29-30H,16H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461031
(CHEMBL4228190)Show SMILES O=C(Cc1cccnc1)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12 Show InChI InChI=1S/C25H19N3O/c29-24(15-17-7-6-14-26-16-17)27-22-12-3-1-8-18(22)20-10-5-11-21-19-9-2-4-13-23(19)28-25(20)21/h1-14,16,28H,15H2,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461004
(CHEMBL4228373)Show SMILES CC(=O)Nc1cccc(C)c1-c1cccc2c3ccccc3[nH]c12 |(72.68,-7.47,;71.36,-8.24,;71.37,-9.78,;70.02,-7.48,;68.7,-8.26,;68.7,-9.8,;67.36,-10.58,;66.03,-9.81,;66.03,-8.26,;64.7,-7.49,;67.36,-7.5,;67.36,-5.96,;68.7,-5.18,;68.7,-3.62,;67.36,-2.86,;66.02,-3.64,;64.55,-3.18,;63.93,-1.78,;62.4,-1.62,;61.5,-2.87,;62.13,-4.27,;63.65,-4.42,;64.56,-5.67,;66.03,-5.18,)| Show InChI InChI=1S/C21H18N2O/c1-13-7-5-12-19(22-14(2)24)20(13)17-10-6-9-16-15-8-3-4-11-18(15)23-21(16)17/h3-12,23H,1-2H3,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461015
(CHEMBL4228040)Show InChI InChI=1S/C19H16N2O2S/c1-24(22,23)21-18-12-5-3-8-14(18)16-10-6-9-15-13-7-2-4-11-17(13)20-19(15)16/h2-12,20-21H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461017
(CHEMBL4229283)Show SMILES Cc1ccc(CC(=O)Nc2ccccc2-c2cccc3c4ccccc4[nH]c23)cn1 Show InChI InChI=1S/C26H21N3O/c1-17-13-14-18(16-27-17)15-25(30)28-23-11-4-2-7-19(23)21-9-6-10-22-20-8-3-5-12-24(20)29-26(21)22/h2-14,16,29H,15H2,1H3,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461018
(CHEMBL4228450)Show SMILES O=C(Cc1cnccn1)Nc1ccccc1-c1cccc2c3ccccc3[nH]c12 Show InChI InChI=1S/C24H18N4O/c29-23(14-16-15-25-12-13-26-16)27-21-10-3-1-6-17(21)19-8-5-9-20-18-7-2-4-11-22(18)28-24(19)20/h1-13,15,28H,14H2,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50461035
(CHEMBL4227531)Show SMILES CS(=O)(=O)Nc1cc(ccc1-c1cccc2c1[nH]c1ccccc21)C#N Show InChI InChI=1S/C20H15N3O2S/c1-26(24,25)23-19-11-13(12-21)9-10-15(19)17-7-4-6-16-14-5-2-3-8-18(14)22-20(16)17/h2-11,22-23H,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Binding affinity to PARP14 MD2 (A994 to N1191 residues) (unknown origin) expressed in bacterial expression system by ITC assay |
Bioorg Med Chem 26: 2965-2972 (2018)
Article DOI: 10.1016/j.bmc.2018.03.020
BindingDB Entry DOI: 10.7270/Q24T6N1Q |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50397960
(CHEMBL2179989)Show InChI InChI=1S/C11H10N2O4/c12-11(17)7-2-1-3-8(6-7)13-9(14)4-5-10(15)16/h1-6H,(H2,12,17)(H,13,14)(H,15,16)/b5-4- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a |
Ume£ University
Curated by ChEMBL
| Assay Description
Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells by isothermal titration calorimetry |
J Med Chem 55: 7706-18 (2012)
Article DOI: 10.1021/jm300746d
BindingDB Entry DOI: 10.7270/Q2GT5P9F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594269
(CHEMBL5187195)Show SMILES COC(=O)c1sccc1NS(=O)(=O)c1ccc(cc1[N+]([O-])=O)C(F)(F)F | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)Show SMILES NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@@H]1CCCNC1 |r| Show InChI InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01012
BindingDB Entry DOI: 10.7270/Q2Z03D7J |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50084621
(BMN 673 | Talazoparib)Show SMILES Cn1ncnc1[C@@H]1[C@H](Nc2cc(F)cc3c2c1n[nH]c3=O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C19H14F2N6O/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28/h2-8,15-16,24H,1H3,(H,26,28)/t15-,16-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01012
BindingDB Entry DOI: 10.7270/Q2Z03D7J |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50446130
(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)Show SMILES CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23 Show InChI InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01012
BindingDB Entry DOI: 10.7270/Q2Z03D7J |
More data for this
Ligand-Target Pair | |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50397961
(CHEMBL2179988)Show InChI InChI=1S/C11H10N2O4/c12-11(17)7-2-1-3-8(6-7)13-9(14)4-5-10(15)16/h1-6H,(H2,12,17)(H,13,14)(H,15,16)/b5-4+ | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| n/a | n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a |
Ume£ University
Curated by ChEMBL
| Assay Description
Binding affinity at human recombinant ARTD8 expressed in Escherichia coli BL21 (DE3) R3 pRARE cells by isothermal titration calorimetry |
J Med Chem 55: 7706-18 (2012)
Article DOI: 10.1021/jm300746d
BindingDB Entry DOI: 10.7270/Q2GT5P9F |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human)) | BDBM50594270
(CHEMBL5201988)Show SMILES COc1ccc(cc1)-n1[nH]c(C)c(Cc2c(Cl)cccc2Cl)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 1.62E+5 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00281
BindingDB Entry DOI: 10.7270/Q26D5Z03 |
More data for this
Ligand-Target Pair | |
Search and Browse
